2025
High- vs low-dose oxytocin protocols for labor induction: a systematic review and meta-analysis
Grasch J, Costantine M, Cahill A, Subramaniam A, Son M, Raghuraman N, Grobman W, Frey H. High- vs low-dose oxytocin protocols for labor induction: a systematic review and meta-analysis. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101691. PMID: 40334983, DOI: 10.1016/j.ajogmf.2025.101691.Peer-Reviewed Original ResearchConceptsLow-dose oxytocin protocolsOxytocin protocolInduction of laborLabor inductionCesarean deliveryLow-dose protocolVaginal deliveryNeonatal outcome of inductionFrequency of postpartum hemorrhageRisk of cesarean deliveryLikelihood of cesarean deliveryDuration of labor inductionFrequency of cesarean deliveryHigh-dose oxytocin protocolRelative riskCochrane risk of bias assessment toolSystematic reviewRisk of bias assessment toolOxytocin infusion protocolOperative vaginal deliveryHigh-dose oxytocinConfidence intervalsDuration of laborOutcome of inductionHigh risk of biasHigh- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis
Logue T, Zullo F, van Biema F, Son M, London L, Paranandi S, Sciscione A, Rizzo G, Mascio D, Chauhan S. High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101604. PMID: 39788427, DOI: 10.1016/j.ajogmf.2025.101604.Peer-Reviewed Original ResearchConceptsHigh-dose oxytocin regimenRisk of low Apgar scoreOxytocin regimensLabor augmentationApgar score <7Low-dose regimensUmbilical artery pH <Cesarean deliveryLow Apgar scoreArterial pH <High-dose regimensOxytocin doseAugmentation of laborControlled TrialsHead-to-head meta-analysesAdverse labor outcomesContinuous oxytocin infusionCoprimary outcomesNeonatal acidosisApgar scoreRandom-effect head-to-head meta-analysesMeta-analysisIncidence of Apgar score < 7Quasi-randomized controlled trialsRandomized Controlled Trials
2024
Peripartum interventions for people with class III obesity: a systematic review and meta-analysis
Kominiarek M, Espinal M, Cassimatis I, Peace J, Premkumar A, Toledo P, Shramuk M, Wafford E. Peripartum interventions for people with class III obesity: a systematic review and meta-analysis. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101354. PMID: 38494155, DOI: 10.1016/j.ajogmf.2024.101354.Peer-Reviewed Original ResearchConceptsRandomized Controlled TrialsCesarean deliveryProphylactic negative-pressure wound therapyControlled TrialsMeta-analysisPeripartum interventionsCohort studyPlanned vaginal deliveryCesarean delivery techniquesPlanned cesarean deliveryNegative-pressure wound therapySurgical site infectionOutcomes of peopleWound morbidityClass III obesityPooled risk ratioLabor inductionSite infectionVaginal deliveryWound therapySystematic reviewInclusion criteriaRisk ratioCesareanIII obesity
2023
From “disappointing” to “fantastic”: Women's experiences with labor induction in a U.S. tertiary hospital
Danilack V, Siegel‐Reamer L, Lum L, Kesselring C, Brousseau E, Guthrie K. From “disappointing” to “fantastic”: Women's experiences with labor induction in a U.S. tertiary hospital. Birth 2023, 50: 959-967. PMID: 37475194, DOI: 10.1111/birt.12750.Peer-Reviewed Original ResearchConceptsLabor inductionSemi-structured qualitative interviewsQualitative interviewsPersonal toleranceSide effectsWay interventionsMother-baby unitFoley balloon catheterProcess of careQuality of careShape patient experiencesInterview questionsPerceptionInduction patientsTertiary hospitalBalloon catheterPatients' perceptionsDifferent interventionsSeries of interventionsPatient experienceHealth outcomesInterventionWomen's perceptionsBirthing processExpectationsMaternal and Delivery Characteristics and Self-Reported Perceived Control During Labor
Mallett G, Hill K, Doherty L, Grobman W, Reddy U, Tita A, Silver R, Rice M, El-Sayed Y, Wapner R, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H, Macones G. Maternal and Delivery Characteristics and Self-Reported Perceived Control During Labor. Obstetrics And Gynecology 2023, 142: 117-124. PMID: 37290106, PMCID: PMC10330140, DOI: 10.1097/aog.0000000000005230.Peer-Reviewed Original ResearchMeSH KeywordsDelivery, ObstetricFemaleHumansInfantInfant, NewbornLabor PainLabor, InducedLabor, ObstetricPregnancySelf ReportConceptsBody mass indexWeeks of gestationLabor Agentry ScaleScale scoreLabor painPrivate health insuranceDelivery characteristicsLabor pain scoresPrevious pregnancy lossSpontaneous vaginal deliverySevere neonatal complicationsHealth insuranceMode of deliveryFinal multivariable modelMultivariable linear regressionSelf-administered questionnaireSelf-reported raceNeonatal complicationsExpectant managementPain scoresLabor inductionNonprivate insuranceOperative deliveryCesarean deliveryVaginal deliveryMaximum Dose Rate of Intrapartum Oxytocin Infusion and Associated Obstetric and Perinatal Outcomes
