2025
Five-year outcomes after surgical treatment of infant postinfectious hydrocephalus in sub-Saharan Africa: results of a randomized trial.
Mbabazi-Kabachelor E, Peterson M, Mugamba J, Ssenyonga P, Onen J, Nalule E, Magombe J, Cherukuri V, Monga V, Schiff S, Kulkarni A, Warf B. Five-year outcomes after surgical treatment of infant postinfectious hydrocephalus in sub-Saharan Africa: results of a randomized trial. Journal Of Neurosurgery Pediatrics 2025, 1-10. PMID: 40315611, DOI: 10.3171/2025.1.peds24417.Peer-Reviewed Original ResearchHydrocephalus Outcome QuestionnairePostinfectious hydrocephalusVABS-3HOQ scoresBrain volumeVentriculoperitoneal shuntRandomized trialsQuality of lifeAssessed developmental outcomesPerinatal neurologic insultChoroid plexus cauterizationSurgical treatment armHUI-3Endoscopic third ventriculostomyVentriculoperitoneal shunt treatmentVineland Adaptive Behavior ScalesFollow-up resultsLong-term outcomesFive-year outcomesBrain volume outcomesQuality of life metricsAdaptive Behavior ScalesPublic health burdenSub-Saharan AfricaTreatment failure
2024
Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017
Zheng X, Wang T, Hao H, D’Souza R, Strickland M, Warren J, Darrow L, Chang H. Influenza Activity and Preterm Birth in the Atlanta Metropolitan Area: A Time-Series Analysis from 2010 to 2017. Epidemiology 2024, 36: 141-148. PMID: 39588975, PMCID: PMC11785485, DOI: 10.1097/ede.0000000000001819.Peer-Reviewed Original ResearchInfluenza-like illnessExposure lagTest positivityPreterm birthPregnant peopleRisk of adverse birth outcomesIncreased risk of adverse birth outcomesInfluenza activityAssociated with increased risk of preterm birthInterquartile range increaseAdverse birth outcomesTime-varying confoundersComposite measureRisk of preterm birthShort-term associationsAssociated with increased riskPublic health burdenPoisson log-linear modelSymptoms of influenza-like illnessEstimate associationsBirth outcomesEffect modificationAnnual influenza epidemicsRange increaseMaternal characteristicsNeuroimaging Biomarkers in Parkinson’s Disease
Holmes S, Tinaz S. Neuroimaging Biomarkers in Parkinson’s Disease. Advances In Neurobiology 2024, 40: 617-663. PMID: 39562459, DOI: 10.1007/978-3-031-69491-2_21.Peer-Reviewed Original ResearchConceptsPublic health burdenNeuroimaging biomarkersTreatment developmentRisk of developing PDParkinson's diseaseHealth burdenDiagnosis of PDMultimodal neuroimaging techniquesIdiopathic Parkinson's diseaseNon-motorDifferential diagnosis of PDNeuroimaging techniquesProdromal phaseDifferential diagnosisSymptomatic treatmentDisease progressionClinical applicationBiomarkersUsing eGFR and Albumin Creatinine Ratio as an Initial Screening Tool in Trinidadian Primary Care to Identify High-risk Population for CKD: A Cross-Sectional Study
Mahadevappa K, Nayak S, Maharaj R, Bhaktha G. Using eGFR and Albumin Creatinine Ratio as an Initial Screening Tool in Trinidadian Primary Care to Identify High-risk Population for CKD: A Cross-Sectional Study. Indian Journal Of Nephrology 2024, 34: 332-337. PMID: 39156845, PMCID: PMC11328054, DOI: 10.25259/ijn_451_23.Peer-Reviewed Original ResearchEastern Regional Health AuthorityCross-sectional studyChronic kidney diseaseCross-sectional study of adultsChronic disease clinicsPrimary care settingPrimary care levelPrimary care physiciansAlbumin-creatinine ratioRegional Health AuthorityRisk of chronic kidney diseaseStudy of adultsPublic health burdenHigh-risk populationPrimary careCare levelNCD patientsCare settingsCare physiciansCreatinine ratioEpidemiology CollaborationProportion of riskType 2 diabetes mellitusHealth authoritiesChronic Kidney Disease Epidemiology CollaborationSelf-injurious unnatural death among Veterans with HIV
Smith A, Goulet J, Vlahov D, Justice A, Womack J. Self-injurious unnatural death among Veterans with HIV. AIDS 2024, 38: 1570-1578. PMID: 38814683, DOI: 10.1097/qad.0000000000003940.Peer-Reviewed Original ResearchVeterans Aging Cohort StudyNested Case-Control StudyModifiable risk factorsRisk of suicideCase-control studyRisk factorsIdentification of modifiable risk factorsCategorization of deathsIncidence density samplingAging Cohort StudyCohort of veteransIncreased risk of suicideConditional logistic regressionHigher pain levelsUse disorderPublic health burdenDrug use disordersUnnatural deathsDeath codesUnintentional causesInternational ClassificationHIV statusExcess deathsPrevention effortsAlcohol use disorderThe Role of the Clinical Psychologist in the Care of Adults With Cardiovascular Disease
