2023
Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens
Bee G, Lokken-Toyli K, Yeung S, Rodriguez L, Zangari T, Anderson E, Ghosh S, Rothlin C, Brodin P, Khanna K, Weiser J. Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. Immunity 2023, 56: 1255-1268.e5. PMID: 37059107, PMCID: PMC10330046, DOI: 10.1016/j.immuni.2023.03.018.Peer-Reviewed Original ResearchConceptsAge-dependent differencesNeonatal neutrophilsEarly lifeModulation of CD11bCD11b surface expressionAge-dependent susceptibilitySpn infectionPeripheral bloodMore CD11bMouse modelInfection outcomesStreptococcus pneumoniaeNeutrophilsCD11bEfferocytosisSystemic expressionSurface expressionNeonatesOpsonophagocytosisInvasive pathogensOutcomesPopulation levelCD169PathogensExpression
1989
Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function
Herson V, Block C, Eisenfeld L, Maderazo E, Krause P. Effects of Intravenous Fat Infusion on Neonatal Neutrophil and Platelet Function. Journal Of Parenteral And Enteral Nutrition 1989, 13: 620-622. PMID: 2515309, DOI: 10.1177/0148607189013006620.Peer-Reviewed Original ResearchConceptsPolymorphonuclear leukocytesIntralipid infusionNeonatal intensive care unitAdult polymorphonuclear leukocytesIntensive care unitIntravenous fat infusionPresence of infectionAdverse hematologic effectsNeonatal polymorphonuclear leukocytesParenteral nutritionIll neonatesNeonatal neutrophilsPMN countCare unitPlatelet countPlatelet activityHematologic effectsIntravenous fatPlatelet functionPlatelet numberUnchanged preFat infusionPlatelet aggregationInfusionIntralipid
1985
1094 THE EFFECT OF BETAMETHASONE ON THE CHEMOTACTIC RESPONSE OF NEONATAL NEUTROPHILS
Fuenfer M, Ingardia C, Raye J, Block C, Krause P. 1094 THE EFFECT OF BETAMETHASONE ON THE CHEMOTACTIC RESPONSE OF NEONATAL NEUTROPHILS. Pediatric Research 1985, 19: 293-293. DOI: 10.1203/00006450-198504000-01124.Peer-Reviewed Original ResearchEffect of betamethasoneMaternal steroid administrationPerinatal bacterial infectionHealthy term neonatesFetal lung maturationRisk of infectionSteroid administrationTerm neonatesHost defense systemNeonatal neutrophilsLung maturationNeutrophil functionCord bloodPMN functionNeonatal PMNTherapeutic concentrationsPMN chemokinesisBacterial infectionsBetamethasoneNeonatesPMN motilitySignificant inhibitionRandom migrationMicropore filtersFurther compromise
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