Son M, Roy A, Grobman W, Miller E, Dude A, Peaceman A, Stetson B. Maximum Dose Rate of Intrapartum Oxytocin Infusion and Associated Obstetric and Perinatal Outcomes. Obstetrics And Gynecology 2023, 141: 379-386. PMID: 36649339, DOI: 10.1097/aog.0000000000005058.Peer-Reviewed Original ResearchMeSH KeywordsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleHumansInfant, NewbornLabor, InducedOxytocicsOxytocinPregnancyConceptsTitration regimenCesarean deliveryVaginal deliveryMultivariable analysisAdverse outcomesNeonatal intensive care unit admissionComposite severe neonatal morbidityIntensive care unit admissionSecondary analysisCumulative proportionPerinatal adverse outcomesCare unit admissionSevere neonatal morbiditySpontaneous vaginal deliveryMagnesium sulfate infusionUnderwent cesarean deliveryRupture of membranesWeeks of gestationNICU admissionUnit admissionHypertensive disordersLack of evidenceNeonatal morbidityNulliparous patientsPerinatal outcomes
2022
Oxytocin utilization for women undergoing an induction of labor by 1 kg/m2 increase in body mass index
Polnaszek B, Reilly J, Raker C, Lewkowitz A, Danilack V. Oxytocin utilization for women undergoing an induction of labor by 1 kg/m2 increase in body mass index. American Journal Of Obstetrics And Gynecology 2022, 227: 546-547. PMID: 35671778, PMCID: PMC10308358, DOI: 10.1016/j.ajog.2022.05.070.Peer-Reviewed Original ResearchSexual and/or gender minority disparities in obstetrical and birth outcomes
Leonard S, Berrahou I, Zhang A, Monseur B, Main E, Obedin-Maliver J. Sexual and/or gender minority disparities in obstetrical and birth outcomes. American Journal Of Obstetrics And Gynecology 2022, 226: 846.e1-846.e14. PMID: 35358492, DOI: 10.1016/j.ajog.2022.02.041.Peer-Reviewed Original ResearchConceptsGender minority patientsBirth patientsMinority patientsSociodemographic factorsBirth outcomesBirth certificatesMultifetal gestationMother's partnerModified Poisson regression modelsPopulation-based cohort studyGender minority individualsIndependent of sociodemographic factorsMultivariable modified Poisson regression modelsRisk ratioSevere maternal morbidityCenters for Disease Control and PreventionDisease Control and PreventionSevere morbidityPoisson regression modelsMinority individualsGender minoritiesControl and PreventionHypertensive disorders of pregnancyLow Apgar scoreLabor inductionIntrapartum nipple stimulation therapy for labor induction: a randomized controlled external pilot study of acceptability and feasibility
Stark EL, Athens ZG, Son M. Intrapartum nipple stimulation therapy for labor induction: a randomized controlled external pilot study of acceptability and feasibility. American Journal Of Obstetrics & Gynecology MFM 2022, 4: 100575. PMID: 35042047, DOI: 10.1016/j.ajogmf.2022.100575.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentFeasibility StudiesFemaleHumansInfant, NewbornLabor, InducedMaleNipplesOxytocicsOxytocinPilot ProjectsPregnancyConceptsObstetrical care providersExternal pilot studyLabor inductionStimulation therapyOxytocin infusionNipple stimulationPain levelsCare providersPilot studyInitiation of oxytocinPrimary outcome measureElectric breast pumpWeeks of gestationNeonatal intensive careParticipants' pain levelsNon-English speakingEligible womenMedian durationIntervention startMedian timeIntensive careMinutes of stimulationBreast pumpLabor progressOutcome measuresHypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial
Bartal M, Premkumar A, Rice M, Reddy U, Tita ATN, Silver RM, El‐Sayed Y, Wapner R, Rouse DJ, Saade GR, Thorp JM, Costantine M, Chien EK, Casey BM, Srinivas SK, Swamy GK, Simhan HN, Health H. Hypertension in pregnancy and adverse outcomes among low‐risk nulliparous women expectantly managed at or after 39 weeks: a secondary analysis of a randomised controlled trial. BJOG An International Journal Of Obstetrics & Gynaecology 2022, 129: 1396-1403. PMID: 34927787, PMCID: PMC9207156, DOI: 10.1111/1471-0528.17059.Peer-Reviewed Original ResearchConceptsAdverse maternal outcomesLow-risk nulliparous womenHypertensive disordersMaternal outcomesSecondary outcomesNulliparous womenAdverse outcomesComposite adverse maternal outcomeIntensive care unit admissionSecondary analysisCare unit admissionSevere neonatal complicationsWeeks of gestationMode of deliveryNulliparous individualsMaternal compositeNeonatal complicationsPerinatal compositePostpartum infectionUnit admissionCaesarean deliveryExpectant managementPlacental abruptionVenous thromboembolismGestational age
2021
Misoprostol for labour induction
