2023
Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium
Sperotto F, Gutiérrez-Sacristán A, Makwana S, Li X, Rofeberg V, Cai T, Bourgeois F, Omenn G, Hanauer D, Sáez C, Bonzel C, Bucholz E, Dionne A, Elias M, García-Barrio N, González T, Issitt R, Kernan K, Laird-Gion J, Maidlow S, Mandl K, Ahooyi T, Moraleda C, Morris M, Moshal K, Pedrera-Jiménez M, Shah M, South A, Spiridou A, Taylor D, Verdy G, Visweswaran S, Wang X, Xia Z, Zachariasse J, EHR T, Aaron J, Adam A, Agapito G, Albayrak A, Albi G, Alessiani M, Alloni A, Amendola D, Angoulvant F, Anthony L, Aronow B, Ashraf F, Atz A, Avillach P, Panickan V, Azevedo P, Badenes R, Balshi J, Batugo A, Beaulieu-Jones B, Beaulieu-Jones B, Bell D, Bellasi A, Bellazzi R, Benoit V, Beraghi M, Bernal-Sobrino J, Bernaux M, Bey R, Bhatnagar S, Blanco-Martínez A, Boeker M, Bonzel C, Booth J, Bosari S, Bourgeois F, Bradford R, Brat G, Bréant S, Brown N, Bruno R, Bryant W, Bucalo M, Bucholz E, Burgun A, Cai T, Cannataro M, Carmona A, Cattelan A, Caucheteux C, Champ J, Chen J, Chen K, Chiovato L, Chiudinelli L, Cho K, Cimino J, Colicchio T, Cormont S, Cossin S, Craig J, Cruz-Bermúdez J, Cruz-Rojo J, Dagliati A, Daniar M, Daniel C, Das P, Devkota B, Dionne A, Duan R, Dubiel J, DuVall S, Esteve L, Estiri H, Fan S, Follett R, Ganslandt T, García-Barrio N, Garmire L, Gehlenborg N, Getzen E, Geva A, Goh R, González T, Gradinger T, Gramfort A, Griffier R, Griffon N, Grisel O, Gutiérrez-Sacristán A, Guzzi P, Han L, Hanauer D, Haverkamp C, Hazard D, He B, Henderson D, Hilka M, Ho Y, Holmes J, Honerlaw J, Hong C, Huling K, Hutch M, Issitt R, Jannot A, Jouhet V, Kainth M, Kate K, Kavuluru R, Keller M, Kennedy C, Kernan K, Key D, Kirchoff K, Klann J, Kohane I, Krantz I, Kraska D, Krishnamurthy A, L'Yi S, Leblanc J, Lemaitre G, Lenert L, Leprovost D, Liu M, Loh N, Long Q, Lozano-Zahonero S, Luo Y, Lynch K, Mahmood S, Maidlow S, Makoudjou A, Makwana S, Malovini A, Mandl K, Mao C, Maram A, Maripuri M, Martel P, Martins M, Marwaha J, Masino A, Mazzitelli M, Mazzotti D, Mensch A, Milano M, Minicucci M, Moal B, Ahooyi T, Moore J, Moraleda C, Morris J, Morris M, Moshal K, Mousavi S, Mowery D, Murad D, Murphy S, Naughton T, Neto C, Neuraz A, Newburger J, Ngiam K, Njoroge W, Norman J, Obeid J, Okoshi M, Olson K, Omenn G, Orlova N, Ostasiewski B, Palmer N, Paris N, Patel L, Pedrera-Jiménez M, Pfaff A, Pfaff E, Pillion D, Pizzimenti S, Priya T, Prokosch H, Prudente R, Prunotto A, Quirós-González V, Ramoni R, Raskin M, Rieg S, Roig-Domínguez G, Rojo P, Romero-Garcia N, Rubio-Mayo P, Sacchi P, Sáez C, Salamanca E, Samayamuthu M, Sanchez-Pinto L, Sandrin A, Santhanam N, Santos J, Vidorreta F, Savino M, Schriver E, Schubert P, Schuettler J, Scudeller L, Sebire N, Serrano-Balazote P, Serre P, Serret-Larmande A, Shah M, Abad Z, Silvio D, Sliz P, Son J, Sonday C, South A, Sperotto F, Spiridou A, Strasser Z, Tan A, Tan B, Tan B, Tanni S, Taylor D, Terriza-Torres A, Tibollo V, Tippmann P, Toh E, Torti C, Trecarichi E, Vallejos A, Varoquaux G, Vella M, Verdy G, Vie J, Visweswaran S, Vitacca M, Wagholikar K, Waitman L, Wang X, Wassermann D, Weber G, Wolkewitz M, Wong S, Xia Z, Xiong X, Ye Y, Yehya N, Yuan W, Zachariasse J, Zahner J, Zambelli A, Zhang H, Zöller D, Zuccaro V, Zucco C, Newburger J, Avillach P. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium. EClinicalMedicine 2023, 64: 102212. PMID: 37745025, PMCID: PMC10511777, DOI: 10.1016/j.eclinm.2023.102212.Peer-Reviewed Original ResearchSystemic inflammatory response syndromeSARS-CoV-2 eraMultisystem inflammatory syndromeLower lymphocyte countsLower troponinInflammatory syndromeLymphocyte countRisk differenceClinical phenotypeLower C-reactive proteinSARS-CoV-2 infectionPooled risk differenceInflammatory response syndromeLength of hospitalizationObservational retrospective studyC-reactive proteinElectronic health record dataSARS-CoV-2 variantsOutcomes of MISHealth record dataEffect sizeAnticoagulation therapyClinical characteristicsRespiratory symptomsRare complication
