2024
Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018
Ji S, Qu Y, Sun Q, Zhao F, Qiu Y, Li Z, Li Y, Song H, Zhang M, Zhang W, Fu H, Cai J, Zhang Z, Zhu Y, Cao Z, Lv Y, Shi X. Mediating Role of Liver Dysfunction in the Association between Arsenic Exposure and Diabetes in Chinese Adults: A Nationwide Cross-Sectional Study of China National Human Biomonitoring (CNHBM) 2017–2018. Environmental Science And Technology 2024, 58: 2693-2703. PMID: 38285630, DOI: 10.1021/acs.est.3c08718.Peer-Reviewed Original ResearchConceptsSerum alanine aminotransferaseLiver dysfunctionAlanine aminotransferaseNationwide cross-sectional studyRestricted cubic spline modelsGeneralized linear mixed modelsEffects of liver dysfunctionMediation analysisCross-sectional studyArsenic exposureAspartate aminotransferaseCubic spline modelsHuman biomonitoringAssociated with TADiabetes prevalenceChinese adultsLow-to-moderateLinear mixed modelsUrinary totalLowest quartileAlcohol consumptionLiver diseaseOverall populationDiabetesDermatologic Changes in Experimental Model of Long COVID
Hussain H, Paidas M, Rajalakshmi R, Fadel A, Ali M, Chen P, Jayakumar A. Dermatologic Changes in Experimental Model of Long COVID. Microorganisms 2024, 12: 272. PMID: 38399677, PMCID: PMC10892887, DOI: 10.3390/microorganisms12020272.Peer-Reviewed Original ResearchMurine hepatitis virus-1Consistent with human studiesAbsence of hair folliclesPost-SARS-CoV-2 infectionHair folliclesAnti-inflammatory responseLong-term health repercussionsPulmonary complicationsFollicle lossDermal layerLiver dysfunctionKidney impairmentCutaneous findingsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Tissue destructionDermatological changesAcute stageCoronavirus disease-19Pathophysiological changesHuman studiesCollagen depositionSkin alterationsSyndrome coronavirus 2
2023
Deucravacitinib in moderate to severe plaque psoriasis: liver transaminase results from the phase 3 POETYK PSO program
Lebwohl M, Egeberg A, Linaberry M, Hoyt K, Banerjee S, Kisa R, Strober B. Deucravacitinib in moderate to severe plaque psoriasis: liver transaminase results from the phase 3 POETYK PSO program. SKIN The Journal Of Cutaneous Medicine 2023, 7: s116. DOI: 10.25251/skin.7.supp.116.Peer-Reviewed Original ResearchSevere plaque psoriasisAlanine aminotransferasePlaque psoriasisConcomitant medicationsWeeks 0Week 16Multiple laboratory parametersCommon Terminology CriteriaMean levelsTreatment of adultsWeeks of treatmentPatient-level dataOral placeboTerminology CriteriaAST elevationLiver transaminasesAminotransferase levelsCTCAE gradeLiver dysfunctionSystemic therapyLaboratory parametersAST levelsTreatment armsLiver conditionsSeverity gradeHBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocol
Cheng Z, Li L, Zhang Y, Ren Y, Gu J, Wang X, Zhao H, Lu H. HBV-infected hepatocellular carcinoma can be robustly classified into three clinically relevant subgroups by a novel analytical protocol. Briefings In Bioinformatics 2023, 24: bbac601. PMID: 36736372, DOI: 10.1093/bib/bbac601.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaClinical stageImmune microenvironmentTumor sizeHepatitis B virus infectionLow alpha-fetoprotein levelsMetabolism-related proteinsRelevant subgroupsB virus infectionSevere liver dysfunctionGood liver functionHigh AFP levelsAlpha-fetoprotein levelsPrimary liver malignancySmaller tumor sizeLarger tumor sizeLower clinical stageHigher clinical stageCancer-related deathProliferation activityPrevention of HBVNear-normal levelsLow proliferation activityLiver dysfunctionHigh proliferation activity
2022
COVID-19 and the liver: a narrative review of the present state of knowledge
Thandassery RB, Dranoff JA, Perisetti A, Taddei T. COVID-19 and the liver: a narrative review of the present state of knowledge. Translational Gastroenterology And Hepatology 2022, 0: 0-0. PMID: 36300154, PMCID: PMC9468988, DOI: 10.21037/tgh-20-243.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic liver diseaseLiver diseaseLiver injuryComorbid conditionsAcute respiratory distress syndromeDirect viral cytotoxicityNon-immunosuppressed patientsAdvanced liver diseaseLiver function testsThird of patientsEpithelial cellsRespiratory distress syndromeResolution of diseaseResolution of illnessOngoing pandemicNovel corona virus diseaseType 2 pneumocytesCOVID-19Biliary epithelial cellsGastrointestinal epithelial cellsCorona Virus DiseaseLiver dysfunctionDistress syndromeFunction testsUninterrupted careCoagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.
