2025
Modeling the Impact of Smoking on Mortality in Argentina From 2000 to 2100. A Maximum Potential Reduction in Premature Mortality Analysis
Salgado M, Cao P, Jeon J, Sanchez-Romero L, Holford T, Levy D, Tam J, Mejia R, Meza R. Modeling the Impact of Smoking on Mortality in Argentina From 2000 to 2100. A Maximum Potential Reduction in Premature Mortality Analysis. Nicotine & Tobacco Research 2025, ntaf117. PMID: 40448284, DOI: 10.1093/ntr/ntaf117.Peer-Reviewed Original ResearchSmoking-attributable deathsTobacco control interventionsSmoking-attributable mortalitySmoking prevalenceControl interventionsLife yearsAdult smoking prevalenceSmoking-related mortalityPremature deathBurden of smokingPotential health gainsReduce smoking ratesPublic health effortsYears of lifeImpact of smokingSmoking trendsPopulation healthSmoking ratesHealth effortsHealth gainsPremature mortalityModel of cigarette smokeMortality burdenBirth cohortStatus quo scenarioAll-Cause Mortality is Higher in Generalized Pustular Psoriasis (GPP) than Plaque Psoriasis and the General Population: A US-Based Claims Analysis.
Gottlieb A, Crooke Kwiatkowski H, Semeco J, Lakshminarasimhan B, Strober B, Lebwohl M. All-Cause Mortality is Higher in Generalized Pustular Psoriasis (GPP) than Plaque Psoriasis and the General Population: A US-Based Claims Analysis. Journal Of Psoriasis And Psoriatic Arthritis 2025, 24755303251344155. PMID: 40454110, PMCID: PMC12125009, DOI: 10.1177/24755303251344155.Peer-Reviewed Original ResearchAll-Cause MortalityGeneralized pustular psoriasisMortality riskGeneral populationMaximum follow-upFollow-upElevated mortality riskPlaque psoriasisPustular psoriasisAll-CauseMortality burdenClaims dataDays post-indexIndex dateMedical claimsPopulation of patientsObservational studyUS claims dataUS-basedPropensity score matchingCohortLimited literaturePost-indexBalance covariatesMortalityEstimating the urban heat-related mortality burden due to greenness: a global modelling study
Wu Y, Wen B, Ye T, Huang W, Liu Y, Gasparrini A, Sera F, Tong S, Lavigne E, Roye D, Achilleos S, Ryti N, Pascal M, Zeka A, de'Donato F, da Silva S, Madureira J, Mistry M, Armstrong B, Bell M, Schwartz J, Guo Y, Li S, Network M. Estimating the urban heat-related mortality burden due to greenness: a global modelling study. The Lancet Planetary Health 2025 PMID: 40318693, DOI: 10.1016/s2542-5196(25)00062-2.Peer-Reviewed Original ResearchHeat-mortality associationsEnhanced Vegetation IndexHeat-related deathsMortality burdenIncreased greennessMeta-regression modelsGlobal model studiesUrban areasCollaborative research networksModeling studiesHeat-related mortalityMeta-analytic approachDaily mortalityHealth impactsResearch NetworkHealth impacts of heat exposureRandom forest modelPublic health threatVegetation indexWarm seasonMulti-countryMean temperatureImpact of heat exposureDaily temperatureMitigation strategiesExcess Mortality Rate in Black Children Since 1950 in the United States: A 70-Year Population-Based Study of Racial Inequalities.
