2025
Limited evidence for anesthesia and analgesia for outpatient primary knee and hip arthroplasty: A scoping review
Li J, Ardon A, Johnson R, Gillespie N, Lai Y, Ouanes J, Shilling A, Tokita H, Ledford C, Wilson S. Limited evidence for anesthesia and analgesia for outpatient primary knee and hip arthroplasty: A scoping review. Orthopaedics & Traumatology Surgery & Research 2025, 111: 104318. PMID: 40523471, DOI: 10.1016/j.otsr.2025.104318.Peer-Reviewed Original ResearchConceptsScoping ReviewSpinal anesthesiaPatient-centered outcomesPeripheral nervesPeriarticular infiltrationNational Library of Medicine's MedlineLength of stayLocal infiltration analgesiaPeripheral nerve blocksLower extremity arthroplastyOutpatient settingLimited evidenceAmbulatory populationHip arthroplastyKneeLiterature searchPain scoresPeriarticular injectionHipInfiltration analgesiaNerve blockExtremity arthroplastyLocal infiltrationAmbulanceKnee arthroplasty
2024
Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Nishino J, Hu W, Kishtagari A, Shen B, Gao X, Blackman C, Kassim A, Marneni N, Cherukuri A, Vittrup R, Kalkan F, Shah R, Ahn C, Gao A, Ahmedrabie A, Collins R, Zeidan A, Bidikian A, Gowda L, Shaffer B, Madanat Y, Zhao Z, Chung S, Morrison S. Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants. Cancer Discovery 2024, 15: 748-766. PMID: 39786370, PMCID: PMC11962394, DOI: 10.1158/2159-8290.cd-24-0719.Peer-Reviewed Original ResearchAllogeneic hematopoietic cell transplantationHematopoietic cell transplantationB-blockersCell transplantationHematopoietic regenerationGraft-versus-host disease prophylaxisAutologous hematopoietic cell transplantationDelayed platelet engraftmentImpaired hematopoietic regenerationPost-transplant chemotherapyGraft-versus-hostAdrenergic receptor signalingBone marrow regenerationInhibitory effectPlatelet engraftmentInhibit engraftmentReceptor inhibitorsDisease prophylaxisMarrow regenerationMouse hematopoiesisHematopoietic cellsEngraftmentLarger dosesReceptor signalingPeripheral nervesNeuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle
Cioffi L, Diviccaro S, Chrostek G, Caruso D, Garcia-Segura L, Melcangi R, Giatti S. Neuroactive steroids fluctuate with regional specificity in the central and peripheral nervous system across the rat estrous cycle. The Journal Of Steroid Biochemistry And Molecular Biology 2024, 243: 106590. PMID: 39053702, DOI: 10.1016/j.jsbmb.2024.106590.Peer-Reviewed Original ResearchNeuroactive steroidsMenstrual cycleNervous systemEstrous cycleRat estrous cycleNeuroactive steroid levelsLevels of pregnenoloneSex steroid hormone levelsOvarian cycleRegulation of nervous functionsPeripheral nervous systemSteroid hormone levelsPsychiatric disordersSteroid patternBrain regionsHormone levelsTherapeutic consequencesNeuropathological eventsPeripheral nervesSteroid levelsNeuroprotective agentsNervous functionSteroidsPhysiological regulationProgesteroneCase report: Solitary mass of the sciatic nerve confirmed as a primary extranodal manifestation of diffuse large B-cell lymphoma in a geriatric patient
Becker H, Vogelsberg A, Feucht D, Estler A, Tafrali D, Schittenhelm J, Milla J, Kurz S, Fend F, Tatagiba M, Schuhmann M, Hurth H. Case report: Solitary mass of the sciatic nerve confirmed as a primary extranodal manifestation of diffuse large B-cell lymphoma in a geriatric patient. Frontiers In Oncology 2024, 14: 1354073. PMID: 38585009, PMCID: PMC10995294, DOI: 10.3389/fonc.2024.1354073.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaMalignant peripheral nerve sheath tumorManifestation of diffuse large B-cell lymphomaLarge B-cell lymphomaPeripheral nerve sheath tumorsB-cell lymphomaContrast-enhancing lesionsNerve sheath tumorsComprehensive diagnostic workupSheath tumorsSciatic nerveExtranodal manifestationsHematologic neoplasmsSolitary massTumor boardAcute onsetBenign peripheral nerve sheath tumorsPeripheral nervesPalliative local radiotherapyRadical tumor resectionHigh-grade malignancyInterdisciplinary tumor boardRadiological diagnostic featuresInfiltration of nervesIndividualized treatment approachNeuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience
Živković S, Lacomis D, Soman P. Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience. Frontiers In Cardiovascular Medicine 2024, 11: 1345608. PMID: 38410247, PMCID: PMC10894993, DOI: 10.3389/fcvm.2024.1345608.Peer-Reviewed Original ResearchATTRwt patientsPeripheral neuropathyPrevalence of peripheral neuropathySuspected peripheral neuropathyCases of neuropathyDistal sensory lossTransthyretin amyloid depositionCardiomyopathy patientsClinical featuresTransthyretin genotypingMusculoskeletal manifestationsNeuropathy symptomsATTRwtTransthyretin amyloidosisElderly patientsHeart failureTransthyretin mutationFrequent comorbiditiesMultiple potential causesNeuropathySensory lossElderly menPatientsSenile amyloidosisPeripheral nerves
2023
Peripheral Nerve Stimulation for Pain Management: A Review
Chow R, Lee R, Rajput K. Peripheral Nerve Stimulation for Pain Management: A Review. Current Pain And Headache Reports 2023, 27: 321-327. PMID: 37523121, DOI: 10.1007/s11916-023-01143-0.Peer-Reviewed Original ResearchConceptsPeripheral nerve stimulationNerve stimulationChronic painChronic low back painSingle peripheral nerveUse of PNSChronic pain conditionsPost-amputation painLong-term outcomesLow back painWidespread disease processNeuropathic etiologyUpcoming evidenceNeuropathic painPain reliefOccipital neuralgiaPain conditionsPain managementBack painPeripheral nervesPainRecent FindingsThereDisease processImproved functionAvailable evidenceEvaluating chest pain in patients with post COVID conditions permission to think outside of the box
Becker R. Evaluating chest pain in patients with post COVID conditions permission to think outside of the box. Journal Of Thrombosis And Thrombolysis 2023, 55: 592-603. PMID: 37052772, PMCID: PMC10098243, DOI: 10.1007/s11239-023-02808-8.Peer-Reviewed Original Research
2022
Fetal akinesia deformation sequence syndrome associated with recessive TTN variants
Alkhunaizi E, Martin N, Jelin A, Rosner M, Bailey D, Steiner L, Lakhani S, Ji W, Katzman P, Forster K, Jarinova O, Shannon P, Chitayat D, Consortium C. Fetal akinesia deformation sequence syndrome associated with recessive TTN variants. American Journal Of Medical Genetics Part A 2022, 191: 760-769. PMID: 36495114, PMCID: PMC9928776, DOI: 10.1002/ajmg.a.63071.Peer-Reviewed Original ResearchConceptsArthrogryposis multiplex congenitaPathogenic variantsCompound heterozygous pathogenic variantsNext-generation gene sequencingHeterozygous pathogenic variantsSkeletal muscle abnormalitiesVariety of disordersFetal exposureClinical manifestationsPeripheral nervesSpinal cordLive birthsMultiplex congenitaHigh incidenceMuscle abnormalitiesRecurrence riskNeuromuscular junctionPhenotypic presentationSingle gene disordersTTN variantsConnective tissueRecessive variantsRecessive inheritanceObligate carriersMolecular diagnosisLate sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes
Fouda MA, Ghovanloo M, Ruben PC. Late sodium current: incomplete inactivation triggers seizures, myotonias, arrhythmias, and pain syndromes. The Journal Of Physiology 2022, 600: 2835-2851. PMID: 35436004, DOI: 10.1113/jp282768.Peer-Reviewed Original ResearchConceptsLate sodium currentSodium currentSkeletal muscleAction potential durationRepetitive action potentialsVoltage-gated sodium channelsSeizure disorderTrigger seizuresPeripheral nervesPotential durationSodium channelopathiesAction potentialsSodium channelsChannel inactivationPainDysfunctionMyotoniaMuscleHeartGating propertiesNerveSeizuresArrhythmiasChannelopathiesDisease
2021
Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy
Jones J, Costa C, Cooney C, Goldberg D, Ponticiello M, Cohen M, Mellado W, C. T, Willis D. Failure to Upregulate the RNA Binding Protein ZBP After Injury Leads to Impaired Regeneration in a Rodent Model of Diabetic Peripheral Neuropathy. Frontiers In Molecular Neuroscience 2021, 14: 728163. PMID: 34949989, PMCID: PMC8688773, DOI: 10.3389/fnmol.2021.728163.Peer-Reviewed Original ResearchDiabetic peripheral neuropathyResponse to injuryPeripheral neuropathyDorsal root ganglion neuronsModel of type I diabetesInjured dorsal root ganglion neuronsSciatic nerve injuryRegeneration of peripheral axonsNeuronal response to injuryPeripheral nerve degenerationType I diabetesNerve injuryGanglion neuronsImpaired regenerationDecreased axonal regenerationNerve degenerationDiabetic patientsDiabetic rodentsRodent modelsPeripheral axonsTherapeutic opportunitiesPeripheral nervesAxonal regenerationInjured axonsDecreased levels
