2018
NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis
O'Leary JG, Reddy KR, Garcia‐Tsao G, Biggins SW, Wong F, Fallon MB, Subramanian RM, Kamath PS, Thuluvath P, Vargas HE, Maliakkal B, Tandon P, Lai J, Thacker LR, Bajaj JS. NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis. Hepatology 2018, 67: 2367-2374. PMID: 29315693, DOI: 10.1002/hep.29773.Peer-Reviewed Original ResearchConceptsEnd-stage liver disease (MELD) scoreLiver Disease scoreOrgan failureHospitalized patientsBedside toolDisease scoreChronic liver failure scoreTertiary-care hepatology centersWhite blood cell countAlcohol-induced cirrhosisExtrahepatic organ failureMedian Child scoreReliable bedside toolChronic liver failureDiagnosis of cirrhosisBlood cell countRisk of mortalityPresence of infectionSimple bedside toolNorth American ConsortiumHepatology centersNACSELD-ACLFSeparate multicenterUninfected patientsProspective cohort
2016
A Survey of Pediatric Critical Care Providers on the Presence, Severity, and Assessment of Capillary Leak in Critically Ill Children
Pierce R, Luckett PM, Faustino EVS. A Survey of Pediatric Critical Care Providers on the Presence, Severity, and Assessment of Capillary Leak in Critically Ill Children. Journal Of Pediatric Intensive Care 2016, 06: 145-151. PMID: 31073440, PMCID: PMC6260295, DOI: 10.1055/s-0036-1593388.Peer-Reviewed Original ResearchPediatric critical care providersCapillary leakCritical care providersIll childrenCardiopulmonary bypassCare providersCritically Ill ChildrenStandardized clinical evaluationPresence of infectionPatient factorsSeptic shockGeneral anesthesiaCardiac arrestClinical evaluationGeneralized edemaPhysical examClinical significanceProviders' opinionsPatient scenariosPulmonary cracklesTreatment factorsSeverityElectronic surveyBypassChildren
2015
Outcomes of Aortic Root Replacement After Previous Aortic Root Replacement: The “True” Redo Root
Jassar AS, Desai ND, Kobrin D, Pochettino A, Vallabhajosyula P, Milewski RK, McCarthy F, Maniaci J, Szeto WY, Bavaria JE. Outcomes of Aortic Root Replacement After Previous Aortic Root Replacement: The “True” Redo Root. The Annals Of Thoracic Surgery 2015, 99: 1601-1609. PMID: 25754965, DOI: 10.1016/j.athoracsur.2014.12.038.Peer-Reviewed Original ResearchConceptsAortic root replacementDe novo groupRedo root replacementRoot replacementNovo groupRedo groupPrevious aortic root replacementRedo aortic root replacementFirst-time sternotomyFull aortic root replacementLow perioperative morbidityStructural valve deteriorationRisk of complicationsPresence of infectionAortic reoperationHospital lengthLate deathsPerioperative deathsSternal infectionUnderwent reoperationMidterm survivalPerioperative morbidityRenal failureOverall mortalityValve deterioration
2014
Use of procalcitonin for the prediction and treatment of acute bacterial infection in children
Pierce R, Bigham MT, Giuliano JS. Use of procalcitonin for the prediction and treatment of acute bacterial infection in children. Current Opinion In Pediatrics 2014, 26: 292-298. PMID: 24739491, DOI: 10.1097/mop.0000000000000092.Peer-Reviewed Original ResearchConceptsAntibiotic therapySerum procalcitoninTreatment failureNoninfectious systemic inflammatory response syndromeBacterial infectionsSystemic inflammatory response syndromeSerial PCT measurementsDuration of therapyCentral venous cathetersInflammatory response syndromeAcute bacterial infectionUse of procalcitoninC-reactive proteinInvasive bacterial infectionsPresence of infectionReliable serum markerSickle cell diseaseNoninfectious inflammationPCT levelsVenous cathetersResponse syndromeBacterial sepsisSerum markersPrognostic utilityPatient population
2012
GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals
Shenoy AR, Wellington DA, Kumar P, Kassa H, Booth CJ, Cresswell P, MacMicking JD. GBP5 Promotes NLRP3 Inflammasome Assembly and Immunity in Mammals. Science 2012, 336: 481-485. PMID: 22461501, DOI: 10.1126/science.1217141.Peer-Reviewed Original ResearchMeSH KeywordsAlum CompoundsAnimalsApoptosis Regulatory ProteinsCARD Signaling Adaptor ProteinsCarrier ProteinsCaspase 1Cell LineCytoskeletal ProteinsGTP-Binding ProteinsHumansInflammasomesInterferon-gammaInterleukin-1betaLipopolysaccharidesListeria monocytogenesListeriosisMacrophagesMiceNLR Family, Pyrin Domain-Containing 3 ProteinProtein MultimerizationRNA InterferenceSalmonella typhimuriumUric AcidConceptsGuanylate binding protein 5IL-1β/ILImpaired host defensePresence of infectionNLRP3 inflammasome activationCaspase-1 cleavageNLRP3 inflammasome responseNLRP3 inflammasome assemblyInflammasome assemblyBinding protein 5Inflammatory responseInflammasome activationImmune systemTissue damageInflammasome responseHost defenseInflammasome complexCaspase-1Sensory complexProtein 5InflammasomePathogenic bacteriaILInterleukinNLR
