2024
Non-dominant, Lesional Mesial Temporal Lobe Epilepsy
Mahmoud N, Herlopian A, Mattson R. Non-dominant, Lesional Mesial Temporal Lobe Epilepsy. 2024, 47-61. DOI: 10.1007/978-3-031-23828-4_3.Peer-Reviewed Original ResearchNon-dominant, Non-lesional Insular epilepsy
Herlopian A. Non-dominant, Non-lesional Insular epilepsy. 2024, 287-326. DOI: 10.1007/978-3-031-23828-4_13.Peer-Reviewed Original ResearchDominant, Lesional Mesial Temporal Lobe Epilepsy
Herlopian A. Dominant, Lesional Mesial Temporal Lobe Epilepsy. 2024, 33-45. DOI: 10.1007/978-3-031-23828-4_2.Peer-Reviewed Original Research
2023
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy
Khoshkhoo S, Wang Y, Chahine Y, Erson-Omay E, Robert S, Kiziltug E, Damisah E, Nelson-Williams C, Zhu G, Kong W, Huang A, Stronge E, Phillips H, Chhouk B, Bizzotto S, Chen M, Adikari T, Ye Z, Witkowski T, Lai D, Lee N, Lokan J, Scheffer I, Berkovic S, Haider S, Hildebrand M, Yang E, Gunel M, Lifton R, Richardson R, Blümcke I, Alexandrescu S, Huttner A, Heinzen E, Zhu J, Poduri A, DeLanerolle N, Spencer D, Lee E, Walsh C, Kahle K. Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy. JAMA Neurology 2023, 80: 578-587. PMID: 37126322, PMCID: PMC10152377, DOI: 10.1001/jamaneurol.2023.0473.Peer-Reviewed Original ResearchConceptsDrug-resistant mesial temporal lobe epilepsyMesial temporal lobe epilepsyPathogenic somatic variantsTemporal lobe epilepsyMedian ageLobe epilepsyTemporal neocortexHippocampal tissueLevel 4 epilepsy centerAvailable frozen tissueSomatic variantsControl brain tissueMedial temporal lobectomyNew therapeutic targetsMolecular assaysGene panel sequencingRas/Raf/MAPK signalingAntiseizure medicationsMost patientsCommon indicationGermline genetic variantsEpilepsy centersTemporal lobectomyEpilepsy surgerySex-matched neurotypical controls
2022
Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing
Quraishi IH, Brown FC, Johnson MH, Hirsch LJ. Hippocampal recording via the RNS system reveals marked ipsilateral activation of epileptiform activity during Wada testing. Epilepsy & Behavior 2022, 134: 108854. PMID: 35905518, DOI: 10.1016/j.yebeh.2022.108854.Peer-Reviewed Original ResearchConceptsResponsive neurostimulation systemWada testingEpileptiform activityElicitation of seizuresTemporal lobe resectionInternal carotid arteryMedial temporal structuresHippocampal vasculatureIpsilateral activationLobe resectionPosterior circulationElectrographic seizuresTemporal lobectomyElectrographic changesIntractable epilepsyClinical correlatesWada testCarotid arteryHippocampal spikesNegative findingsNeurostimulation systemHippocampal EEGHippocampal activityPatientsTransient increase
2017
Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy
Herlopian A, Shihabuddin B. Predictive Value of Electrocorticography in Patients With Mesial Temporal Lobe Epilepsy Undergoing Selective Amygdalohippocampectomy. Journal Of Clinical Neurophysiology 2017, 34: 370-374. PMID: 28306691, DOI: 10.1097/wnp.0000000000000376.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisTemporal lobe epilepsyPostoperative seizure freedomSelective amygdalohippocampectomyLobe epilepsyIntraoperative electrocorticographySeizure freedomPredictive valueStandard temporal lobectomyNormal brain MRIElectrocorticography findingsSeizure outcomeTemporal sclerosisPostoperative outcomesConsecutive patientsTemporal lobectomyMean durationSingle neurosurgeonRetrospective analysisBrain MRIPatientsEpilepsySeizuresElectrocorticographySurgical outcome in adolescents with mesial temporal sclerosis: Is it different?