2020
Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells
Azizi S, Azizi S. Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells. Journal Of NeuroVirology 2020, 26: 631-641. PMID: 32876900, PMCID: PMC7465881, DOI: 10.1007/s13365-020-00903-7.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin-Converting Enzyme 2BetacoronavirusBrainBrain DiseasesBystander EffectCoronavirus InfectionsCOVID-19Epithelial CellsGene Expression RegulationHost-Pathogen InteractionsHumansLungNeuronsOlfaction DisordersPandemicsPeptidyl-Dipeptidase APneumonia, ViralPulmonary EmbolismSARS-CoV-2Signal TransductionSpike Glycoprotein, CoronavirusStrokeConceptsCOVID-19 patientsBystander injuryNeurological complicationsSARS-CoV-2Cerebral vascular endothelial cellsSecondary to hypoxiaInitial symptoms of COVID-19Post-COVID-19 patientsInflammatory neuromuscular diseasesVascular endothelial cellsImmunological abnormalitiesHost cellsSymptoms of COVID-19Oral cavityMetabolic abnormalitiesThrombo-EmbolismEpithelial/endothelial cellsInitial symptomsNeurological injuryEpithelial cellsFunctional receptorsPatientsPeripheral nervesMolecular mimicryEndothelial cells
2019
Implantable wireless device for study of entrapment neuropathy
Malka R, Guarin D, Mohan S, Hernández I, Gorelik P, Mazor O, Hadlock T, Jowett N. Implantable wireless device for study of entrapment neuropathy. Journal Of Neuroscience Methods 2019, 329: 108461. PMID: 31626845, PMCID: PMC7325518, DOI: 10.1016/j.jneumeth.2019.108461.Peer-Reviewed Original ResearchConceptsAnimal modelsFunctional lossNeural dysfunctionGrade V injuriesFacial nerve functionSmall animal modelsPartial functional lossComplete functional lossWhisker displacementSurgical decompressionEntrapment syndromeDecompression surgeryNerve functionBell's palsyNerve damageFunctional recoveryGrade IIIFacial nervePeripheral nervesCompartment pressuresMurine modelDisease processInsufficient evidenceLive animal modelsOptimal timingStain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy
Mohan S, Hernández I, Selig M, Shibata S, Jowett N. Stain-Free Resolution of Unmyelinated Axons in Transgenic Mice Using Fluorescence Microscopy. Journal Of Neuropathology & Experimental Neurology 2019, 78: 1178-1180. PMID: 31642916, PMCID: PMC7967843, DOI: 10.1093/jnen/nlz099.Peer-Reviewed Original Research
2018
MR Neurography of the Lumbosacral Plexus for Lower Extremity Radiculopathy: Frequency of Findings, Characteristics of Abnormal Intraneural Signal, and Correlation with Electromyography
Chazen JL, Cornman-Homonoff J, Zhao Y, Sein M, Feuer N. MR Neurography of the Lumbosacral Plexus for Lower Extremity Radiculopathy: Frequency of Findings, Characteristics of Abnormal Intraneural Signal, and Correlation with Electromyography. American Journal Of Neuroradiology 2018, 39: 2154-2160. PMID: 30262644, PMCID: PMC7655367, DOI: 10.3174/ajnr.a5797.Peer-Reviewed Original ResearchConceptsMR neurographyElectrodiagnostic study findingsFrequency of findingsSignificant correlationElectronic medical recordsSubjective clinical findingsElectrodiagnostic studiesElectrodiagnostic testingRetrospective reviewClinical findingsClinical symptomsPrognostic valuePhysical examinationBody of evidenceMedical recordsPeripheral nervesSignal abnormalitiesLower extremitiesLumbosacral plexusObjective findingsInclusion criteriaBlinded fashionT2 signalAdjacent vasculatureUseful adjunct
2017
“Long-term stability of stimulating spiral nerve cuff electrodes on human peripheral nerves”
