2025
Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Ntshiqa T, Velen K, Ginindza S, Nhlangulela L, Charalambous S, Hawn T, Churchyard G, Boom W, Chihota V, Wallis R. Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa. PLOS ONE 2025, 20: e0318819. PMID: 40343976, PMCID: PMC12063869, DOI: 10.1371/journal.pone.0318819.Peer-Reviewed Original ResearchConceptsIsoniazid preventive therapyTuberculin skin testCD4 countQFT-PlusAssociated with lower CD4 countsTST responseQuantiFERON-TB Gold PlusBody mass index >Median CD4 countLow CD4 countExposure to TBRates of HIVLongitudinal cohort studyMedian ageTST/IGRAAntiretroviral treatmentMedian timePreventive therapySkin testFollow-upCohort studyLogistic regressionHIVMonthsAssay conversionTime to direct-acting antiviral initiation and liver-related events in people with HIV and hepatitis C virus
Chalouni M, Van Santen D, Berenguer J, Jarrin I, Miro J, Klein M, Young J, Torgersen J, Rentsch C, Gill M, Epstein R, Linas B, Zangerle R, Surial B, Rauch A, Touloumi G, Papadopoulos A, Wittkop L, Van Der Valk M, Boyd A, Monforte A, Puoti M, Logan R, Rein S, Hernán M, Lodi S. Time to direct-acting antiviral initiation and liver-related events in people with HIV and hepatitis C virus. AIDS 2025, 39: 1074-1079. PMID: 39970192, PMCID: PMC12122233, DOI: 10.1097/qad.0000000000004161.Peer-Reviewed Original ResearchRisk of liver-related eventsDirect-acting antivirals initiationHIV-HCV co-infectionLiver-related eventsDirect-acting antiviralsHIV virologic suppressionAntiretroviral treatmentVirologic suppressionHIV-HCVCo-InfectionHistory of injection drug useInjection drug useHepatitis C virusAntiviral initiationSuppress HIVDAA initiationHCV transmissionC virusEarly initiationCure HCVDelayed initiationHIVRisk differenceClinical practiceDrug use
2024
Africa Health Research Institute (AHRI) Household Contact study: a study protocol, statistical analysis and modelling plan
Khan P, Govender I, McCreesh N, Sweeney S, Sithole M, Ording-Jespersen G, Buthelezi X, Houben R, Baisley K, Smit T, Wong E, Hanekom W, White R, Vassall A, Fielding K, Grant A. Africa Health Research Institute (AHRI) Household Contact study: a study protocol, statistical analysis and modelling plan. Wellcome Open Research 2024, 9: 622. DOI: 10.12688/wellcomeopenres.22974.1.Peer-Reviewed Original ResearchAfrica Health Research InstituteQuantiFERON-TB Gold PlusHealth systemAntiretroviral treatmentReport symptomsCost-effectiveness of interventionsAntiretroviral treatment careRoutine health servicesDemographic surveillance areaTuberculosis case findingHealth Research InstituteM. tuberculosis transmissionChild household contactsPotential epidemiological impactTuberculosis screening strategiesHealthcare utilisationHIV testingHealth facilitiesPulmonary tuberculosisHealth servicesSymptom screeningCase findingCost-effectiveTuberculosis screeningEffects of antiretroviral treatmentHigh rates of deferring antiretroviral treatment for patients with HIV and substance use disorders: Results from a national sample of HIV physicians in Ukraine
Ottesen T, Wickersham J, Lawrence J, Antoniak S, Zezuilin O, Polonsky M, Antonyak S, Rozanova J, Dvoriak S, Pykalo I, Filippovych M, Altice F. High rates of deferring antiretroviral treatment for patients with HIV and substance use disorders: Results from a national sample of HIV physicians in Ukraine. PLOS ONE 2024, 19: e0305086. PMID: 39028735, PMCID: PMC11259278, DOI: 10.1371/journal.pone.0305086.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy prescriptionAntiretroviral therapyCD4 countSubstance use disordersIncreased levels of stigmaNational sampleLevel of stigmaIndependent of risk groupSuboptimal antiretroviral therapyInitiate antiretroviral therapyPopulation of peopleHIV expertsHIV incidenceHIV physiciansHIV treatmentKey populationsTransgender womenAntiretroviral treatmentFeeling thermometerDrinking alcoholSex workersPhysiciansSex partnersPWHRisk groupsExploring the feasibility, acceptability and preliminary effects of a nurse delivered mhealth intervention for women living with HIV in South India: a pilot randomized controlled trial
