2024
Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium
St. Hillien S, Robinson J, Ouyang T, Patidar K, Belcher J, Cullaro G, Regner K, Chung R, Ufere N, Velez J, Neyra J, Asrani S, Wadei H, Teixeira J, Saly D, Levitsky J, Orman E, Sawinski D, Dageforde L, Allegretti A, Consortium H. Acute Kidney Injury in Patients with Cirrhosis and Chronic Kidney Disease: Results from the HRS-HARMONY Consortium. Clinical Gastroenterology And Hepatology 2024 PMID: 39675402, PMCID: PMC12163100, DOI: 10.1016/j.cgh.2024.10.023.Peer-Reviewed Original ResearchAcute kidney injuryChronic kidney diseaseLiver function parametersKidney diseaseKidney injuryAssociated with lower 90-day mortalityRates of intensive care unit admissionLiver diseaseAlcohol-associated liver diseaseIntensive care unit admissionMELD-Na scoreRenal replacement therapyShort-term outcomesFunction parametersComparison of outcomesPeak creatinineAdmission creatinineTransplant listing statusReplacement therapyUnit admissionPrimary outcomeCirrhosisMetabolic dysfunctionHospitalized patientsPatientsAssociation of Hepatorenal Syndrome-Acute Kidney Injury with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy
Cama-Olivares A, Ouyang T, Takeuchi T, St. Hillien S, Robinson J, Chung R, Cullaro G, Karvellas C, Levitsky J, Orman E, Patidar K, Regner K, Saly D, Sawinski D, Sharma P, Teixeira J, Ufere N, Velez J, Wadei H, Wahid N, Allegretti A, Neyra J, Belcher J, Cama-Olivares A, Ouyang T, Takeuchi T, St. Hillien S, Robinson J, Chung R, Cullaro G, Karvellas C, Levitsky J, Orman E, Patidar K, Regner K, Saly D, Sawinski D, Sharma P, Teixeira J, Ufere N, Velez J, Wadei H, Wahid N, Allegretti A, Neyra J, Belcher J. Association of Hepatorenal Syndrome-Acute Kidney Injury with Mortality in Patients with Cirrhosis Requiring Renal Replacement Therapy. Kidney360 2024, 6: 247-256. PMID: 39348201, PMCID: PMC11882256, DOI: 10.34067/kid.0000000589.Peer-Reviewed Original ResearchEtiology of AKIHRS-AKIAKI-RRTRenal replacement therapyContinuous RRTIntermittent hemodialysisAdult patientsHospitalized patientsAKI etiologyReplacement therapyAssociated with increased 90-day mortalityMulticenter retrospective cohort studyNon-HRS-AKIAssociated with increased mortalityConsecutive adult patientsRetrospective cohort studyHospital network systemHepatorenal syndromeContemporary cohortInpatient populationMechanical ventilationRRT modalityCohort studyClinical variablesPrimary outcomeShort term outcomes and resource utilization in de-novo versus acute on chronic heart failure related cardiogenic shock: a nationwide analysis
Quien M, Bae J, Jang S, Davila C. Short term outcomes and resource utilization in de-novo versus acute on chronic heart failure related cardiogenic shock: a nationwide analysis. Frontiers In Cardiovascular Medicine 2024, 11: 1454884. PMID: 39314766, PMCID: PMC11416976, DOI: 10.3389/fcvm.2024.1454884.Peer-Reviewed Original ResearchChronic heart failureIn-Hospital MortalityCardiogenic shockHeart failureAdvanced heart failure therapiesRight heart catheterizationEtiology of cardiogenic shockHeart failure therapyNon-ischemic etiologyProportion of patientsRenal replacement therapyShort-term outcomesReadmission mortalityNationwide Readmissions DatabaseMechanical circulatory supportCS subgroupsHeart catheterizationClinical courseFailure therapyReplacement therapyHeart transplantationTerm outcomesIn-HospitalCS casesReadmissions DatabaseOutcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium
T. A, Allegretti A, Cullaro G, Ouyang T, Asrani S, Chung R, Przybyszewski E, Wilechansky R, Robinson J, Sharma P, Simonetto D, Jalal P, Orman E, Wadei H, St. Hillien S, Saly D, Ufere N, Dageforde L, Regner K, Belcher J, Patidar K, Consortium F. Outcomes of patients with alcohol‐associated hepatitis and acute kidney injury – Results from the HRS Harmony Consortium. Alimentary Pharmacology & Therapeutics 2024, 60: 778-786. PMID: 39010302, PMCID: PMC11349455, DOI: 10.1111/apt.18159.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAcute kidney injuryAcute kidney injury phenotypesHepatorenal syndromeMELD-NaDevelopment of acute kidney injuryCumulative incidence of deathConsecutive adult patientsOutcomes of patientsAlcohol Abuse and Alcoholism (NIAAANon-AH groupRenal replacement therapyPresence of AHAcute tubular necrosisRetrospective cohort studyPredictors of mortalityIncidence of deathAKI stageClinical courseReplacement therapyAdult patientsKidney injuryCumulative incidencePoor prognosisTubular necrosisUse of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity Score Matching AnalysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically Ventilated PatientsCritically ill patientsOutcomes of Adult Patients With COVID-19 Transitioning From Venovenous to Venoarterial or Hybrid Extracorporeal Membrane Oxygenation in the Extracorporeal Life Support Organization Registry
Nguyen K, Altibi A, Prasad P, Mukundan S, Shekar K, Ramanathan K, Zakhary B. Outcomes of Adult Patients With COVID-19 Transitioning From Venovenous to Venoarterial or Hybrid Extracorporeal Membrane Oxygenation in the Extracorporeal Life Support Organization Registry. ASAIO Journal 2024, 70: 1040-1045. PMID: 38810234, DOI: 10.1097/mat.0000000000002243.Peer-Reviewed Original ResearchExtracorporeal membrane oxygenationVv-extracorporeal membrane oxygenationVenovenous extracorporeal membrane oxygenationExtracorporeal Life Support OrganizationMembrane oxygenationAdult patientsTreated with VV ECMOExtracorporeal Life Support Organization registryOutcomes of adult patientsFactors associated with conversionRisk factors associated with conversionIn-hospital mortality rateExtracorporeal membrane oxygenation configurationRenal replacement therapyLife Support OrganizationIn-Hospital MortalityPrimary outcome measureRisk of mortalityRisk of conversionCOVID-19 patientsInotrope requirementPre-ECMOPropensity score matchingVA-ECMOInotropic agentsVasoplegic syndrome during heart transplantation: A systematic review and meta-analysis
Kumar N, Fitzsimons M, Iyer M, Essandoh M, Kumar J, Dalia A, Osho A, Sawyer T, Bardia A. Vasoplegic syndrome during heart transplantation: A systematic review and meta-analysis. The Journal Of Heart And Lung Transplantation 2024, 43: 931-943. PMID: 38428755, DOI: 10.1016/j.healun.2024.02.1458.Peer-Reviewed Original ResearchVasoplegic syndromeHeart transplantationLonger cardiopulmonary bypass timeBlood product transfusion requirementsVenoarterial extracorporeal membrane oxygenationSystematic reviewHigh-risk patient populationCardiopulmonary bypass timeVA-ECMO supportHigher Body Mass IndexExtracorporeal membrane oxygenationHigh-risk patientsCalcium channel blockersStudy of treatment strategiesRenal replacement therapyPrevalence of VSPublished clinical dataIncidence of VSBody mass indexAmiodarone usageBypass timeTransfusion requirementsIntraoperative characteristicsVA-ECMOPostoperative outcomesP-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY
Idalsoaga F, Díaz L, Corsi O, Ayares G, Arnold J, Dunn W, Li Y, Singal A, Simonetto D, Ayala-Valverde M, Ramirez C, Morales-Arraez D, Zhang W, Qian S, Ahn J, Buryska S, Mehta H, Waleed M, Stefanescu H, Horhat A, Bumbu A, Attar B, Agrawal R, Cabezas J, Cuyàs B, Poca M, Pastor G, Sarin S, Maiwall R, Jalal P, La Tijera M, Kulkarni A, Rao N, Salazar P, Skladaný L, Bystrianska N, Prado V, Clemente-Sanchez A, Rincón D, Haider T, Chacko K, Romero G, Pollarsky F, Restrepo J, Toro L, Yaquich P, Mendizabal M, Garrido M, Marciano S, Dirchwolf M, Vargas V, Jimenez C, García-Tsao G, Ortiz G, Abraldes J, Kamath P, Shah V, Bataller R, Arab J. P-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY. Annals Of Hepatology 2024, 29: 101206. DOI: 10.1016/j.aohep.2023.101206.Peer-Reviewed Original ResearchRenal replacement therapyVariables associated with mortalityModerate AHAlcohol-associated hepatitisPrognostic factorsLiver transplantationMaddrey's discriminant functionAssociated with high mortalityMultiple organ failureRetrospective cohort studyMultivariate-adjusted modelsShort-term mortalityAssociated with mortalityCompeting-risks modelMedian ageCause of deathReplacement therapyMulticenter studyMELD scoreOrgan failureUnivariate analysisCohort studyFrequent causeSevere entitySurvival rateA synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress
