2019
Implantable wireless device for study of entrapment neuropathy
Malka R, Guarin D, Mohan S, Hernández I, Gorelik P, Mazor O, Hadlock T, Jowett N. Implantable wireless device for study of entrapment neuropathy. Journal Of Neuroscience Methods 2019, 329: 108461. PMID: 31626845, PMCID: PMC7325518, DOI: 10.1016/j.jneumeth.2019.108461.Peer-Reviewed Original ResearchConceptsAnimal modelsFunctional lossNeural dysfunctionGrade V injuriesFacial nerve functionSmall animal modelsPartial functional lossComplete functional lossWhisker displacementSurgical decompressionEntrapment syndromeDecompression surgeryNerve functionBell's palsyNerve damageFunctional recoveryGrade IIIFacial nervePeripheral nervesCompartment pressuresMurine modelDisease processInsufficient evidenceLive animal modelsOptimal timing
2015
Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin
Ambrosino P, Alaimo A, Bartollino S, Manocchio L, De Maria M, Mosca I, Gomis-Perez C, Alberdi A, Scambia G, Lesca G, Villarroel A, Taglialatela M, Soldovieri MV. Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin. Biochimica Et Biophysica Acta 2015, 1852: 1856-1866. PMID: 26073431, DOI: 10.1016/j.bbadis.2015.06.012.Peer-Reviewed Original ResearchBenign familial neonatal seizuresKv7.2/Kv7.3 channelsFunctional modulationPatch-clamp recordingsPotential therapeutic approachFamilial neonatal seizuresComplete functional lossNeonatal seizuresEpileptic encephalopathyPathogenetic mechanismsTherapeutic approachesChannel dysfunctionCaM affinityEpilepsy-causing mutationsKv7.3 channelsFunctional lossCaM overexpressionFunctional changesEpileptic diseasePhenotypic presentationChannel subunitsKCNQ2 geneKv7.2Significant alterationsC-terminal fragment
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