2025
Methodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults
Ali D, Khan A, Mirza R, Appelman-Dijkstra N, Brandi M, Carpenter T, Chaussain C, Imel E, de Beur S, Florenzano P, Morrison A, Alrob H, Alexander R, Alsarraf F, Beck-Nielsen S, Biosse-Duplan M, Cohen-Solal M, Crowley R, Dandurand K, Filler G, Fukumoto S, Gagnon C, Goodyer P, Grasemann C, Grimbly C, Hussein S, Javaid M, Khan S, Khan A, Lehman A, Lems W, Lewiecki E, McDonnell C, Morgante E, Portale A, Rhee Y, Siggelkow H, Tosi L, Ward L, Guyatt G. Methodology for the international working group clinical practice guidelines on X-linked hypophosphatemia in children and adults. Journal Of Bone And Mineral Metabolism 2025, 43: 193-202. PMID: 40119067, DOI: 10.1007/s00774-025-01585-z.Peer-Reviewed Original ResearchConceptsCertainty of evidenceGRADE recommendationsImpact of medical interventionsManagement of "X-linked hypophosphatemiaX-linked hypophosphatemiaClinical practice guidelinesPatient-important outcomesRisk of biasNarrative literature reviewClinical practice surveyPatient partnersGuideline methodologistsGuideline panelFindings tablePractice guidelinesSystematic reviewPractice surveyMedical interventionsPregnant womenRecommendation strengthTreatment recommendationsInternational expertsPatient populationComprehensive guidelinesBody of evidenceUnclean cooking fuel use and all health outcomes, a systematic review and meta-analysis
Pizzol D, Trott M, Yon D, Rahmati M, Shin J, Kamholz B, Karmacharya B, Shrestha P, Underwood B, Butler L, Barnett Y, Veronese N, Soysal P, Gomez G, Mortara S, Malfatti E, Ahluwalia S, Concari A, Corinaldi A, Marrufo T, Uberti F, Sánchez G, Smith L. Unclean cooking fuel use and all health outcomes, a systematic review and meta-analysis. Health Interactions 2025, 1: 2463654. DOI: 10.1080/29963257.2025.2463654.Peer-Reviewed Original ResearchHealth outcomesCooking fuel useOdds ratioMental health outcomesMeta-analysisCooking fuelUnclean cooking fuelsWeb of ScienceMental healthAssociated with several comorbiditiesSystematic reviewFuel usersCognitive impairmentDigestive diseasesClean cooking fuel useBody of evidenceHealthRespiratory diseaseGrowing body of evidenceChronic coughChronic bronchitisSevere comorbiditiesAssociationCINAHLOutcomesTargeting the SARS-CoV-2 reservoir in long COVID
Proal A, Aleman S, Bomsel M, Brodin P, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Hewitt S, Iwasaki A, Krumholz H, Locci M, Marconi V, Mehandru S, Muller-Trutwin M, Painter M, Pretorius E, Price D, Putrino D, Qian Y, Roan N, Salmon D, Tan G, VanElzakker M, Wherry E, Van Weyenbergh J, Yonker L, Peluso M. Targeting the SARS-CoV-2 reservoir in long COVID. The Lancet Infectious Diseases 2025, 25: e294-e306. PMID: 39947217, PMCID: PMC12151306, DOI: 10.1016/s1473-3099(24)00769-2.Peer-Reviewed Original ResearchSARS-CoV-2Duration of treatmentPotential combination approachSARS-CoV-2 persistenceSARS-CoV-2 infectionPost Hoc AnalysisHIV reservoirHepatitis CMechanism of actionPatient subgroupsInterpretation of trialsDebilitating disease statesPrecision oncologyMonoclonal antibodiesGrowing body of evidenceBody of evidenceAntidopaminergic medications in Huntington's disease