Paternina-Caicedo A, Espinosa O, Sheth S, Hupert N, Saghafian S. Excess Mortality Rate in Black Children Since 1950 in the United States: A 70-Year Population-Based Study of Racial Inequalities. Annals Of Internal Medicine 2025, 178: 490-497. PMID: 40127447, DOI: 10.7326/annals-24-02794.Peer-Reviewed Original ResearchConceptsExcess mortality ratioMortality ratioBlack AmericansYears of potential lifePersistent excess mortalityEffect of health inequalityMortality rateWhite AmericansAge-standardized mortalityBlack infantsCenters for Disease Control and PreventionLife expectancyCalculated mortality ratesDisease Control and PreventionExcess mortality ratesControl and PreventionExcess mortality burdenUnited StatesHealth inequalitiesMortality dataMortality burdenExcess deathsExcess mortalityAbsolute life expectancyChildhood mortalityCancer Mortality
Hjartåker A, Weiderpass E, Bray F. Cancer Mortality. 2025, 171-182. DOI: 10.1016/b978-0-323-99967-0.00162-9.Peer-Reviewed Original ResearchCancer mortality burdenMortality burdenCancer mortality trendsGlobal cancer controlCancer deathCancer mortality dataHigher-income settingsProportion of deathsMortality trendsMortality dataCause of cancer deathCancer controlColorectal cancerMiddle-income economiesMeasure of progressLiver cancerCancer formsMortality rateColorectalBurdenData sourcesWorld regionsCancerDeathFrequent cause
2024
The mortality burden of cachexia or weight loss in patients with colorectal or pancreatic cancer: A systematic literature review
Dunne R, Crawford J, Smoyer K, McRae T, Rossulek M, Revkin J, Tarasenko L, Bonomi P. The mortality burden of cachexia or weight loss in patients with colorectal or pancreatic cancer: A systematic literature review. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1628-1640. PMID: 39095951, PMCID: PMC11446707, DOI: 10.1002/jcsm.13510.Peer-Reviewed Original ResearchWeight loss categoriesSystematic literature reviewPancreatic cancerColorectal cancerAssessment of weight changeStatistically significant poorer survivalLoss categoriesUnintentional weight lossRisk of cachexiaWeight lossPoor survivalInternational consensusAssociated with significantly poorer survivalMortality burdenLiterature reviewEligibility criteriaPRISMA guidelinesCancer-associated cachexiaColorectalProgressive functional impairmentClinical practiceFunctional impairmentWasting disordersPoor prognosisWeight changeGlobal and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time
Hundessa S, Huang W, Zhao Q, Wu Y, Wen B, Alahmad B, Armstrong B, Gasparrini A, Sera F, Tong S, Madureira J, Kyselý J, Schwartz J, Vicedo-Cabrera A, Hales S, Johnson A, Li S, Guo Y, Jaakkola J, Ryti N, Urban A, Tobias A, Royé D, Lavigne E, Ragettli M, Åström C, Raz R, Pascal M, Kan H, Goodman P, Zeka A, Hashizume M, Diaz M, Seposo X, Nunes B, Kim H, Lee W, Íñiguez C, Guo Y, Pan S, Zanobetti A, Dang T, Van Dung, Schneider A, Entezari A, Analitis A, Forsberg B, Ameling C, Houthuijs D, Indermitte E, Mayvaneh F, Acquaotta F, de'Donato F, Carrasco-Escobar G, Orru H, Katsouyanni K, de Sousa Zanotti Stagliorio Coelho M, Ortega N, Scovronick N, Michelozzi P, Correa P, Saldiva P, Abrutzky R, Osorio S, Colistro V, Huber V, Honda Y, Kim Y, Bell M, Xu R, Yang Z, Roradeh H, Arellano E, Rao S, Chua P, da Silva S, da Silva S, De la Cruz Valencia C. Global and Regional Cardiovascular Mortality Attributable to Nonoptimal Temperatures Over Time. Journal Of The American College Of Cardiology 2024, 83: 2276-2287. PMID: 38839202, DOI: 10.1016/j.jacc.2024.03.425.Peer-Reviewed Original ResearchConceptsCardiovascular deathCardiovascular mortalityExcess mortality ratesCardiovascular mortality riskMultivariate meta-regression modelTemperature-mortality associationsMeta-regression modelsTemperature-related deathsMortality burdenMortality riskEffect estimatesHeat-related deathsSub-Saharan AfricaMortality attributesTemporal trendsCold-related deathsMortality rateGlobal assessmentSub-SaharanInvestigated spatiotemporal trendsDeath ratioMortalityBurdenComprehensive global assessmentDeathGlobal, regional, and national burden of heatwave-related mortality from 1990 to 2019: A three-stage modelling study