Faustino EVS, Karam O, Parker RI, Hanson SJ, Brandão LR, Monagle P. Coagulation Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. 2022, 149: s79-s83. PMID: 34970670, DOI: 10.1542/peds.2021-052888l.Peer-Reviewed Original ResearchConceptsCoagulation dysfunctionIll childrenCritical illnessStandard data extraction formOrgan-specific outcomesPediatric critical illnessPODIUM Consensus ConferenceD-dimer valuesInternational normalized ratioPatient-centered outcomesData extraction formOutcomes of interestLiver dysfunctionPlatelet countAdverse outcomesNormalized ratioFunctional statusEligible studiesFibrinogen levelsBias assessmentCoagulation testsCurrent evidenceConsensus conferenceElectronic searchTask force members
2021
Delphi Consensus Recommendations on Management of Dosing, Adverse Events, and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib
Rahaghi F, Belperio JA, Fitzgerald J, Gulati M, Hallowell R, Highland KB, Huie TJ, Kim HJ, Kolb M, Lasky JA, Southern BD, Swigris JJ, de Andrade JA. Delphi Consensus Recommendations on Management of Dosing, Adverse Events, and Comorbidities in the Treatment of Idiopathic Pulmonary Fibrosis with Nintedanib. Therapeutic Advances In Pulmonary And Critical Care Medicine 2021, 15: 11795484211006050. PMID: 33854398, PMCID: PMC8013629, DOI: 10.1177/11795484211006050.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisConsensus recommendationsAdverse eventsPulmonary fibrosisPrescribing informationManagement of comorbiditiesManagement of patientsAdverse event managementClinical trial dataEvidence-based literatureReal-world evidenceCytochrome P450 3A4Delphi consensus recommendationsConcomitant medicationsLiver dysfunctionTolerability issuesConcomitant administrationGastrointestinal effectsDisease progressionNintedanibComorbiditiesAppropriate managementTrial dataPatientsP450 3A4
2020
Common Congenital Syndromes and Disease States Impacting Regional Anesthesiology Techniques
Thomas D, Missih O, Zhu R, Suchy T, Vadivelu N. Common Congenital Syndromes and Disease States Impacting Regional Anesthesiology Techniques. 2020, 111-122. DOI: 10.1007/978-3-030-55660-0_6.ChaptersHigh riskCommon congenital syndromeLimited neck mobilityTurner syndromeBicuspid aortic valveRisk of aspirationType 2 diabetesIntraoperative hypertensionLiver dysfunctionAortic dissectionHearing changesKidney functionHorseshoe kidneyInsulin resistanceNeck mobilityAortic valveAnesthesiology techniquesArched palateCongenital syndromeMaxillary hypoplasiaAnatomic differencesCognitive impairmentNormal tracheaKidney abnormalitiesShort stature
2019
Predicting in-hospital rupture of type A aortic dissection using Random Forest
Wu J, Qiu J, Xie E, Jiang W, Zhao R, Qiu J, Zafar MA, Huang Y, Yu C. Predicting in-hospital rupture of type A aortic dissection using Random Forest. Journal Of Thoracic Disease 2019, 11: 4634-4646. PMID: 31903252, PMCID: PMC6940214, DOI: 10.21037/jtd.2019.10.82.Peer-Reviewed Original ResearchAortic height indexArtery involvementPeriaortic hematomaPredictive valueNumbness/painRenal artery involvementSimple clinical informationAcute liver dysfunctionAortic dissection patientsNegative predictive valuePositive predictive valueLiver dysfunctionTAAD patientsAortic dissectionConsecutive patientsAcute phaseAortic sizeDissection patientsPleural effusionRisk stratificationPatient counsellingStudy populationClinical informationSurgical triagePatientsLong-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic Syndrome
