2025
The Impact and Safety of GLP‐1 Agents and Breast Cancer
Parsons K, Montalvo M, Fischbach N, Taylor M, Alfaro S, Lustberg M. The Impact and Safety of GLP‐1 Agents and Breast Cancer. Cancer Medicine 2025, 14: e70932. PMID: 40552446, PMCID: PMC12186097, DOI: 10.1002/cam4.70932.Peer-Reviewed Original ResearchConceptsBreast cancer patientsGLP-1 receptor agonistsBreast cancerBreast cancer-specific mortalityCancer patientsBreast cancer incidenceBreast cancer ratesWeight management interventionsProportion of breast cancer patientsNon-cancer populationObese post-menopausal womenReceptor agonistsBreast cancer outcomesBreast cancer progressionWeight loss interventionWeight management strategiesEffective weight managementGLP-1Quality of lifeAll-Cause MortalityCancer-specific mortalityImprove patient outcomesObesity prevalenceWeb of ScienceCancer incidenceProspective decision impact study of the Breast Cancer Index: Results from the BCI Registry study.
Sanft T, Siuliukina N, O'Neal B, Anderson A, Jankowitz R, Pegram M, Diab S, Zhang Y, Treuner K, O'Shaughnessy J. Prospective decision impact study of the Breast Cancer Index: Results from the BCI Registry study. Journal Of Clinical Oncology 2025, 43: 531-531. DOI: 10.1200/jco.2025.43.16_suppl.531.Peer-Reviewed Original ResearchPercentage of physiciansBreast Cancer IndexPhysician confidenceRegistry studyPatient preferencesTest questionnaireEndocrine therapyReduce patient concernsPhysician decision-makingEarly-stage breast cancerQuality of lifeClinical decision-makingCancer indexPhysician recommendationWilcoxon Signed Rank TestLikelihood of benefitPatient concernsClinical careBenefit of endocrine therapyBreast cancer patientsLong-term clinical outcomesDrug safetyDecision impact studyEndocrine therapy benefitLate distant recurrencePTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence
Zhan H, Antony V, Tang H, Theriot J, Liang Y, Hui P, Krishnamurti U, DiGiovanna M. PTEN inactivating mutations are associated with hormone receptor loss during breast cancer recurrence. Breast Cancer Research And Treatment 2025, 211: 441-447. PMID: 40063317, DOI: 10.1007/s10549-025-07660-3.Peer-Reviewed Original ResearchConceptsPten inactivating mutationsBreast cancerER+/HER2- tumorsRecurrent tumorsER+/HER2- breast cancer patientsInactivating mutationsAssociated with worse clinical outcomesTreatment historyER+/HER2- breast cancerTriple negative phenotypeBreast cancer recurrenceBreast cancer patientsHormone receptor lossResultsThe average timeHR+ tumorsDistant recurrenceHR statusER expressionRecurrent diseaseTumor histologyTumor recurrenceHER2 expressionHormone independencePatient ageClinicopathological characteristics127 Analytical Validation and Prospective Study of a High-Sensitivity HER2 (HS-HER2) Quantitative Immunofluorescence Assay for Enhanced Stratification of HER2-Low Breast Cancer Patients
Chan N, Gaule P, Benanto J, Robbins C, Scott L, Hill S, Morrison R, Liebler D, Fulton R, Rimm D. 127 Analytical Validation and Prospective Study of a High-Sensitivity HER2 (HS-HER2) Quantitative Immunofluorescence Assay for Enhanced Stratification of HER2-Low Breast Cancer Patients. Laboratory Investigation 2025, 105: 102351. DOI: 10.1016/j.labinv.2024.102351.Peer-Reviewed Original ResearchHEalth-Related Quality of Life-Intervention in Survivors of Breast and Other Cancers Experiencing Cancer-Related Fatigue and Associated Cognitive Symptoms Using TraditionAL Chinese Medicine: The ‘HERBAL’ Trial
Chan A, Chan D, Ng D, Zheng H, Tan Q, Tan C, Toh J, Yap N, Toh Y, Ke Y, Wang E, Lim Q, Ho H, Chew L, Tan T. HEalth-Related Quality of Life-Intervention in Survivors of Breast and Other Cancers Experiencing Cancer-Related Fatigue and Associated Cognitive Symptoms Using TraditionAL Chinese Medicine: The ‘HERBAL’ Trial. Integrative Cancer Therapies 2025, 24: 15347354251314514. PMID: 39840742, PMCID: PMC11755541, DOI: 10.1177/15347354251314514.Peer-Reviewed Original ResearchConceptsCancer-related fatigueQuality of lifeCancer survivorsSurvivors of breastQuality of life interventionsPerceived cognitive functionFatigued cancer survivorsHealth-related qualityPerceived cognitive impairmentCognitive symptomsPatient-reported outcomesGeneralizability of trial findingsStage 2 cancerIntegrative modalitiesChinese medicineLife interventionsEmotional fatigueFatigue symptomsRelieving fatigueBreast cancer patientsTraditional Chinese medicineIntegrative therapiesTrial findingsPilot trialCognitive impairmentSocial support, fear of cancer recurrence and sleep quality in breast cancer: A moderated network analysis