Zhao Q, Li S, Ye T, Wu Y, Gasparrini A, Tong S, Urban A, Vicedo-Cabrera A, Tobias A, Armstrong B, Royé D, Lavigne E, de’Donato F, Sera F, Kan H, Schwartz J, Pascal M, Ryti N, Goodman P, Saldiva P, Bell M, Guo Y, Network O. Global, regional, and national burden of heatwave-related mortality from 1990 to 2019: A three-stage modelling study. PLOS Medicine 2024, 21: e1004364. PMID: 38743771, PMCID: PMC11093289, DOI: 10.1371/journal.pmed.1004364.Peer-Reviewed Original ResearchConceptsMortality burdenExcess deathsGlobal mortality burdenTemporal changesAssociated with heatwavesMultivariate meta-regressionAdaptation planningGeographic disparitiesNational burdenLow-incomeClimate changeHeatwavesMeta-RegressionPremature deathSector adaptationDaily deathsClimateLack of dataResidentsBurdenDisparitiesDeath ratioAssociationEstimates of global mortality burden associated with short-term exposure to fine particulate matter (PM2·5)
Yu W, Xu R, Ye T, Abramson M, Morawska L, Jalaludin B, Johnston F, Henderson S, Knibbs L, Morgan G, Lavigne E, Heyworth J, Hales S, Marks G, Woodward A, Bell M, Samet J, Song J, Li S, Guo Y. Estimates of global mortality burden associated with short-term exposure to fine particulate matter (PM2·5). The Lancet Planetary Health 2024, 8: e146-e155. PMID: 38453380, DOI: 10.1016/s2542-5196(24)00003-2.Peer-Reviewed Original ResearchConceptsExposure to fine particulate matterFine particulate matterExposure-response functionsGlobal mortality burdenParticulate matterShort-term exposure to fine particulate matterShort-term exposure to air pollutionExposure to air pollutionUrban areasHealth effects of short-termGlobal urban areasAcute health effectsAnnual population countsAir pollutionMortality burdenHuman healthSpatiotemporal variationsEstimates of mortalityExposure levelsMitigation strategiesPopulation countsPremature deathTheoretical minimum risk exposure levelEffects of short-termLag effectImpact of population aging on future temperature-related mortality at different global warming levels
Chen K, de Schrijver E, Sivaraj S, Sera F, Scovronick N, Jiang L, Roye D, Lavigne E, Kyselý J, Urban A, Schneider A, Huber V, Madureira J, Mistry M, Cvijanovic I, Gasparrini A, Vicedo-Cabrera A. Impact of population aging on future temperature-related mortality at different global warming levels. Nature Communications 2024, 15: 1796. PMID: 38413648, PMCID: PMC10899213, DOI: 10.1038/s41467-024-45901-z.Peer-Reviewed Original ResearchGlobal, regional, and national burden of mortality associated with cold spells during 2000–19: a three-stage modelling study
Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Guo Y, Li S, Network M, Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Bell M, Hales S, Honda Y, Jaakkola J, Tobias A, Vicedo-Cabrera A, Abrutzky R, de Sousa Zanotti Stagliorio Coelho M, Saldiva P, Correa P, Ortega N, Kan H, Osorio S, Roye D, Orru H, Indermitte E, Schneider A, Katsouyanni K, Analitis A, Carlsen H, Mayvaneh F, Roradeh H, Raz R, Michelozzi P, de'Donato F, Hashizume M, Kim Y, Alahmad B, Cauchy J, Diaz M, Arellano E, De la Cruz Valencia C, Overcenco A, Houthuijs D, Ameling C, Rao S, Carrasco G, Seposo X, Chua P, da Silva S, Nunes B, Holobaca I, Cvijanovic I, Mistry M, Scovronick N, Acquaotta F, Kim H, Lee W, Íñiguez C, Åström C, Ragettli M, Guo Y, Pan S, Colistro V, Zanobetti A, Schwartz J, Dang T, Van Dung, Guo Y, Li S. Global, regional, and national burden of mortality associated with cold spells during 2000–19: a three-stage modelling study. The Lancet Planetary Health 2024, 8: e108-e116. PMID: 38331527, DOI: 10.1016/s2542-5196(23)00277-2.Peer-Reviewed Original ResearchConceptsAssociated with cold spellsGlobal mortality burdenExcess death rateMortality burdenExcess deathsMeta-regression modelsMortality associationsDeath rateAnnual excess deathsMultivariate meta-regression modelExposure to cold spellsDeath ratioQuasi-Poisson regressionAssociated with mortalityNational burdenPublic health threatBurdenAssociationHealth threatMortalityCold spellsDeath