Awadie H, Khoury J, Zohar Y, Yaccob A, Veitsman E, Saadi T. Long-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic Syndrome. Rambam Maimonides Medical Journal 2019, 10: e0020. PMID: 31335311, PMCID: PMC6649775, DOI: 10.5041/rmmj.10373.Peer-Reviewed Original ResearchHypereosinophilic syndromeIdiopathic hypereosinophilic syndromeLiver involvementLong-term follow-upIsolated liver involvementSolid organ involvementRare systemic diseaseEnd-organ damageIntensive immunosuppressive treatmentAdvanced liver failureHigher eosinophil countsEosinophilic hepatitisImmunosuppressive treatmentChronic hepatitisLiver dysfunctionOrgan involvementLiver biopsyLiver failureEosinophil countOrgan damageRare presentationSystemic diseaseFollow-upAppropriate treatmentLow dose
2018
Tailored treatment of patients with hepatocellular carcinoma with portal vein invasion: experience from a multidisciplinary hepatobiliary tumor program within a NCI comprehensive cancer center
Walcott-Sapp S, Naugler S, Lim JY, Wagner J, Orloff SL, Farsad K, Kolbeck KJ, Kaufman J, Maynard E, Enestvedt CK, Mayo SC, Billingsley KG. Tailored treatment of patients with hepatocellular carcinoma with portal vein invasion: experience from a multidisciplinary hepatobiliary tumor program within a NCI comprehensive cancer center. Journal Of Gastrointestinal Oncology 2018, 9: 1074-1083. PMID: 30603126, PMCID: PMC6286927, DOI: 10.21037/jgo.2018.08.11.Peer-Reviewed Original ResearchPortal vein invasionLiver-directed therapiesIntra-arterial brachytherapyHepatocellular carcinomaTransarterial chemoembolizationVein invasionInitial HCC diagnosisLiver-directed treatmentsMean Child-TurcotteMedian alkaline phosphataseSupportive care groupLimited treatment optionsTreatment of patientsKaplan-Meier plotsComprehensive cancer centerLog-rank methodPalliative chemotherapyChild-TurcottePugh scoreLiver dysfunctionLiver involvementVenous involvementConsecutive patientsMost patientsOverall survivalSurgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes
Park CJ, Armenia SJ, Keung CH, Compton JT, Cowles RA. Surgical modifications of the Kasai hepatoportoenterostomy minimize invasiveness without compromising short- and medium-term outcomes. Journal Of Pediatric Surgery 2018, 54: 537-542. PMID: 30041859, DOI: 10.1016/j.jpedsurg.2018.06.028.Peer-Reviewed Original ResearchConceptsKasai hepatoportoenterostomyBiliary atresiaLiver transplantLiver transplant proceduresNative liver survivalEffective surgical therapyMedium-term outcomesYears of ageLiver survivalLiver dysfunctionOverall survivalSurgical therapyLiver failureBile stasisMedian timeProgressive fibrosisBile drainageTransplant proceduresMean ageBiliary treeSingle institutionPatient outcomesPortal plateSurgical modificationsAbdominal cavity
2017
OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation
Bow L, Ekong U, Morotti R, Antala S, Emre S. OR51 Correlation of class II antibody development with acute cellular rejection and fibrosis in pediatric liver transplantation. Human Immunology 2017, 78: 47. DOI: 10.1016/j.humimm.2017.06.057.Peer-Reviewed Original ResearchAcute cellular rejectionClass II DSAPediatric liver transplantationLiver transplantationCellular rejectionHLA antibodiesFibrosis scoreDe novo HLA antibodiesNovo HLA antibodiesSided p valueDiagnosis of antibodyWilcoxon rank sumContinuous variablesGraft dysfunctionMean fibrosisSinusoidal fibrosisGraft functionPost transplantRejection gradeAvailable biopsiesLiver dysfunctionPatient characteristicsAntibody levelsDSA developmentSpecificity of antibodiesProtein Requirements for Critically Ill Patients With Renal and Liver Failure
