2025
Antispike IgG antibody decay after immunisation with fractional versus full booster doses of COVID-19 vaccines: a 6-month longitudinal analysis of the FRACT-COV trial in Brazil
Verruck J, Puga M, de Oliveira R, da Silva P, Charu V, Hedlin H, Lu D, Zhang A, Ritter V, Shaw B, Rosser J, Seidman J, Carter A, Qamar F, Luby S, Garret D, Croda J. Antispike IgG antibody decay after immunisation with fractional versus full booster doses of COVID-19 vaccines: a 6-month longitudinal analysis of the FRACT-COV trial in Brazil. BMJ Public Health 2025, 3: e002331. PMID: 40620571, PMCID: PMC12228459, DOI: 10.1136/bmjph-2024-002331.Peer-Reviewed Original ResearchDose of BNT162b2Fractionated dosesFollow-up visitIgG antibody levelsFollow-upFull doseAntibody levelsAntibody titresDays of follow-upDays post-booster vaccinationBaseline antibody titresClinically protective levelsFollow-up periodHealthy adultsDose of COVID-19 vaccineDays post-boosterBooster dose of BNT162b2Post-booster vaccinationFull-doseBooster doseIgG levelsAZD1222Post-boosterBNT162b2High antibody titres1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity
MATSON B, GUNAWAN F, ROTHMAN D, MASON G, NEWGARD C, HWANG J. 1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1727-p.Peer-Reviewed Original ResearchCentral nervous systemAcute hyperglycemiaLean controlsBrain glucose levelsMass spectrometry-based metabolomic profilingMeasured plasma amino acidsInsulin resistanceGlucose levelsBranched chain amino acidsPlasma amino acidsDevelopment of insulin resistanceAromatic amino acid levelsChain amino acidsAcid suppressionResponse to hyperglycemiaMetabolomic profilesImpaired suppressionHyperglycemic clampObesityInsulin sensitivityHyperglycemiaNervous systemAmino acid changesBrain glucoseHealthy adults358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans
MATSON B, CHANG W, PALMIOTTO J, ROTHMAN D, BELFORT DE AGUIAR R, MASON G, HWANG J. 358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans. Diabetes 2025, 74 DOI: 10.2337/db25-358-or.Peer-Reviewed Original ResearchElevation of non-esterified fatty acidsNon-esterified fatty acid levelsHyperglycemic clampBrain glucose uptakeCirculating non-esterified fatty acidsBrain glucoseAcute elevationIntralipid infusionInsulin resistanceIntravenous infusion of salineAbsence of insulin resistanceNon-esterified fatty acidsInduce peripheral insulin resistanceHealthy adultsInfusion of salinePresence of hyperglycemiaGlucose uptakeMeasures of insulin sensitivityPeripheral insulin resistanceHigh-fat dietGlucose infusion rateIntravenous infusionPlasma glucoseLean individualsMRS scansAssociation between loneliness and suicidality among general populations and persons with depressive and bipolar disorders: A systematic review
Lu A, Chan A, Menon T, Le G, Wong S, Ho R, Lo H, Rhee T, Lim P, Guillen-Burgos H, McIntyre R. Association between loneliness and suicidality among general populations and persons with depressive and bipolar disorders: A systematic review. Journal Of Affective Disorders 2025, 380: 777-801. PMID: 40157511, DOI: 10.1016/j.jad.2025.03.150.Peer-Reviewed Original ResearchConceptsGeneral population sampleBipolar disorderSystematic reviewPopulation sampleAge groupsHealthy adultsWeb of ScienceOlder adultsUnadjusted modelsDepressive symptomsData extractionDepressive disorderEligibility criteriaModerate positive correlationNIH toolPositive associationLonelinessEvaluate personalitySuicideAdultsClinical diagnosisDisordersQuality assessmentAssociationComprehensive assessment
2024
A preliminary examination of the TOMM2 in a sample of Spanish speakers in the United States