2023
Atmospheric elemental carbon pollution and its regional health disparities in China
Hang Y, Meng X, Xi Y, Zhang D, Lin X, Liang F, Tian H, Li T, Wang T, Cao J, Fu Q, Dey S, Li S, Huang K, Kan H, Shi X, Liu Y. Atmospheric elemental carbon pollution and its regional health disparities in China. Environmental Research Letters 2023, 18: 124017. PMID: 39036363, PMCID: PMC11259311, DOI: 10.1088/1748-9326/ad0862.Peer-Reviewed Original ResearchCause-specific accidental deaths and burdens related to ambient heat in a warming climate: A nationwide study of China
He C, Yin P, Chen R, Gao Y, Liu W, Schneider A, Bell M, Kan H, Zhou M. Cause-specific accidental deaths and burdens related to ambient heat in a warming climate: A nationwide study of China. Environment International 2023, 180: 108231. PMID: 37778287, DOI: 10.1016/j.envint.2023.108231.Peer-Reviewed Original ResearchConceptsAccidental deathHigh riskNationwide studyDeath recordsCase-crossover study designRisk of deathYounger age groupsUnintentional injuriesMortality burdenMain subtypesAge groupsStudy designYoung populationHealth effectsYoung individualsVulnerable populationsDeathDifferent causesRiskMortalitySubtypesRacial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States
Ma Y, Zang E, Opara I, Lu Y, Krumholz H, Chen K. Racial/ethnic disparities in PM2.5-attributable cardiovascular mortality burden in the United States. Nature Human Behaviour 2023, 7: 2074-2083. PMID: 37653149, PMCID: PMC10901568, DOI: 10.1038/s41562-023-01694-7.Peer-Reviewed Original ResearchConceptsNon-Hispanic White peopleCVD deathMortality burdenNon-Hispanic black peopleCardiovascular disease mortality ratesDisease mortality ratesNon-Hispanic blacksRace/ethnicityMortality rateLong-term exposureWhite peopleEthnic disparitiesHealth benefitsHispanic peopleSignificant differencesBurdenDeathUS countiesEthnic groupsAbsolute disparityAssociationExposureEthnic minoritiesDisparitiesAmbient fine particulate matter (PM2.5) concentrationsYears of life lost due to deaths of despair and COVID-19 in the United States in 2020: patterns of excess mortality by gender, race and ethnicity
Entrup P, Brodsky L, Trimble C, Garcia S, Mohamed N, Deaner M, Martell J, Teater J, Jordan A, Tetrault J, Hall O. Years of life lost due to deaths of despair and COVID-19 in the United States in 2020: patterns of excess mortality by gender, race and ethnicity. International Journal For Equity In Health 2023, 22: 161. PMID: 37612748, PMCID: PMC10464324, DOI: 10.1186/s12939-023-01949-9.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol-Related DisordersAmerican Indian or Alaska NativeAsianBlack or African AmericanCause of DeathCost of IllnessCOVID-19Cross-Sectional StudiesDrug OverdoseEthanolEthnicityFemaleHealth InequitiesHispanic or LatinoHumansLife ExpectancyMaleMortality, PrematureNative Hawaiian or Pacific IslanderRace FactorsSex FactorsSocial Determinants of HealthSuicideUnited StatesWhiteConceptsYears of lifeDeaths of despairCOVID-19Mental health workforce developmentCross-sectional studyICD-10 codesCause of deathCOVID-19 mortalityCDC WONDER databaseSubstance use treatmentHealth workforce developmentLatino personsExcess mortalityMortality burdenMore deathsDeath recordsHigh mortalityBehavioral health researchSocial determinantsGreater burdenYLLUse treatmentConclusionsThis studyPandemic onsetMortalityThe mortality burden of cachexia in patients with non-small cell lung cancer: A meta-analysis.
