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Guido J. Falcone

Associate Professor of Neurology; Academic Chief, Division of Neurocritical Care, Neurology; Director of Clinical Research in Neurocritical Care, Neurology; Training Director, Yale/AHA Bugher Center for Intracerebral Hemorrhage Research, Neurology; Staff Neurointensivist, Neurology

Contact Information

Guido J. Falcone, MD, ScD, MPH

Patient Care Location

Office Location



I am a Neurologist with subspecialty training in Neurocritical Care and Stroke, and an Epidemiologist with expertise in Population Genetics and Big Data. While on clinical duties, I treat critically ill patients that have sustained a significant neurological injury due to ischemic stroke, subarachnoid hemorrhage, intraparenchymal hemorrhage, traumatic brain injury, seizures, recent neurosurgery, decompensated neuromuscular diseases, and several others.

My research lies at the interphase of clinical neurology, neuroimaging, population genetics and genomic medicine. I am interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome and recurrence of stroke, both hemorrhagic and ischemic. Genetic variants influencing these phenotypes can be used for numerous applications, including: (1) identification of novel biological mechanisms involved in causing stroke and determining its severity and outcome, (2) answering non-genetic epidemiological questions using gene mutations as instruments (in the statistical sense of the word), and (3) risk stratification of patients according to their genetic profile. Through the International Stroke Genetics Consortium, I work in close collaboration with numerous investigators interested in stroke genomics from around the world.

Education & Training

  • Board Certification
    United Council for Neurologic Subspecialties, Neurocritical Care (2017)
  • Neurocritical Care Fellowship
    Harvard Medical School / Massachusetts General Hospital / Brigham and Women's Hospital (2016)
  • SPOTRIAS Fellowship
    Massachusetts General Hospital (2014)
  • ScD
    Harvard School of Public Health, Department of Epidemiology (2014)
  • MPH
    Harvard School of Public Health, Quantitative Methods (2010)
  • Neurology Residency
    F.L.E.N.I. (2008)
  • MD
    University of Buenos Aires School of Medicine (2002)

Honors & Recognition

AwardAwarding OrganizationDate
Paul Dudley White International Scholar Award (last author) - Highest ranking abstract from the United States submitted to the 2022 International Stroke ConferenceAmerican Heart Association2022
Michael S. Pessin Stroke Leadership PrizeAmerican Academy of Neurology2021
Get With The Guidelines (Stroke) Early Career Investigator AwardAmerican Heart Association2020
American Society of Clinical Investigation Young Physician-Scientist AwardAmerican Society of Clinical Investigation2020
Bernard J. Tyson Career Development AwardAmerican Heart Association2020
Paul Dudley White International Scholar Award (first author) - Highest ranking abstract from the United States submitted to the 2020 International Stroke ConferenceAmerican Heart Association2020
Robert G. Siekert New Investigator AwardAmerican Heart Association2020
Best e-poster, 2019 European Stroke Organization ConferenceEuropean Stroke Organization2019
Paul B. Beeson Emerging Leaders Career Development Award in AgingNational Institute on Aging2018
Neurocritical Care Society Research Training GrantNeurocritical Care Society2017
Yale Claude D. Pepper Older Americans Independence Center Research ScholarYale Claude D. Pepper Older Americans Independence Cente2017
Travel Award for Junior Investigators, International Stroke Genetics Consortium MeetingInternational Stroke Genetics Consortium2013
Travel Award for Junior Investigators, Neurocritical Care Society MeetingNeurocritical Care Society2013
Travel Award for Junior Investigators, International Stroke ConferenceAmerican Heart Association2013
magna cum laudeUniversity of Buenos Aires2003

Departments & Organizations