Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants
Nishino J, Hu W, Kishtagari A, Shen B, Gao X, Blackman C, Kassim A, Marneni N, Cherukuri A, Vittrup R, Kalkan F, Shah R, Ahn C, Gao A, Ahmedrabie A, Collins R, Zeidan A, Bidikian A, Gowda L, Shaffer B, Madanat Y, Zhao Z, Chung S, Morrison S. Nonselective β-Adrenergic Receptor Inhibitors Impair Hematopoietic Regeneration in Mice and Humans after Hematopoietic Cell Transplants. Cancer Discovery 2024, 15: 748-766. PMID: 39786370, PMCID: PMC11962394, DOI: 10.1158/2159-8290.cd-24-0719.Peer-Reviewed Original ResearchAllogeneic hematopoietic cell transplantationHematopoietic cell transplantationB-blockersCell transplantationHematopoietic regenerationGraft-versus-host disease prophylaxisAutologous hematopoietic cell transplantationDelayed platelet engraftmentImpaired hematopoietic regenerationPost-transplant chemotherapyGraft-versus-hostAdrenergic receptor signalingBone marrow regenerationInhibitory effectPlatelet engraftmentInhibit engraftmentReceptor inhibitorsDisease prophylaxisMarrow regenerationMouse hematopoiesisHematopoietic cellsEngraftmentLarger dosesReceptor signalingPeripheral nerves
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