Usuga D, Ayearst L, Rivera D, Krch D, Perrin P, Carrión C, Valdés G, Loro D, Rodriguez M, Munoz G, Drago C, García P, Rivera P, Arango-Lasprilla J. A preliminary examination of the TOMM2 in a sample of Spanish speakers in the United States. NeuroRehabilitation An International Interdisciplinary Journal 2024, 55: 235-242. PMID: 39240592, DOI: 10.3233/nre-240085.Peer-Reviewed Original ResearchConceptsNormative dataPerformance validity measuresSpanish speakersItem-level analysesCognitively healthy adultsRecognition trialsNormative samplePsychiatric disordersTOMMCutoff scoreSpanish versionHispanic individualsDescriptive normsU.S. METHODSValidity measuresCultural appropriatenessHealthy adultsDescriptive analysisTrial 1ScoresItemsSpeakersTrial 2United StatesCognitionEcologically Assessed Sleep Duration and Arterial Stiffness in Healthy Men and Women
Gaffey A, Walenczyk K, Schwartz J, Hall M, Burg M. Ecologically Assessed Sleep Duration and Arterial Stiffness in Healthy Men and Women. Biopsychosocial Science And Medicine 2024, 86: 740-747. PMID: 39225340, PMCID: PMC11560491, DOI: 10.1097/psy.0000000000001335.Peer-Reviewed Original ResearchSelf-reported sleep durationArterial stiffnessSleep durationAverage sleep durationActigraphy-assessed sleepAmbulatory arterial stiffness indexSex-specific associationsArterial stiffness indexAssessment of ASResting CaiHealth covariatesValid contextsSex-stratifiedQuadratic associationHealthy menCAIXAssess sleepExploratory analysisYoung adultsStiffness indexHealthy adultsSex-SpecificMultivariate regressionSleepAssociationAssociation between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study
Sun P, Guo X, Ding E, Li C, Ren H, Xu Y, Qian J, Deng F, Shi W, Dong H, Lin E, Guo P, Fang J, Zhang Q, Zhao W, Tong S, Lu X, Pollitt K, Shi X, Tang S. Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60–69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study. Environmental Health Perspectives 2024, 132: 077005. PMID: 39028628, PMCID: PMC11259245, DOI: 10.1289/ehp13865.Peer-Reviewed Original ResearchConceptsFat mass indicatorsHealthy older adultsBayesian kernel machine regressionVisceral fat areaOlder adultsPercent body fatBody compositionBody fat massExposome-wide association studyPrevention of chronic diseasesAir pollution exposureBody composition indicatorsMediation analysisInBody 770 deviceHealthy adultsAssociated with increased body fat massBody composition changesKernel machine regressionBayesian kernel machine regression modelsChronic diseasesPollution exposureBody fatAssociation studiesAdverse health effectsFat areaMRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children
Hodgdon E, Anderson R, Al Azzawi H, Wilson T, Calhoun V, Wang Y, Solis I, Greve D, Stephen J, Ciesielski K. MRI morphometry of the anterior and posterior cerebellar vermis and its relationship to sensorimotor and cognitive functions in children. Developmental Cognitive Neuroscience 2024, 67: 101385. PMID: 38713999, PMCID: PMC11096723, DOI: 10.1016/j.dcn.2024.101385.Peer-Reviewed Original ResearchConceptsLobules I-VCognitive functionCerebellar vermis volumePosterior brain structuresCerebellar vermisVI-VIIAnterior cerebellar vermisLobules VI-VIIWASI-IIEmotional processingVermis volumeNeuropsychological scoresPosterior cerebellar vermisBrain structuresDevelopmental trajectoriesMRI morphometryCerebellar anatomyPosterior vermisSensorimotorDevelopmental studiesHuman cerebellumHealthy adultsAdult volumeVermisHigh-resolution MRIMild cognitive impairment among LRRK2 and GBA1 patients with Parkinson's disease
Thaler A, Livne V, Rubinstein E, Omer N, Faust-Socher A, Cohen B, Giladi N, Shirvan J, Cedarbaum J, Gana-Weisz M, Goldstein O, Orr-Urtreger A, Alcalay R, Mirelman A. Mild cognitive impairment among LRRK2 and GBA1 patients with Parkinson's disease. Parkinsonism & Related Disorders 2024, 123: 106970. PMID: 38691978, DOI: 10.1016/j.parkreldis.2024.106970.Peer-Reviewed Original ResearchMild cognitive impairmentIdiopathic PDMovement Disorder SocietyIncidence of mild cognitive impairmentFrequency of mild cognitive impairmentDiagnosis of mild cognitive impairmentCognitive impairmentLRRK2-PDLevel I criteriaParkinson's diseaseLevel II criteriaCarriers of mutationsMotor symptom onsetHoehn and YahrGBA1-PDCognitive batteryGender-matched controlsCognitive domainsEarly-stage PDI criteriaClinical characteristicsPD cohortDisorder SocietySymptom onsetHealthy adultsUse of a Single-Item Ecological Momentary Assessment to Measure Daily Exercise: Agreement with Accelerometer-Measured Exercise
