Nicolas Gaspard, PhD
Assistant Professor AdjunctAbout
Research
Publications
2024
Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome
van Putten M, Ruijter B, Horn J, van Rootselaar A, Tromp S, van Kranen-Mastenbroek V, Gaspard N, Hofmeijer J, Investigators F. Quantitative Characterization of Rhythmic and Periodic EEG Patterns in Patients in a Coma After Cardiac Arrest and Association With Outcome. Neurology 2024, 103: e209608. PMID: 38991197, DOI: 10.1212/wnl.0000000000209608.Peer-Reviewed Original ResearchTrends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis
Hanin A, Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Wainwright M, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L. Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis. Epilepsia 2024 PMID: 38837761, DOI: 10.1111/epi.18014.Peer-Reviewed Original ResearchNew-onset refractory status epilepticusSecond-line immunotherapyKetogenic dietStatus epilepticusDuration of status epilepticusRefractory status epilepticusStatus epilepticus onsetManagement of patientsEvolving treatment landscapeTreatment landscapeImmunotherapyConsensus recommendationsInterim analysisPatientsPatient outcomesAnakinraEpilepticusShort durationMedianORCIDietDaysTocilizumabIncreased useTreatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs
Au Y, Kananeh M, Rahangdale R, Moore T, Panza G, Gaspard N, Hirsch L, Fernandez A, Shah S. Treatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs. JAMA Neurology 2024, 81: 534-548. PMID: 38466294, DOI: 10.1001/jamaneurol.2024.0108.Peer-Reviewed Original ResearchAssociated with mortalityRefractory status epilepticusTreatment of refractory status epilepticusOutcome variablesPreferred Reporting ItemsAssociated with lower mortalityRisk of biasCompare outcome measuresPeer-reviewed studiesNon-English articlesStatus epilepticusBinary logistic regressionWeb of ScienceRSE etiologyReporting ItemsOutcome measuresStudy selectionPredictors of mortalitySystematic reviewLogistic regressionManual searchIntravenous anesthetic drugsRefractory status epilepticus treatmentTreatment goalsIndependent extractionComparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis
Jimenez A, Gopaul M, Asbell H, Aydemir S, Basha M, Batra A, Damien C, Day G, Eka O, Eschbach K, Fatima S, Fields M, Foreman B, Gerard E, Gofton T, Haider H, Hantus S, Hocker S, Jongeling A, Aparicio M, Kandula P, Kang P, Kazazian K, Kellogg M, Kim M, Lee J, Marcuse L, McGraw C, Mohamed W, Orozco J, Pimentel C, Punia V, Ramirez A, Steriade C, Struck A, Taraschenko O, Treister A, Yoo J, Zafar S, Zhou D, Zutshi D, Gaspard N, Hirsch L, Hanin A. Comparative analysis of patients with new onset refractory status epilepticus preceded by fever (febrile infection‐related epilepsy syndrome) versus without prior fever: An interim analysis. Epilepsia 2024, 65: e87-e96. PMID: 38625055, DOI: 10.1111/epi.17988.Peer-Reviewed Original ResearchFebrile infection-related epilepsy syndromeRefractory status epilepticusMacrophage inflammatory protein-1 alphaOnset refractory status epilepticusStatus epilepticusCerebrospinal fluidFIRES patientsCerebrospinal fluid interleukin-6Magnetic resonance imaging findingsComparative analysis of patientsAnalysis of patientsChemokine ligand 2Presenting symptomsFebrile infectionsClinical featuresGastrointestinal prodromeImaging findingsInflammatory biomarkersAntiseizure medicationsInterleukin-6Epilepsy syndromesInterim analysisPatientsEpilepticusFeverMachine Learning-informed Subtyping of Generalized Periodic Discharges in Cardiac Arrest (S23.006)
Karukonda V, Aghaeeaval M, Kandhare P, Zheng W, Jing J, Ghassemi M, Lee J, Herman S, Sivaraju A, Gaspard N, Hofmeijer J, van Putten M, Westover M, Amorim E. Machine Learning-informed Subtyping of Generalized Periodic Discharges in Cardiac Arrest (S23.006). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000204918.Peer-Reviewed Original ResearchClinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE)
