2024
The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice
McGovern J, Perry C, Ghincea A, Herzog E, Shao S, Sun H. The effect of adrenalectomy on bleomycin-induced pulmonary fibrosis in mice. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2024, 328: l15-l29. PMID: 39470613, PMCID: PMC11905795, DOI: 10.1152/ajplung.00062.2024.Peer-Reviewed Original ResearchLung fibrosisSurgical adrenalectomyBronchoalveolar lavageLung tissueBleomycin-Induced Pulmonary FibrosisAlpha-smooth muscle actinModel of lung fibrosisBleomycin model of lung fibrosisProgressive lung fibrosisLimited treatment optionsSmooth muscle actinWild type miceEffects of adrenalectomyProduction of catecholaminesDecrease of lymphocytesAdrenal ablationAldosterone levelsBleomycin administrationBleomycin modelSham surgeryAld levelsLung remodelingPulmonary fibrosisType miceAdrenal gland
2020
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Contreras KM, Caillaud M, Neddenriep B, Bagdas D, Roberts JL, Ulker E, White AB, Aboulhosn R, Toma W, Khalefa T, Adel A, Mann JA, Damaj MI. Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype. Behavioural Brain Research 2020, 399: 113009. PMID: 33181181, PMCID: PMC8961431, DOI: 10.1016/j.bbr.2020.113009.Peer-Reviewed Original ResearchConceptsNeuropathic pain modelChronic constriction injuryMechanical withdrawal thresholdPain modelStrains of miceWithdrawal thresholdDBA/2J miceVoluntary wheelChronic neuropathic pain modelPaclitaxel-treated miceVehicle-treated miceUnilateral intraplantar injectionLower mechanical thresholdsChronic pain reportQuality of lifeChemotherapy agent paclitaxelImpact of sexDifferent mouse strainsCCI miceCCI surgeryConstriction injuryIntraplantar injectionSham surgeryMale C57BL/6JNovel analgesicsAnticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats
Kim J, Hagen C, Kumar S, Park J, Zimmerman M, Hong J. Anticholestatic Effect of Bardoxolone Methyl on Hepatic Ischemia-reperfusion Injury in Rats. Transplantation Direct 2020, 6: e584. PMID: 32766432, PMCID: PMC7371100, DOI: 10.1097/txd.0000000000001017.Peer-Reviewed Original ResearchHepatic ischemia-reperfusion injuryHepatocyte membrane transportersIschemia-reperfusion injuryMultidrug resistance-associated protein 3Multidrug resistance-associated protein 2Bardoxolone methyl administrationSodium-taurocholate cotransporterBardoxolone methylProtein 3Bile salt export pumpProtein 2Serum bile acidsNuclear factor-erythroid 2-related factor 2 activationNuclear factor erythroid 2-related factor 2Factor erythroid 2-related factor 2Erythroid 2-related factor 2Sham surgerySurrogate markerExport pumpAnticholestatic effectsBlood samplesMRNA levelsViable tissueNecrotic areasProtein levelsDepletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke
Harris NM, Roy-O'Reilly M, Ritzel RM, Holmes A, Sansing LH, O'Keefe LM, McCullough LD, Chauhan A. Depletion of CD4 T cells provides therapeutic benefits in aged mice after ischemic stroke. Experimental Neurology 2020, 326: 113202. PMID: 31954116, PMCID: PMC7059209, DOI: 10.1016/j.expneurol.2020.113202.Peer-Reviewed Original ResearchConceptsIP-10 levelsMiddle cerebral artery occlusionCD4 T cellsT cellsIschemic strokeStroke patientsIsotype controlBrain-infiltrating T cellsCD4 T-cell depletionCerebral artery occlusionT-cell depletionAged mouse modelAged male micePro-inflammatory factorsT cell dysfunctionPro-inflammatory cytokinesAnti-CD4 antibodiesAged stroke patientsIgG isotype controlCD4 treatmentDepletion antibodyArtery occlusionExperimental strokeStroke onsetSham surgery
2019
Abstract TMP32: Post-Stroke Systemic Inflammation: Immunomodulation by Progesterone and Vitamin D Hormone
