2024
Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience
Živković S, Lacomis D, Soman P. Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience. Frontiers In Cardiovascular Medicine 2024, 11: 1345608. PMID: 38410247, PMCID: PMC10894993, DOI: 10.3389/fcvm.2024.1345608.Peer-Reviewed Original ResearchATTRwt patientsPeripheral neuropathyPrevalence of peripheral neuropathySuspected peripheral neuropathyCases of neuropathyDistal sensory lossTransthyretin amyloid depositionCardiomyopathy patientsClinical featuresTransthyretin genotypingMusculoskeletal manifestationsNeuropathy symptomsATTRwtTransthyretin amyloidosisElderly patientsHeart failureTransthyretin mutationFrequent comorbiditiesMultiple potential causesNeuropathySensory lossElderly menPatientsSenile amyloidosisPeripheral nerves
2019
Medical Therapies for Treatment of BPH: Special Considerations in Elderly Men
Bortnick E, Simma-Chiang V, Omidele O, Kaplan S. Medical Therapies for Treatment of BPH: Special Considerations in Elderly Men. Current Geriatrics Reports 2019, 8: 310-314. DOI: 10.1007/s13670-019-00299-1.Peer-Reviewed Original ResearchDepressive symptoms among elderly men and women who transition to widowhood: comparisons with long term married and long term widowed over a 10-year period
Yu J, Kahana E, Kahana B, Han C. Depressive symptoms among elderly men and women who transition to widowhood: comparisons with long term married and long term widowed over a 10-year period. Journal Of Women & Aging 2019, 33: 231-246. PMID: 31671028, DOI: 10.1080/08952841.2019.1685855.Peer-Reviewed Original Research0138 Physiological Effects of Respiratory Events that Terminate Without Arousals During Sleep
Liu J, Qin L, Yaggi H. 0138 Physiological Effects of Respiratory Events that Terminate Without Arousals During Sleep. Sleep 2019, 42: a56-a57. DOI: 10.1093/sleep/zsz067.137.Peer-Reviewed Original ResearchHigh-frequency EEG powerRespiratory eventsHeart rateTest-retest reliabilityCortical neural activityZ-scoreREM sleepRespiratory arousalsEEG powerCommunity-dwelling elderly menPoor cardiovascular outcomesObstructive sleep apneaNeural activityMean z-scoreStage 2 sleepExcellent test-retest reliabilityNon-REM sleepSignificant increaseCardiovascular outcomesCardiac effectsSympathetic surgeSleep apneaElderly menMrOS StudyFrequent arousals
2018
Prostate cancer aggressiveness and age: Impact of p53, BCL-2 and microvessel density
Calvocoressi L, Uchio E, Ko J, Radhakrishnan K, Aslan M, Concato J. Prostate cancer aggressiveness and age: Impact of p53, BCL-2 and microvessel density. Journal Of Investigative Medicine 2018, 66: 1142-1146. PMID: 30297390, DOI: 10.1136/jim-2018-000804.Peer-Reviewed Original ResearchConceptsGleason scoreMicrovessel densityProstate cancerBcl-2Prostate-specific antigen levelProstate cancer deathAdvanced prostate cancerAggressive prostate cancerB-cell lymphoma 2Prostate cancer aggressivenessPositive Bcl-2Impact of p53Cell lymphoma 2Anatomic stageMen 70Adjusted ORsAntigen levelsCategories of ageCancer deathElderly menDisease progressionImmunohistochemical stainingStudy populationCancer aggressivenessProstate tumorsSubacute liver failure due to autochthonous hepatitis E virus infection in an elderly man in the United States
Landry M, Kamili S, Jain D. Subacute liver failure due to autochthonous hepatitis E virus infection in an elderly man in the United States. Human Pathology Reports 2018, 12: 68-70. DOI: 10.1016/j.ehpc.2018.02.007.Peer-Reviewed Original ResearchHepatitis E virus infectionE virus infectionLiver failureElderly menDifferential diagnosisVirus infectionToxic injuryAutochthonous hepatitis E virus infectionAutochthonous hepatitis EAcute hepatitis CAnti-HEV IgMHistologic differential diagnosisANA positivityPanlobular hepatitisSubsequent serologyCholestatic hepatitisHepatitis CHepatitis EBiliary obstructionLiver biopsyImmunocompetent individualsFatal outcomeGenotype 3Early diagnosisAppropriate management
2015