Tan A, Geva M, Goldberg Y, Schuring H, Sanson B, Rosser A, Raymond L, Reilmann R, Hayden M, Anderson K. Antidopaminergic medications in Huntington's disease. Journal Of Huntington's Disease 2025, 14: 16-29. PMID: 39973394, DOI: 10.1177/18796397241304312.Peer-Reviewed Original ResearchConceptsAntidopaminergic medicationsSymbol Digit Modalities TestHuntington's diseaseComposite Unified Huntington’s Disease Rating Scale,Unified Huntington's Disease Rating ScaleExtrapyramidal symptomsWord readingHuntington's Disease Rating ScaleVMAT2 inhibitorsBehavioral impairmentsBehavioral disordersCognitive dysfunctionCognitive functionRating ScaleADM useDisease Rating ScaleHD symptomsTotal functional capacityModal testingMotor disturbancesFunctional impairmentProgressive neurodegenerative disorderMounting body of evidenceSide effectsBody of evidence
2024
Building Frontline Capability for Shared Decision-Making (SDM) in a Major Academic Oncology Center Caring for People With Non–Small Cell Lung Cancer: Performance Outcomes of a SDM Simulation Training Program
Alexander C, Hakim H, Rudell E, Ingram M, Agrawal T, Peterson P, Davies M, Adelson K, Oliver B. Building Frontline Capability for Shared Decision-Making (SDM) in a Major Academic Oncology Center Caring for People With Non–Small Cell Lung Cancer: Performance Outcomes of a SDM Simulation Training Program. The Permanente Journal 2024, 28: 200-211. PMID: 39269220, PMCID: PMC11404653, DOI: 10.7812/tpp/23.160.Peer-Reviewed Original ResearchConceptsShared decision-makingPractice settingsImplementation of shared decision-makingSDM trainingTraining programSimulation training programMultidisciplinary cliniciansCentered carePatient goalsPost-trainingClinician experienceFocus groupsClinical careSelf-EfficacyParticipants' understandingClinician awarenessPostinterventionPilot studyActive participationParticipantsProgram designCareCliniciansBody of evidenceGrowing body of evidenceExercise and Fear and Safety Learning
Azar A, Hubert T, Adams T, Cisler J, Crombie K. Exercise and Fear and Safety Learning. Current Topics In Behavioral Neurosciences 2024, 67: 125-140. PMID: 39039358, DOI: 10.1007/7854_2024_494.Peer-Reviewed Original ResearchExtinction learningRecall of extinction memoryFear conditioning paradigmExposure therapy sessionsExposure-based therapyFear extinction learningEffects of exerciseFear acquisitionExtinction memoryFear conditioningConditioning paradigmFear outcomesExtinction outcomesTherapy sessionsImprove treatment outcomesTreatment outcomesAnxietyBody of evidenceDisordersClinical scienceFearLearning processLearningPotential mechanismsExtinctionPrevalence of Dietary Modification and Supplement Use in Patients with Metastatic Renal Cell Carcinoma Receiving Systemic Therapy
Ebrahimi H, Battle D, Salgia N, Zengin Z, Dizman N, Meza L, Bergerot C, Barragan-Carrillo R, Hsu J, Castro D, Mercier B, Chawla N, Li X, Tripathi A, Liu S, Chehrazi-Raffle A, Vaishampayan U, Staehler M, Pal S. Prevalence of Dietary Modification and Supplement Use in Patients with Metastatic Renal Cell Carcinoma Receiving Systemic Therapy. Nutrients 2024, 16: 1630. PMID: 38892563, PMCID: PMC11174627, DOI: 10.3390/nu16111630.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaRenal cell carcinomaCell carcinomaDietary modificationSupplement useDiagnosis of renal cell carcinomaFirst-line treatmentSupplement usageSystemic therapyCombination therapyAntineoplastic therapyKetogenic dietCarcinomaCancer therapyMediterranean dietPhysician-patient dialoguePatientsTherapyCancer treatmentGrowing body of evidenceBody of evidenceDietary changesCancerCancer diagnosisCannabidiolTranslating an Integrative Metacognitive Model of Psychotherapy for Serious Mental Illness Into a Group Format: A Pilot Investigation on Feasibility