2022
Commentary on “Predictors of postoperative systemic inflammatory response syndrome after scoliosis surgery in adolescents with cerebral palsy: A retrospective analysis”
Oghenesume O, Grauer J. Commentary on “Predictors of postoperative systemic inflammatory response syndrome after scoliosis surgery in adolescents with cerebral palsy: A retrospective analysis”. North American Spine Society Journal (NASSJ) 2022, 12: 100173. PMID: 36589691, PMCID: PMC9797607, DOI: 10.1016/j.xnsj.2022.100173.Commentaries, Editorials and Letters
2019
Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women
Bauer ME, Housey M, Bauer ST, Behrmann S, Chau A, Clancy C, Clark EAS, Einav S, Langen E, Leffert L, Lin S, Madapu M, Maile MD, McQuaid-Hanson E, Priessnitz K, Sela HY, Shah A, Sobolewski P, Toledo P, Tsen LC, Bateman BT. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 31743182, PMCID: PMC7543988, DOI: 10.1213/ane.0000000000003709.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeQuick Sequential Organ Failure AssessmentRisk factorsDelivery hospitalizationsMaternal sepsisSepsis casesCommon causeMortality rateMaternal Early Warning CriteriaSequential Organ Failure AssessmentScreening toolHours of diagnosisTiming of antibioticsOrgan Failure AssessmentCohort of patientsInflammatory response syndromePotential risk factorsHalf of casesAcademic medical centerDate of deliveryQSOFA criteriaControl patientsAntibiotic therapyResponse syndromeSignificant morbidityClinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study
Uy G, Minden M, Montesinos P, DeAngelo D, Altman J, Koprivnikar J, Vyas P, Fløisand Y, Vidriales M, Gjertsen B, Esteve J, Buchholz T, Couto S, Fan J, Hanna B, Li L, Pierce D, Hege K, Pourdehnad M, Zeidan A. Clinical Activity of CC-90009, a Cereblon E3 Ligase Modulator and First-in-Class GSPT1 Degrader, As a Single Agent in Patients with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML): First Results from a Phase I Dose-Finding Study. Blood 2019, 134: 232. DOI: 10.1182/blood-2019-123966.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsCereblon E3 ligase modulatorSystemic inflammatory response syndromeCC-90009Phase 1 studyR AMLHighest dose levelDose levelsCelgene CorporationDaiichi SankyoSpeakers bureauGrade 3/4 treatment-emergent adverse eventsDay 1Jazz PharmaceuticalsObserved treatment-emergent adverse eventOpen-label phase 1 studySerious treatment-emergent adverse eventsHyperglycemic hyperosmolar nonketotic syndromeIncomplete blood count recoveryMorphologic leukemia-free stateRefractory acute myeloid leukemiaHigh-risk myelodysplastic syndromeAdvisory CommitteeAntileukemic activityI Dose-Finding StudyRuxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigens
Carnes H, Mehrkens B, Stegman M, Rajagopalan G. Ruxolitinib, a selective JAK1/2 inhibitor, for the treatment of serious diseases caused by Staphylococcus aureus superantigens. The Journal Of Immunology 2019, 202: 190.34-190.34. DOI: 10.4049/jimmunol.202.supp.190.34.Peer-Reviewed Original ResearchSystemic inflammatory response syndromeMulti-organ failureT cellsHLA-DR3 transgenic miceHLA class II moleculesVehicle-treated miceVivo studiesInflammatory response syndromeT cell subsetsToxic shock syndromeJAK 1/2 inhibitorSelective JAK1/2 inhibitorClass II moleculesStaphylococcus aureusDose-dependent mannerSerious diseaseJanus kinaseIL-17Response syndromeOrgan failureJAK1/2 inhibitorActivation markersCell subsetsShock syndromeIL-2Clozapine‐Induced Cardiotoxicity Presenting as Sepsis: A Case Report and Literature Review