Atif F, Yousuf S, Harris W, Espinosa-Garcia C, Stein D. Abstract TMP32: Post-Stroke Systemic Inflammation: Immunomodulation by Progesterone and Vitamin D Hormone. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tmp32.Peer-Reviewed Original ResearchTransient middle cerebral artery occlusion/reperfusionPeripheral immune dysfunctionVitamin D hormoneSystemic inflammationImmune dysfunctionD hormoneAdult male Sprague-Dawley ratsSubsets of immune cellsTukey HSD post hoc testMale Sprague-Dawley ratsNeuronal inflammationFunctional deficitsPost-stroke infectionsSpontaneous locomotor activitySprague-Dawley ratsInjection of lipopolysaccharideStandard of careCombination of P4Flow cytometric analysisMiddle cerebral artery occlusion/reperfusionPost hoc testSham + vehicleImproving functional deficitsCombination therapySham surgery
2018
Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition
Ying LD, Breuer GA, Hubbard MO, Nadzam GS, Hwa J, Martin KA. Technical Feasibility of a Murine Model of Sleeve Gastrectomy with Ileal Transposition. Obesity Surgery 2018, 29: 593-600. PMID: 30353248, PMCID: PMC6365182, DOI: 10.1007/s11695-018-3555-7.Peer-Reviewed Original ResearchConceptsIleal transpositionSleeve gastrectomySham surgeryMouse modelReproducible mouse modelIntestinal identityQuantitative polymerase chain reactionBackgroundSleeve gastrectomySham procedureC57BL/6J miceObesogenic dietPolymerase chain reactionGastrectomyMurine modelPorcine modelWeight gainWeight lossMiceChain reactionMolecular pathwaysGene expression analysisWeeksFuture studiesLong-term survivabilityTechnical feasibilityMouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure
Acevedo‐Alvarez M, Yeh J, Alvarez‐Lugo L, Lu M, Sukumar N, Hill WG, Chai TC. Mouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure. Neurourology And Urodynamics 2018, 37: 2398-2405. PMID: 29682797, DOI: 10.1002/nau.23592.Peer-Reviewed Original ResearchConceptsUrinary tract infectionOveractive bladderOVX miceVoiding behaviorFemale C57BL6/J miceC57BL6/J micePost-menopausal womenEffects of ovariectomyBehavior changeMicturition changesTransurethral instillationLPS instillationTract infectionsSham surgeryLPS exposureJ miceCOX-2OVX surgeryDay 1Day 3Consecutive daysSurgeryMiceSpot assayGene expression changes
2016
Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain
Taylor SR, Smith CM, Keeley KL, McGuone D, Dodge CP, Duhaime AC, Costine BA. Neuroblast Distribution after Cortical Impact Is Influenced by White Matter Injury in the Immature Gyrencephalic Brain. Frontiers In Neuroscience 2016, 10: 387. PMID: 27601978, PMCID: PMC4994423, DOI: 10.3389/fnins.2016.00387.Peer-Reviewed Original ResearchTraumatic brain injuryWhite matter injuryCortical impactSubventricular zoneWhite matterGyrencephalic brainBrain regionsInjury sitePostnatal populationGray matterPostnatal day 7Age-dependent increaseNumber of neuroblastsCortical contusionNeurogenic responseCortical injuryMajor white matterSham surgeryPND 14PND 5Potential complicationsBrain injuryPopulation of neuroblastsDay 7Chronic effects
2014
Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY
Canales BK, Schafer AL, Shoback DM, Carpenter TO. Gastric bypass in obese rats causes bone loss, vitamin D deficiency, metabolic acidosis, and elevated peptide YY. Surgery For Obesity And Related Diseases 2014, 10: 878-884. PMID: 24969093, PMCID: PMC4113565, DOI: 10.1016/j.soard.2014.01.021.Peer-Reviewed Original ResearchConceptsBone turnover markersDiet-induced obeseWeeks of ageSham surgeryBone lossPeptide YYRYGB animalsBone volumeHigher serum parathyroid hormoneLower trabecular bone volumeMale Sprague-Dawley ratsBone mass differencesElevated peptide YYHigher serum CTXVitamin D malabsorptionSerum parathyroid hormoneGastric bypass surgeryLow serum bicarbonateVitamin D deficiencyNormal calcium dietCortical bone volumeSham control ratsTrabecular bone volumeSprague-Dawley ratsMetabolic bone disease