Patel J, McClain C, Sarav M, Hamilton‐Reeves J, Hurt R. Protein Requirements for Critically Ill Patients With Renal and Liver Failure. Nutrition In Clinical Practice 2017, 32: 101s-111s. PMID: 28208022, DOI: 10.1177/0884533616687501.Peer-Reviewed Original ResearchConceptsDecompensated liver cirrhosisAcute kidney injuryAcute liver failureNegative nitrogen balanceMuscle wastingRenal replacement therapyCritically ill patientsRespiratory failureLiver dysfunctionReplacement therapyKidney injuryLiver failureLiver cirrhosisAmino acid lossesICU admissionIncreased riskOptimal protein supplementationSevere formIll patientsCritical illnessNitrogen balanceProtein abnormalitiesAssociated with proteolysisProtein requirementsAcid loss
2016
Delisting of liver transplant candidates with chronic hepatitis C after viral eradication: A European study
Belli LS, Berenguer M, Cortesi PA, Strazzabosco M, Rockenschaub SR, Martini S, Morelli C, Donato F, Volpes R, Pageaux GP, Coilly A, Fagiuoli S, Amaddeo G, Perricone G, Vinaixa C, Berlakovich G, Facchetti R, Polak W, Muiesan P, Duvoux C, Association E. Delisting of liver transplant candidates with chronic hepatitis C after viral eradication: A European study. Journal Of Hepatology 2016, 65: 524-531. PMID: 27212241, DOI: 10.1016/j.jhep.2016.05.010.Peer-Reviewed Original ResearchConceptsDirect acting antiviralsOral direct acting antiviralsClinical improvementChild-PughLiver transplantationActing antiviralsAdvanced liver diseaseChronic hepatitis CLiver transplant candidatesLow MELD scoresRemarkable clinical improvementHepatitis C virusDAA therapyDelta MELDDelta-albuminDAA combinationsHepatitis CMELD scoreViral eradicationCumulative incidenceLiver dysfunctionTransplant candidatesAntiviral therapyLiver diseaseLiver function
2015
Evidence of Mild Liver Dysfunction Identifies Stable Heart Failure Outpatients with Reversible Renal Dysfunction
Brisco MA, Cheng SJ, Laur O, Kula AJ, Testani JM. Evidence of Mild Liver Dysfunction Identifies Stable Heart Failure Outpatients with Reversible Renal Dysfunction. Cardiorenal Medicine 2015, 5: 229-236. PMID: 26195975, PMCID: PMC4478303, DOI: 10.1159/000430505.Peer-Reviewed Original ResearchReversible renal dysfunctionStable HF outpatientsMild liver dysfunctionAlanine aminotransferaseAspartate aminotransferaseHF outpatientsRenal dysfunctionElevated bilirubinLiver dysfunctionHeart failurePoor perfusionBeta-Blocker EvaluationDecompensated heart failureHeart failure outpatientsGlomerular filtration rateSigns of congestionBaseline characteristicsRenal functionPathophysiologic factorsLiver parametersFiltration ratePatientsDysfunctionOutpatientsBilirubinAcute presentation of gestational diabetes insipidus with pre‐eclampsia complicated by cerebral vasoconstriction: A case report and review of the published work