Jiang Y, Wu X, Li H, Xiong Y, Knobf M, Ye Z. Social support, fear of cancer recurrence and sleep quality in breast cancer: A moderated network analysis. European Journal Of Oncology Nursing 2025, 74: 102799. PMID: 39842318, DOI: 10.1016/j.ejon.2025.102799.Peer-Reviewed Original ResearchFear of cancer recurrenceSocial supportSleep qualityPittsburgh Sleep Quality Index scalePerceived Social Support ScaleLevels of social supportEffect of social supportModerating effect of social supportHigh social supportSocial Support ScaleGeneralized anxietyBreast cancerCancer recurrenceCancer patientsSleep efficiencySupport ScaleMental healthBreast cancer patientsIndex scaleSleep problemsBuffering factorsJohnson-NeymanAnxietyFearSupportBreast Cancer Diagnosis and Management in an Area of Protracted Conflict: A Case Series from Northwest Syria
Hamze M, Alawa J, Alahdab F, Al-Shemali A, Alhussein A, Arab N, Galal B, Debel J, Jemo A, khalil M, Chagpar A, Atassi B, Khoshnood K, Abbara A. Breast Cancer Diagnosis and Management in an Area of Protracted Conflict: A Case Series from Northwest Syria. Avicenna Journal Of Medicine 2025, 15: 009-016. PMID: 40395698, PMCID: PMC12088791, DOI: 10.1055/s-0045-1802585.Peer-Reviewed Original ResearchBreast cancerBurden of breast cancerRetrospective analysis of breast cancer patientsLate-stage breast cancerOncology centersAnalysis of breast cancer patientsSymptom onset to diagnosisBreast cancer diagnosisSignificant public health challengeRates of mastectomyInvasive ductal carcinomaPublic health challengeBreast cancer patientsCancer careOncology careChemical weapons exposureNorthwest SyriaOncology servicesDuctal carcinomaMedian intervalReferral centerClinical presentationImprove accessFemale patientsHealth challenges
2024
Association Between Delayed/Forgone Medical Care and Resource Utilization Among Women with Breast Cancer in the United States
Reddy K, Jarrell K, Berkowitz C, Hulse S, Elmore L, Fishman R, Greenup R, Mateo A, Rothman J, Sataloff D, Tchou J, Zafar S, Fayanju O. Association Between Delayed/Forgone Medical Care and Resource Utilization Among Women with Breast Cancer in the United States. Annals Of Surgical Oncology 2024, 32: 2534-2544. PMID: 39694997, PMCID: PMC11882630, DOI: 10.1245/s10434-024-16586-x.Peer-Reviewed Original ResearchConceptsBreast cancer careCancer careEmergency departmentBreast cancerWeighted proportion of patientsMedical Expenditure Panel SurveyPrescription medication expendituresOffice-based encountersProportion of patientsOffice-based visitsOut-of-pocketAssociated with increased resource utilizationChi-square testRao-ScottFinancial barriersHealthcare expendituresInpatient expendituresMedical careHealthcare spendingBreast cancer patientsMedical expendituresCareUnited StatesResource utilizationPanel SurveyAssessing the long-term prognostic ability of the 70 gene expression signature MammaPrint in an Italian single-center prospective cohort study of early-stage intermediate-risk breast cancer patients
Generali D, Rocca A, Strina C, Milani M, Fiorino E, Cervoni V, Azzini C, Saracino A, Ciliberto I, Ziglioli N, Alberio M, Giudici F, Dester M, Ciani O, Fornaro G, Aguggini S, Dreezen C, Pronin D, Ende S. Assessing the long-term prognostic ability of the 70 gene expression signature MammaPrint in an Italian single-center prospective cohort study of early-stage intermediate-risk breast cancer patients. Heliyon 2024, 10: e39485. PMID: 39553665, PMCID: PMC11564935, DOI: 10.1016/j.heliyon.2024.e39485.Peer-Reviewed Original ResearchLow-risk tumorsHigh-risk tumorsRisk tumorsOverall survivalBreast cancerFollow-upPrognostic performanceHigh-risk BC patientsIntermediate-risk breast cancerLong-term prognostic abilitySingle-center prospective cohort studyPathologic tumor characteristicsProgesterone receptor-positiveSingle-center prospective cohortMedian Follow-UpBreast cancer patientsGenomic riskProspective cohort studyCox regression modelsPersonalize treatment choicesNodal statusReceptor statusReceptor-positiveTumor characteristicsTumor sizeModeling epithelial-mesenchymal transition in patient-derived breast cancer organoids