Fedeles B, Bhardwaj R, Ishikawa Y, Khumsubdee S, Krappitz M, Gubina N, Volpe I, Andrade D, Westergerling P, Staudner T, Campolo J, Liu S, Dong K, Cai Y, Rehman M, Gallagher A, Ruchirawat S, Croy R, Essigmann J, Fedeles S, Somlo S. A synthetic agent ameliorates polycystic kidney disease by promoting apoptosis of cystic cells through increased oxidative stress. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2317344121. PMID: 38241440, PMCID: PMC10823221, DOI: 10.1073/pnas.2317344121.Peer-Reviewed Original ResearchConceptsCyst cellsAutosomal dominant polycystic kidney diseaseMouse models of autosomal dominant polycystic kidney diseasePolycystic kidney diseaseModel of autosomal dominant polycystic kidney diseaseKidney diseaseDeveloped primersMitochondrial oxidative stressPathophysiology of autosomal dominant polycystic kidney diseaseOxidative stressInduce apoptosisMitochondrial respirationCystic cellsUp-regulating aerobic glycolysisHomozygous inactivationMonogenic causeDominant polycystic kidney diseaseAerobic glycolysisRenal replacement therapyApoptosisEnd-stage kidney diseaseAnti-tumor agentsAdult mouse modelChronic kidney diseaseAlkylate DNA
2023
American Burn Association Clinical Practice Guidelines on Burn Shock Resuscitation
Cartotto R, Johnson L, Savetamal A, Greenhalgh D, Kubasiak J, Pham T, Rizzo J, Sen S, Main E. American Burn Association Clinical Practice Guidelines on Burn Shock Resuscitation. Journal Of Burn Care & Research 2023, 45: 565-589. PMID: 38051821, DOI: 10.1093/jbcr/irad125.Peer-Reviewed Original ResearchBurn shock resuscitationClinical practice guidelinesResuscitation fluid volumeShock resuscitationFresh frozen plasmaPICO questionPractice guidelinesEarly continuous renal replacement therapyContinuous renal replacement therapyHigh-dose vitamin CTotal body surface areaAcute fluid resuscitationOutcomes of survivalRenal replacement therapyComputer decision support softwareFluid volumeBody surface areaSystematic literature searchHuman albumin solutionResuscitation volumeLevels of screeningFluid resuscitationUrine outputWeak recommendationReplacement therapyAssociation of AKI-Hepatorenal Syndrome (HRS) with Mortality in Hospitalized Cirrhotic Patients Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium
Cama-Olivares A, Ouyang T, Takeuchi T, St. Hillien S, Robinson J, Patidar K, Cullaro G, Chung R, Regner K, Velez J, Wahid N, Sharma P, Allegretti A, Neyra J, Belcher J. Association of AKI-Hepatorenal Syndrome (HRS) with Mortality in Hospitalized Cirrhotic Patients Requiring Renal Replacement Therapy: Results from the HRS-HARMONY Consortium. Journal Of The American Society Of Nephrology 2023, 34: 103-104. DOI: 10.1681/asn.20233411s1103c.Peer-Reviewed Original ResearchSGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction
Avula V, Sharma G, Kosiborod M, Vaduganathan M, Neilan T, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang E, Ky B, Lenihan D, Nohria A, Dani S, Ganatra S. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction. JACC Heart Failure 2023, 12: 67-78. PMID: 37897456, DOI: 10.1016/j.jchf.2023.08.026.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionSGLT2 inhibitor useGuideline-directed medical therapyHeart failureInhibitor useSGLT2 inhibitorsMedical therapyCardiac dysfunctionAntineoplastic therapyAtrial fibrillation/flutterType 2 diabetes mellitusAcute HF exacerbationCox proportional HRsAcute kidney injuryRenal replacement therapyRetrospective cohort analysisIschemic heart diseaseRisk of cardiomyopathyAggregate patient dataTriNetX Research NetworkProportional HRsCause hospitalizationCause mortalityHF exacerbationKidney injuryEarly Clinical Outcomes of Patients With Stress-Induced Cardiomyopathy Receiving Acute Mechanical Support in the US
