Jonadab Dos Santos Silva, MD, PhD
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Jonadab dos Santos Silva is a physician and researcher with a background in neurology and neuroimaging. He graduated with a degree in medicine from the Fluminense Federal University in Brazil. He also attended UCLA during medical school. He was a postdoctoral research fellow at the Icahn School of Medicine, where he worked on the clinical and cognitive manifestations of multiple sclerosis using ultra-high-field MRI to study the mechanisms of cortical lesion formation and repair, as well as how these processes are related to brain remodeling and disease progression. He has worked with various modalities in clinical studies, such as structural and functional MRI, EEG source localization, and tractography. His primary interests are the interplay between brain lesions and their clinical and cognitive manifestations, and his work aims to translate cutting-edge research into clinical practice, enhancing diagnostic and therapeutic strategies for patients with neurological conditions.
Last Updated on July 14, 2024.
Departments & Organizations
Education & Training
- PhD
- Universidade Federal Fluminense, Neurology (2025)
- Postdoctoral Research Fellow
- Icahn School of Medicine at Mount Sinai (2024)
- MD
- Universidade Federal Fluminense, Medicine (2022)
- MD
- University of California, Los Angeles, Medicine, Exchange Program (2016)
Research
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Overview
Medical Research Interests
Cognition; Diffusion Tensor Imaging; Epilepsy; Functional Neuroimaging; Magnetic Resonance Imaging; Multiparametric Magnetic Resonance Imaging; Multiple Sclerosis; Neuroimaging; Neurology; Neuropsychology
ORCID
0000-0002-4216-333X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jonadab Dos Santos Silva's published research.
Publications Timeline
A big-picture view of Jonadab Dos Santos Silva's research output by year.
Research Interests
Research topics Jonadab Dos Santos Silva is interested in exploring.
Andrew Solomon, PhD
42Publications
229Citations
Magnetic Resonance Imaging
Multiple Sclerosis
Diffusion Tensor Imaging
Neuroimaging
Publications
2026
Regional Cortical Demyelination Predicts Word-Finding Difficulty in Early Multiple Sclerosis (S8.007)
Cheshire M, Dereskewicz E, Ayci B, Dos Santos Silva J, Feng Q, Galasso J, La Rosa F, Sumowski J, Beck E. Regional Cortical Demyelination Predicts Word-Finding Difficulty in Early Multiple Sclerosis (S8.007). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000215151.Peer-Reviewed Original ResearchCorrelation Between Visual Network Integrity and Visual Function in Multiple Sclerosis Patients (P5-19.005)
Veloso V, Dos Santos Silva J, Carvalho V, Walvekar S, Azambuja L, Pereira A, dos Passos G, Sato D, Becker J. Correlation Between Visual Network Integrity and Visual Function in Multiple Sclerosis Patients (P5-19.005). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000216004.Peer-Reviewed Original ResearchReduced Intrinsic Connectivity Secondary to Multiple Sclerosis as a Functional Marker of Impaired Verbal Memory Encoding and Retrieval (P5-19.010)
Crelier V, Dos Santos Silva J, Veloso V, Walvekar S, Azambuja L, Pereira A, Passos G, Sato D, Becker J. Reduced Intrinsic Connectivity Secondary to Multiple Sclerosis as a Functional Marker of Impaired Verbal Memory Encoding and Retrieval (P5-19.010). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000216015.Peer-Reviewed Original ResearchNormative Brain Atrophy Modeling Incorporating Intracranial Volume Improves Pre-clinical Detection of Dementia Risk (P1-13.002)
Dos Santos Silva J, La Rosa F, Dereskewicz E, Galasso J, Graney R, Garcia N, Levy S, Sumowski J, Beck E. Normative Brain Atrophy Modeling Incorporating Intracranial Volume Improves Pre-clinical Detection of Dementia Risk (P1-13.002). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000217637.Peer-Reviewed Original ResearchConceptsSynergistic and Distinct Central Effects of Dapagliflozin and Exenatide on Brain Networks Intrinsic Connectivity in Obesity and Type 2 Diabetes: A Randomized Controlled Trial (P1-13.001)
Dos Santos Silva J, van Ruiten C, IJzerman R, van Duinkerken E. Synergistic and Distinct Central Effects of Dapagliflozin and Exenatide on Brain Networks Intrinsic Connectivity in Obesity and Type 2 Diabetes: A Randomized Controlled Trial (P1-13.001). Neurology 2026, 106 DOI: 10.1212/wnl.0000000000217682.Peer-Reviewed Original ResearchCannabinoids for Alzheimer's disease: A promising trial, although not yet ready for the prescription pad.