Kumar N, Haas D, Weeks A. Misoprostol for labour induction. Best Practice & Research Clinical Obstetrics & Gynaecology 2021, 77: 53-63. PMID: 34607746, DOI: 10.1016/j.bpobgyn.2021.09.003.Peer-Reviewed Original ResearchMeSH KeywordsCesarean SectionDinoprostoneFemaleHumansInfant, NewbornLabor, InducedMisoprostolOxytocicsPregnancyConceptsVaginal birthVaginal misoprostolOral misoprostolCaesarean sectionRate of caesarean sectionCaesarean section rateFoetal heart rate changesPerinatal adverse eventsUterine hyperstimulationBalloon catheterLabor inductionSection rateEffective induction methodMisoprostolNeonatal complicationsHeart rate changesNo significant differenceRandomised comparisonAdverse eventsSide effectsBirthSignificant differenceHyperstimulationCatheterDinoprostoneMaternal and Neonatal Outcomes in Nulliparous Participants Undergoing Labor Induction by Cervical Ripening Method
Andrikopoulou M, Bushman E, Rice M, Grobman W, Reddy U, Silver R, El-Sayed Y, Rouse D, Saade G, Thorp J, Chauhan S, Costantine M, Chien E, Casey B, Srinivas S, Swamy G, Simhan H. Maternal and Neonatal Outcomes in Nulliparous Participants Undergoing Labor Induction by Cervical Ripening Method. American Journal Of Perinatology 2021, 40: 1061-1070. PMID: 34352922, PMCID: PMC8817048, DOI: 10.1055/s-0041-1732379.Peer-Reviewed Original ResearchMeSH KeywordsCervical RipeningDinoprostoneFemaleHumansInfant, NewbornLabor, InducedOxytocicsOxytocinPregnancyConceptsAdverse neonatal outcomesCervical ripeningNeonatal outcomesLabor inductionNulliparous participantsComposite outcomeAdverse maternal outcomesCervical ripening methodsMaternal composite outcomeNeonatal composite outcomeLow-risk womenLength of laborConcurrent oxytocinCoprimary outcomesNeonatal compositeExpectant managementMaternal outcomesCesarean deliverySecondary outcomesFetal demisePatient characteristicsMultivariable analysisCervical dilationLower riskSecondary analysisLow‐dose oral misoprostol for induction of labour
Kerr R, Kumar N, Williams M, Cuthbert A, Aflaifel N, Haas D, Weeks A. Low‐dose oral misoprostol for induction of labour. Cochrane Database Of Systematic Reviews 2021, 2021: cd014484. PMID: 34155622, PMCID: PMC8218159, DOI: 10.1002/14651858.cd014484.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravaginalAdministration, OralApgar ScoreCesarean SectionDinoprostoneDrug Administration ScheduleFemaleHeart Rate, FetalHumansIntensive Care, NeonatalLabor, InducedMisoprostolOxytocicsOxytocinParturitionPlacebosPregnancyRandomized Controlled Trials as TopicTime FactorsUterusConceptsLow-dose oral misoprostolFoetal heart rate changesTranscervical Foley catheterVaginal birthRates of hyperstimulationOral misoprostolLow-dose misoprostolVaginal dinoprostoneCaesarean sectionHeart rate changesUterine hyperstimulationLabor inductionVaginal misoprostolRate of vaginal birthFoetal distressRisk of uterine hyperstimulationRate of caesarean sectionRisk of caesarean sectionThird trimesterLabour induction methodsFoley catheterChildbirth's Trials RegisterSubgroup analysisWHO International Clinical Trials Registry PlatformAssociated with similar rates
2020
Optimizing Term Delivery and Mode of Delivery
Wen T, Turitz A. Optimizing Term Delivery and Mode of Delivery. Clinics In Perinatology 2020, 47: 799-815. PMID: 33153663, DOI: 10.1016/j.clp.2020.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAbruptio PlacentaeCesarean SectionCholestasis, IntrahepaticCongenital AbnormalitiesDelivery, ObstetricDiabetes, GestationalFemaleFetal Growth RetardationHumansHypertensionHypertension, Pregnancy-InducedLabor, InducedOligohydramniosPregnancyPregnancy ComplicationsPregnancy Complications, CardiovascularPregnancy in DiabeticsPregnancy in ObesityPregnancy, TwinSeverity of Illness IndexStillbirthTerm BirthTime FactorsTerm Labor Induction and Cesarean Delivery Risk among Obese Women with and without Comorbidities
Glazer K, Danilack V, Field A, Werner E, Savitz D. Term Labor Induction and Cesarean Delivery Risk among Obese Women with and without Comorbidities. American Journal Of Perinatology 2020, 39: 154-164. PMID: 32722823, DOI: 10.1055/s-0040-1714422.Peer-Reviewed Original ResearchConceptsCesarean delivery riskLow-risk nulliparous womenPrior vaginal deliveryCesarean riskCesarean deliveryLabor inductionElective inductionNulliparous womenVaginal deliveryWeeks' gestationMaternal ageTerm inductionEarly term inductionTerm labor inductionPrior cesarean deliveryAdjusted risk ratioBody mass indexElective labor inductionWeeks of gestationDelivery riskRisk reductionARRIVE trialExpectant managementHypertensive disordersObstetric populationPrediction Model for Vaginal Birth After Induction of Labor in Women With Hypertensive Disorders of Pregnancy.