Martin A, Bullock J, Fiszdon J, Stacy M, Martino S, James AV, Wiesepape C, Lysaker PH. Translating an Integrative Metacognitive Model of Psychotherapy for Serious Mental Illness Into a Group Format: A Pilot Investigation on Feasibility. Psychological Services 2024, 21: 130-138. PMID: 36066852, PMCID: PMC10484016, DOI: 10.1037/ser0000706.Peer-Reviewed Original ResearchSerious mental illnessMental illnessOutpatient psychiatric settingsRoutine clinical careGroup-based interventionBody of evidenceClinical carePsychiatric settingsIllnessPilot investigationInsight therapyGroup formatProgram evaluation measuresClinical demandGroup psychotherapyInterventionGroupParticipantsInpatientsPsychotherapyTherapy
2023
To trust or not to trust in the thrall of the COVID-19 pandemic: Conspiracy endorsement and the role of adverse childhood experiences, epistemic trust, and personality functioning
Kampling H, Riedl D, Hettich N, Lampe A, Nolte T, Zara S, Ernst M, Brähler E, Sachser C, Fegert J, Gingelmaier S, Fonagy P, Krakau L, Kruse J. To trust or not to trust in the thrall of the COVID-19 pandemic: Conspiracy endorsement and the role of adverse childhood experiences, epistemic trust, and personality functioning. Social Science & Medicine 2023, 341: 116526. PMID: 38169177, DOI: 10.1016/j.socscimed.2023.116526.Peer-Reviewed Original ResearchAdverse childhood experiencesCOVID-19 pandemicPublic health challengeEarly childhood adversityChildhood experiencesBody of evidenceGeneral populationChildhood adversityHealth challengesDetrimental roleDevelopmental burdenCross-sectional dataConfidence intervalsSuccessful containmentAssociationPersonality functioningDirect associationMediatorsPandemicGood model fitIndividual proneDetrimental effectsGerman surveyFunctioningFit indicesChallenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework
Ingenhoff R, Robertson N, Munana R, Bodnar B, Weswa I, Sekitoleko I, Gaal J, Kirenga B, Kalyesubula R, Knauf F, Siddharthan T. Challenges to Implementation of Community Health Worker-Led Chronic Obstructive Pulmonary Disease (COPD) Screening and Referral in Rural Uganda: A Qualitative Study using the Implementation Outcomes Framework. International Journal Of Chronic Obstructive Pulmonary Disease 2023, 18: 2769-2783. PMID: 38046984, PMCID: PMC10693197, DOI: 10.2147/copd.s420137.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseImplementation Outcomes FrameworkCOPD screeningRural UgandaBurden of COPDReferral processCommunity health worker interventionHealth worker interventionObstructive pulmonary diseaseHealthcare providers' perceptionsCause of deathHigh patient volumeCommunity-based interventionsCHW supportCOPD awarenessCOPD careMiddle-income countriesPulmonary diseaseMedication accessBody of evidenceOutcomes FrameworkQualitative studyHealth outcomesProviders' perceptionsPatient volumeMitigating the effects of climate change on human health with vaccines and vaccinations
Kim C, Agampodi S, Marks F, Kim J, Excler J. Mitigating the effects of climate change on human health with vaccines and vaccinations. Frontiers In Public Health 2023, 11: 1252910. PMID: 37900033, PMCID: PMC10602790, DOI: 10.3389/fpubh.2023.1252910.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virus infectionCost-effective public health interventionsSyncytial virus infectionVaccine-preventable diseasesPublic health interventionsUse of vaccinesResource-poor countriesTransmissible infectious diseasesPublic health consequencesWorld Health OrganizationBody of evidenceHelminthic infectionsVirus infectionVaccine researchGlobal vaccine developmentVaccine developmentHealth interventionsNarrative reviewInfectious diseasesHealth consequencesVaccinationDiseaseAvailable evidenceHealth OrganizationVaccineNonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
