High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis
Logue T, Zullo F, van Biema F, Son M, London L, Paranandi S, Sciscione A, Rizzo G, Mascio D, Chauhan S. High- vs low-dose oxytocin regimens for labor augmentation: a systematic review and meta-analysis. American Journal Of Obstetrics & Gynecology MFM 2025, 7: 101604. PMID: 39788427, DOI: 10.1016/j.ajogmf.2025.101604.Peer-Reviewed Original ResearchConceptsHigh-dose oxytocin regimenRisk of low Apgar scoreOxytocin regimensLabor augmentationApgar score <7Low-dose regimensUmbilical artery pH <Cesarean deliveryLow Apgar scoreArterial pH <High-dose regimensOxytocin doseAugmentation of laborControlled TrialsHead-to-head meta-analysesAdverse labor outcomesContinuous oxytocin infusionCoprimary outcomesNeonatal acidosisApgar scoreRandom-effect head-to-head meta-analysesMeta-analysisIncidence of Apgar score < 7Quasi-randomized controlled trialsRandomized Controlled Trials
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