2010
Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder
Gouvea F, Lopes A, Greenberg B, Canteras M, Taub A, Mathis M, Miguel E. Response to Sham and Active Gamma Ventral Capsulotomy in Otherwise Intractable Obsessive-Compulsive Disorder. Stereotactic And Functional Neurosurgery 2010, 88: 177-182. PMID: 20431329, DOI: 10.1159/000313870.Peer-Reviewed Original ResearchConceptsRefractory obsessive-compulsive disorderGamma ventral capsulotomyClinical responseSham surgeryObsessive-compulsive disorderSurgical techniquePsychopathological changesRadiosurgical proceduresRemarkable ameliorationActive interventionCompulsive disorderDisordersActive procedureCapsulotomySurgeryShamRadiosurgery
2008
Neuropathic Pain Memory Is Maintained by Rac1-Regulated Dendritic Spine Remodeling after Spinal Cord Injury
Tan AM, Stamboulian S, Chang YW, Zhao P, Hains AB, Waxman SG, Hains BC. Neuropathic Pain Memory Is Maintained by Rac1-Regulated Dendritic Spine Remodeling after Spinal Cord Injury. Journal Of Neuroscience 2008, 28: 13173-13183. PMID: 19052208, PMCID: PMC6671613, DOI: 10.1523/jneurosci.3142-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsComputer SimulationDendritic SpinesDisease Models, AnimalEnzyme ActivationEnzyme InhibitorsExcitatory Postsynaptic PotentialsHyperalgesiaLearningMaleMemoryNeuralgiaNeuronal PlasticityPain MeasurementPain ThresholdPosterior Horn Cellsrac1 GTP-Binding ProteinRatsRats, Sprague-DawleySpinal Cord InjuriesSynaptic TransmissionConceptsSpinal cord injuryNeuropathic painCord injuryWide dynamic range neuronsContusion spinal cord injuryDendritic spine pathologyInjury-induced hyperexcitabilityNoxious peripheral stimuliRats 1 monthChronic neuropathic painDorsal horn neuronsDendritic spine remodelingIncreased spine densityRange neuronsSpine morphometryDH neuronsTactile allodyniaNeuronal hyperexcitabilitySCI animalsThermal hyperalgesiaSham surgerySpine densityLamina IVControl neuronsSynaptic basisMolecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling
Zhang J, Nie L, Razavian M, Ahmed M, Dobrucki LW, Asadi A, Edwards DS, Azure M, Sinusas AJ, Sadeghi MM. Molecular Imaging of Activated Matrix Metalloproteinases in Vascular Remodeling. Circulation 2008, 118: 1953-1960. PMID: 18936327, PMCID: PMC2637824, DOI: 10.1161/circulationaha.108.789743.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonAnimalsApolipoproteins EAutoradiographyCarotid Artery InjuriesCarotid Artery, CommonDisease Models, AnimalFemaleFluorescent Antibody TechniqueIndiumMatrix Metalloproteinase 2Matrix Metalloproteinase 9MiceMice, Mutant StrainsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsVascular remodelingCarotid arteryCommon carotid artery injuryInjury-induced vascular remodelingCarotid wire injuryCarotid artery injuryMicroSPECT/CTMatrix metalloproteinase activationVessel wall areaArtery injuryCarotid injurySham surgerySignificant hyperplasiaContralateral arteryWire injuryFocal uptakeHyperplastic processesMicroSPECT imagingQuantitative autoradiographyTracer uptakeMetalloproteinase activationMMP activityArteryInjuryMatrix metalloproteinases
2006
Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension
Grobe JL, Mecca AP, Mao H, Katovich MJ. Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension. AJP Heart And Circulatory Physiology 2006, 290: h2417-h2423. PMID: 16415071, DOI: 10.1152/ajpheart.01170.2005.Peer-Reviewed Original ResearchConceptsDOCA-salt modelBlood pressureCardiac hypertrophyCardiac fibrosisCardiac remodelingDeoxycorticosterone acetate pelletsDOCA-salt animalsBlood pressure responseCarotid artery cannulationDOCA-salt treatmentTail-cuff methodWk of treatmentPerivascular collagen depositionSprague-Dawley ratsNormal drinking waterAngiotensin fragmentsChronic angiotensinDOCA animalsAngiotensin infusionArtery cannulationPerivascular fibrosisSham surgeryAngiotensin IIOsmotic minipumpsMyocyte diameter
