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Brian Richard Smith, MD

Professor of Laboratory Medicine, of Biomedical Engineering, of Medicine (Hematology) and of Pediatrics; Deputy Dean for Research, (Clinical and Translational); Director, Clinical Immunology Laboratory, Laboratory Medicine; Chair, Laboratory Medicine; Chief, Laboratory Medicine

Contact Information

Brian Richard Smith, MD

Office Locations

Mailing Address

  • Yale School of Medicine

    333 Cedar Street, SHM L-206, P.O. Box 208055

    New Haven, CT 06520-8055

    United States

Research Summary

Dr. Smith is Co-Director of the Yale Center for Clinical Investigation (Co-PI of the Yale CTSA Award). In addition, he is the Deputy Dean for Clinical and Translational Research. In these capacities, he has broad responsibilities for enhancing these missions both across the School of Medicine as well as across the University as a whole.

Dr. Smith's research laboratory primarily investigates the inflammation-coagulation interface, especially at the cellular level, i.e., the interaction of leukocytes and platelets, but also at the level of soluble mediators such as the complement system. A major interest is in relating basic biological events to human disease, for example, studying the mechanisms and consequences of platelet, leukocyte and complement activation during cardiac surgery, as a consequence of transfusion, in the pathophysiology of tumor metastasis, and in primary hematologic disorders. Because of the importance of inflammation-coagulation in the success or failure of clinically utilized biomechanical devices, the laboratory is also engaged in aspects of biomedical engineering.

In addition to these areas, Dr. Smith is involved in clinically oriented research designed to improve hematologic and immunologic diagnostics and ''personalized'' cell therapy, has published in the area of bioethics, and is engaged in educational methodology research to improve medical student education in Laboratory Medicine.

Specialized Terms: Inflammation-Coagulation Interface; Hematology; Bioethics; Biomedical Engineering; Laboratory Medicine Education; Therapeutic Pathology


Research Interests

Biomedical Engineering; Blood; Blood Cells; Bone Marrow Cells; Curriculum; Education, Professional; Ethics; Hematology; Hematopoietic System; Hemic and Lymphatic Diseases; Immune System; Laboratories; Lymphoid Tissue; Practice Patterns, Physicians'; Religion and Medicine; Religion and Science; Stem Cells; Students; Students, Medical; Teaching; Medical Laboratory Science; Point-of-Care Systems; Disease Management; Diagnostic Techniques and Procedures

Research Image

Selected Publications

Clinical Trials

ConditionsStudy Title
Children's Health; Diseases of the Endocrine System; Genetics - Adult; Genetics - Pediatric; Mental Health & Behavioral ResearchYale Center for Clinical Investigation (YCCI) Specimen and Data Repository