Jang S, Webber F, Alam M, Bae J, Aggarwal A, Thomas A, Zarich S, Ahmad T, Miller P, Davila C. Early Clinical Outcomes of Patients With Stress-Induced Cardiomyopathy Receiving Acute Mechanical Support in the US. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101185. PMID: 39131072, PMCID: PMC11308019, DOI: 10.1016/j.jscai.2023.101185.Peer-Reviewed Original ResearchAcute mechanical circulatory supportStress-induced cardiomyopathyRenal replacement therapyCardiogenic shockIndex hospitalizationReplacement therapyIntra-aortic balloon pumpAggressive hemodynamic supportHospital mortality rateNationwide Readmissions DatabaseMechanical circulatory supportFuture prospective studiesLarge national databaseObserved mortality differencesHospital mortalityMore comorbiditiesHospital deathHemodynamic supportBalloon pumpMembrane oxygenationClinical outcomesCirculatory supportProspective studyAdministrative databasesImpellaDistinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study
Asperen R, la Roi-Teeuw H, van Amstel R, Bos L, Tissing W, Jordan I, Dohna-Schwake C, Bottari G, Pappachan J, Crazzolara R, Comoretto R, Mizia-Malarz A, Moscatelli A, Sánchez-Martín M, Willems J, Rogerson C, Bennett T, Luo Y, Atreya M, Faustino E, Geva A, Weiss S, Schlapbach L, Sanchez-Pinto L, consortium of ESPNIC A, Caballero M, Margarit A, Campos R, Möller P, Serpe C, Amigoni A, Damps M, Montaguti A, Tardini G, group T, Bubeck-Wardenburg J, Farris R, Hall M, Chong G, Shah S, Khemani R, Stroup E. Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes—an international multicentre retrospective study. EClinicalMedicine 2023, 65: 102252. PMID: 37842550, PMCID: PMC10570699, DOI: 10.1016/j.eclinm.2023.102252.Peer-Reviewed Original ResearchPaediatric intensive care unitPaediatric cancer patientsLatent class analysisSepsis phenotypesCancer patientsPatient populationInternational multicentre retrospective studyEunice Kennedy Shriver National Institute of Child HealthPaediatric intensive care unit admissionSeverity of organ dysfunctionStem cell transplantationMulticentre retrospective studyOR of deathPhenotype 1Renal replacement therapyNon-cancer patientsPhenotype 2National Institute of Child HealthInstitute of Child HealthIntensive care unitPrecision medicine approachSpecific patient populationsChild healthHigher mortality rateCell transplantationEfficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis
Aldairi N, Al Ali A, Alabdulqader M, Al Jeraisy M, Cyrus J, Karam O. Efficacy of Prostacyclin Anticoagulation in Critically Ill Patients Requiring Extracorporeal Support: A Systematic Review and Meta-Analysis. Cureus 2023, 15: e39967. PMID: 37416033, PMCID: PMC10320736, DOI: 10.7759/cureus.39967.Peer-Reviewed Original ResearchContinuous renal replacement therapyExtracorporeal membrane oxygenationMolecular adsorbent recirculating systemRenal replacement therapyHypotensive eventsCircuit lifespanReplacement therapyAnticoagulation strategiesMeta-analysisThrombotic eventsExtracorporeal supportSystematic reviewAssociated with fewer bleeding eventsControl seriesProportion of bleedingMortality rateCritically Ill ChildrenCritically ill patientsStatistically significant decreaseMultiple electronic databasesRandomized Controlled TrialsRisk of biasBleeding eventsMembrane oxygenationSupport modalitiesThe Detrimental Impact of End-Stage Kidney Disease Is Not Reflected in Autopsy Reports.