Satyanarayana V, Duggal M, Jeon S, Singh P, Desai A, Chandra P, Reynolds N. Exploring the feasibility, acceptability and preliminary effects of a nurse delivered mhealth intervention for women living with HIV in South India: a pilot randomized controlled trial. Archives Of Women's Mental Health 2024, 27: 751-763. PMID: 38630259, DOI: 10.1007/s00737-024-01462-0.Peer-Reviewed Original ResearchMobile phone interventionPhone interventionRandomized Controlled TrialsPsychosocial vulnerabilityQuality of life subscalesAntiretroviral treatmentPsychological quality of lifeAdherence to antiretroviral treatmentPsychosocial risk factorsMental health issuesWeeks post-randomizationRates of eligibilityRural South IndiaQuality of lifeIntervention fidelityIllness perceptionsBasic nursingPreliminary effectivenessLife subscalesImprove adherence to antiretroviral treatmentCounseling interventionAdherence ratesDepressive symptomsPost-randomizationPreliminary efficacyTuberculosis Preventive Treatment Update — U.S. President’s Emergency Plan for AIDS Relief, 36 Countries, 2016–2023
Ajiboye A, O’Connor S, Smith J, Ahmedov S, Coggin W, Charles M, Ghosh S, Pierre P, Shah N, Teran R, Moonan P, Date A. Tuberculosis Preventive Treatment Update — U.S. President’s Emergency Plan for AIDS Relief, 36 Countries, 2016–2023. MMWR Morbidity And Mortality Weekly Report 2024, 73: 233-238. PMID: 38512767, PMCID: PMC10967683, DOI: 10.15585/mmwr.mm7311a1.Peer-Reviewed Original ResearchConceptsU.S. President's Emergency PlanPresident's Emergency Plan for AIDS ReliefTB preventive treatmentAIDS ReliefAntiretroviral treatmentU.S. President's Emergency Plan for AIDS ReliefElectronic medical record systemPresident's Emergency PlanPatient-centered approachFiscal yearNational HIV programTB-attributed deathsMedical record systemTB-related deathsOverall completion rateHIV programsCompletion ratesRecording systemTB diseaseStandard of careHIVHigh riskPersonsEmergency planningShorter regimens
2022
Correlation between CD4/CD8 ratio and neurocognitive performance during early HIV infection
Le LT, Price RW, Gisslén M, Zetterberg H, Emu B, Fabre R, Christian P, Andersen S, Spudich S, Vassallo M. Correlation between CD4/CD8 ratio and neurocognitive performance during early HIV infection. HIV Medicine 2022, 24: 442-452. PMID: 36134890, DOI: 10.1111/hiv.13411.Peer-Reviewed Original ResearchConceptsCD4/CD8 ratioPrimary HIV infectionCD8 ratioImmune activationHIV infectionNeuronal injuryAntiretroviral treatmentNeurocognitive performanceMean CD4/CD8 ratioCSF neurofilament light chainART-naïve participantsEarly HIV infectionCerebrospinal fluid markersNeurofilament light chainNeuropsychological testing performancePsychomotor speed performancePHI participantsStudy cohortCSF markersChronic infectionBrain injuryRetrospective analysisFluid markersInfectionInjuryPractices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey
Bold KW, Deng Y, Dziura J, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL, Edelman EJ. Practices, attitudes, and confidence related to tobacco treatment interventions in HIV clinics: a multisite cross-sectional survey. Translational Behavioral Medicine 2022, 12: 726-733. PMID: 35608982, PMCID: PMC9260059, DOI: 10.1093/tbm/ibac022.Peer-Reviewed Original ResearchConceptsTobacco use disorderHIV clinicHIV cliniciansExact testBrief smoking cessation interventionMultisite cross-sectional surveyHIV clinic settingFirst-line medicationImpact of smokingMedication side effectsClinical practice guidelinesSmoking cessation interventionTobacco treatment interventionsFisher's exact testCross-sectional surveyProvision of careChi-square testAntiretroviral treatmentCounseling patientsTobacco treatmentCessation interventionsClinic settingPractice guidelinesTobacco useProvider characteristicsStudy protocol of a randomized controlled trial comparing two linkage models for HIV prevention and treatment in justice-involved persons
Springer SA, Nijhawan AE, Knight K, Kuo I, Di Paola A, Schlossberg E, Frank CA, Sanchez M, Pankow J, Proffitt RP, Lehman W, Pulitzer Z, Thompson K, Violette S, Harding KK. Study protocol of a randomized controlled trial comparing two linkage models for HIV prevention and treatment in justice-involved persons. BMC Infectious Diseases 2022, 22: 380. PMID: 35428213, PMCID: PMC9013109, DOI: 10.1186/s12879-022-07354-x.Peer-Reviewed Original ResearchConceptsJustice-involved individualsAntiretroviral treatmentHIV preventionUse disordersStudy participantsStimulant useSubstance use disorder servicesCommunity-based HIVPost-release interventionsPrimary implementation outcomeHIV viral loadPre-exposure prophylaxisOpioid use disorderTreatment of HIVHIV risk behaviorsRisk of HIVSubstance use disordersHigh-risk communitiesHybrid type 1Justice-involved personsHCV testingLinkage interventionHIV careSecondary outcomesART adherenceIron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania
Andersen CT, Duggan CP, Manji K, Seage GR, Spiegelman D, Perumal N, Ulenga N, Fawzi WW. Iron supplementation and paediatric HIV disease progression: a cohort study among children receiving routine HIV care in Dar es Salaam, Tanzania. International Journal Of Epidemiology 2022, 51: 1533-1543. PMID: 35167662, PMCID: PMC9557856, DOI: 10.1093/ije/dyac017.Peer-Reviewed Original ResearchConceptsDisease stage progressionIron supplementationStage progressionCohort studyDisease progressionRoutine HIV careHIV disease progressionProspective cohort studyManagement of anemiaRisk of anemiaHigher hazard rateProportional hazards modelIron supplement useDar es SalaamHaematological outcomesAntiretroviral therapyHIV careClinic visitsSupportive careAntiretroviral treatmentClinical outcomesClinical visitsAnemia statusSupplement useVital status
2021
HIV care continuum among cisgender and transgender women sex workers in Greater Kuala Lumpur, Malaysia
Ranjit YS, Gibson BA, Altice FL, Kamarulzaman A, Azwa I, Wickersham JA. HIV care continuum among cisgender and transgender women sex workers in Greater Kuala Lumpur, Malaysia. AIDS Care 2021, 35: 784-790. PMID: 34723714, PMCID: PMC9056582, DOI: 10.1080/09540121.2021.1995839.Peer-Reviewed Original ResearchConceptsTransgender women sex workersHIV care continuumAntiretroviral treatmentSex workersCare continuumWomen sex workersTransgender womenImportant key populationProportion of womenRespondent-driven sampling studyEvidence-based strategiesAntiretroviral therapyHIV careHIV prevalenceHIV epidemicHIVKey populationsWomenKuala LumpurCisgender womenCount testUnique needsSmall proportionTherapyPopulationA SMARTTT approach to Treating Tobacco use disorder in persons with HIV (SMARTTT): Rationale and design for a hybrid type 1 effectiveness-implementation study