Sundquist K, Schwartz J, Burg M, Davidson K, Diaz K. Use of a Single-Item Ecological Momentary Assessment to Measure Daily Exercise: Agreement with Accelerometer-Measured Exercise. Sensors 2024, 24: 946. PMID: 38339663, PMCID: PMC10857316, DOI: 10.3390/s24030946.Peer-Reviewed Original ResearchConceptsEcological momentary assessmentPhysical activityDaily exerciseSelf-reports of exerciseObjectively quantify physical activityMeasure physical activityMomentary assessmentSelf-reported exerciseSmartphone-based ecological momentary assessmentLong-term exerciseAssociated with agreementPredictors of agreementRandomized Controlled TrialsExercise boutFitbit devicesSelf-ReportExerciseDemographic predictorsEnd-of-dayKappa statisticComplete dataMean kappaHealthy adultsParticipantsAccelerometerThe infraclavicular approach for venous thoracic outlet syndrome
Loh S, Tonnessen B. The infraclavicular approach for venous thoracic outlet syndrome. Seminars In Vascular Surgery 2024, 37: 74-81. PMID: 38704187, DOI: 10.1053/j.semvascsurg.2024.01.003.Peer-Reviewed Original ResearchCorrelates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Mendez Colmenares A, Kramer A, Li K, Lee J, Lee P, Thomas M. Correlates of axonal content in healthy adult span: Age, sex, myelin, and metabolic health. Cerebral Circulation - Cognition And Behavior 2024, 6: 100203. PMID: 38292016, PMCID: PMC10827486, DOI: 10.1016/j.cccb.2024.100203.Peer-Reviewed Original ResearchNeurologically healthy adultsHealthy adultsLow metabolic riskAdult spanNeural targetsSex differencesIntracranial volumeModifiable health risk factorsMetabolic riskMyelin contentHealth risk factorsAlzheimer's diseaseWhite matterNeurite orientation dispersionPeripheral metabolismMRI approachModifiable factorsAdiposity scoreAdultsMetabolic healthRisk factorsMetabolic syndromeVulnerabilityNeurologyWMNeural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin
Stoliker D, Novelli L, Vollenweider F, Egan G, Preller K, Razi A. Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin. Biological Psychiatry 2024, 96: 57-66. PMID: 38185235, DOI: 10.1016/j.biopsych.2024.01.002.Peer-Reviewed Original ResearchCentral executive networkDefault mode networkResting-state networksEffective connectivitySalience networkNeural mechanismsAltered cognitionLarge-scale resting-state networksBasic cognitive functionsCognitive systemBehavioral measuresExecutive networkHierarchical organizationEmotional effectsMode networkCognitive functionSubcortical systemsSubjective experienceCognitionFunctional MRIPsychedelic therapyAmygdalaEmotionsHealthy adultsPsychiatric disorders
2023
Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults
Burzynska A, Anderson C, Arciniegas D, Calhoun V, Choi I, Colmenares A, Hiner G, Kramer A, Li K, Lee J, Lee P, Oh S, Umland S, Thomas M. Metabolic syndrome and adiposity: Risk factors for decreased myelin in cognitively healthy adults. Cerebral Circulation - Cognition And Behavior 2023, 5: 100180. PMID: 38162292, PMCID: PMC10757180, DOI: 10.1016/j.cccb.2023.100180.Peer-Reviewed Original ResearchMetS risk scoreRisk scoreRisk factorsMetabolic syndromeCognitively healthy adultsHealthy adultsTreatment of cognitive declineNeurologically healthy adultsCluster of conditionsPathophysiology of dementiaElevated blood pressureExcess adiposityChronic diseasesContext of MetSRandomized clinical trialsMyelin water fractionWhite matterDementiaCognitive dysfunctionCognitive declineMaintenance of myelin integrityLate-myelinatingMetSAdiposity reductionAssociation fibersGreater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample. Neurobiology Of Stress 2023, 26: 100557. PMID: 37501940, PMCID: PMC10369475, DOI: 10.1016/j.ynstr.2023.100557.Peer-Reviewed Original ResearchTraumatic eventsGrimAge accelerationMore traumatic eventsWhite participantsExploratory mediation analysisMajor life eventsImpact of stressAssaultive traumaPsychological dataCross-sectional sampleCommunity sampleLife eventsMediation analysisLifetime stressRace-related differencesChronic stressorsCumulative stressorsYoung adultsCumulative stressChronic illnessYoung adult populationStressorsGreater stressHealthy adultsParticipantsRelationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential ageResting‐state dynamic functional network connectivity predicts cognition in 37,784 participants of UK Biobank
