Mahsa Mayeli, MD, MPH
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Titles
Postdoctoral Associate
Biography
Dr. Mahsa Mayeli is an Associate Research Scientist at Yale School of Medicine and a physician-scientist specializing in neuroimaging and neurodegenerative disease research. Her research focuses on the application of advanced PET and MRI techniques to investigate the biological mechanisms underlying Alzheimer’s disease, Parkinson’s disease, and related neuropsychiatric disorders. Her work integrates multimodal neuroimaging, molecular and genetic biomarkers, and environmental and social determinants of health to better understand brain aging, disease progression, and cognitive decline.
Dr. Mayeli has expertise in the analysis of large-scale longitudinal and multimodal datasets, including the Alzheimer’s Disease Neuroimaging Initiative (ADNI) and Parkinson’s Progression Markers Initiative (PPMI), as well as PET, diffusion MRI, resting-state fMRI, and imaging genetics. Her research incorporates advanced statistical and computational approaches to identify imaging and biological markers associated with disease risk and progression. She is particularly interested in leveraging neuroimaging, artificial intelligence, and data-driven approaches to advance early disease detection, improve patient stratification, and ultimately translate imaging biomarkers into clinically meaningful tools.
Appointments
Radiology & Biomedical Imaging
Postdoctoral AssociatePrimary
Other Departments & Organizations
Education & Training
- MD
- Tehran University Of Medical Sciences, Doctor of Medicine (2022)
- MPH
- Tehran University Of Medical Sciences, Master of Public Health (2022)
Research
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Overview
Dr. Mahsa Mayeli is an associate research scientist at Yale School of Medicine, specializing in brain imaging. As a physician-scientist, Dr. Mayeli studies the application of advanced PET and MRI techniques to investigate neurodegenerative diseases, including Alzheimer’s disease and Parkinson's disease. Her work integrates imaging biomarkers, genetics, and environmental factors to investigate the mechanisms underlying cognitive decline in neuropsychiatric disorders. Dr. Mayeli’s expertise includes multimodal data analysis, using large-scale cohort studies such as ADNI and PPMI, and developing statistical models to examine the impact of social determinants of health on brain aging. She is passionate about leveraging neuroimaging and artificial intelligence to improve early diagnosis and patient outcomes.
Medical Research Interests
Public Health Interests
ORCID
0000-0003-4656-156X
Research at a Glance
Yale Co-Authors
Publications Timeline
Wei Li, MD, MPH, PhD
David Matuskey, MD
Suneth Agampodi, MBBS, MSc, MPH, MD
Xiaofeng Liu
Richard Carson, PhD
Jae Il Shin, MD, PhD
Publications
2026
Exploratory imaging in SWEDD: Insights from dopaminergic PET, synaptic density PET, and volumetric MRI
Ebrahimian Sadabad F, Volpi T, Tinaz S, Honhar P, Colon L, Mayeli M, Pittman B, Naganawa M, Dias M, Angarita G, Comley R, Carson R, Finnema S, Matuskey D. Exploratory imaging in SWEDD: Insights from dopaminergic PET, synaptic density PET, and volumetric MRI. Parkinsonism & Related Disorders 2026, 152: 108960. PMID: 42691866, DOI: 10.1016/j.parkreldis.2026.108960.Peer-Reviewed Original ResearchImaging suspected posterior circulation stroke in the emergency department: a practical modality-based review
Peng A, Mayeli M, Sison J, Wira C, Navaratnam D, Johnson J, Tu L. Imaging suspected posterior circulation stroke in the emergency department: a practical modality-based review. Emergency Radiology 2026, 1-16. PMID: 42472769, DOI: 10.1007/s10140-026-02518-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImpulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study