Bonomi P, Crawford J, Dunne R, Roeland E, Smoyer K, Siddiqui M, McRae T, Rossulek M, Revkin J, Tarasenko L. The mortality burden of cachexia in patients with non-small cell lung cancer: A meta-analysis. Journal Of Clinical Oncology 2023, 41: e24075-e24075. DOI: 10.1200/jco.2023.41.16_suppl.e24075.Peer-Reviewed Original ResearchNon-small cell lung cancerInternational consensus criteriaCell lung cancerOverall survivalSubgroup analysisWeight lossLung cancerStatistical heterogeneityTreatment of NSCLCInferior overall survivalImpact of cachexiaRisk of mortalityFunnel plot analysisHigher mortality riskPrevious weight lossHigh statistical heterogeneitySystematic literature reviewRandom-effects modelBase-case analysisSubstantial publication biasMeta-analysis resultsPoor outcomeMortality burdenCachexiaMortality riskThe mortality burden of extreme heat in Connecticut: A time series analysis
Goddard E, Lin C, Ma Y, Chen K. The mortality burden of extreme heat in Connecticut: A time series analysis. PLOS Climate 2023, 2: e0000164. DOI: 10.1371/journal.pclm.0000164.Peer-Reviewed Original ResearchMortality burdenGlobal Burden of Disease 2019 studyClimate changeHealth impact estimatesStatistically significant positive associationTemperature percentileQuasi-Poisson regressionSignificant positive associationAll-Cause MortalityNegative health effectsTime series analysisLong-term trendsGlobal burdenHeat-related mortalityRelative riskEpidemiological evidenceGeneralized linear modelClimate change planningSeasonal deathsHealth impactsPublic healthPositive associationRegional policy decisionsWarm seasonHealthThe mortality burden of cachexia in patients with colorectal or pancreatic cancer: A systematic literature review.
Dunne R, Bonomi P, Crawford J, Smoyer K, McRae T, Rossulek M, Revkin J, Tarasenko L. The mortality burden of cachexia in patients with colorectal or pancreatic cancer: A systematic literature review. Journal Of Clinical Oncology 2023, 41: 87-87. DOI: 10.1200/jco.2023.41.4_suppl.87.Peer-Reviewed Original ResearchPancreatic cancerPoor survivalInternational Consensus Diagnostic CriteriaRisk of cachexiaUnintentional weight lossCancer-associated cachexiaSystematic literature reviewConsensus diagnostic criteriaProgressive functional impairmentPoor prognosisColorectal cancerUnivariate analysisMortality burdenFunctional impairmentCachexiaPRISMA guidelinesDiagnostic criteriaEligibility criteriaPatientsClinical practiceRoutine assessmentMultivariate analysisSignificant associationWasting disorderCancer
2022
Association between Short-Term Exposure to Air Pollution and COVID-19 Mortality: A Population-Based Case-Crossover Study Using Individual-Level Mortality Registry Confirmed by Medical Examiners
Kim H, Samet J, Bell M. Association between Short-Term Exposure to Air Pollution and COVID-19 Mortality: A Population-Based Case-Crossover Study Using Individual-Level Mortality Registry Confirmed by Medical Examiners. Environmental Health Perspectives 2022, 130: 117006. PMID: 36367781, PMCID: PMC9651183, DOI: 10.1289/ehp10836.Peer-Reviewed Original ResearchConceptsCOVID-19 mortalityShort-term exposureCOVID-19Cook County Medical Examiner's OfficeTime-stratified case-crossover designCounty Medical Examiner's OfficeRisk of mortalityCase-crossover studyInterquartile range increaseLocation of deathCase-crossover analysisCase-crossover designDay of deathIndications of modificationMedical Examiner's OfficeAmbient air pollutionCOVID-19 deathsRace/ethnicityComorbid conditionsMortality registryPotential confoundersMortality burdenIQR increaseEpidemiological studiesMortalityPredicting the long-term impact of rotavirus vaccination in 112 countries from 2006 to 2034: A transmission modeling analysis
Kraay A, Steele M, Baker J, Hall E, Deshpande A, Saidzosa B, Mukaratirwa A, Boula A, Mpabalwani E, Kiulia N, Tsolenyanu E, Enweronu-Laryea C, Abebe A, Beyene B, Tefera M, Willilo R, Batmunkh N, Pastore R, Mwenda J, Antoni S, Cohen A, Pitzer V, Lopman B. Predicting the long-term impact of rotavirus vaccination in 112 countries from 2006 to 2034: A transmission modeling analysis. Vaccine 2022, 40: 6631-6639. PMID: 36210251, PMCID: PMC10351612, DOI: 10.1016/j.vaccine.2022.09.072.Peer-Reviewed Original ResearchConceptsRotavirus vaccinationRotavirus positivityVaccine introductionOne-dose scheduleTwo-dose seriesRotavirus burdenRotavirus casesRotavirus gastroenteritisHospital admissionMiddle-income countriesVaccine impactVaccinated individualsLong-term impactMortality burdenPercent reductionVaccinationLife yearsIndirect protectionLow-income countriesLong-term magnitudePositivityDeathBurdenYearsIntroduction Data
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