Edelman EJ, Dziura J, Deng Y, Bold KW, Murphy SM, Porter E, Sigel KM, Yager JE, Ledgerwood DM, Bernstein SL. A SMARTTT approach to Treating Tobacco use disorder in persons with HIV (SMARTTT): Rationale and design for a hybrid type 1 effectiveness-implementation study. Contemporary Clinical Trials 2021, 110: 106379. PMID: 33794354, PMCID: PMC8478961, DOI: 10.1016/j.cct.2021.106379.Peer-Reviewed Original ResearchConceptsTobacco use disorderNicotine replacement therapyUse disordersHIV clinicHybrid type 1 effectiveness-implementation designHIV viral load suppressionCD4 cell countViral load suppressionEffectiveness-implementation studyOptimal treatment approachPharmacist-delivered interventionSequential multiple assignmentHealth of personsImplementation science frameworkSecondary outcomesAntiretroviral treatmentPrimary outcomeClinical pharmacistsReplacement therapySmoking abstinenceTreatment approachesCell countHealth systemHIVContingency management
2020
Early access to antiretroviral therapy versus standard of care among HIV‐positive participants in Eswatini in the public health sector: the MaxART stepped‐wedge randomized controlled trial
Khan S, Spiegelman D, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Chao A, Bärnighausen T, Okello V. Early access to antiretroviral therapy versus standard of care among HIV‐positive participants in Eswatini in the public health sector: the MaxART stepped‐wedge randomized controlled trial. Journal Of The International AIDS Society 2020, 23: e25610. PMID: 32949103, PMCID: PMC7507004, DOI: 10.1002/jia2.25610.Peer-Reviewed Original ResearchConceptsViral suppressionStandard of careAntiretroviral treatmentCox proportional hazards modelHealth systemART-naïve participantsHIV-positive patientsHIV-positive adultsViral load monitoringHIV-positive participantsAppropriate care managementProportional hazards modelEarly accessPublic sector health facilitiesHealth system effectsPublic health systemHealth system's abilityClinic transitionAntiretroviral therapyCD4 countCare retentionVL monitoringPublic health sectorDisease stageEndpoint rateAn Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment
Francis J, Barnes KI, Workman L, Kredo T, Vestergaard LS, Hoglund RM, Byakika-Kibwika P, Lamorde M, Walimbwa SI, Chijioke-Nwauche I, Sutherland CJ, Merry C, Scarsi KK, Nyagonde N, Lemnge MM, Khoo SH, Bygbjerg IC, Parikh S, Aweeka FT, Tarning J, Denti P. An Individual Participant Data Population Pharmacokinetic Meta-analysis of Drug-Drug Interactions between Lumefantrine and Commonly Used Antiretroviral Treatment. Antimicrobial Agents And Chemotherapy 2020, 64: 10.1128/aac.02394-19. PMID: 32071050, PMCID: PMC7179577, DOI: 10.1128/aac.02394-19.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsAntiretroviral therapyDolutegravir-based antiretroviral therapyPotential drug-drug interactionsDay 7 concentrationsIndividual participant dataConcomitant efavirenzLopinavir-ritonavirLumefantrine exposureLumefantrine regimenAntituberculosis treatmentUncomplicated malariaAntiretroviral treatmentHIV infectionTreatment failurePopulation pharmacokineticsLumefantrine concentrationsLarger body weightBody weightEfavirenzParticipant dataLumefantrineMalariaAdult participantsRifampinOptimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges
Cao W, Hsieh E, Li T. Optimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges. Current HIV/AIDS Reports 2020, 17: 26-34. PMID: 31939111, PMCID: PMC6989417, DOI: 10.1007/s11904-019-00478-x.BooksConceptsNational Free Antiretroviral Therapy ProgramAntiretroviral therapyHIV/AIDSChinese patientsFree antiretroviral therapy (ART) programLong-term antiretroviral therapyHIV/AIDS patientsFree antiretroviral drugsLifelong antiretroviral therapyHIV care cascadeAIDS/STD ControlAntiretroviral therapy coverageAntiretroviral therapy programsHIV/AIDS diagnosisHIV/AIDS treatmentNumber of patientsMulti-center studyAvailable ART regimensART regimensCare cascadeChronic complicationsAntiretroviral treatmentOverall mortalityAIDS patientsChronic inflammation
2019
HIV Risk and Prevention Outcomes in a Probability-Based Sample of Gay and Bisexual Men in the United States.