Sendi M, Zendehrouh E, Miller R, Salat D, Calhoun V. Resting‐state dynamic functional network connectivity predicts cognition in 37,784 participants of UK Biobank. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.065832.Peer-Reviewed Original ResearchFunctional network connectivityDynamic FNCDynamic functional network connectivityCognitive scoresFluid intelligenceCognitive declineAge-related cognitive declineGroup independent component analysisResting-state functional MRIBrain functional changesResting-state fMRIBrain functional network connectivityReaction timeParticipants of UK BiobankRT taskFunctional MRIRs-fMRIPairing taskCognitionIndependent component analysisUK BiobankBrainNetwork connectivityHealthy adultsData-driven componentsHippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults
Odriozola P, Kribakaran S, Cohodes E, Zacharek S, McCauley S, Haberman J, Quintela L, Hernandez C, Spencer H, Pruessner L, Caballero C, Gee D. Hippocampal Involvement in Safety Signal Learning Varies With Anxiety Among Healthy Adults. Biological Psychiatry Global Open Science 2023, 4: 155-164. PMID: 38298801, PMCID: PMC10829678, DOI: 10.1016/j.bpsgos.2023.05.007.Peer-Reviewed Original ResearchSafety signal learningDorsal anterior cingulate cortexTrait anxietyFear reductionEffects of noveltyHippocampal activationSignal learningThreat responsesNeural mechanismsAnxiety disordersFunctional connectivityVentrolateral prefrontal cortex activationInhibition of fearLow trait anxietyCross-species evidenceInferior frontal gyrusHigh trait anxietyPrefrontal cortex activationAnterior cingulate cortexHealthy adultsNeural correlatesFrontal gyrusAnterior hippocampusCortex activationHippocampal involvementTrace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples
Lin E, Nason S, Zhong A, Fortner J, Godri Pollitt K. Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples. The Science Of The Total Environment 2023, 883: 163530. PMID: 37094673, PMCID: PMC10248884, DOI: 10.1016/j.scitotenv.2023.163530.Peer-Reviewed Original ResearchConceptsPolyfluoroalkyl substancesLiquid chromatography-high resolution mass spectrometryResolution mass spectrometryWater-repellent propertiesVenous blood samplesBlood samplesTrace levelsTrace analysisMass spectrometryWhole blood samplesChemical analysisAlkyl substancesHealthy adultsMan-made chemicalsAdverse health outcomesAnalytical methodBlank correctionHousehold productsHealth outcomesPFAS exposureInvasive methodBlood collectionBlood spotsCritical windowEnvironmental exposuresSymmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter
Colmenares A, Hefner M, Calhoun V, Salerno E, Fanning J, Gothe N, McAuley E, Kramer A, Burzynska A. Symmetric data-driven fusion of diffusion tensor MRI: Age differences in white matter. Frontiers In Neurology 2023, 14: 1094313. PMID: 37139071, PMCID: PMC10149813, DOI: 10.3389/fneur.2023.1094313.Peer-Reviewed Original ResearchDiffusion tensor imagingAge differencesExamination of age differencesPattern of age differencesFractional anisotropyRadial diffusivityJoint independent component analysisCognitively healthy adultsWhite matterDiffusion tensor imaging parametersFluid abilitiesPrefrontal WMProcessing speedDiagnostic classificationWM pathologyDiffusion tensor imaging datasetsAging WMUnimodal analysisTensor imagingIndependent component analysisClinical samplesHealthy agingCognitionCorpus callosumHealthy adults
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