Farooque P, Hirsch L, Levy S, Testa F, Mattson R, Spencer D. Surgical outcome in adolescents with mesial temporal sclerosis: Is it different? Epilepsy & Behavior 2017, 69: 24-27. PMID: 28235653, DOI: 10.1016/j.yebeh.2016.10.028.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisTemporal sclerosisStatus epilepticusTemporal lobectomySurgical outcomesAdolescent patientsIctal onsetMore lobesEpilepsy surgery databaseScalp EEGSeizure freedomPatient populationSurgery DatabaseRisk factorsPatientsElectrographic dataLobectomyEpilepticusTwo yearsSclerosisHypometabolismNovel findingsAdolescentsMRIOutcomes
2010
Visual memory in patients after anterior right temporal lobectomy and adult normative data for the Brown Location Test
Brown FC, Tuttle E, Westerveld M, Ferraro FR, Chmielowiec T, Vandemore M, Gibson-Beverly G, Bemus L, Roth RM, Blumenfeld H, Spencer DD, Spencer SS. Visual memory in patients after anterior right temporal lobectomy and adult normative data for the Brown Location Test. Epilepsy & Behavior 2010, 17: 215-220. PMID: 20056493, PMCID: PMC2825669, DOI: 10.1016/j.yebeh.2009.11.026.Peer-Reviewed Original ResearchConceptsVisual memoryLocation learningNormative dataLocation testLarge meta-analytic studiesAnterior mesial temporal lobeTemporal lobectomyRight temporal lobectomyAdult normative dataTemporal lobe changesMeta-analytic studyMemory testNormative sampleMemory deficitsMesial temporal lobectomyTemporal lobeStandardized scoresWorse performanceMemoryMesial temporal lobeHealthy adultsPresent findingsLearningLobectomy groupConsistent relationship
2007
ApoE, MemorE, and EpilepsE
Hirsch LJ. ApoE, MemorE, and EpilepsE. Epilepsy Currents 2007, 7: 149-150. PMID: 18049720, PMCID: PMC2096726, DOI: 10.1111/j.1535-7511.2007.00208.x.Peer-Reviewed Original ResearchMemory performanceIntractable temporal lobe epilepsyTemporal lobe epilepsyPoorer memory performanceApoE-4 statusTemporal lobectomyDuration of epilepsyLobe epilepsyNonverbal measuresTest performanceReduced memoryAPOE-4 alleleSignificant interactionAdult patientsAPOE 4EpilepsyPatientsLonger durationMemoryLobectomyRelationshipApoE
2006
Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis
McClelland S, Garcia RE, Peraza DM, Shih TT, Hirsch LJ, Hirsch J, Goodman RR. Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis. Epilepsia 2006, 47: 1337-1342. PMID: 16922878, DOI: 10.1111/j.1528-1167.2006.00557.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisAnteromedial temporal lobectomyTemporal lobe epilepsyTLE onsetTemporal sclerosisTemporal lobectomyRight amygdalaEarly-onset patientsLate-onset patientsEarly-onset groupLate-onset groupAmygdalar damageAge 6 yearsFER impairmentPostsurgical populationLobe epilepsyLeft-hemisphere language dominancePreoperative MRIPatientsFrightened expressionImpaired facial emotion recognitionLobectomySclerosisAmygdalaOnset
2000
Contribution of the Anteromedial Temporal Lobes to the Evaluation of Facial Emotion
Anderson A, Spencer D, Fulbright R, Phelps E. Contribution of the Anteromedial Temporal Lobes to the Evaluation of Facial Emotion. Neuropsychology 2000, 14: 526-536. PMID: 11055255, DOI: 10.1037/0894-4105.14.4.526.Peer-Reviewed Original ResearchConceptsAnteromedial temporal lobeSubcortical limbic regionsAnteromedial temporal lobectomyTemporal lobectomyCortical lesionsLimbic regionsLTL patientsAdjacent cortexCortical functionTemporal lobeNormal controlsRight amygdalaCortical contributionNeural circuitsPatientsSevere deficitsAmygdala damageIntensity ratingsHemispheric specializationGlobal deficitDeficitsExpressionLobectomyLesionsAmygdalaChoroid plexus changes after temporal lobectomy.
Saluja S, Sato N, Kawamura Y, Coughlin W, Putman C, Spencer D, Sze G, Bronen R. Choroid plexus changes after temporal lobectomy. American Journal Of Neuroradiology 2000, 21: 1650-3. PMID: 11039344, PMCID: PMC8174865.Peer-Reviewed Original ResearchConceptsTemporal lobectomyChoroid plexusPostoperative changesResection siteNormal postoperative changesRecurrent brain tumorsContrast-enhanced T1-weighted imagesPresence of infectionContrast-enhanced MR imagingDegree of enhancementT1-weighted imagesChoroid plexus changesHippocampal sclerosisRecurrent tumorsIntractable epilepsyNodular patternPathologic changesPostoperative siteLobectomyBrain tumorsEnhancement patternSurgical manipulationPlexusMorphologic changesMR imaging
1999
Language-related cognitive declines after left temporal lobectomy in children
Dlugos D, Moss E, Duhaime A, Brooks-Kayal A. Language-related cognitive declines after left temporal lobectomy in children. Pediatric Neurology 1999, 21: 444-449. PMID: 10428428, DOI: 10.1016/s0887-8994(99)00032-6.Peer-Reviewed Original ResearchConceptsTemporal lobectomy patientsVerbal learningCognitive declineLobectomy patientsTemporal lobectomyRight temporal lobectomy patientsSight word recognitionMeasurements of IQNeuropsychologic testingIntelligence quotient (IQ) testingSchool-aged childrenVisual memoryWord recognitionVerbal IQCognitive deficitsIQ testingNeuropsychologic evaluationSchool-aged patientsDeficitsTemporal lobe epilepsyIQEducational performanceComprehensionLobe epilepsyLearning
1997
Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG
King D, Bronen R, Spencer D, Spencer S. Topographic distribution of seizure onset and hippocampal atrophy: Relationship between MRI and depth EEG. Clinical Neurophysiology 1997, 103: 692-697. PMID: 9546496, DOI: 10.1016/s0013-4694(97)00090-4.Peer-Reviewed Original ResearchConceptsMedial temporal lobe epilepsyMagnetic resonance imagingSegmental atrophyHippocampal atrophyIctal onsetCell lossTopographic distributionDepth EEGHippocampal cell lossAnterior temporal lobectomyTemporal lobe epilepsyHippocampal depth electrodesMedial temporal structuresDistribution of onsetMost patientsTemporal lobectomyFocal onsetLobe epilepsyExcellent outcomesIctal recordingsDentate gyrusHippocampal segmentsSeizure onsetSubdural stripsDepth electrode contactsPostoperative changes in the brain: MR imaging findings in patients without neoplasms.