Costello D, Matthews E, Aurangzeb S, Doran E, Stack J, Wesselingh R, Dugan P, Choi H, Depondt C, Devinsky O, Doherty C, Kwan P, Monif M, O'Brien T, Sen A, Gaspard N. Clinical outcomes among initial survivors of cryptogenic new‐onset refractory status epilepsy (NORSE). Epilepsia 2024, 65: 1581-1588. PMID: 38498313, DOI: 10.1111/epi.17950.Peer-Reviewed Original ResearchActive epilepsyClinical outcomesMental health outcomesMonths post-dischargeMonths of dischargeTreatment strategiesAcute phaseHealth outcomesLonger-term outcomesGlobal disabilityPost-dischargeMinority of patientsTertiary care centerTailored treatment strategiesNature of treatmentSevere clinical syndromeCare centerDeterminants of outcomePsychiatric comorbiditiesWell-characterized casesFunctional outcomesSurvivorsInvestigated patientsFollow-upSpecialist centersDouble, Double Toil and Trouble: Recurrent Episodes of Status Epilepticus Are Associated With Increasingly Worse Outcomes
Gaspard N. Double, Double Toil and Trouble: Recurrent Episodes of Status Epilepticus Are Associated With Increasingly Worse Outcomes. Epilepsy Currents 2024 DOI: 10.1177/15357597231223587.Peer-Reviewed Original ResearchCombined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value
Yuan F, Damien C, Schuind S, Salvagno M, Taccone F, Legros B, Gaspard N. Combined depth and scalp electroencephalographic monitoring in acute brain injury: Yield and prognostic value. European Journal Of Neurology 2024, 31: e16208. PMID: 38270448, DOI: 10.1111/ene.16208.Peer-Reviewed Original ResearchIctal-interictal continuumAcute brain injuryAcute brain injury patientsIctal-interictal continuum patternsDepth electroencephalographyRate of poor outcomeSporadic epileptiform dischargesElectrophysiological activityIctal rhythmic dischargesSpike-and-waveBrain injuryAbnormal electrophysiological activityElectrographic seizuresEpileptiform dischargesPoor outcomeRhythmic dischargesPatientsElectroencephalographic monitoringConcomitant seizuresScalp EEGPeriodic dischargesSeizuresNeuromonitoringABI patientsInjurySustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE)
Damien C, Leitinger M, Kellinghaus C, Strzelczyk A, De Stefano P, Beier C, Sutter R, Kämppi L, Strbian D, Taubøll E, Rosenow F, Helbok R, Rüegg S, Damian M, Trinka E, Gaspard N. Sustained effort network for treatment of status epilepticus/European academy of neurology registry on adult refractory status epilepticus (SENSE-II/AROUSE). BMC Neurology 2024, 24: 19. PMID: 38178048, PMCID: PMC10765797, DOI: 10.1186/s12883-023-03505-y.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusRefractory status epilepticusStatus epilepticusEuropean AcademyCommon neurological emergencyMulticenter prospective registryLarge randomized trialsProspective multicenter observational registryMulticenter observational registryDeep general anesthesiaDifferent patient groupsDistinct EEG patternsConvulsive SEMulticenter registryObservational registryProspective registryConsecutive adultsNeurological emergencyRandomized trialsRefractory SEGeneral anesthesiaPatient groupTreatment modalitiesClinical trialsFunctional decline
2023
Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG
Feys O, Wens V, Rovai A, Schuind S, Rikir E, Legros B, De Tiège X, Gaspard N. Delayed effective connectivity characterizes the epileptogenic zone during stereo-EEG. Clinical Neurophysiology 2023, 158: 59-68. PMID: 38183887, DOI: 10.1016/j.clinph.2023.12.013.Peer-Reviewed Original ResearchSingle-pulse electrical stimulationEpileptogenic zoneRefractory focal epilepsyEffective connectivityEffective connectivity changesResection limitsEpileptogenic networksFocal epilepsyAbnormal responseCortico-subcorticoCortical levelElectrical stimulationStereo-EEGPatientsDepth electrodesConnectivity changesStereoelectroencephalographyAnalysis of varianceCharacteristic curveOccurrence of spikesCCEPsStimulationHigh-frequency oscillationsAssociationResponse