Mor A, Fuchs Y, Zafra K, Haberman S, Tal R. Acute presentation of gestational diabetes insipidus with pre‐eclampsia complicated by cerebral vasoconstriction: A case report and review of the published work. Journal Of Obstetrics And Gynaecology Research 2015, 41: 1269-1272. PMID: 25832854, DOI: 10.1111/jog.12694.Peer-Reviewed Original ResearchConceptsGestational diabetes insipidusCerebral vasoconstrictionLiver dysfunctionDiabetes insipidusImpaired liver functionSelf-limiting complicationsMagnetic resonance angiographyAcute presentationPregnancy complicationsRenal insufficiencyCesarean sectionSevere featuresWeeks' gestationLiver functionCase reportHigh indexResonance angiographyTypical signsVasoconstrictionComplicationsPregnancyGestationInsipidusDysfunctionPatients
2013
Biochemical Evidence of Mild Hepatic Dysfunction Identifies Decompensated Heart Failure Patients With Reversible Renal Dysfunction
Brisco MA, McCauley BD, Chen J, Parikh CR, Testani JM. Biochemical Evidence of Mild Hepatic Dysfunction Identifies Decompensated Heart Failure Patients With Reversible Renal Dysfunction. Journal Of Cardiac Failure 2013, 19: 739-745. PMID: 24263117, PMCID: PMC3884639, DOI: 10.1016/j.cardfail.2013.10.005.Peer-Reviewed Original ResearchConceptsReversible renal dysfunctionRenal dysfunctionLiver dysfunctionElevated international normalized ratioDecompensated heart failure patientsBaseline renal dysfunctionCharacteristic laboratory abnormalitiesDecompensated HF patientsLiver dysfunction resultsSigns of HFGlomerular filtration rateHeart failure patientsMild liver dysfunctionInternational normalized ratioIntrinsic kidney diseaseBiochemical evidenceHF patientsFailure patientsLaboratory abnormalitiesRenal functionPathophysiologic factorsDischarge diagnosisKidney diseaseMultifactorial pathophysiologyNormalized ratioSex Disparities in Overall Burden of Disease Among HIV-Infected Individuals in the Veterans Affairs Healthcare System
Blackstock OJ, Tate JP, Akgün KM, Crystal S, Duggal M, Edelman EJ, Gibert CL, Gordon KS, Rimland D, Rodriguez-Barradas MC, Wang EA, Fiellin DA, Justice AC. Sex Disparities in Overall Burden of Disease Among HIV-Infected Individuals in the Veterans Affairs Healthcare System. Journal Of General Internal Medicine 2013, 28: 577-582. PMID: 23807068, PMCID: PMC3695278, DOI: 10.1007/s11606-013-2346-z.Peer-Reviewed Original ResearchConceptsVeterans Affairs Healthcare SystemART initiationOverall burdenAntiretroviral therapyVeterans Aging Cohort Study Virtual CohortVACS Index scoreART-naïve HIVLower hemoglobin levelsHuman immunodeficiency virusBurden of diseaseHealthcare systemHIV biomarkersVACS IndexVACS-VCCause mortalityHIV careLiver dysfunctionART adherenceHemoglobin levelsImmunodeficiency virusHIV treatmentModifiable factorsPharmacy dataResultsComplete dataMultivariable regression
2011
Intensive care of the patient with cirrhosis
Olson JC, Wendon JA, Kramer DJ, Arroyo V, Jalan R, Garcia‐Tsao G, Kamath PS. Intensive care of the patient with cirrhosis. Hepatology 2011, 54: 1864-1872. PMID: 21898477, DOI: 10.1002/hep.24622.Peer-Reviewed Original ResearchConceptsMultiple organ failureIntensive care unitCare unitOrgan failureLiver functionSignificant survival benefitPresence of infectionFurther deteriorationQuality of lifeNumber of organsLiver support systemsAlcoholic hepatitisLiver transplantationVariceal hemorrhageAcute deteriorationCommon organLiver dysfunctionSurvival benefitViral hepatitisIll patientsIntensive careCritical carePatientsHigh mortalityTeam approach
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply