2025
Elevated serum cortisol associated with early‐detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study
Salardini A, Himali J, Abdullah M, Chaudhari R, Young V, Zilli E, McGrath E, Gonzales M, Thibault E, Salinas J, Aparicio H, Himali D, Ghosh S, Buckley R, Satizabal C, Johnson K, DeCarli C, Fakhri G, Vasan R, Beiser A, Seshadri S. Elevated serum cortisol associated with early‐detected increase of brain amyloid deposition in Alzheimer's disease imaging biomarkers among menopausal women: The Framingham Heart Study. Alzheimer's & Dementia 2025, 21: e70179. PMID: 40271551, PMCID: PMC12019305, DOI: 10.1002/alz.70179.Peer-Reviewed Original ResearchConceptsPost-menopausal womenFramingham Heart Study participantsIncreased risk of ADFramingham Heart StudyRisk of ADNo significant associationHeart StudyEarly risk factorsStudy participantsMenopausal statusMultivariate regression analysisApolipoprotein E4Significant associationAlzheimer's diseaseIncreased riskRisk factorsCognitive impairmentMenopausal womenBrain amyloid depositionRegression analysisWomenAnalyzed dataPositron emission tomographyIncreased amyloid depositionBurden
2024
8203 A Solitary Fibrous Tumor Mimicking a Non-functional Pituitary Macroadenoma
Rivera L, Omay S, Huttner A, Inzucchi S. 8203 A Solitary Fibrous Tumor Mimicking a Non-functional Pituitary Macroadenoma. Journal Of The Endocrine Society 2024, 8: bvae163.1113. PMCID: PMC11454692, DOI: 10.1210/jendso/bvae163.1113.Peer-Reviewed Original ResearchSolitary fibrous tumorMyelodysplastic syndromeCentral nervous systemFibrous tumorSoft tissue tumor of mesenchymal originHistory of primary hypothyroidismNon-functioning pituitary macroadenomaAdult growth hormone deficiencyHigh risk of recurrenceTumors of mesenchymal originCellular spindle cell neoplasmCentral adrenal insufficiencyProgressive visual lossGrowth hormone deficiencySpindle cell neoplasmPost-operative courseRisk of recurrenceConsistent with hemangiopericytomaBrain MRI findingsPost-menopausal womenSoft tissue tumorsAggressive mesenchymal tumorAnterior cerebral arteryHormonal workupFractionated RadiotherapyCirculating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
Rinaldi S, Dossus L, Keski‐Rahkonen P, Kiss A, Navionis A, Biessy C, Travis R, Weiderpass E, Romieu I, Eriksen A, Tjonneland A, Kvaskoff M, Canonico M, Truong T, Katzke V, Kaaks R, Catalano A, Panico S, Masala G, Tumino R, Lukic M, Olsen K, Zamora‐Ros R, Santiuste C, Atxega A, Guevara M, Rodriguez‐Barranco M, Sandstrom M, Hennings J, Almquist M, Kouassivi E, Christakoudi S, Gunter M, Franceschi S. Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women. International Journal Of Cancer 2024, 154: 2064-2074. PMID: 38357914, DOI: 10.1002/ijc.34872.Peer-Reviewed Original ResearchConceptsSex hormone binding globulinSex steroid hormonesThyroid cancerRisk of differentiated thyroid carcinomaOdds ratioSex steroidsSex hormone binding globulin concentrationsSteroid hormonesCancer-free controlsPre-menopausal womenRisk of differentiated TCEuropean Prospective InvestigationPost-menopausal womenEndogenous sex steroidsBorderline significant increaseConditional logistic regression modelsSex steroid productionNo significant associationCirculating sex steroidsCirculating sex steroid hormonesPostmenopausal womenConcentrations of testosteroneProgesterone/estradiol ratioThyroid carcinomaBorderline decrease
2023
Higher circulating cortisol is associated with amyloidogenesis in post‐menopausal women: The Framingham Heart Study
Salardini A, Zilli E, Himali J, Gonzales M, Himali D, Ghosh S, McGrath E, Buckley R, Satizabal C, Johnson K, Decarli C, Fakhri G, Vasan R, Seshadri S. Higher circulating cortisol is associated with amyloidogenesis in post‐menopausal women: The Framingham Heart Study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.080594.Peer-Reviewed Original ResearchFramingham Heart StudyHeart StudyProspective cohort studyCross sectional studyPostmenopausal womenCognitively normal individualsPost-menopausal womenSectional studyAPOE4 statusAPOE4-positiveLongitudinal cohortSuperior temporal sulcusCortisol levelsMenopausal statusSecondary outcomesAlzheimer's diseaseAssociated with amyloidogenesisCortisol dysregulationBaseline plasma cortisolMorning plasma cortisolTertileFraminghamWomenAssess interactionsProgression of Alzheimer's diseaseOvarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient
Roth L, Smith A, Buza N, Coons B, Stitelman D, Vash-Margita A. Ovarian Leydig Cell Tumor Associated with Recurrent Torsion and Virilization in an Adolescent Patient. Journal Of Pediatric And Adolescent Gynecology 2023, 37: 217-219. PMID: 38110028, DOI: 10.1016/j.jpag.2023.11.014.Peer-Reviewed Original ResearchPolycystic ovarian syndromeOvarian tumorsCell tumorsRecurrent ovarian torsionAbnormal uterine bleedingPost-menopausal womenLeydig cell tumorUterine bleedingOvarian syndromeOvarian torsionYounger patientsOvarian functionOvarian hilumAdolescent patientsNodular proliferationSecrete androgensTumor AssociatedRecurrent torsionPrimary amenorrheaCurrent recommendationsReinke crystalsTumorsLeydig cellsIncidence increasesVirilization
2021
Preoperative MRI and LDH in women undergoing intra-abdominal surgery for fibroids: Effect on surgical route
Kim A, Boyd L, Ringel N, Meyer J, Bennett G, Lerner V. Preoperative MRI and LDH in women undergoing intra-abdominal surgery for fibroids: Effect on surgical route. PLOS ONE 2021, 16: e0246807. PMID: 33561167, PMCID: PMC7872248, DOI: 10.1371/journal.pone.0246807.Peer-Reviewed Original ResearchConceptsAbnormal magnetic resonance imagingMagnetic resonance imaging resultsIntra-abdominal surgeryMagnetic resonance imagingPower morcellationSurgical routeAbnormal magnetic resonance imaging resultsOpen approachResonance imagingSerum lactate dehydrogenase levelPost-protocol groupPre-protocol groupRetrospective cohort studyBaseline patient characteristicsSubset of womenPost-menopausal womenLactate dehydrogenase levelsHigh-risk casesPreoperative magnetic resonanceDiffusion-weighted imagingHigh rateImaging resultsSymptomatic fibroidsChart reviewCohort study
2020
Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival
Brieger KK, Peterson S, Lee AW, Mukherjee B, Bakulski KM, Alimujiang A, Anton-Culver H, Anglesio MS, Bandera EV, Berchuck A, Bowtell DDL, Chenevix-Trench G, Cho KR, Cramer DW, DeFazio A, Doherty JA, Fortner RT, Garsed DW, Gayther SA, Gentry-Maharaj A, Goode EL, Goodman MT, Harris HR, Høgdall E, Huntsman DG, Shen H, Jensen A, Johnatty SE, Jordan SJ, Kjaer SK, Kupryjanczyk J, Lambrechts D, McLean K, Menon U, Modugno F, Moysich K, Ness R, Ramus SJ, Richardson J, Risch H, Rossing MA, Trabert B, Wentzensen N, Ziogas A, Terry KL, Wu AH, Hanley GE, Pharoah P, Webb PM, Pike MC, Pearce CL, Consortium F. Menopausal hormone therapy prior to the diagnosis of ovarian cancer is associated with improved survival. Gynecologic Oncology 2020, 158: 702-709. PMID: 32641237, PMCID: PMC7487048, DOI: 10.1016/j.ygyno.2020.06.481.Peer-Reviewed Original ResearchConceptsMenopausal hormone therapyOvarian cancer survivalMHT useResidual diseaseHormone therapyCancer survivalOvarian cancerHigh-grade serous carcinomaMacroscopic residual diseaseHormone therapy useFavorable prognostic factorPost-menopausal womenOvarian Cancer Association ConsortiumProportional hazards modelRecency of useImproved survivalPrognostic factorsTherapy useSerous carcinomaOvarian carcinomaHazards modelSmall studyAdvanced stageLarger studyLogistic regressionResponse to neoadjuvant chemotherapy and the 21-gene breast recurrence score in young women with estrogen receptor-positive early breast cancer.