Christie BP, Freeberg M, Memberg WD, Pinault GJC, Hoyen HA, Tyler DJ, Triolo RJ. “Long-term stability of stimulating spiral nerve cuff electrodes on human peripheral nerves”. Journal Of NeuroEngineering And Rehabilitation 2017, 14: 70. PMID: 28693584, PMCID: PMC5504677, DOI: 10.1186/s12984-017-0285-3.Peer-Reviewed Original ResearchConceptsSpiral nerve cuff electrodesNerve cuff electrodesHuman peripheral nervesMotor unit populationPeripheral nervesCuff electrodeUnit populationNerve cuffSpiral cuffPrimary outcome measureSpinal cord injuryUpper limb amputationLong-term clinical useMethodsSince 2005Femoral nerveNormal walking speedFoot dropCord injuryUpper extremityMotor functionDifferent nervesDorsiflexion momentOutcome measuresPlantarflexion momentLimb amputation
2014
Neuromuscular diseases
Tokuno H, Fattahi P, Patwa H. Neuromuscular diseases. 2014, 50-68. DOI: 10.2217/ebo.13.463.ChaptersNeuromuscular diseaseGeneral neurology practiceGuillain-Barré syndromeCommon neuromuscular diseasesCurrent treatment optionsAmyotrophic lateral sclerosisMyasthenia gravisClinical profileTreatment optionsPeripheral nervesNeurology practiceMotor neuronsLateral sclerosisNeuromuscular junctionDiseaseBroad spectrumGravisSclerosisNerveSyndromeNeurons
2011
CNPase Expression in Olfactory Ensheathing Cells
Radtke C, Sasaki M, Lankford KL, Gallo V, Kocsis JD. CNPase Expression in Olfactory Ensheathing Cells. BioMed Research International 2011, 2011: 608496. PMID: 22174557, PMCID: PMC3228405, DOI: 10.1155/2011/608496.Peer-Reviewed Original ResearchConceptsOuter nerve layerOlfactory bulbNerve layerPeripheral nervesCNPase expressionOlfactory nerve axonsTransplantation of OECsSpinal cord injuryEndogenous Schwann cellsExpression of CNPaseTransplantation of olfactoryOlfactory Ensheathing CellsEnhanced green fluorescent proteinMyelination potentialCord injuryAxonal regenerationRegenerated axonsSchwann cellsTransgenic miceNerve axonsPeripheral myelinNerveCNPaseMyelinOECs
2008
Autosomal dominant sensory ataxia: a neuroaxonal dystrophy
Moeller JJ, Macaulay RJ, Valdmanis PN, Weston LE, Rouleau GA, Dupré N. Autosomal dominant sensory ataxia: a neuroaxonal dystrophy. Acta Neuropathologica 2008, 116: 331-336. PMID: 18347805, DOI: 10.1007/s00401-008-0362-6.Peer-Reviewed Original ResearchConceptsDorsal column nucleiDorsal columnsSpinal cordAxonal spheroidsNeuroaxonal dystrophyPatchy chronic inflammationSkeletal muscleCongestive heart failureThoracolumbar spinal cordCentral sensory pathwaysPeripheral nerve rootsMajor pathological processesAutosomal dominant sensory ataxiaMicroglial activationClinical patternHeart failureNeuronal lossVentral hornCerebral cortexChronic inflammationNerve rootsPathological featuresWallerian degenerationPeripheral nervesSensory ataxiaHIV/AIDS of the Central Nervous System
Spudich S. HIV/AIDS of the Central Nervous System. 2008, 430-445. DOI: 10.1016/b978-012373960-5.00019-8.Peer-Reviewed Original ResearchNeurological disordersMajority of HIVPublic health burdenDisease-specific therapiesCentral nervous systemHIV/AIDSAntiretroviral treatmentOpportunistic infectionsPeripheral nervesVascular disordersSpinal cordHealth burdenHIV-1Nervous systemImportant causeNeurological diseasesNutritional diseasesDisordersHIVInfectionAIDSDiseaseDisease epidemicsMorbidityNerve
2006
Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
Dombrowski MA, Sasaki M, Lankford KL, Kocsis JD, Radtke C. Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells. Brain Research 2006, 1125: 1-8. PMID: 17112480, PMCID: PMC2673087, DOI: 10.1016/j.brainres.2006.09.089.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell Adhesion Molecules, NeuronalCell TransplantationGreen Fluorescent ProteinsImmunohistochemistryMicroscopy, ImmunoelectronMyelin SheathNAV1.6 Voltage-Gated Sodium ChannelNerve RegenerationNeurofilament ProteinsNeurogliaOlfactory BulbRanvier's NodesRatsRats, Sprague-DawleySciatic NeuropathySodium ChannelsTime FactorsConceptsPeripheral nerve fibersPeripheral nervesNodes of RanvierFunctional outcomeAxonal regenerationNerve fibersRegenerated peripheral nerve fibersSciatic nerve crush lesionNerve crush lesionPeripheral-type myelinSpinal cord resultsTransplantation of olfactoryPeripheral axonal regenerationParanodal CasprCrush lesionCord resultsFunctional improvementOlfactory bulbTransection siteTransgenic ratsLesion zoneNerveNodal formationTransplantation siteOECs
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