Role of D-dimer Assays in the Diagnostic Evaluation of Pulmonary Embolism
Jain S, Khera R, Suneja M, Gehlbach B, Kuperman E, Lopez F. Role of D-dimer Assays in the Diagnostic Evaluation of Pulmonary Embolism. The American Journal Of The Medical Sciences 2015, 350: 501-507. PMID: 25719981, DOI: 10.1097/maj.0000000000000405.Peer-Reviewed Case Reports and Technical NotesConceptsDiagnosis of PEPulmonary embolismClinical featuresD-dimerDiagnostic algorithmPositive D-dimer testNonspecific clinical featuresSimple noninvasive testD-dimer testD-dimer assayClinician suspicionInitial imagingAlternative diagnosesElderly menNoninvasive testsClinical algorithmDiagnostic evaluationChest imagingDiagnosisEmbolismLittle valueImagingComorbiditiesPneumoniaPatients
2012
Clinical Outcomes and Biomarker Profiles of Elderly Pretreated NSCLC Patients from the BATTLE Trial
Tsao AS, Liu S, Lee JJ, Alden C, Blumenschein G, Herbst R, Davis SE, Kim E, Lippman S, Stewart D, Tang XM, Wistuba I, Hong WK. Clinical Outcomes and Biomarker Profiles of Elderly Pretreated NSCLC Patients from the BATTLE Trial. Journal Of Thoracic Oncology 2012, 7: 1645-1652. PMID: 23059780, PMCID: PMC5161038, DOI: 10.1097/jto.0b013e31826910ff.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsBexaroteneBiomarkers, TumorCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellDrug Resistance, NeoplasmErlotinib HydrochlorideFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingNiacinamidePhenylurea CompoundsPiperidinesPrognosisQuinazolinesRetrospective StudiesSalvage TherapySorafenibSurvival RateTetrahydronaphthalenesConceptsProgression-free survivalDisease control rateNSCLC patientsOverall survivalElderly menGrade 3Older womenOlder menBetter median progression-free survivalHigher disease control rateLung Cancer Elimination (BATTLE) trialMedian progression-free survivalAge groupsBetter progression-free survivalCell lung cancer patientsBiomarker-Integrated ApproachesBiopsy-related pneumothoraxElderly NSCLC patientsMore grade 3Treatment-related deathsTumor tissue biomarkersRetrospective subgroup analysisSubset of patientsHigher overall survivalLung cancer patients
2011
Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction
Nguyen HL, Saczynski JS, Gore JM, Waring ME, Lessard D, Yarzebski J, Reed G, Spencer FA, Li SX, Goldberg RJ. Long-term Trends in Short-term Outcomes in Acute Myocardial Infarction. The American Journal Of Medicine 2011, 124: 939-946. PMID: 21962314, PMCID: PMC3185241, DOI: 10.1016/j.amjmed.2011.05.023.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionShort-term outcomesOlder patientsAtrial fibrillationMyocardial infarctionAdverse short-term outcomesGreater Worcester medical centersShort-term death ratesShort-term mortality rateMen 75 yearsShort-term mortalityTargeted treatment approachCardiogenic shockHeart failureMajor complicationsAge differencesElderly menMedical CenterStudy populationMortality rateTreatment approachesPatientsDeath rateFemale residentsWomen
2010
Temporal Trends in the Treatment of Elderly Men with Low and Moderate Risk Prostate Cancer: The Effect of Life Expectancy on the Administration of Curative Therapy
Raldow A, Sharma R, Presley C, Cramer L, Yu J, Soulos P, Gross C. Temporal Trends in the Treatment of Elderly Men with Low and Moderate Risk Prostate Cancer: The Effect of Life Expectancy on the Administration of Curative Therapy. International Journal Of Radiation Oncology • Biology • Physics 2010, 78: s562. DOI: 10.1016/j.ijrobp.2010.07.1312.Peer-Reviewed Original Research
2008
The Impact of Occupation-Related Noise Exposure on Hearing Thresholds in Middle-Aged and Elderly Men: The Normative Aging Study
Choi Y, Hu H, Weisskopf M, Mukherjee B, Sparrow D, Spiro A, Tak S, Park S. The Impact of Occupation-Related Noise Exposure on Hearing Thresholds in Middle-Aged and Elderly Men: The Normative Aging Study. Epidemiology 2008, 19: s276-s277. DOI: 10.1097/01.ede.0000340305.17534.65.Peer-Reviewed Original Research
2005
Effects of Aerobic Training on Gene Expression in Skeletal Muscle of Elderly Men