Sella T, Gelber S, Poorvu P, Kim H, Guzman Arocho Y, Collins L, Ruddy K, Tamimi R, Peppercorn J, Schapira L, Borges V, Come S, Warner E, Snow C, Jakubowski D, Russell C, Winer E, Rosenberg S, Partridge A. Response to neoadjuvant chemotherapy and the 21-gene breast recurrence score in young women with estrogen receptor-positive early breast cancer. Journal Of Clinical Oncology 2020, 38: 514-514. DOI: 10.1200/jco.2020.38.15_suppl.514.Peer-Reviewed Original ResearchPathologic complete responseBreast Recurrence ScoreNeoadjuvant chemotherapyBreast cancerRecurrence scoreBreast Cancer StudyYoung womenHER2- BCEstrogen receptor-positive early breast cancerHER-2 negative breast cancerReceptor-positive early breast cancerYoung Women's Breast Cancer StudyNeoadjuvant endocrine therapyResidual invasive tumorEarly breast cancerPost-menopausal womenNegative breast cancerHigh gradeLogistic regression modelingAdjuvant chemotherapyDuctal histologyPgR negativityEndocrine therapyNeoadjuvant therapyProspective cohort
2019
Investigating racial differences in treatment responses through analysis of real-world data (RWD).
Liu Z, Ma M, Grover K, Li L, Goldsweig H, Yadav K, Zhou X, Mullaney T, Redfern A, Jappe W, Zimmerman M, Prentice T, Pan Q, Oh W, Schadt E, Li D, Chen R. Investigating racial differences in treatment responses through analysis of real-world data (RWD). Journal Of Clinical Oncology 2019, 37: e18141-e18141. DOI: 10.1200/jco.2019.37.15_suppl.e18141.Peer-Reviewed Original ResearchAdvanced non-small cell lung cancerMetastatic castration-resistant prostate cancerMetastatic breast cancerMedian TTDTreatment discontinuationUnresectable hepatocellular carcinomaCheckpoint inhibitorsHepatocellular carcinomaClinical trialsTreatment responseNon-small cell lung cancerEvidence-based cancer careCastration-resistant prostate cancerTherapeutic agentsEGFR tyrosine kinase inhibitorsLonger TTDSurrogate clinical endpointsImmune checkpoint inhibitorsMetastatic colorectal cancerRace groupsCell lung cancerPost-menopausal womenEGFR antibody cetuximabClinical trial resultsWild-type KRAS
2018
Mouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure
Acevedo‐Alvarez M, Yeh J, Alvarez‐Lugo L, Lu M, Sukumar N, Hill WG, Chai TC. Mouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure. Neurourology And Urodynamics 2018, 37: 2398-2405. PMID: 29682797, DOI: 10.1002/nau.23592.Peer-Reviewed Original ResearchConceptsUrinary tract infectionOveractive bladderOVX miceVoiding behaviorFemale C57BL6/J miceC57BL6/J micePost-menopausal womenEffects of ovariectomyBehavior changeMicturition changesTransurethral instillationLPS instillationTract infectionsSham surgeryLPS exposureJ miceCOX-2OVX surgeryDay 1Day 3Consecutive daysSurgeryMiceSpot assayGene expression changesAnimal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation
Shams-White MM, Chung M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Shi J, Wallace TC, Weaver CM. Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation. PLOS ONE 2018, 13: e0192459. PMID: 29474360, PMCID: PMC5825010, DOI: 10.1371/journal.pone.0192459.Peer-Reviewed Original ResearchConceptsBone mineral densityBone mineral contentTB bone mineral contentStrength of evidenceTotal hipLumbar spineBone healthTotal bodyFemoral neck (FN) BMDHealthy adultsSystematic reviewTB bone mineral densityIsoflavone-rich soy proteinProspective cohort studyAdult bone healthPost-menopausal womenSoy protein consumptionNational Osteoporosis FoundationMeta-analysis resultsCohort studyBMD outcomesBone biomarkersMineral densityStatistical heterogeneityResorption biomarkers
2017
ANIMAL VERSUS PLANT PROTEIN INTAKE AND BONE HEALTH‐A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Shams‐White M, Fu Z, Karlsen M, Sackey J, Shi J, Insogna K, LeBoff M, Shapses S, Weaver C, Wallace T, Chung M. ANIMAL VERSUS PLANT PROTEIN INTAKE AND BONE HEALTH‐A SYSTEMATIC REVIEW AND META‐ANALYSIS OF RANDOMIZED CONTROLLED TRIALS. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.139.3.Peer-Reviewed Original ResearchBone-specific alkaline phosphataseBone mineral densityPlant protein intakeBone mineral contentRandomized Controlled TrialsPost-menopausal womenProtein intakeLumbar spineTotal bodyFemoral neckCollagen type 1 cross-linked C-telopeptideCross-linked C-telopeptideBone mineral density outcomesTotal hipCross-linked N-telopeptideMeta-analysis of randomized controlled trialsTB bone mineral contentControlled TrialsSystematic reviewLow statistical heterogeneityMeta-analysisBone health outcomesHealthy adultsRandom-effects meta-analysesEffects meta-analyses