Khalid M, Jegede O, Gayam V, Yang YC, Shrestha B, Mandal A, Mukhtar O, Garlapati P, Khalid M, Dufresne A. Clozapine‐Induced Cardiotoxicity Presenting as Sepsis: A Case Report and Literature Review. Case Reports In Medicine 2019, 2019: 3435108. PMID: 31049067, PMCID: PMC6462315, DOI: 10.1155/2019/3435108.Peer-Reviewed Original ResearchLife-threatening side effectsSystolic functionSide effectsSystemic inflammatory response syndromeClose hematological monitoringMedication-resistant schizophreniaInflammatory response syndromeManagement of sepsisElevated triglyceride levelsAtypical antipsychotic agentsManagement of schizophreniaClozapine cardiotoxicityIntravenous antibioticsRepeat echocardiogramElevated troponinPostural hypotensionClozapine useHematological monitoringResponse syndromeSerious complicationsCase reportTriglyceride levelsAntipsychotic agentsPsychiatric illnessClozapine
2018
Septic Shock
Abdel‐Razeq S, Norwitz E. Septic Shock. 2018, 599-629. DOI: 10.1002/9781119129400.ch38.Peer-Reviewed Original ResearchSystemic inflammatory response syndromeAcute respiratory distress syndromeSeptic shockPercent of patientsGeneralized inflammatory responseInflammatory response syndromeInadequate tissue oxygenationRespiratory distress syndromeVascular smooth muscleVariety of insultsMicrobiologic pathogensFetal outcomesSevere sepsisCirculatory failureDistress syndromeResponse syndromeClinical spectrumClinical syndromeInflammatory responsePregnant hostsSmooth muscleTissue oxygenationPhysiologic adaptationsHost responseFluid homeostasisDevelopment of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1)
Bayarri-Olmos R, Kirketerp-Moller N, Pérez-Alós L, Skjodt K, Skjoedt M, Garred P. Development of a Quantitative Assay for the Characterization of Human Collectin-11 (CL-11, CL-K1). Frontiers In Immunology 2018, 9: 2238. PMID: 30323815, PMCID: PMC6172411, DOI: 10.3389/fimmu.2018.02238.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodies, MonoclonalCHO CellsChromatography, GelCollectinsComplement C4CricetulusEnzyme-Linked Immunosorbent AssayFreezingHumansLectinsMannose-Binding Protein-Associated Serine ProteasesProtein BindingStatistics, NonparametricSystemic Inflammatory Response SyndromeZymosanConceptsPlasma levelsSystemic inflammatory response syndromeQuantitative ELISACL-11Immunoprecipitation of serumDisseminated intravascular coagulationInflammatory response syndromeMean plasma concentrationCollectin-11Pattern recognition moleculesIntravascular coagulationResponse syndromeIntensive careUrinary schistosomiasisHealthy controlsPlasma concentrationsClinical toolHost defenseSensitive ELISAMonoclonal antibodiesELISACongenital disorderSignificant decreaseLectin pathwayZymosan
2017
Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis
Buxbaum JL, Quezada M, Da B, Jani N, Lane C, Mwengela D, Kelly T, Jhun P, Dhanireddy K, Laine L. Early Aggressive Hydration Hastens Clinical Improvement in Mild Acute Pancreatitis. The American Journal Of Gastroenterology 2017, 112: 797. PMID: 28266591, DOI: 10.1038/ajg.2017.40.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeMild acute pancreatitisBlood urea nitrogenAggressive intravenous hydrationClinical improvementStandard hydrationAcute pancreatitisIntravenous hydrationPersistent systemic inflammatory response syndromeClear liquid dietInflammatory response syndromeCox regression analysisAcute pancreatitis treatmentLactated Ringer's solutionAggressive hydrationEpigastric painImproved painOral dietPrimary endpointInitial managementOrgan failureResponse syndromeRandomized trialsVolume overloadMean age