RADOM-AIZIK S, HAYEK S, SHAHAR I, RECHAVI G, KAMINSKI N, BEN-DOV I. Effects of Aerobic Training on Gene Expression in Skeletal Muscle of Elderly Men. Medicine & Science In Sports & Exercise 2005, 37: 1680-1696. PMID: 16260967, DOI: 10.1249/01.mss.0000181838.96815.4d.Peer-Reviewed Original ResearchConceptsGene expressionGlobal gene expressionSkeletal muscleExpression of genesCatabolism genesTranscriptional responseHeme biosynthesisMonths of trainingElderly menGeneChip arraysGenesEnergy metabolismHealthy elderly menPeak O2 uptakeExpressionProtein catabolismPathwayAerobic trainingNeedle biopsyPhysical activityEnergy pathwaysVastus lateralisBeneficial effectsDephosphorylationRibosomes
2002
Depression and Risk of Heart Failure Among the Elderly: A Prospective Community-Based Study
Williams SA, Kasl SV, Heiat A, Abramson JL, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among the Elderly: A Prospective Community-Based Study. Biopsychosocial Science And Medicine 2002, 64: 6-12. PMID: 11818580, DOI: 10.1097/00006842-200201000-00002.Peer-Reviewed Original ResearchConceptsHeart failureIndependent risk factorCoronary heart diseaseImpact of depressionEffect of depressionHospital admissionComorbidity factorsCox regressionProspective CommunityElderly menFunctional statusHeart diseaseRisk factorsElderly womenBaseline differencesEpidemiological studiesFunctional limitationsGreater riskUnderlying causeDepressionIncidenceEstablished PopulationsCommunity sampleDepressed participantsWomen
1998
Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991
Mendes de Leon CF, Krumholz HM, Seeman TS, Vaccarino V, Williams CS, Kasl SV, Berkman LF. Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991. JAMA Internal Medicine 1998, 158: 2341-2348. PMID: 9827785, DOI: 10.1001/archinte.158.21.2341.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedCause of DeathCohort StudiesConnecticutCoronary DiseaseDeath CertificatesDepressionFemaleForecastingHospitalizationHumansIncidenceInterviews as TopicMaleMedical AuditMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionReproducibility of ResultsRisk FactorsSex FactorsSurvival RateConceptsCoronary heart diseaseCHD risk factorsDepressive symptomsRisk factorsCHD outcomesHeart diseaseAge-adjusted relative riskImpaired physical functionIncident coronary diseasePhysical function impairmentIncident CHD eventsNonfatal myocardial infarctionIndependent risk factorMedical chart reviewHealthy older womenCause of deathCHD deathCHD eventsCHD mortalityChart reviewCHD incidenceCoronary diseaseFunction impairmentPhysical functionElderly men
1992
Cardiomegaly on chest x-ray: Prognostic implications from a ten-year cohort study of elderly subjects: A report from the Bronx Longitudinal Aging Study
Frishman W, Nadelmann J, Ooi W, Greenberg S, Heiman M, Kahn S, Guzik H, Lazar E, Aronson M. Cardiomegaly on chest x-ray: Prognostic implications from a ten-year cohort study of elderly subjects: A report from the Bronx Longitudinal Aging Study. American Heart Journal 1992, 124: 1026-1030. PMID: 1388323, DOI: 10.1016/0002-8703(92)90987-7.Peer-Reviewed Original ResearchConceptsCohort studyElderly menMyocardial infarctionTime of entryCardiovascular diseaseCox proportional hazards regression analysisBronx Longitudinal Aging StudyCommunity-dwelling elderly menProportional hazards regression analysisChest X-ray studyTransverse diameterTen-year cohort studyCardiovascular disease incidenceHazards regression analysisChest X-rayLongitudinal Aging StudyX-ray filmsCardiothoracic ratioIndependent predictorsCigarette smokingPoor prognosisPrognostic implicationsCardiac silhouetteElderly subjectsCardiomegaly
1988
Blastomycosis presenting as polyarticular septic arthritis.
Robert M, Kauffman C. Blastomycosis presenting as polyarticular septic arthritis. The Journal Of Rheumatology 1988, 15: 1438-42. PMID: 3199404.Peer-Reviewed Original Research
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