2016
Protein Intake and Bone Mineral Density‐ a Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Shams‐White M, Sackey J, Fu Z, Karlsen M, Du M, Insogna K, LeBoff M, Shapses S, Weaver C, Chung M. Protein Intake and Bone Mineral Density‐ a Systematic Review and Meta‐Analysis of Randomized Controlled Trials. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.678.6.Peer-Reviewed Original ResearchBone mineral densityRisk of bias assessmentRandomized Controlled TrialsProtein intakeMeta-analysis resultsSystematic reviewBMD lossBias assessmentMeta-analysisFemoral neck bone mineral densityBone mineral density siteBone mineral density outcomesNeck bone mineral densityTotal hipMeta-analysis of randomized controlled trialsControlled TrialsSpine BMD lossRandom-effects meta-analysesPlant protein intakeFull-text screeningPost-menopausal womenHealthy adultsAttenuating BMD lossEffects meta-analysesHigher protein intakeDietary Intake of Isoflavone and All‐Cause Mortality in Women with Breast Cancer: the Breast Cancer Family Registry
Haslam D, John E, Terry M, Knight J, Andrulis I, Daly M, Buys S, Zhang F. Dietary Intake of Isoflavone and All‐Cause Mortality in Women with Breast Cancer: the Breast Cancer Family Registry. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.902.8.Peer-Reviewed Original ResearchBreast Cancer Family RegistryBody mass indexCancer Family RegistryCause mortalityDietary intakeBreast cancerFamily RegistryPhysical activityRace/ethnicityHormonal therapyNormal weightMass indexFirst primary invasive breast cancerPrimary invasive breast cancerTumor estrogen receptor statusHealth Eating IndexTumor hormone receptorsDrinks/weekFood frequency questionnaireInvasive breast cancerEstrogen receptor statusPost-menopausal womenTotal fiber intakeBreast cancer survivalHigh dietary intake
2014
Postmenopausal Hypertension and Sodium Sensitivity
Kim J, Kim T, Lee H, Lee S, Wang T. Postmenopausal Hypertension and Sodium Sensitivity. Journal Of Menopausal Medicine 2014, 20: 1-6. PMID: 25371885, PMCID: PMC4217569, DOI: 10.6118/jmm.2014.20.1.1.Peer-Reviewed Original ResearchReduced systolic BPBlood pressureSystolic BPSex hormonesDevelopment of postmenopausal hypertensionOral hormone replacement therapyEffect of salt intakeElevation of systolic BPAngiotensin type 2 receptorPrevalence of salt sensitivityAnti-aldosterone activityHormone replacement therapyLack of estrogenWomen to levelsIncidence rate of hypertensionLow-salt dietPost-menopausal womenType 2 receptorFemale sex hormonesRegulation of arterial pressureRenal regulatory mechanismsNitric oxideSalt sensitivityStimulate nitric oxideRates of hypertensionBody Mass Index and Breast Cancer Defined by Biological Receptor Status in Pre-Menopausal and Post-Menopausal Women: A Multicenter Study in China
Li J, Huang Y, Zhang BN, Fan JH, Huang R, Zhang P, Wang SL, Zheng S, Zhang B, Yang HJ, Xie XM, Tang ZH, Li H, He JJ, Hsieh E, Qiao YL, Li JY. Body Mass Index and Breast Cancer Defined by Biological Receptor Status in Pre-Menopausal and Post-Menopausal Women: A Multicenter Study in China. PLOS ONE 2014, 9: e87224. PMID: 24489874, PMCID: PMC3906138, DOI: 10.1371/journal.pone.0087224.Peer-Reviewed Original ResearchConceptsBody mass indexPost-menopausal womenHigher Body Mass IndexReceptor statusBreast cancerLogistic regression modelsMass indexBMI dataMultivariate logistic regression modelBreast cancer patientsRank correlation analysisEstrogen metabolism pathwayBreast cancer casesFisher's exact testChi-square testPre-MenopausalMedical chartsPathologic featuresRegression modelsEligible casesMulticenter studyCancer patientsRisk factorsCancer casesExact test
2013
A pilot chemoprevention study of isopropanolic black cohosh extract in women with ductal carcinoma in situ.
Hofstatter E, Stavris K, Horowitz N, Killelea B, Tsangaris T, Lannin D, Andrejeva L, Cong X, Yao X, Rimm D, Chagpar A. A pilot chemoprevention study of isopropanolic black cohosh extract in women with ductal carcinoma in situ. Journal Of Clinical Oncology 2013, 31: tps1609-tps1609. DOI: 10.1200/jco.2013.31.15_suppl.tps1609.Peer-Reviewed Original ResearchIsopropanolic black cohosh extractBlack cohosh extractBlack cohoshDuctal carcinomaBreast cancerBreast epithelial cell proliferationPre-operative courseTwo-sided significance levelDisease-free survivalLiver function testsBreast cancer preventionSerum hormone levelsAnti-inflammatory effectsBreast cancer patientsPost-menopausal womenCohort of womenRecent preclinical dataSignificant protective effectKi-67 stainingBreast core biopsyLevels of Ki67Years of ageEpithelial cell proliferationWilcoxon signed-rank testEligible subjectsRelative effectiveness of letrozole alone or in sequence with tamoxifen for patients diagnosed with invasive lobular carcinoma.
Metzger Filho O, Giobbie-Hurder A, Mallon E, Viale G, Winer E, Thurlimann B, Gelber R, Regan M, Colleoni M, Ejlertsen B, Bonnefoi H, Forbes J, Neven P, Wardley A, Lang I, Smith I, Price K, Coates A, Goldhirsch A. Relative effectiveness of letrozole alone or in sequence with tamoxifen for patients diagnosed with invasive lobular carcinoma. Journal Of Clinical Oncology 2013, 31: 529-529. DOI: 10.1200/jco.2013.31.15_suppl.529.Peer-Reviewed Original ResearchMagnitude of benefitMonotherapy armYears of tamoxifenPost-menopausal womenInvasive lobular carcinomaILC patientsBetter DFSBIG 1Early BCClinicopathological variablesHistological subtypesLobular carcinomaILC subsetsPatientsTreatment assignmentDFSSignificant predictorsTamoxifenHistologyIDCGreater magnitudeClassic ILCOSArmPrevious dataObesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium
Olsen CM, Nagle CM, Whiteman DC, Ness R, Pearce CL, Pike MC, Rossing MA, Terry KL, Wu AH, _ _, _ _, Risch HA, Yu H, Doherty JA, Chang-Claude J, Hein R, Nickels S, Wang-Gohrke S, Goodman MT, Carney ME, Matsuno RK, Lurie G, Moysich K, Kjaer SK, Jensen A, Hogdall E, Goode EL, Fridley BL, Vierkant RA, Larson MC, Schildkraut J, Hoyo C, Moorman P, Weber RP, Cramer DW, Vitonis AF, Bandera EV, Olson SH, Rodriguez-Rodriguez L, King M, Brinton LA, Yang H, Garcia-Closas M, Lissowska J, Anton-Culver H, Ziogas A, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Webb PM. Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium. Endocrine Related Cancer 2013, 20: 251-262. PMID: 23404857, PMCID: PMC3857135, DOI: 10.1530/erc-12-0395.Peer-Reviewed Original ResearchConceptsOvarian Cancer Association ConsortiumHistological subtypesHigher BMIOdds ratioOvarian cancerHormone replacement therapy usersPost-menopausal hormone useInvasive serous cancerCommon histological subtypeOvarian cancer deathsPre-menopausal womenPrevalence of obesityPost-menopausal womenDifferent histological subtypesOvarian cancer riskCase-control studyOvarian cancer subtypesRandom-effects modelMenopausal statusSerous cancerHormone useTherapy usersInvasive cancerModifiable factorsPooled analysis
2012
Postmenopausal hormone therapy and ductal carcinoma in situ: A population-based case–control study
Calvocoressi L, Stowe MH, Carter D, Claus EB. Postmenopausal hormone therapy and ductal carcinoma in situ: A population-based case–control study. Cancer Epidemiology 2012, 36: 161-168. PMID: 22317899, PMCID: PMC3613248, DOI: 10.1016/j.canep.2012.01.001.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyCase-control studyHormone therapySitu breast cancerBreast cancerDuctal carcinomaRisk of DCISPostmenopausal hormone therapyFrequency-matched controlsInvasive breast cancerPost-menopausal womenDuration of usePostmenopausal womenIncident casesBreast carcinomaDCISLarger studyCarcinomaCancerImportant covariatesEstrogenTherapyAge intervalsWomenCurrent use
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