2024
Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study
Carrasco-Marín F, Zhao L, Hébert J, Wirth M, Petermann-Rocha F, Phillips N, Malcomson F, Mathers J, Ferguson L, Ho F, Pell J, Celis-Morales C, Molina-Recio G, Molina-Luque R. Association of a dietary inflammatory index with cardiometabolic, endocrine, liver, renal and bones biomarkers: cross-sectional analysis of the UK Biobank study. Nutrition Metabolism And Cardiovascular Diseases 2024, 34: 1731-1740. PMID: 38664123, DOI: 10.1016/j.numecd.2024.03.010.Peer-Reviewed Original ResearchConceptsPro-inflammatory dietLiver functionUK Biobank participantsUK Biobank studyHealthy individualsDiet Inflammatory IndexDietary inflammatory indexCross-sectional studyCross-sectional analysisAnti-inflammatory dietBiobank participantsBiobank studyCardiometabolic healthChronic diseasesInflammatory indexRenal functionBone biomarkersProfiles of biomarkersBone healthMetabolic biomarkersCardiometabolicRenal markersIGF-1Metabolic healthTotal cholesterol
2022
OR13-1 Long-Term Burosumab Therapy Provides Sustained Benefit in Patients with Tumor-Induced Osteomalacia: End of Study Findings From the Pivotal Phase 2 Study
Carpenter T, Cimms T, Hetzer J, Insogna K, Kumar R, Merritt J, Miller P, Peacock M, Rauch F, Stanciu I, Weber T, De Beur S. OR13-1 Long-Term Burosumab Therapy Provides Sustained Benefit in Patients with Tumor-Induced Osteomalacia: End of Study Findings From the Pivotal Phase 2 Study. Journal Of The Endocrine Society 2022, 6: a191-a191. PMCID: PMC9624705, DOI: 10.1210/jendso/bvac150.394.Peer-Reviewed Original ResearchTumor-induced osteomalaciaWeek 240Week 144Week 24Serum phosphorusBurosumab therapyWeek 48Bone biomarkersSafety profileNormal rangeExcess fibroblast growth factor 23SF-36 bodily pain scoresTreatment of TIOPivotal phase 2 studySF-36 physical healthSF-36 vitality scoreFibroblast growth factor 23Surface/bone surfaceBodily pain scoresMean serum phosphorusObserved safety profileRadionucleotide bone scansRare paraneoplastic syndromeBrief Pain InventoryOsteoid surface/bone surfaceLong-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia
Weber TJ, Imel EA, Carpenter TO, Peacock M, Portale AA, Hetzer J, Merritt JL, Insogna K. Long-term Burosumab Administration Is Safe and Effective in Adults With X-linked Hypophosphatemia. The Journal Of Clinical Endocrinology & Metabolism 2022, 108: 155-165. PMID: 36072994, PMCID: PMC9759172, DOI: 10.1210/clinem/dgac518.Peer-Reviewed Original ResearchConceptsSerum phosphate levelsPatient-reported outcomesNormal rangeBurosumab therapyTreatment optionsEffective long-term treatment optionLong-term extension studyLong-term treatment optionNew safety findingsBone turnover markersLong-term administrationPhosphate levelsRespective normal rangesProportion of subjectsLong-term safetyLast doseAdult patientsClinical responseSafety findingsTurnover markersSerum phosphateBone biomarkersStudy endWeek 12Burosumab treatment
2018
Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation
Shams-White MM, Chung M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Shi J, Wallace TC, Weaver CM. Animal versus plant protein and adult bone health: A systematic review and meta-analysis from the National Osteoporosis Foundation. PLOS ONE 2018, 13: e0192459. PMID: 29474360, PMCID: PMC5825010, DOI: 10.1371/journal.pone.0192459.Peer-Reviewed Original ResearchConceptsBone mineral densityBone mineral contentTB bone mineral contentStrength of evidenceTotal hipLumbar spineBone healthTotal bodyFemoral neck (FN) BMDHealthy adultsSystematic reviewTB bone mineral densityIsoflavone-rich soy proteinProspective cohort studyAdult bone healthPost-menopausal womenSoy protein consumptionNational Osteoporosis FoundationMeta-analysis resultsCohort studyBMD outcomesBone biomarkersMineral densityStatistical heterogeneityResorption biomarkers
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