Pell J, Nagata S, Menon M. Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm. Kidney360 2023, 4: e1325-e1331. PMID: 37461136, PMCID: PMC10550003, DOI: 10.34067/kid.0000000000000216.Peer-Reviewed Original ResearchConceptsApolipoprotein L1Progressive renal failureAPOL1 risk variantsImmune response genesParadigm of diseasesMechanisms of diseaseRenal failureKidney diseaseBody of evidenceImmune cellsClinical dataRecent African ancestryRisk genotypesAPOL1 variantsDiseaseEndothelial cellsPutative signaling pathwaysGenetic factorsSeminal dataPhenotype progressionCausal rolePodocytesRisk variantsSignaling pathwaysEvolving ParadigmOxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications
AlAshqar A, Lulseged B, Mason-Otey A, Liang J, Begum U, Afrin S, Borahay M. Oxidative Stress and Antioxidants in Uterine Fibroids: Pathophysiology and Clinical Implications. Antioxidants 2023, 12: 807. PMID: 37107181, PMCID: PMC10135366, DOI: 10.3390/antiox12040807.Peer-Reviewed Original ResearchUterine fibroidsClinical implicationsOxidative stressFibroid developmentUterine fibroid developmentProfibrotic mechanismsBody of evidenceDietary factorsNeoplastic entitiesComplex pathobiologyCurrent evidenceFibroidsPathobiologyPharmaceutical antioxidantsAntioxidantsPathophysiologyTumorsDiagnosisHypoxiaBiomarkers
2022
The association of anxiety with granuloma annulare: a case–control study of the National Institutes of Health ‘All of Us’ research programme
Belzer A, Leasure A, Damsky W, Cohen J. The association of anxiety with granuloma annulare: a case–control study of the National Institutes of Health ‘All of Us’ research programme. British Journal Of Dermatology 2022, 188: 558-560. PMID: 36715356, DOI: 10.1093/bjd/ljac114.Peer-Reviewed Original ResearchConceptsCase-control studyGranuloma annulareMental health conditionsInflammatory dermatosesHealth conditionsInflammatory skin diseaseImprovement of depressionAssociation of anxietyPost-traumatic stress disorderOpioid dependenceAutoimmune disordersProinflammatory cytokinesBody of evidenceDear EditorSkin diseasesSignificant associationDermatosesStress disorderNational InstituteAnnulareAssociationDisordersDepressionAnxietyDyslipidaemiaTransfusion Strategies in the 21st Century A Case-Based Narrative Report
Shenker J, Abuelhija H, Karam O, Nellis M. Transfusion Strategies in the 21st Century A Case-Based Narrative Report. Critical Care Clinics 2022, 39: 287-298. PMID: 36898774, DOI: 10.1016/j.ccc.2022.09.005.Peer-Reviewed Original ResearchA narrative review on the application of high-intensity focused ultrasound for the treatment of occlusive and thrombotic arterial disease
Brahmandam A, Chan SM, Dardik A, Nassiri N, Aboian E. A narrative review on the application of high-intensity focused ultrasound for the treatment of occlusive and thrombotic arterial disease. JVS Vascular Science 2022, 3: 292-305. PMID: 36276806, PMCID: PMC9579503, DOI: 10.1016/j.jvssci.2022.08.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAtherosclerotic arterial diseaseArterial diseaseEndovascular techniquesClinical studiesLow-density lipoprotein cholesterolPercutaneous endovascular techniquesThrombotic arterial diseasesAtherosclerotic plaque burdenPositive clinical outcomesAtherosclerotic plaque progressionHuman clinical studiesApplication of HIFUEnglish-language articlesEfficacy of HIFUHindlimb ischemic modelArterial recanalizationLipoprotein cholesterolThrombotic strokeClinical outcomesPlaque burdenUterine tumorsDiameter stenosisBody of evidenceIschemic modelClinical dataSex Differences in Depression and Sleep Disturbance as Inter-Related Risk Factors of Diabetes