Sato N, Bronen R, Sze G, Kawamura Y, Coughlin W, Putman C, Spencer D. Postoperative changes in the brain: MR imaging findings in patients without neoplasms. Radiology 1997, 204: 839-46. PMID: 9280269, DOI: 10.1148/radiology.204.3.9280269.Peer-Reviewed Original ResearchConceptsPostoperative MR imagesPostoperative changesDural enhancementEnhancement patternThin linear enhancementContrast enhancement patternMagnetic resonance imagingMR imagesSurgical marginsTemporal lobectomyNeoplastic changesExtraaxial fluidIntracranial airContrast material-enhanced MR imagesDay 5Day 51Day 30Resonance imagingSurgeryBrainPatientsTime courseContrast enhancementLinear enhancementDaysA Role for the Right Anterior Temporal Lobe in Taste Quality Recognition
Small D, Jones-Gotman M, Zatorre R, Petrides M, Evans A. A Role for the Right Anterior Temporal Lobe in Taste Quality Recognition. Journal Of Neuroscience 1997, 17: 5136-5142. PMID: 9185551, PMCID: PMC6573307, DOI: 10.1523/jneurosci.17-13-05136.1997.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowAnteromedial temporal lobeGroup of patientsTemporal lobeRight anterior temporal lobectomyOrbitofrontal cortexCaudolateral orbitofrontal cortexAnterior temporal lobectomyCerebral blood flowRight anterior temporal lobePrimary taste cortexTreatment of epilepsyPositron emission tomographyRight cerebral hemisphereAnterior temporal lobeRCBF increasesTemporal lobectomyGustatory functionTaste cortexBlood flowCerebral hemispheresControl groupEmission tomographyPatientsTaste sensation
1996
Medial temporal lobe epilepsy without hippocampal atrophy
King D, Spencer S, Bouthillier A, Kim J, de Lanerolle N, Bronen R, McCarthy G, Luby M, Spencer D. Medial temporal lobe epilepsy without hippocampal atrophy. Epilepsy Research 1996, 9: 291-297. DOI: 10.1016/s0896-6974(96)00039-4.Peer-Reviewed Original ResearchMedial temporal lobe epilepsyHippocampal atrophyTemporal lobe epilepsyHippocampal sclerosisTemporal lobectomyLobe epilepsyMagnetic resonance imaging (MRI) volumetric studiesPresence of HADuration of epilepsyAnteromedial temporal lobectomyQuantitative cell countsPathologic evidenceSurgical outcomesClinical syndromeSeizure onsetPatientsCell countEpilepsyDepth EEGLonger durationAtrophyIncidenceVolumetric studiesInsufficient localizationOutcomes
1991
Imaging findings in hippocampal sclerosis: correlation with pathology.
Bronen R, Cheung G, Charles J, Kim J, Spencer D, Spencer S, Sze G, McCarthy G. Imaging findings in hippocampal sclerosis: correlation with pathology. American Journal Of Neuroradiology 1991, 12: 933-40. PMID: 1950925, PMCID: PMC8333515.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyCryptogenic temporal lobe epilepsyHippocampal sclerosisLobe epilepsyHippocampal atrophyNeuronal densityPathologic criteriaQualitative histologic findingsUnilateral hippocampal atrophyNeuronal cell lossImportant therapeutic consequencesPreoperative radiologic imagingAdjacent white matterLong TR scansGranular cell layerTemporal lobectomyPreoperative diagnosisIntractable epilepsyRadiologic imagingHistologic findingsSurgical specimensCornu ammonisTherapeutic consequencesMR findingsTemporal lobe
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