Smolderen K, Gillaspy S, Evers A, Kovacs A, Massa-Carroll I, Moons P, Mena-Hurtado C. The Role of the Clinical Psychologist in the Care of Adults With Cardiovascular Disease. JACC Advances 2024, 3: 100910. PMID: 38939655, PMCID: PMC11198723, DOI: 10.1016/j.jacadv.2024.100910.Peer-Reviewed Original ResearchPsychological mechanismsEvidence-based psychological interventionsMental health conditionsClinical psychologistsNeuropsychological assessmentCardiovascular diseaseIntegration of behavioral healthPsychological interventionsCognitive rehabilitationTarget behaviorsCardiovascular disease careBehavior change interventionsScope of practiceBehavioral careHealth disordersBehavioral healthCardiovascular disease populationPublic health burdenChange interventionsHealth conditionsPain managementCardiovascular disease spectrumHealth burdenProfessional organizationsTraining pathwaysVirology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis
Zubair A, McAlpine L, Gobeske K. Virology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis. Journal Of The Neurological Sciences 2024, 457: 122886. PMID: 38278094, DOI: 10.1016/j.jns.2024.122886.Peer-Reviewed Original Research
2023
Emergency general surgery verification: Quality improvement and the case for optimal resources and process standards
Coleman J, Davis K, Savage S, Staudenmayer K, Coimbra R. Emergency general surgery verification: Quality improvement and the case for optimal resources and process standards. Journal Of Trauma And Acute Care Surgery 2023, 96: e1-e4. PMID: 37678150, DOI: 10.1097/ta.0000000000004135.Peer-Reviewed Original ResearchConceptsEmergency general surgeryEmergency surgical interventionDay of surgeryAcute care surgeryPublic health burdenQuality Improvement ProgramPostoperative complicationsCare surgeryHospital admissionIll patientsSurgical interventionFormal quality improvement programHealth burdenGeneral surgeryPatient careCare deliverySurgeryPrograms/servicesField of traumaOutcomes researchPatientsAdmissionHospitalNational databankPractice standardsIdentification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects
Zhong H, Zhu J, Liu S, Ghoneim D, Surendran P, Liu T, Fahle S, Butterworth A, Alam A, Deng H, Yu H, Wu C, Wu L. Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects. Human Molecular Genetics 2023, 32: 3181-3193. PMID: 37622920, PMCID: PMC10630250, DOI: 10.1093/hmg/ddad139.Peer-Reviewed Original ResearchConceptsPCa riskProstate cancerHuge public health burdenEtiology of PCaBlood protein biomarkersConventional epidemiologic studiesProstate cancer riskPublic health burdenConventional observational studiesCancer Genome AtlasPCa patientsHealth burdenProtein biomarker candidatesObservational studyEpidemiologic studiesCancer riskTherapeutic strategiesCancer-related pathwaysSignificant associationBiomarker candidatesGenome AtlasProtein levelsDrug repurposingRiskPositive associationHarmful algal bloom aerosols and human health
Lim C, Yoon J, Reynolds K, Gerald L, Ault A, Heo S, Bell M. Harmful algal bloom aerosols and human health. EBioMedicine 2023, 93: 104604. PMID: 37164781, PMCID: PMC10363441, DOI: 10.1016/j.ebiom.2023.104604.Peer-Reviewed Original ResearchConceptsHealth effectsPublic health burdenDose-response relationshipPopulation-level exposureExposure assessment methodsAdverse health effectsRespiratory outcomesHealth burdenEpidemiological designHealth databasesLong-term exposureHealth outcomesEvidence gapsConcurrent exposureThreshold doseMixture of toxinsVulnerable subpopulationsAdditional studiesNumber of studiesSubsequent exposureExposureOutcomesHuman healthToxin concentrationHealthA Review of the Mental Health Sequelae of the SARS-CoV-2 (COVID-19): Preparedness Perspective