Mayeli M, Worhunsky P, Carson R, Potenza M, Angarita G, Matuskey D. Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study. Psychiatry Research 2026, 364: 117239. PMID: 42229023, DOI: 10.1016/j.psychres.2026.117239.Peer-Reviewed Original ResearchAltmetricOptimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J
Khattar N, Matuskey D, Gallezot J, Naganawa M, Holmes S, Sadabad F, Mayeli M, Esterlis I, van Dyck C, Mecca A, D’Souza D, Nabulsi N, Finnema S, Huang Y, Carson R, Toyonaga T. Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson’s disease and control groups with [11C]UCB-J. Journal Of Cerebral Blood Flow And Metabolism : Official Journal Of The International Society Of Cerebral Blood Flow And Metabolism 2026, 46: 2302-2311. PMID: 41960765, PMCID: PMC13068773, DOI: 10.1177/0271678x261441071.Peer-Reviewed Original ResearchCitationsAltmetricAssociations between ventricular boundary shift integral and composite cognitive domains across the alzheimer’s disease continuum
Nasiri H, Azimizonuzi H, Khosravi F, Hosseini S, Khoshrou A, Rezakhani S, Badri R, Kazemi D, Toorani N, Soltanikhadiv K, Behrouzieh S, Alavi S, Shakeri S, Mayeli M, Shahkarami F. Associations between ventricular boundary shift integral and composite cognitive domains across the alzheimer’s disease continuum. Scientific Reports 2026, 16: 14092. PMID: 41851228, PMCID: PMC13136413, DOI: 10.1038/s41598-026-39465-9.Peer-Reviewed Original ResearchAltmetricDefault mode network connectivity is associated with executive and language performance in mild cognitive impairment
Nasiri H, Mohammadtaheri B, Khosravi F, Ghadiminia N, Saberian P, Mohammadian M, Shakeri S, Hendudari F, Rood Y, Hassanpoor A, Sadat S, Bagheri F, Mayeli M, Initiative F. Default mode network connectivity is associated with executive and language performance in mild cognitive impairment. Neuroscience Letters 2026, 876: 138545. PMID: 41707903, DOI: 10.1016/j.neulet.2026.138545.Peer-Reviewed Original ResearchCitationsAltmetricSocial determinants of brain structure and cognition
Mayeli M, Matuskey D, Initiative F. Social determinants of brain structure and cognition. Social Science & Medicine 2026, 394: 119045. PMID: 41662789, PMCID: PMC13034436, DOI: 10.1016/j.socscimed.2026.119045.Peer-Reviewed Original ResearchAltmetric
2025
Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment
Abtahi Y, Falahati M, Sharabiani S, Gila F, Omidi S, Goharmanesh F, Nourbakhsh Y, Chaleshtari M, Nourbakhshi M, Mahmoudi P, Zamiri R, Dalir L, Gharehdaghi Z, Nasiri H, Mayeli M, Azimizonuzi H, Initiative F. Cardiovascular risk factors, aging, and incidence of dementia (CAIDE) risk score and its association with cognitive performance and volumetric brain measures in mild cognitive impairment. IBRO Neuroscience Reports 2025, 20: 76-83. PMID: 41550977, PMCID: PMC12809402, DOI: 10.1016/j.ibneur.2025.12.007.Peer-Reviewed Original ResearchFive-Year Longitudinal Trajectories of Non-Motor Symptoms in Relation to Baseline Dopaminergic Decline in Parkinson’s Disease
Mozafar M, Mirhosseini H, Farahani S, Harandi H, Garousi S, Samadian F, Rezaei A, Hamidi H, Jameie M, Rezaei S, Mottahedi M, Mayeli M. Five-Year Longitudinal Trajectories of Non-Motor Symptoms in Relation to Baseline Dopaminergic Decline in Parkinson’s Disease. Brain Disorders 2025, 20: 100288. DOI: 10.1016/j.dscb.2025.100288.Peer-Reviewed Original ResearchCitationsAltmetricSerum bile acids associated with brain hypometabolism in patients across the Alzheimer’s disease continuum
Shushtari A, Shekari K, Mohammad S, Alizadeh S, Allahverdloo M, Sadeghi M, Zargari Z, Haghighi V, Kadaei F, Zarif Z, Eranji F, Ghahrieh F, Shafie M, Mayeli M, Initiative F, Consortium T. Serum bile acids associated with brain hypometabolism in patients across the Alzheimer’s disease continuum. Neuroscience 2025, 591: 177-185. PMID: 41205899, DOI: 10.1016/j.neuroscience.2025.11.001.Peer-Reviewed Original ResearchCitationsAltmetric
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