Bar-Hai N, Ben-Yishay R, Arbili-Yarhi S, Herman N, Avidan-Noy V, Menes T, Mansour A, Awwad F, Balint-Lahat N, Goldinger G, Hout-Siloni G, Adileh M, Berger R, Ishay-Ronen D. Modeling epithelial-mesenchymal transition in patient-derived breast cancer organoids. Frontiers In Oncology 2024, 14: 1470379. PMID: 39469640, PMCID: PMC11513879, DOI: 10.3389/fonc.2024.1470379.Peer-Reviewed Original ResearchEpithelial-mesenchymal transitionPatient-derived breast cancer modelsCancer patientsCell plasticityTGF-bBreast cancer organoidsCancer cell plasticityBreast cancer modelBreast cancer patientsEMT-like featuresE-cadherin downregulationEMT-like processCancer modelsOrganoid linesCancer organoidsEpithelial plasticityInvasive phenotypeCellular plasticityE-cadherinOrganoidsPatientsCancerDedifferentiation processMorphological changesCytoskeletal reorganizationPredicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach
Wei S, Zhang Y, Sowmiyanarayanan S, Yehia Z, Jan I, Yue N, Haffty B, Nie K. Predicting Radiation-Induced Acute Toxicity in Breast Cancer Patients: A Radiogenomic Approach. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e341. DOI: 10.1016/j.ijrobp.2024.07.752.Peer-Reviewed Original ResearchBreast cancer patientsRadiation dermatitisSide effectsCancer patientsBreast cancer patients treated with radiationRadiogenomic approachCancer patients treated with radiationRadiation-induced acute toxicityPatients treated with radiationRadiomic featuresSingle nucleotide polymorphismsAcute radiation dermatitisBreast-conserving surgeryRadiation side effectsPeripheral blood samplesTotal radiation dosePersonalized treatment strategiesGenetic statusRadiation therapyMammographic patternsRadiomic texture featuresTherapy side effectsClinical parametersRetrospective studyClinical featuresClinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation
Shalaby A, Jan I, Ohri N, Yehia Z, Toppmeyer D, Haffty B. Clinical Outcomes in Breast Cancer Patients with Underlying Germline PALB2 Mutations Treated with Radiation. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e331-e332. DOI: 10.1016/j.ijrobp.2024.07.731.Peer-Reviewed Original ResearchBreast-conserving surgeryPALB2 variantsBreast cancer patientsInterpretations of pathogenicityClinical outcomesPathogenic variantsHYPO-RTBreast cancer patients treated with radiationCancer patients treated with radiationCancer patientsRisk of radiation toxicitySentinel lymph node dissectionPatients treated with radiationMedical recordsPALB2 pathogenic variantsContralateral breast cancerExternal beam radiationMedian tumor sizeLymph node dissectionSuppression of cancer developmentGrade 2 fibrosisRecurrence 4 monthsMultigene panel testingDNA double-strand break repairDouble-strand break repairArtificial-Intelligence Cloud-Based Platform to Support Shared Decision-Making in the Locoregional Treatment of Breast Cancer: Protocol for a Multidimensional Evaluation Embedded in the CINDERELLA Clinical Trial
Borsoi L, Listorti E, Ciani O. Artificial-Intelligence Cloud-Based Platform to Support Shared Decision-Making in the Locoregional Treatment of Breast Cancer: Protocol for a Multidimensional Evaluation Embedded in the CINDERELLA Clinical Trial. PharmacoEconomics - Open 2024, 8: 945-959. PMID: 39264499, PMCID: PMC11499581, DOI: 10.1007/s41669-024-00519-1.Peer-Reviewed Original ResearchBreast cancer patientsBackgroundShared decision-makingBreast cancer careCloud-based approachPatient decision aidsMultidimensional evaluationCloud-based platformReduce decision regretCost-utility analysisCancer patientsCancer carePatient-level dataHealthcare professionalsArtificial-intelligenceMobile applicationsPersonalized contentDecision regretCountry-specific unit costsFocus groupsLocoregional treatmentPatient questionnaireDecision aidPatient valuationsReal-world settingsWeb platformPTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer
Choi J, Hardy-Abeloos C, Lozano A, Hanlon A, Vargas C, Maduro J, Bradley J, Offersen B, Haffty B, Pankuch M, Amos R, Kim N, MacDonald S, Kirova Y, Mutter R. PTCOG international survey of practice patterns and trends in utilization of proton therapy for breast cancer. Clinical And Translational Radiation Oncology 2024, 48: 100847. PMID: 39280125, PMCID: PMC11399555, DOI: 10.1016/j.ctro.2024.100847.Peer-Reviewed Original ResearchProton beam therapyBreast cancer patientsParticle Therapy Co-Operative GroupPatient selection methodsBreast cancerCancer patientsTreat breast cancer patientsRegional nodal irradiationFisher's exact testSurvey of practice patternsModerate hypofractionationNodal irradiationRadiation oncologistsBeam therapyPBT patientsProton therapyExact testU.S. CentersDescriptive statisticsEuropean centersPractice patternsPatientsResponding centersBreastAsian centersComparison of incident breast cancer cases in the largest national US tumor registries
Plichta J, Thomas S, Chanenchuk T, Chan K, Hyslop T, Hwang E, Greenup R. Comparison of incident breast cancer cases in the largest national US tumor registries. Cancer 2024, 131: e35525. PMID: 39154223, PMCID: PMC11695170, DOI: 10.1002/cncr.35525.Peer-Reviewed Original ResearchIncident breast cancer casesUS Cancer StatisticsBreast cancer casesNational Cancer DatabaseNon-HispanicNon-Hispanic American Indian/Alaska NativesCancer casesTumor RegistryIn situ breast cancerPopulation cancer registryNon-Hispanic blacksSamples of breast cancer patientsNon-Hispanic whitesAmerican Indian/Alaska NativeEnd Results ProgramBreast cancerPacific IslandersCancer RegistryCancer statisticsIndian/Alaska NativeCase ascertainmentInterpretation of findingsResults ProgramBreast cancer patientsRegistryThe black box of the relationship between breast cancer patients and accompanying patients: the accompanied patients’ point of view
Pomey M, Iliescu Nelea M, Vialaron C, Normandin L, Côté M, Desforges M, Pomey-Carpentier P, Adjtoutah N, Fortin I, Ganache I, Régis C, Rosberger Z, Charpentier D, Bélanger L, Dorval M, Ghadiri D, Lavoie-Tremblay M, Boivin A, Pelletier J, Fernandez N, Danino A, de Guise M. The black box of the relationship between breast cancer patients and accompanying patients: the accompanied patients’ point of view. BMC Cancer 2024, 24: 822. PMID: 38987731, PMCID: PMC11234724, DOI: 10.1186/s12885-024-12585-z.Peer-Reviewed Original ResearchConceptsSemi-structured interviewsCare trajectoryClinical teamBreast cancer patientsCare trajectory of peopleMethodsA qualitative studyEmotional Well-BeingQuality of lifeEnhance overall qualityCancer patientsResultsThree themesHealth professionalsPatient experienceHealthcare professionalsProvince of QuebecPatient communicationPatients' perceptionsEmotional reassuranceThematic analysisHealthcare systemUniversity Medical CenterQualitative studyPatient's pointTrajectories of peopleReduce anxietyClinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer
Sun T, Golestani R, Zhan H, Krishnamurti U, Harigopal M, Zhong M, Liang Y. Clinicopathologic Characteristics of MYC Copy Number Amplification in Breast Cancer. International Journal Of Surgical Pathology 2024, 33: 59-64. PMID: 38839260, DOI: 10.1177/10668969241256109.Peer-Reviewed Original ResearchBreast cancerCopy number amplificationClinicopathological characteristicsAssociation with <i>TP53</i> mutation. InAssociated with invasive ductal carcinomaEstrogen receptor (ER)-negativeDisease-free survival timeGene copy number amplificationC-myc immunostainingNon-amplified tumorsTP53</i> mutationsTriple-negative statusMetastatic breast cancerInvasive ductal carcinomaMYC protein overexpressionBreast cancer patientsTriple-negativeDuctal carcinomaClinicopathological featuresGenetic abnormalitiesClinical dataImmunohistochemical studiesCancer patientsProtein overexpressionSurvival timePredicting peripheral neuropathy following neoadjuvant therapy in patients with breast cancer.