Li C, Porta R, Chaudhary S. Sex Differences in Depression and Sleep Disturbance as Inter-Related Risk Factors of Diabetes. Frontiers In Clinical Diabetes And Healthcare 2022, 3: 914451. PMID: 36992768, PMCID: PMC10012092, DOI: 10.3389/fcdhc.2022.914451.Peer-Reviewed Original ResearchSleep disturbancesRisk factorsDepression frequencySleep hoursNational Health Interview SurveyBody mass indexRisk of diabetesMultivariate logistic regressionDiagnosis of diabetesHealth Interview SurveyNightly sleep durationMass indexBody of evidenceOdds ratioNightly durationPhysical activitySleep durationDiabetes diagnosisSelf-reported frequencyDiabetesSex-dependent relationshipLogistic regressionEffects of sexPhysical healthSleep levelsFatty Acid Metabolism and T Cells in Multiple Sclerosis
Pompura SL, Hafler DA, Dominguez-Villar M. Fatty Acid Metabolism and T Cells in Multiple Sclerosis. Frontiers In Immunology 2022, 13: 869197. PMID: 35603182, PMCID: PMC9116144, DOI: 10.3389/fimmu.2022.869197.Peer-Reviewed Original ResearchConceptsT cell functionT cellsMultiple sclerosisSpecific lipid speciesEffector T cellsRegulatory T cellsCell functionT helper subsetsMetabolic programsT cell activationT cell transitionLipid speciesFatty acid metabolismTh subsetsHelper subsetsEffector stateBody of evidenceCell activationDisease settingsDisease statesFunctional phenotypeOrganismal levelAcid metabolismMetabolic remodelingNutrient availabilityMotivational Interviewing for Functional Movement Disorder
Tolchin B, Martino S. Motivational Interviewing for Functional Movement Disorder. Current Clinical Neurology 2022, 223-235. DOI: 10.1007/978-3-030-86495-8_18.Peer-Reviewed Original ResearchFunctional movement disordersFunctional neurological disorderPhysical therapyMovement disordersUse of MIHealthy behaviorsOverview of MIPatients' own reasonsLimited patient engagementPatient adherenceTreatment adherenceBody of evidenceWorse outcomesMedical treatmentPatient engagementTherapeutic interventionsTreatment planNeurological disordersPatientsTherapyMedical settingsMI efficacyDisordersInterventionBehavioral changesNivolumab/ipilimumab with or without CBM588 in metastatic renal cell carcinoma: A randomized phase Ib study and the evolution of the functionality of microbial communities with treatment.
Dizman N, Meza L, Bergerot P, Alcantara M, Dorff T, Lyou Y, Frankel P, Llamas M, Hsu J, Zengin Z, Malhotra J, Gillece J, Reining L, Trent J, Takahashi M, Oka K, Higashi S, Highlander S, Pal S. Nivolumab/ipilimumab with or without CBM588 in metastatic renal cell carcinoma: A randomized phase Ib study and the evolution of the functionality of microbial communities with treatment. Journal Of Clinical Oncology 2022, 40: 371-371. DOI: 10.1200/jco.2022.40.6_suppl.371.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaNivolumab/ipilimumabRenal cell carcinomaClinical outcomesIpilimumab armCell carcinomaTissue next-generation sequencingPhase Ib studyProtocol-based therapyHigh-risk diseaseGut microbial compositionGut microbiome functionalityGut microbiome functionPrior nephrectomyObjective responseSarcomatoid featuresMedian ageRisk diseaseWeek 12Body of evidenceIpilimumabStool samplesClear cellsTreatment responseIb study
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