Beninati M, Ramos S, Danilack V, Has P, Savitz D, Werner E. Prediction Model for Vaginal Birth After Induction of Labor in Women With Hypertensive Disorders of Pregnancy. Obstetrics And Gynecology 2020, 136: 402-410. PMID: 32649502, DOI: 10.1097/aog.0000000000003938.Peer-Reviewed Original ResearchConceptsInduction of laborCesarean deliveryHypertensive disordersVaginal deliveryHosmer-Lemeshow testLabor inductionIntrapartum magnesium sulfateStepwise backward logistic regressionVaginal delivery successPrior cesarean deliveryBody mass indexPrelabor cesarean deliveryWeeks of gestationBackward logistic regressionFuture external validationSimilar discriminatory abilitySeizure prophylaxisCervical ripeningRetrospective cohortSingleton pregnanciesSpontaneous laborGestational ageMass indexStudy cohortVaginal birthAssociation of Oxytocin Rest During Labor Induction of Nulliparous Women With Mode of Delivery.
McAdow M, Xu X, Lipkind H, Reddy UM, Illuzzi JL. Association of Oxytocin Rest During Labor Induction of Nulliparous Women With Mode of Delivery. Obstetrics And Gynecology 2020, 135: 569-575. PMID: 32028487, DOI: 10.1097/aog.0000000000003709.Peer-Reviewed Original ResearchMeSH KeywordsAdultCesarean SectionFemaleHumansLabor, InducedOxytocicsOxytocinParityPregnancyRetrospective StudiesYoung AdultConceptsMode of deliveryInduction of laborNeonatal morbidityCesarean deliveryNulliparous womenLatent laborOxytocin infusionLatent phaseMultivariable logistic regression analysisContinuous oxytocin infusionRetrospective cohort analysisLarge academic medical centerBody mass indexLogistic regression analysisAcademic medical centerContinuous oxytocinSingleton gestationsLabor inductionGestational ageMass indexPotential confoundersMaternal ageOdds ratioCohort analysisMedical Center
2019
Labor augmentation strategies: What's the evidence?
Son M. Labor augmentation strategies: What's the evidence? Seminars In Perinatology 2019, 44: 151219. PMID: 31839438, DOI: 10.1016/j.semperi.2019.151219.Commentaries, Editorials and LettersThe impact of induction of labor at 39 weeks in low-risk women on the incidence of stillbirth
Po' G, Oliver EA, Reddy UM, Silver RM, Berghella V. The impact of induction of labor at 39 weeks in low-risk women on the incidence of stillbirth. American Journal Of Obstetrics And Gynecology 2019, 222: 88-90. PMID: 31545942, DOI: 10.1016/j.ajog.2019.09.032.Peer-Reviewed Original Research
2018
Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis
Lønfeldt NN, Verhulst FC, Strandberg-Larsen K, Plessen KJ, Lebowitz ER. Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis. Psychological Medicine 2018, 49: 881-890. PMID: 30444210, DOI: 10.1017/s0033291718003021.Peer-Reviewed Original ResearchMeSH KeywordsChildFemaleHumansInfant, NewbornLabor, InducedNeurodevelopmental DisordersOxytocicsOxytocinPregnancyRisk AssessmentConceptsAttention-deficit/hyperactivity disorderPooled risk estimatesCognitive impairmentRisk estimatesNewcastle-Ottawa Quality Assessment ScaleNarrative summaryQuality Assessment ScaleNeurodevelopment of childrenUse of oxytocinAutism spectrum disorderEnglish-language studiesQuality of studiesIndependent risk estimatesOxytocin exposureLabor inductionObstetric guidelinesObservational studyNeurodevelopmental problemsPsychiatric symptomsDate restrictionsCurrent evidenceSystematic reviewAssessment ScaleAvailable evidenceHyperactivity disorder
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