2016
SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol
Kopp MA, Liebscher T, Watzlawick R, Martus P, Laufer S, Blex C, Schindler R, Jungehulsing GJ, Knüppel S, Kreutzträger M, Ekkernkamp A, Dirnagl U, Strittmatter SM, Niedeggen A, Schwab JM. SCISSOR—Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol. BMJ Open 2016, 6: e010651. PMID: 27466236, PMCID: PMC4964175, DOI: 10.1136/bmjopen-2015-010651.Peer-Reviewed Original ResearchConceptsSpinal cord injurySystemic inflammatory response syndromeNeuropathic painHeterotopic ossificationMotor complete spinal cord injuryPrimary safety end pointEnd pointOpen-label pilot trialImproved motor recoveryPrimary safety analysisSafety end pointSecondary end pointsSerious adverse eventsSevere gastrointestinal bleedingInflammatory response syndromeSecondary outcome assessmentsWarrants clinical investigationAnti-inflammatory drugsClinical study protocolClinical trial protocolGood clinical practiceRho inhibitionDeclaration of HelsinkiGastroduodenal bleedingGastrointestinal bleedingSevere non-infective systemic inflammatory response syndrome, shock, and end-organ dysfunction after zoledronic acid administration in a child
Trivedi S, Al-Nofal A, Kumar S, Tripathi S, Kahoud R, Tebben P. Severe non-infective systemic inflammatory response syndrome, shock, and end-organ dysfunction after zoledronic acid administration in a child. Osteoporosis International 2016, 27: 2379-2382. PMID: 26892041, DOI: 10.1007/s00198-016-3528-4.Peer-Reviewed Case Reports and Technical NotesConceptsZoledronic acidPediatric patientsMethodsA 7-year-old boyInfusion of zoledronic acidModerate acute respiratory distress syndromeNon-infective systemic inflammatory response syndromeIncreased bone mineral densitySystemic inflammatory response syndromeElevated C-reactive proteinAcute respiratory distress syndromeIntensive cardiorespiratory supportZoledronic acid infusionAbnormal coagulation profileZoledronic acid therapyHypoxic-ischemic encephalopathyPediatric intensive care unitEnd-organ dysfunctionZoledronic acid administrationInflammatory response syndromeBone mineral densityRespiratory distress syndromeRisk of fractureC-reactive proteinIncreased oxygen requirementIntensive care unitPlasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock
Belsky JB, Morris DC, Bouchebl R, Filbin MR, Bobbitt KR, Jaehne AK, Rivers EP. Plasma levels of F-actin and F:G-actin ratio as potential new biomarkers in patients with septic shock. Biomarkers 2016, 21: 180-185. PMID: 26754286, DOI: 10.3109/1354750x.2015.1126646.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeNoninfectious systemic inflammatory response syndromeSeptic shockThymosin beta 4Healthy controlsSIRS groupPlasma levelsInflammatory response syndromePotential new biomarkersResponse syndromeActin ratioNew biomarkersPotential biomarkersBeta 4PatientsBiomarkersActin levelsF-actinGroupSyndromeLevelsDiagnosis
2015
Typical evanescent and atypical persistent polymorphic cutaneous rash in an adult Brazilian with Still’s disease: a case report and review of the literature
Michailidou D, Shin J, Forde I, Gopalratnam K, Cohen P, DeGirolamo A. Typical evanescent and atypical persistent polymorphic cutaneous rash in an adult Brazilian with Still’s disease: a case report and review of the literature. Autoimmunity Highlights 2015, 6: 39-46. PMID: 26423534, PMCID: PMC4633415, DOI: 10.1007/s13317-015-0071-9.Peer-Reviewed Original ResearchAtypical cutaneous manifestationsCutaneous manifestationsSevere systemic inflammatory response syndromeSystemic inflammatory response syndromeMaculopapular skin rashPolymorphic cutaneous manifestationsInflammatory response syndromeDistinctive pathological featuresAuto-inflammatory conditionsCoalescent papulesCutaneous rashHigh feverResponse syndromeSkin rashUnknown etiologyPathological featuresCase reportAdult onsetSkin biopsiesSevere diseaseSkin lesionsLinear lesionsBrazilian menAOSDDiseaseDelayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis
Lee F, Ohanian E, Rheem J, Laine L, Che K, Kim JJ. Delayed endoscopic retrograde cholangiopancreatography is associated with persistent organ failure in hospitalised patients with acute cholangitis. Alimentary Pharmacology & Therapeutics 2015, 42: 212-220. PMID: 25997554, DOI: 10.1111/apt.13253.Peer-Reviewed Original ResearchConceptsEarly endoscopic retrograde cholangiopancreatographyPersistent organ failureEarly ERCPOrgan failureEndoscopic retrograde cholangiopancreatographyAcute cholangitisRetrograde cholangiopancreatographySystemic inflammatory response syndromeConsecutive hospitalised patientsCharlson Comorbidity IndexInflammatory response syndromeRelative risk increaseComorbidity indexHospitalised patientsPrimary outcomeResponse syndromeBenign obstructionMalignant stricturesCholangitisPatientsMultivariate analysisRisk increaseHospitalisationHypoalbuminemiaBacteremia
2014
Use of procalcitonin for the prediction and treatment of acute bacterial infection in children
Pierce R, Bigham MT, Giuliano JS. Use of procalcitonin for the prediction and treatment of acute bacterial infection in children. Current Opinion In Pediatrics 2014, 26: 292-298. PMID: 24739491, DOI: 10.1097/mop.0000000000000092.Peer-Reviewed Original ResearchConceptsAntibiotic therapySerum procalcitoninTreatment failureNoninfectious systemic inflammatory response syndromeBacterial infectionsSystemic inflammatory response syndromeSerial PCT measurementsDuration of therapyCentral venous cathetersInflammatory response syndromeAcute bacterial infectionUse of procalcitoninC-reactive proteinInvasive bacterial infectionsPresence of infectionReliable serum markerSickle cell diseaseNoninfectious inflammationPCT levelsVenous cathetersResponse syndromeBacterial sepsisSerum markersPrognostic utilityPatient population
2013
1041
Kapoor S, Yunen R, Tabrizian P, Semoin S, Jibara G, Benjamin E, Labow D, Bassily-Marcus A. 1041. Critical Care Medicine 2013, 41: a262. DOI: 10.1097/01.ccm.0000440277.93127.11.Peer-Reviewed Original ResearchDay mortalityEarly detection of infectious complicationsICU courseDetection of infectious complicationsICU managementSystemic inflammatory response syndromeAssociated with high morbidityProlonged hospital length of stayPostoperative ICU coursePostoperative ICU managementHyperthermic intraperitoneal chemotherapyIntra-abdominal abscessTertiary academic medical centerPostoperative blood transfusionAggressive fluid resuscitationAcute respiratory failureAcute renal failureHospital length of stayInflammatory response syndromePatients admitted to ICUMedian APACHE-II scoreAPACHE-II scoreManagement of patientsMedian ICU LOSProlonged hospital lengthRisk Factors for Conversion from Laparoscopic to Open Surgery: Analysis of 2138 Converted Operations in the American College of Surgeons National Surgical Quality Improvement Program
