2025
High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis
Logue T, Zullo F, van Biema F, Son M, London L, Paranandi S, Sciscione A, Rizzo G, Mascio D, Chauhan S. High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101604. PMID: 39788427, DOI: 10.1016/j.ajogmf.2025.101604.Peer-Reviewed Original ResearchConceptsHigh-dose oxytocin regimenRisk of low Apgar scoreOxytocin regimensLabor augmentationApgar score <7Low-dose regimensUmbilical artery pH <Cesarean deliveryLow Apgar scoreArterial pH <High-dose regimensOxytocin doseAugmentation of laborControlled TrialsHead-to-head meta-analysesAdverse labor outcomesContinuous oxytocin infusionCoprimary outcomesNeonatal acidosisApgar scoreRandom-effect head-to-head meta-analysesMeta-analysisIncidence of Apgar score < 7Quasi-randomized controlled trialsRandomized Controlled Trials
2024
Oxytocin regimen used for induction of labor and pregnancy outcomes
REDDY U, SANDOVAL G, TITA A, SILVER R, MALLETT G, Hill K, EL-SAYED Y, RICE M, WAPNER R, ROUSE D, SAADE G, THORP J, CHAUHAN S, COSTANTINE M, CHIEN E, CASEY B, SRINIVAS S, SWAMY G, SIMHAN H, MACONES G, GROBMAN W, Network E. Oxytocin regimen used for induction of labor and pregnancy outcomes. American Journal Of Obstetrics & Gynecology MFM 2024, 6: 101508. PMID: 39357802, PMCID: PMC11663098, DOI: 10.1016/j.ajogmf.2024.101508.Peer-Reviewed Original ResearchInduction of laborLow-risk nulliparous patientsOxytocin regimensAdjusted relative risksAdjusted odds ratiosCesarean deliveryComposite of perinatal deathConfidence intervalsNeonatal respiratory supportLow-dose regimensHigh-dose oxytocin regimenSevere neonatal complicationsOperative vaginal delivery rateFrequency of cesarean deliverySecondary analysisEstimate adjusted relative risksElective induction of laborPerinatal deathRoutine induction of labourEstimate adjusted odds ratiosVaginal delivery rateRespiratory supportNulliparous patientsMHD groupMultivariable Poisson regression
2021
High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women
Son M, Roy A, Stetson BT, Grady NT, Vanecko MC, Bond N, Swanson K, Grobman WA, Miller ES, Peaceman AM. High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women. Obstetrics And Gynecology 2021, 137: 991-998. PMID: 33957657, DOI: 10.1097/aog.0000000000004399.Peer-Reviewed Original ResearchConceptsHigh-dose groupHigh-dose oxytocin regimenStandard dosingAugmentation of laborUmbilical artery acidemiaLabor durationPrimary outcomeSecondary outcomesNulliparous womenCesarean birthNeonatal intensive care unit admissionIntensive care unit admissionApgar score 3Care unit admissionStandard-dose groupPrespecified secondary outcomesPrimary cesarean birthWeeks of gestationAugment laborClinical chorioamnionitisMorbidity compositeNulliparous participantsUnit admissionObstetric morbidityPerinatal outcomes
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