2011
Intensive care of the patient with cirrhosis
Olson JC, Wendon JA, Kramer DJ, Arroyo V, Jalan R, Garcia‐Tsao G, Kamath PS. Intensive care of the patient with cirrhosis. Hepatology 2011, 54: 1864-1872. PMID: 21898477, DOI: 10.1002/hep.24622.Peer-Reviewed Original ResearchConceptsMultiple organ failureIntensive care unitCare unitOrgan failureLiver functionSignificant survival benefitPresence of infectionFurther deteriorationQuality of lifeNumber of organsLiver support systemsAlcoholic hepatitisLiver transplantationVariceal hemorrhageAcute deteriorationCommon organLiver dysfunctionSurvival benefitViral hepatitisIll patientsIntensive careCritical carePatientsHigh mortalityTeam approach
2005
Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club
Wong F, Bernardi M, Balk R, Christman B, Moreau R, Garcia-Tsao G, Patch D, Soriano G, Hoefs J, Navasa M. Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut 2005, 54: 718. PMID: 15831923, PMCID: PMC1774473, DOI: 10.1136/gut.2004.038679.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastrointestinal bleedSepsis syndromeBacterial infectionsInternational Ascites ClubElevated D-dimerSystemic inflammatory responseSpontaneous bacterial peritonitisFurther tissue injuryPresence of infectionNitric oxide synthaseTumor necrosis factorUse of antibioticsUse of albuminSubclinical coagulopathyProphylactic antibioticsRenal impairmentCirrhotic patientsLiver dysfunctionRenal failureBacterial peritonitisBacterial translocationD-dimerReticuloendothelial functionProduction of superoxideInflammatory response
2001
Fever in subarachnoid hemorrhage
Oliveira–Filho J, Ezzeddine M, Segal A, Buonanno F, Chang Y, Ogilvy C, Rordorf G, Schwamm L, Koroshetz W, McDonald C. Fever in subarachnoid hemorrhage. Neurology 2001, 56: 1299-1304. PMID: 11376177, DOI: 10.1212/wnl.56.10.1299.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhagePoor outcomeTranscranial DopplerNeurologic intensive care unitOlder ageDaily transcranial DopplerGlasgow Coma ScoreHunt-Hess gradeRankin Scale scoreCause of feverIntensive care unitPresence of infectionNontraumatic subarachnoid hemorrhageSymptomatic vasospasmCerebral ischemiaComa ScoreConsecutive patientsAngiographic criteriaCare unitBrain injuryHemorrhage severityVasospasmPatientsFeverScale score
2000
Choroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imaging
1998
Human ehrlichiosis in central Europe.
Lotric-Furlan S, Petrovec M, Avsic-Zupanc T, Nicholson W, Sumner J, Childs J, Strle F. Human ehrlichiosis in central Europe. Wiener Klinische Wochenschrift 1998, 110: 894-7. PMID: 10048172.Peer-Reviewed Original ResearchConceptsFebrile illnessTick biteHGE agentPresence of infectionUniversity Medical CenterBlood smear examinationHuman granulocytic ehrlichiosis (HGE) agentEhrlichiosis casesAcute human diseaseClinical characteristicsAntibiotic therapyDisease coursePhysician awarenessProspective studyLaboratory findingsDifferential diagnosisMedical CenterSmear examinationHuman diseasesHuman ehrlichiosisNumber of casesPatientsHuman infectionsInfectious diseasesDisease
1992
Risk Factors for Delirium in Hospitalized Elderly
Schor J, Levkoff S, Lipsitz L, Reilly C, Cleary P, Rowe J, Evans D. Risk Factors for Delirium in Hospitalized Elderly. JAMA 1992, 267: 827-831. PMID: 1732655, DOI: 10.1001/jama.1992.03480060073033.Peer-Reviewed Original ResearchConceptsPrior cognitive impairmentRisk factorsOdds ratioCognitive impairmentIncidence of deliriumDetection of deliriumIndependent risk factorTertiary care hospitalUse of neurolepticsCohort analytic studyRisk factor dataPresence of infectionAcute care hospitalsPatients' medical recordsYears of ageStepwise logistic regressionHospital deliriumAnticholinergic useElderly patientsMedication groupCare hospitalHospitalized patientsNeuroleptic useSurgical wardsNarcotic use
1989
Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function
Herson V, Block C, Eisenfeld L, Maderazo E, Krause P. Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function. Journal Of Parenteral And Enteral Nutrition 1989, 13: 620-622. PMID: 2515309, DOI: 10.1177/0148607189013006620.Peer-Reviewed Original ResearchConceptsPolymorphonuclear leukocytesIntralipid infusionNeonatal intensive care unitAdult polymorphonuclear leukocytesIntensive care unitIntravenous fat infusionPresence of infectionAdverse hematologic effectsNeonatal polymorphonuclear leukocytesParenteral nutritionIll neonatesNeonatal neutrophilsPMN countCare unitPlatelet countPlatelet activityHematologic effectsIntravenous fatPlatelet functionPlatelet numberUnchanged preFat infusionPlatelet aggregationInfusionIntralipid
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