Metellus P, Jegede O, Brown C, Qureshi D, Nkemjika S. A Review of the Mental Health Sequelae of the SARS-CoV-2 (COVID-19): Preparedness Perspective. Cureus 2023, 15: e37643. PMID: 37200645, PMCID: PMC10187944, DOI: 10.7759/cureus.37643.Peer-Reviewed Original Research
2022
Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil
Eyre MT, Souza FN, Carvalho-Pereira T, Nery N, de Oliveira D, Cruz JS, Sacramento GA, Khalil H, Wunder EA, Hacker KP, Hagan JE, Childs JE, Reis MG, Begon M, Diggle PJ, Ko AI, Giorgi E, Costa F. Linking rattiness, geography and environmental degradation to spillover Leptospira infections in marginalised urban settings: An eco-epidemiological community-based cohort study in Brazil. ELife 2022, 11: e73120. PMID: 36111781, PMCID: PMC9560157, DOI: 10.7554/elife.73120.Peer-Reviewed Original ResearchConceptsInfection riskSignificant global public health burdenCommunity-based cohort studyGlobal public health burdenPublic health burdenAgents of leptospirosisExposure of interestYears of agePublic health interventionsHigh-risk communitiesJoint spatial modellingZoonotic spilloverCohort studyHuman infection riskMale genderSerological evidenceHealth burdenLeptospira infectionLeptospiral infectionInfection rateHealth interventionsEco-epidemiological studiesHealth surveillanceFundação de Amparo à PesquisaOswaldo Cruz FoundationChronic Pain and Psychiatric Conditions
Johnston K, Huckins L. Chronic Pain and Psychiatric Conditions. Complex Psychiatry 2022, 9: 24-43. PMID: 37034825, PMCID: PMC10080192, DOI: 10.1159/000527041.Peer-Reviewed Original ResearchChronic painLinkage disequilibrium score regression analysisPsychiatric conditionsPain comorbidityDSM-5 psychiatric diagnosisRates of chronic painGenetic overlapPublic health burdenDSM-5Chronic pain conditionsAssociated with increased ratesPotential mechanismsHealth burdenPsychiatric diagnosisPain conditionsTreatment strategiesDepressive disorderPainOverview of relationshipsComorbidityRegression analysisADHDDepressionImpact understandingDisordersGlobal, regional, and national neck pain burden in the general population, 1990–2019: An analysis of the global burden of disease study 2019
Shin D, Shin J, Koyanagi A, Jacob L, Smith L, Lee H, Chang Y, Song T. Global, regional, and national neck pain burden in the general population, 1990–2019: An analysis of the global burden of disease study 2019. Frontiers In Neurology 2022, 13: 955367. PMID: 36119688, PMCID: PMC9477009, DOI: 10.3389/fneur.2022.955367.Peer-Reviewed Original ResearchBurden of neck painAge-standardized YLDsNeck painHigh-income North AmericaSocio-demographic IndexGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyInstitute for Health MetricsGlobal Burden of Disease dataAge-standardized ratesBurden of disease dataDisease StudyPublic health burdenHealth metricsNational burdenYLDsPain burdenGeneral populationHealth burdenPositive associationGlobal epidemiologyEpidemiological dataPainPrevalenceConsideration of sex and gender differences in addiction medication response
McKee SA, McRae-Clark AL. Consideration of sex and gender differences in addiction medication response. Biology Of Sex Differences 2022, 13: 34. PMID: 35761351, PMCID: PMC9235243, DOI: 10.1186/s13293-022-00441-3.Peer-Reviewed Original ResearchConceptsSubstance use disordersMedication developmentUse disordersMedication development researchPreventable health conditionsClinical care guidelinesPublic health burdenNational InstituteSex-stratified dataGender differencesCurrent narrative reviewDrugs of abuseMedication trialsSignificant morbidityCare guidelinesMedication responseHealth burdenAbused substancesAlcohol abuseConsideration of sexNarrative reviewIncorporation of sexDrug abuseHealth conditionsSubstance useTrauma as a Public Health Issue: Epidemiology of Trauma and Trauma-Related Disorders
Mew E, Koenen K, Lowe S. Trauma as a Public Health Issue: Epidemiology of Trauma and Trauma-Related Disorders. 2022, 13-40. DOI: 10.1007/978-3-030-97802-0_2.Peer-Reviewed Original ResearchTrauma-related disordersGlobal public health burdenMajor public health concernEpidemiology of traumaPublic health burdenPublic health approachPublic health issuePublic health concernDeterminants of diseaseHealth burdenHigh prevalenceEpidemiologic studiesGlobal prevalenceEpidemiological studiesHealth problemsTrauma exposureHealth approachHealth concernPTE exposureHealth issuesDisordersTraumaCross-study comparisonsPublic healthEpidemiologyDiagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting
Warnasekara J, Srimantha S, Kappagoda C, Jayasundara D, Senevirathna I, Matthias M, Agampodi S, Vinetz J. Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting. PLOS Neglected Tropical Diseases 2022, 16: e0010331. PMID: 35377883, PMCID: PMC9009773, DOI: 10.1371/journal.pntd.0010331.Peer-Reviewed Original ResearchConceptsMicroscopic agglutination testProspective hospital-based studyLeptospirosis casesQuantitative PCRHigh endemic settingHospital-based studyClinical case definitionLarge prospective studiesDisease burden estimatesPublic health burdenStandard diagnostic testMonths of observationUndifferentiated feverAcute leptospirosisProspective studyCase definitionEndemic settingsHealth burdenTimely diagnosisBurden estimatesDiagnostic valueSignificant human mortalityAgglutination testStudy settingDiagnostic testsNicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response
Zakiniaeiz Y, Liu H, Gao H, Najafzadeh S, Ropchan J, Nabulsi N, Huang Y, Matuskey D, Chen MK, Cosgrove KP, Morris ED. Nicotine Patch Alters Patterns of Cigarette Smoking-Induced Dopamine Release: Patterns Relate to Biomarkers Associated With Treatment Response. Nicotine & Tobacco Research 2022, 24: 1597-1606. PMID: 35100429, PMCID: PMC9575980, DOI: 10.1093/ntr/ntac026.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyDopamine releasePlacebo patchDorsal striatumTobacco smokingReplacement therapyFirst-line pharmacological treatmentVentral striatumMajor public health burdenPositron emission tomography scanEmission tomography scanPublic health burdenNicotine dependence levelNicotine metabolism rateNicotinic acetylcholine receptorsCounter-balanced orderTobacco smokersCigarette smokingSmoking cessationDopamine terminalsPharmacological treatmentDependent smokersFast metabolizersSlow metabolizersNicotine acts
2021
Brain growth after surgical treatment for infant postinfectious hydrocephalus in Sub-Saharan Africa: 2-year results of a randomized trial.
Schiff S, Kulkarni A, Mbabazi-Kabachelor E, Mugamba J, Ssenyonga P, Donnelly R, Levenbach J, Monga V, Peterson M, Cherukuri V, Warf B. Brain growth after surgical treatment for infant postinfectious hydrocephalus in Sub-Saharan Africa: 2-year results of a randomized trial. Journal Of Neurosurgery Pediatrics 2021, 28: 326-334. PMID: 34243157, PMCID: PMC8742836, DOI: 10.3171/2021.2.peds20949.Peer-Reviewed Original ResearchPostinfectious hydrocephalusSurgical treatmentBrain volumeBrain growthBSID-III cognitive scoresMajor public health burdenSurgical treatment armSuccessful surgical treatmentBrain volume lossBrain volume changesEndoscopic third ventriculostomyFraction of patientsPublic health burdenChoroid plexus cauterizationBSID-III scoresNormal brain volumePostinfectious etiologySingle centerSub-Saharan AfricaTreatment armsThird ventriculostomyInfection preventionHealth burdenCT scanHydrocephalusOut‐of‐pocket Annual Health Expenditures and Financial Toxicity from Healthcare Costs in Patients with Heart Failure in the United States
Wang SY, Valero‐Elizondo J, Ali H, Pandey A, Cainzos‐Achirica M, Krumholz HM, Nasir K, Khera R. Out‐of‐pocket Annual Health Expenditures and Financial Toxicity from Healthcare Costs in Patients with Heart Failure in the United States. Journal Of The American Heart Association 2021, 10: e022164. PMID: 33998273, PMCID: PMC8483501, DOI: 10.1161/jaha.121.022164.Peer-Reviewed Original ResearchConceptsGreater risk-adjusted oddsRisk-adjusted oddsHeart failureMedical Expenditure Panel SurveyCatastrophic financial burdenPocket healthcare expensesHigh financial burdenFinancial toxicityHealthcare expensesFinancial burdenHealthcare costsCatastrophic burdenMajor public health burdenLow-income familiesBackground Heart failurePublic health burdenInsurance premiumsPanel SurveyPocket healthcare costsAnnual health expenditureWorld Health OrganizationConclusions PatientsHealth insurance premiumsPocket healthcare expenditureHealth burden
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