Papandria D, Lardaro T, Rhee D, Ortega G, Gorgy A, Makary M, Abdullah F. Risk Factors for Conversion from Laparoscopic to Open Surgery: Analysis of 2138 Converted Operations in the American College of Surgeons National Surgical Quality Improvement Program. The American Surgeon 2013, 79: 914-921. PMID: 24069991, DOI: 10.1177/000313481307900930.Peer-Reviewed Original ResearchConceptsAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramRisk factorsQuality Improvement ProgramBariatric proceduresPreoperative systemic inflammatory response syndromeOrgan space surgical site infectionReturn to the operating roomConversion to open surgeryHistory of bleeding disordersLaparoscopic to open surgeryAmerican CollegeSpace surgical site infectionSystemic inflammatory response syndromeConversion risk factorsInfluence surgical practiceInflammatory response syndromeSurgical site infectionAssociated with greater incidenceOperative risk factorsLogistic regression analysisLCO-groupOpen surgery
2012
Systemic inflammation worsens outcomes in emergency surgical patients
Becher RD, Hoth JJ, Miller PR, Meredith JW, Chang MC. Systemic inflammation worsens outcomes in emergency surgical patients. Journal Of Trauma And Acute Care Surgery 2012, 72: 1140-1149. PMID: 22673238, DOI: 10.1097/ta.0b013e3182516a97.Peer-Reviewed Original ResearchMeSH KeywordsAgedDigestive System Surgical ProceduresDisease ProgressionEmergenciesFollow-Up StudiesHumansMiddle AgedMorbidityOutcome Assessment, Health CarePostoperative ComplicationsRetrospective StudiesRisk FactorsSeverity of Illness IndexSurvival RateSystemic Inflammatory Response SyndromeUnited StatesConceptsSystemic inflammatory response syndromeSevere sepsis/septic shockSepsis/septic shockPreoperative systemic inflammationEmergency surgical patientsSystemic inflammatory responseThirty-day survivalSystemic inflammationInflammatory responsePostoperative outcomesSurgical patientsSeptic shockEmergent colon surgeryEmergency general surgeryInflammatory response syndromeTimely surgical interventionAcute care surgeonsKaplan-Meier methodRisk of morbidityDamage control operationPreoperative inflammationColorectal operationsPostoperative complicationsHazard ratioSepsis patientsThe impact of tacrolimus on the immunopathogenesis of staphylococcal enterotoxin-induced systemic inflammatory response syndrome and pneumonia
Tilahun A, Karau M, Clark C, Patel R, Rajagopalan G. The impact of tacrolimus on the immunopathogenesis of staphylococcal enterotoxin-induced systemic inflammatory response syndrome and pneumonia. Microbes And Infection 2012, 14: 528-536. PMID: 22273732, DOI: 10.1016/j.micinf.2012.01.001.Peer-Reviewed Original ResearchConceptsStaphylococcal superantigensT cell activationChemokine levelsCell activationSystemic inflammatory response syndromeDR3 transgenic miceEfficacy of tacrolimusInflammatory response syndromeHuman leukocyte antigenImpact of tacrolimusPotent immunosuppressive agentPost-exposure treatmentT cell proliferationS. aureus strainsSystemic cytokinesGut dysfunctionSerum cytokinesResponse syndromeImmunosuppressive agentsLeukocyte antigenSystemic pathologyTacrolimusLethal pneumoniaPneumoniaTransgenic mice
2009
Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13)
rajagopalan G, Tilahun A, David C. Therapeutic use of proteasome inhibitors in bacterial superantigen- and LPS-induced acute systemic inflammatory response syndromes (93.13). The Journal Of Immunology 2009, 182: 93.13-93.13. DOI: 10.4049/jimmunol.182.supp.93.13.Peer-Reviewed Original ResearchToxic shock syndromeAcute systemic inflammatory response syndromeHLA class II transgenic miceProfound systemic inflammatory responseSystemic inflammatory response syndromeTherapeutic useAcute systemic inflammatory diseaseII transgenic miceInflammatory response syndromeSystemic inflammatory diseaseSystemic inflammatory responseAcute liver failureProteasome inhibitorsPro-inflammatory cytokinesT cell activationSerum biochemical parametersStaphylococcal enterotoxin BPro-apoptotic effectsLiver failureResponse syndromeSerum levelsHistopathological findingsCytokine productionSepsis modelShock syndrome
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