Lerner G, Reynolds M, Setty S, Deeb R, Rastogi P, Moeckel G, Sanchez H, Henriksen K, Chang A. The Detrimental Impact of End-Stage Kidney Disease Is Not Reflected in Autopsy Reports. Archives Of Pathology & Laboratory Medicine 2023, 148: 74-77. PMID: 37014976, DOI: 10.5858/arpa.2022-0338-oa.Peer-Reviewed Original ResearchConceptsEnd-stage kidney diseaseKidney diseaseAutopsy reportsDie of complicationsRenal replacement therapyMicroscopic autopsy findingsCause of deathCommon CODInterpathologist variationRenal impairmentReplacement therapyAutopsy casesAutopsy findingsCardiovascular diseaseDisease findingsAutopsy assessmentCase recordsDiseaseVital statisticsDecedentsDialysisDeathReportDetrimental impactComplications54 COVID-19 and Dialysis Patients
Silberzweig J, Kliger A. 54 COVID-19 and Dialysis Patients. 2023, 491-496. PMCID: PMC9335159, DOI: 10.1016/b978-0-323-79135-9.00054-9.ChaptersDialysis therapyIntermittent renal replacement therapyCOVID-19Continuous dialysis therapyAcute kidney injuryChronic kidney diseaseRenal replacement therapyAcute peritoneal dialysisAssociated risk factorsHome dialysis therapiesHigh rateDepartment of HealthKidney injuryDiabetes mellitusDialysis patientsFacility patientsPeritoneal dialysisKidney diseaseReplacement therapyDialysis programRisk factorsSevere diseaseMedical conditionsSubstantial burdenPatients
2022
Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN)
Carnicelli A, Keane R, Brown K, Loriaux D, Kendsersky P, Alviar C, Arps K, Berg D, Bohula E, Burke J, Dixson J, Gerber D, Goldfarb M, Granger C, Guo J, Harrison R, Kontos M, Lawler P, Miller P, Nativi-Nicolau J, Newby L, Racharla L, Roswell R, Shah K, Sinha S, Solomon M, Teuteberg J, Wong G, van Diepen S, Katz J, Morrow D. Characteristics, therapies, and outcomes of In-Hospital vs Out-of-Hospital cardiac arrest in patients presenting to cardiac intensive care units: From the critical care Cardiology trials network (CCCTN). Resuscitation 2022, 183: 109664. PMID: 36521683, DOI: 10.1016/j.resuscitation.2022.12.002.Peer-Reviewed Original ResearchConceptsCardiac intensive care unitCritical Care Cardiology Trials NetworkOutcome of admissionIntensive care unitCardiac arrestCare unitContemporary cardiac intensive care unitsTertiary cardiac intensive care unitsTrials NetworkLower lactateLower crude mortalityRenal replacement therapyMechanical circulatory supportHospital cardiac arrestHospital mortalityIHCA patientsInvasive hemodynamicsCICU admissionIn-HospitalCoronary diseaseCrude mortalityHeart failureOHCA patientsAtrial fibrillationCirculatory supportImmune checkpoints inhibitors and its link to acute kidney injury and renal prognosis
Kanbay M, Yildiz AB, Siriopol D, Vehbi S, Hasbal NB, Kesgin YE, Celayir M, Selcukbiricik F, Covic A, Perazella MA. Immune checkpoints inhibitors and its link to acute kidney injury and renal prognosis. International Urology And Nephrology 2022, 55: 1025-1032. PMID: 36282399, DOI: 10.1007/s11255-022-03395-y.Peer-Reviewed Original ResearchConceptsAcute kidney injuryImmune checkpoint inhibitorsSolid organ malignanciesCheckpoint inhibitorsKidney injuryOrgan malignanciesNephrotoxic agentsSingle-center retrospective cohort studyType of ICIBaseline serum creatinine levelAcute interstitial nephritisLocation of malignancyRetrospective cohort studySerum creatinine levelsKidney function recoveryRenal replacement therapyUrinary tract obstructionRisk of mortalityICPI treatmentRenal prognosisTract obstructionCohort studyCreatinine levelsFive patientsInterstitial nephritisHemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue. Prostaglandins Leukotrienes And Essential Fatty Acids 2022, 181: 102453. PMID: 35633593, DOI: 10.1016/j.plefa.2022.102453.Peer-Reviewed Original ResearchConceptsRed blood cellsHD treatmentHemodialysis treatmentEnd-stage renal disease patientsHydroxyeicosatetraenoic acidHydroxyeicosapentaenoic acidSingle hemodialysis treatmentChronic kidney diseaseRenal disease patientsRenal replacement therapyFatty acid statusVenous blood samplesHydroxydocosahexaenoic acidEpoxy fatty acidsCause of mortalityLOX pathwayRenal failureFatty acidsKidney diseaseDisease patientsVenous bloodCardiovascular functionAcid statusArteriovenous differenceCardiovascular disease
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