Dodge B, Ford J, Bo N, Tu W, Pachankis J, Herbenick D, Mayer K, Hatzenbuehler ML. HIV Risk and Prevention Outcomes in a Probability-Based Sample of Gay and Bisexual Men in the United States. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: 355-361. PMID: 31517706, PMCID: PMC6817401, DOI: 10.1097/qai.0000000000002151.Peer-Reviewed Original ResearchConceptsHIV riskNational HIV/AIDS StrategyUS National HIV/AIDS StrategyPrevention outcomesPrimary health care providersHIV/AIDS StrategyBisexual menHalf of GBMsMajority of HIVUndetectable viral loadPre-exposure prophylaxisHIV-positive GBMRecent male partnersHealth care providersCross-sectional surveySample of gayAntiretroviral treatmentViral loadPrEP usersHIV preventionAIDS StrategyCare providersDaily adherenceGeneral populationHIVLife-Expectancy Disparities Among Adults With HIV in the United States and Canada: The Impact of a Reduction in Drug- and Alcohol-Related Deaths Using the Lives Saved Simulation Model
Althoff KN, Chandran A, Zhang J, Arevalo WM, Gange SJ, Sterling TR, Gill MJ, Justice AC, Palella FJ, Rebeiro PF, Silverberg MJ, Mayor AM, Horberg MA, Thorne JE, Rabkin CS, Mathews WC, Klein MB, Humes E, Lee J, Hogg R, Moore RD, Research and Design of IeDEA N. Life-Expectancy Disparities Among Adults With HIV in the United States and Canada: The Impact of a Reduction in Drug- and Alcohol-Related Deaths Using the Lives Saved Simulation Model. American Journal Of Epidemiology 2019, 188: 2097-2109. PMID: 31602475, PMCID: PMC7036649, DOI: 10.1093/aje/kwz232.Peer-Reviewed Original ResearchConceptsAlcohol-related deathsInjection drug useKey populationsLife expectancyDrug useHuman immunodeficiency virusLife expectancy benefitAge 20 yearsCause of deathCurrent opioid epidemicAlcohol-related mortalityAntiretroviral treatmentImmunodeficiency virusOpioid epidemicExpected life expectancyWhite womenSubstance useWhite menComparison groupDrugsDeathPLWHLife expectancy disparityMenBlack menImpact of early antiretroviral treatment on sexual behaviour: a randomised comparison
Lampe FC, Rodger AJ, Burman W, Grulich A, Friedland G, Sadr WE, Neaton J, Corbelli GM, Emery S, Molina JM, Orkin C, Gatell J, Gerstoft J, Ruxrungtham K, de Souza M, Phillips AN. Impact of early antiretroviral treatment on sexual behaviour: a randomised comparison. AIDS 2019, 33: 2337-2350. PMID: 31764099, PMCID: PMC6882545, DOI: 10.1097/qad.0000000000002359.Peer-Reviewed Original ResearchConceptsEarly antiretroviral treatmentHIV-serodifferent partnersAntiretroviral treatmentMonth 12Month 24CD4 cell countHIV-positive adultsSexual behaviorHIV infectiousnessImmediate armViral suppressionPrimary outcomeHigh prevalenceCondomless sexCell countMSMCells/Lower absolute levelsSexHeterosexual menTreatmentHeterosexualsArmAbsolute levelsPrevalence
2018
Depression Among Alcohol Consuming, HIV Positive Men on ART Treatment in India
Ha T, Schensul SL, Irving M, Brault MA, Schensul JJ, Prabhughate P, Vaz M. Depression Among Alcohol Consuming, HIV Positive Men on ART Treatment in India. AIDS And Behavior 2018, 23: 1623-1633. PMID: 30446854, PMCID: PMC6525089, DOI: 10.1007/s10461-018-2339-3.Peer-Reviewed Original ResearchConceptsMale PLHIVDepressive symptomsAntiretroviral treatmentHIV statusHIV-positive menSevere depressive symptomsPositive menMiddle-income countriesART treatmentPLHIVPsychosocial factorsIntervention studiesSymptomsAlcohol useBaseline surveyUrban MaharashtraTreatment pointsFamily-related concernsHIVDepressionFeelings of guiltTreatmentWork difficultiesMenPsychological componentsCSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection
Gisslén M, Heslegrave A, Veleva E, Yilmaz A, Andersson LM, Hagberg L, Spudich S, Fuchs D, Price RW, Zetterberg H. CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection. Neurology Neuroimmunology & Neuroinflammation 2018, 6: e512. PMID: 30568991, PMCID: PMC6278890, DOI: 10.1212/nxi.0000000000000512.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-negative controlsMicroglial activationNeuronal injuryCSF concentrationsUntreated HIV-1-infected patientsHIV-1 disease severityHIV-1-infected adultsMacrophage/microglial activationHIV-1-infected patientsRetrospective cross-sectional studyUntreated HIV-1 infectionCNS immune activationCSF sTREM2 levelsSuppressive antiretroviral treatmentT-cell countsMicroglial activation markersT cell lossLevels of CSFNeurofilament light proteinCross-sectional studyCSF sTREM2STREM2 levelsAntiretroviral treatmentActivation markers
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