Feiger B, Biancalana M, Shelton A, Blenman K, Lustberg M. Predicting peripheral neuropathy following neoadjuvant therapy in patients with breast cancer. Journal Of Clinical Oncology 2024, 42: e12639-e12639. DOI: 10.1200/jco.2024.42.16_suppl.e12639.Peer-Reviewed Original ResearchBreast cancer patientsNeoadjuvant chemotherapyPeripheral neuropathyNeoadjuvant therapyBreast cancerCancer patientsAdministration of neoadjuvant chemotherapyCohort of breast cancer patientsLikelihood of breast-conserving surgeryContrast-enhanced magnetic resonance imagingQuality of lifeDynamic contrast-enhanced magnetic resonance imagingBreast-conserving surgeryReduced tumor burdenTreatment-induced neuropathyOccurrence of neuropathyInduce peripheral neuropathyDensity of blood vesselsPatients' quality of lifeMagnetic resonance imagingAmeliorate neuropathyDCE-MRI dataTumor burdenCumulative toxic effectsIntratumoral vascularityCINDERELLA clinical trial: Using artificial intelligence–driven healthcare to enhance breast cancer locoregional treatment decisions.
Bonci E, Kaidar-Person O, Antunes M, Ciani O, Cruz H, Di Micco R, Gentilini O, Heil J, Kabata P, Romariz M, Gonçalves T, Martins H, Borsoi L, Mika M, Pfob A, Romem N, Schinkoethe T, Silva G, Bobowicz M, Cardoso M. CINDERELLA clinical trial: Using artificial intelligence–driven healthcare to enhance breast cancer locoregional treatment decisions. Journal Of Clinical Oncology 2024, 42: tps621-tps621. DOI: 10.1200/jco.2024.42.16_suppl.tps621.Peer-Reviewed Original ResearchPatient expectationsQuality of lifeResults post-interventionPatient-centred careCancer patients' expectationsBreast cancer expertsOverall quality of lifeImprove patient satisfactionWeighted Cohen's kappaPsychological Well-BeingBreast cancer treatmentPost-interventionNon-metastatic breast cancer patientsWilcoxon signed-rank testApp contentClinical study sitesLocoregional treatment decisionsCancer expertsBreast cancer patientsPatient satisfactionSigned-rank testPatient informationAesthetic outcomesEligibility criteriaOutcome levelUltra-sensitive ctDNA mutation tracking to identify molecular residual disease and predict relapse in patients with early breast cancer.
Garcia-Murillas I, Cutts R, Abbott C, Boyle S, Pugh J, Chen R, Dunne K, Bunce C, Johnston S, Ring A, Russell S, Evans A, Skene A, Wheatley D, Smith I, Turner N. Ultra-sensitive ctDNA mutation tracking to identify molecular residual disease and predict relapse in patients with early breast cancer. Journal Of Clinical Oncology 2024, 42: 1010-1010. DOI: 10.1200/jco.2024.42.16_suppl.1010.Peer-Reviewed Original ResearchMolecular residual diseaseCirculating tumor DNAEarly breast cancerBreast cancer patientsFollow-upNeoadjuvant chemotherapyResidual diseaseClinical relapseCtDNA detectionClinical outcomesBreast cancerAssociated with relapse free survivalDetection of molecular residual diseaseCancer patientsCirculating tumor DNA levelsLevels of circulating tumor DNAHigh risk of relapseHigh riskCirculating tumor DNA detectionMedian lead-timeRelapse free survivalDe-escalation studiesBreast cancer relapseShortened overall survivalBaseline prior to treatment
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