2005
Resuscitation-Induced Gut Edema and Intestinal Dysfunction
Moore-Olufemi S, Xue H, Attuwaybi B, Fischer U, Harari Y, Oliver D, Weisbrodt N, Allen S, Moore F, Stewart R, Laine G, Cox C. Resuscitation-Induced Gut Edema and Intestinal Dysfunction. Journal Of Trauma And Acute Care Surgery 2005, 58: 264-270. PMID: 15706186, DOI: 10.1097/01.ta.0000133571.64393.d2.Peer-Reviewed Original ResearchConceptsMesenteric venous hypertensionGut edemaIntra-abdominal hypertensionVenous hypertensionIntestinal transitGroup BAltered gut barrier functionIschemia/reperfusion injuryBarrier functionGut barrier functionML/Mucosal injuryMyeloperoxidase activityFluid resuscitationIntestinal dysfunctionMucosal permeabilityReperfusion injurySham surgeryGut motilityGut functionHypertensionGroup AEdemaTissue resistanceInjury measurements
2003
Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury
Hains B, Black J, Waxman S. Primary cortical motor neurons undergo apoptosis after axotomizing spinal cord injury. The Journal Of Comparative Neurology 2003, 462: 328-341. PMID: 12794736, DOI: 10.1002/cne.10733.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCortical motor neuronsFluoro-GoldCorticospinal tractCord injuryMotor neuronsTerminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphateAdult male Sprague-Dawley ratsRetrograde tracer Fluoro-GoldMale Sprague-Dawley ratsApoptotic cell deathDorsal corticospinal tractPrimary motor cortexTracer Fluoro-GoldSprague-Dawley ratsVoluntary motor controlTUNEL-positive cellsCell deathEvidence of apoptosisSham surgeryDorsal funiculusMotor cortexPyramidal cellsLesion sitePositive cells
1995
Sham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys
Taylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham Surgery does not Ameliorate MPTP-Induced Behavioral Deficits in Monkeys. Cell Transplantation 1995, 4: 13-26. PMID: 7728327, DOI: 10.1177/096368979500400105.Peer-Reviewed Original ResearchConceptsFetal mesencephalic tissueSubstantia nigra graftsSham surgeryBehavioral improvementMesencephalic tissueBehavioral deficitsAdult male African green monkeysDopamine concentrationsMale African green monkeysFetal dopamine neuronsSystemic MPTP administrationIdiopathic Parkinson's diseaseStriatum of MPTPSham-operated monkeysPostmortem brain tissueAfrican green monkeysMore variable effectsNeuronal synaptic connectionsHost neuronsHost striatumHost brainMPTP administrationGestational ageSubstantia nigraNeuronal effectsSham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys
Taylor J, Elsworth J, Sladek J, Collier T, Roth R, Redmond D. Sham surgery does not ameliorate MPTP-induced behavioral deficits in monkeys. Cell Transplantation 1995, 4: 13-26. DOI: 10.1016/0963-6897(94)00035-i.Peer-Reviewed Original ResearchConceptsFetal mesencephalic tissueSubstantia nigra graftsSham surgeryBehavioral improvementMesencephalic tissueBehavioral deficitsAdult male African green monkeysDopamine concentrationsMale African green monkeysFetal dopamine neuronsSystemic MPTP administrationIdiopathic Parkinson's diseaseStriatum of MPTPSham-operated monkeysPostmortem brain tissueAfrican green monkeysMore variable effectsNeuronal synaptic connectionsHost neuronsHost striatumHost brainMPTP administrationGestational ageSubstantia nigraNeuronal effects
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