Dos Santos Silva J. Cannabinoids for Alzheimer's disease: A promising trial, although not yet ready for the prescription pad. Journal Of Alzheimer’s Disease 2026, 13872877261452183. PMID: 42216668, DOI: 10.1177/13872877261452183.Peer-Reviewed Original ResearchAltmetricConceptsAlzheimer's diseaseMini-Mental State ExaminationCognitive improvementPlacebo-controlled trialRandomized placebo-controlled trialBehavioral outcomesMini-MentalCannabis productsState ExaminationMethodological limitationsEvidence-based counselingLow-certainty evidenceAD careReal-world benefitsPrescription padsAlzheimerCannabisCannabinoidCognitionTrialsSample sizeCounselingInformal dialogueCliniciansCollaborative Latin American Imaging Network In Neuroimmunology Research (BRAIMS): Rationale, Structure, Challenges, and Future Directions
Carnero Contentti E, Alonso R, Boldrini V, Cárcamo C, Casas M, Ciampi E, Damanesco A, Dos Santos Silva J, Rimkus C, Marrodan M, Navas C, Patrucco L, Pitombeira M, Ramari C, Sato H, Soler B, Treviño Frenk I, Wagner M, Ontaneda D, Becker J. Collaborative Latin American Imaging Network In Neuroimmunology Research (BRAIMS): Rationale, Structure, Challenges, and Future Directions. Multiple Sclerosis And Related Disorders 2026, 110: 107203. PMID: 42000450, DOI: 10.1016/j.msard.2026.107203.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsMagnetic resonance imagingMagnetic resonance imaging researchMyelin oligodendrocyte glycoprotein antibody-associated diseaseNeuromyelitis optica spectrum disorderSpectrum disorderNeuroimmunological researchAvailability of advanced imaging techniquesMultiple sclerosisAntibody-associated diseaseDiagnostic variablesConsensus-based recommendationsContext-specific evidenceDisordersResonance imagingClinical decision-makingAdvanced imaging techniquesMRI-based approachMagnetic resonance imaging technologyHealthcare systemNeuroimmunological disordersDiagnostic complexDifferential diagnosisMRI availabilityNeuroimmunological diseasesDiagnostic pathwayCollaBoRative Latin American Imaging Network in NeuroiMmunology ReSearch (BRAIMS): Rationale, Structure, Challenges, and Future Directions
Contentti EC, Alonso R, Boldrini V, Cárcamo C, Casas M, Ciampi E, Damanesco A, dos Santos Silva J, Rimkus CDM, Marrodan M, Navas C, Patrucco L, Pitombeira M, Ramari C, Sato HK, Soler B, Frenk IT, Wagner M, Ontaneda D, Becker J. CollaBoRative Latin American Imaging Network in NeuroiMmunology ReSearch (BRAIMS): Rationale, Structure, Challenges, and Future Directions. Multiple Sclerosis And Related Disorders 2026, 107203. DOI: 10.1016/j.msard.2026.107203.Peer-Reviewed Original ResearchNeuroanatomical Correlates of Depressive Symptoms in Early Multiple Sclerosis
Dos Santos Silva J, La Rosa F, Dereskewicz E, Levy S, Graney R, Garcia N, Galasso J, Sumowski J, Beck E. Neuroanatomical Correlates of Depressive Symptoms in Early Multiple Sclerosis. Neurology Open Access 2026, 2 DOI: 10.1212/wn9.0000000000000050.Peer-Reviewed Original ResearchCitationsAltmetricEfficacy of vagus nerve stimulator during transition to adulthood in patients with treatment‐resistant epilepsy
dos Santos Silva J, Boas S, do Prado H, Bezerra D, Meira I. Efficacy of vagus nerve stimulator during transition to adulthood in patients with treatment‐resistant epilepsy. Epileptic Disorders 2026, 28: 142-154. PMID: 41553328, PMCID: PMC12964184, DOI: 10.1002/epd2.70133.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsVagus nerve stimulationTreatment-resistant epilepsyEfficacy of vagus nerve stimulationVagus nerve stimulator implantationAntiseizure medicationsSeizure frequencyStatus epilepticusFollow-upNerve stimulationRetrospective cohort studyEffective adjunctive therapyFisher's exact testInterictal epileptiform activityPre-menarcheal femalesTertiary epilepsy centerMedication-resistant epilepsyPre-VNSEEG findingsPediatric patientsMonths post-implantationSeizure reductionAdjunctive therapyMcHugh classificationEpileptiform activityAdjunctive treatment
Academic Achievements & Community Involvement
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Activities
activity European Charcot Foundation
2022 - PresentProfessional OrganizationsFellowactivity Acta Neurologica Scandinavica
2025 - PresentJournal ServiceRevieweractivity Annals of Neuroscience
2025 - PresentJournal ServiceRevieweractivity Brain Imaging and Behavior
2025 - PresentJournal ServiceRevieweractivity Cerebrovascular Diseases
2025 - PresentJournal ServiceReviewer
Honors
honor Best poster, Neuroimaging at the BMEII Symposium
04/21/2023Other AwardBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount SinaiDetailsUnited Stateshonor ACTRIMS Educational Grant Award
02/12/2023National AwardAmericas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS)DetailsUnited Stateshonor NAIMS Educational Grant Award
02/11/2023National AwardNorth American Imaging in MS CooperativeDetailsUnited Stateshonor CTRIMS-ECF Young Investigator Award & Best oral presentation
06/18/2022International AwardEuropean Charcot FoundationDetailsBrazilhonor Best abstract presentation, 20th Brazilian and International Congress of Neuropsychology
10/09/2021National AwardBrazilian Society of NeuropsychologyDetailsBrazil
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