2024
Shock Index is a Stronger Predictor of Outcomes in Older Compared to Younger Patients
Rafieezadeh A, Prabhakaran K, Kirsch J, Klein J, Shnaydman I, Bronstein M, Con J, Zangbar B. Shock Index is a Stronger Predictor of Outcomes in Older Compared to Younger Patients. Journal Of Surgical Research 2024, 300: 8-14. PMID: 38788482, DOI: 10.1016/j.jss.2024.04.064.Peer-Reviewed Original ResearchConceptsBlood transfusionSurgical interventionShock indexAssociated with mortalityGroup AGroup CPredictors of unfavorable outcomeGeriatric patientsQuality Improvement Program databaseTrauma Quality Improvement Program databaseRate of group CPredictors of outcomeRetrospective studyYounger patientsUnfavorable outcomeProgram databaseGroup BPrimary outcomeTransfusionSecondary outcomesPatientsSevere traumaMortality rateAge groupsBloodImpact of immunotherapy time-of-day infusion on survival and immunologic correlates in patients with metastatic renal cell carcinoma: a multicenter cohort analysis
Patel J, Woo Y, Draper A, Jansen C, Carlisle J, Innominato P, Lévi F, Dhabaan L, Master V, Bilen M, Khan M, Lowe M, Kissick H, Buchwald Z, Qian D. Impact of immunotherapy time-of-day infusion on survival and immunologic correlates in patients with metastatic renal cell carcinoma: a multicenter cohort analysis. Journal For ImmunoTherapy Of Cancer 2024, 12: e008011. PMID: 38531662, PMCID: PMC10966813, DOI: 10.1136/jitc-2023-008011.Peer-Reviewed Original ResearchConceptsInfusions of immune checkpoint inhibitorsMetastatic renal cell carcinomaProgression-free survivalOverall survivalRenal cell carcinomaCell carcinomaInternational Metastatic RCC Database Consortium risk scoreAssociated with longer progression-free survivalLung cancerGroup BGroup ATime of ICI initiationLonger progression-free survivalNon-small cell lung cancerMultivariable Cox proportional hazards regressionImmune checkpoint inhibitorsPretreatment lactate dehydrogenaseCell lung cancerCox proportional hazards regressionAdaptive immune responsesProportional hazards regressionMulticenter cohort analysisCheckpoint inhibitorsICI initiationMetastatic melanoma
2023
1538. Is there value in performing yearly screening for latent tuberculosis infection by interferon-gamma release assay among patients living with HIV in non-endemic settings?
Palacios C, Achhra A, Barakat L, Virata M, Hao R, Baxter J, Malinis M. 1538. Is there value in performing yearly screening for latent tuberculosis infection by interferon-gamma release assay among patients living with HIV in non-endemic settings? Open Forum Infectious Diseases 2023, 10: ofad500.1373. PMCID: PMC10678242, DOI: 10.1093/ofid/ofad500.1373.Peer-Reviewed Original ResearchInterferon-gamma release assaysLatent tuberculosis infectionNew latent tuberculosis infectionsTuberculin skin testingNon-endemic settingRisk factorsCD4 countTuberculosis infectionCurrent guidelinesGroup APositive interferon-gamma release assaysHigher HIV viral loadUrban academic medical centerChest imaging resultsLow CD4 countTB exposure riskTB risk factorsCells/mm3HIV viral loadRetrospective chart reviewFeatures of patientsRisk of reactivationInterferon-gamma releaseCommon risk factorsAcademic medical centerDaytime symptom trajectories among adults with stable heart failure and insomnia: evidence from a randomised controlled trial of cognitive behavioural therapy for insomnia
Conley S, Jeon S, Wang Z, Tocchi C, Linsky S, O'Connell M, Redeker N. Daytime symptom trajectories among adults with stable heart failure and insomnia: evidence from a randomised controlled trial of cognitive behavioural therapy for insomnia. Journal Of Sleep Research 2023, 33: e14058. PMID: 37933085, DOI: 10.1111/jsr.14058.Peer-Reviewed Original ResearchStable heart failureHeart failureSelf-management groupSymptom trajectoriesCognitive behavioral therapyBehavioral therapyHigher Body Mass IndexGroup-based trajectory modellingHigh symptom burdenHealth-related qualityBody mass indexTrial of CBTFunctional performanceSelf-management interventionsBaseline characteristicsSymptom burdenMass indexBaseline fatigueGroup AHigher oddsSleep characteristicsInsomnia severityGroup DPhysical symptomsInsomniaClinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction
Colliard K, Nurko S, Flores A, Rodriguez L. Clinical Utility of Ileal Motility in Children With Defecation Disorders and Children With Chronic Intestinal Pseudo‐Obstruction. Journal Of Pediatric Gastroenterology And Nutrition 2023, 77: 327-331. PMID: 37229777, DOI: 10.1097/mpg.0000000000003841.Peer-Reviewed Original ResearchConceptsAntroduodenal manometryDefecation disordersPostprandial responseGroup BChronic Intestinal Pseudo-ObstructionIntestinal Pseudo-ObstructionNormal postprandial responseModerate agreementSmall bowel motilityLogistic regression analysisOstomy closurePseudo-ObstructionBowel motilityRetrospective reviewIleal motilityIndication groupGroup AClinical utilityYounger agePatientsMotility patternsPhase IIIMotor complexDisordersManometryAssociations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis
Bougie D, Reese S, Birch R, Bookwalter D, Mitchell P, Roh D, Kreuziger L, Cable R, Goel R, Gottschall J, Hauser R, Hendrickson J, Hod E, Josephson C, Kahn S, Kleinman S, Mast A, Ness P, Roubinian N, Sloan S, Study‐IV‐Pediatric F. Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis. Transfusion 2023, 63: 960-972. PMID: 36994786, PMCID: PMC10175171, DOI: 10.1111/trf.17319.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsHazard ratioPatient outcomesMulticenter retrospective analysisPlatelet transfusion requirementsGroup O recipientsRecipient's blood groupRisk of mortalitySpecific patient populationsBlood group ARecipient EpidemiologyTransfusion requirementsB recipientsOverall cohortProspective studyO recipientsPatient populationRetrospective analysisPlatelet dosesGroup ATransfusionABO antigensABO groupPatient exposureSignificant association
2022
Systemic biomarkers of retinopathy of prematurity in preterm babies
Sehgal P, Narang S, Chawla D, Gupta S, Jain S, Sharma U, Katoch D, Kaur J. Systemic biomarkers of retinopathy of prematurity in preterm babies. International Ophthalmology 2022, 43: 1751-1759. PMID: 36443542, PMCID: PMC9707116, DOI: 10.1007/s10792-022-02576-z.Peer-Reviewed Original ResearchConceptsIncreased levels of IL-8Levels of IL-8Treatable ROPHuman ELISA kitIL-8Group BGroup APreterm babiesScreening visitIL-6Time of initial screeningRetinopathy of prematurityLevels of IL-6Median serum valuesUrine samplesSerum IL-8Evaluation of bloodIncreased levelsAUROC curveSerum valuesInflammatory cytokinesSystemic biomarkersIQRBabiesELISA kitsDirect relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly intervention
2021
Polyclonality Strongly Correlates with Biological Outcomes and Is Significantly Increased Following Improvements to the Phase 1/2 HGB-206 Protocol and Manufacturing of LentiGlobin for Sickle Cell Disease (SCD; bb1111) Gene Therapy (GT)
Tisdale J, Thompson A, Mapara M, Kwiatkowski J, Krishnamurti L, Aygun B, Kasow K, Rifkin-Zenenberg S, Schmidt M, Pierciey F, Whitney D, Rogers C, Nnamani M, Foos M, Miller A, Zhang X, Lynch J, Walters M, Kanter J, Bonner M. Polyclonality Strongly Correlates with Biological Outcomes and Is Significantly Increased Following Improvements to the Phase 1/2 HGB-206 Protocol and Manufacturing of LentiGlobin for Sickle Cell Disease (SCD; bb1111) Gene Therapy (GT). Blood 2021, 138: 561. DOI: 10.1182/blood-2021-147760.Peer-Reviewed Original ResearchAcute myeloid leukemiaVaso-occlusive eventsCurrent equity holderSevere vaso-occlusive eventsGroup AGroup CMonth 6Clinical outcomesBluebird BioClinical benefitBusulfan conditioningCell doseRisk of AMLAutologous stem cell transplantTricuspid regurgitant jet velocityAdvisory CommitteeDriver mutationsLentiviral vectorsAML driver mutationsOpioid withdrawal syndromeSerious adverse eventsRegurgitant jet velocityFavorable clinical outcomeConsultancy feesStem cell transplantDevelopment of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene
Manrai PA, Siddon AJ, Hager KM, Hendrickson JE, Keller MA, Tormey CA. Development of anti-Jk3 associated with silenced Kidd antigen expression and a novel single nucleotide variant of the JK gene. Immunohematology 2021, 37: 109-112. PMID: 34591379, DOI: 10.21307/immunohematology-2021-015.Peer-Reviewed Original ResearchConceptsHigh-prevalence antigenReagent red blood cellsDirect antiglobulin testBlood samplesBlood group APatient blood samplesImmunohematology reference laboratoryRare alloantibodyRed blood cellsOncologic careAntiglobulin testGroup APolynesian descentBlood cellsNon-conservative amino acid changeSingle nucleotide variantsReference laboratoryAmino acid changesFamilial backgroundExon 8Antigen expressionExon 7Nucleotide variantsAcid changesExon 4Does the addition of dexmedetomidine to morphine have any clinical benefit on the treatment of pain in patients with metastatic cancer? A pilot study
Yamout R, Viallard M, Hoteit S, Abou-Zeid H, Shebbo F, Naccache N. Does the addition of dexmedetomidine to morphine have any clinical benefit on the treatment of pain in patients with metastatic cancer? A pilot study. Progress In Palliative Care 2021, 29: 272-277. DOI: 10.1080/09699260.2021.1919045.Peer-Reviewed Original ResearchVisual analogue scoreMetastatic cancerPain treatmentGroup BPain managementGroup AAddition of dexmedetomidineOpioid-sparing effectEffect of dexmedetomidineTreatment of painFirst-line drugsMetastatic cancer patientsAnalogue scoreMorphine consumptionPain scoresIntractable painSevere painAnalgesic actionPain intensityClinical benefitLine drugsSedation levelSedation ScaleCancer patientsGroup A.
2020
Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon
Rafei R, Hawli M, Osman M, Khelissa S, Salloum T, Dabboussi F, Tokajian S, Hamze M. Molecular epidemiology of nonpharyngeal group A streptococci isolates in northern Lebanon. Future Microbiology 2020, 15: 1555-1569. PMID: 33236928, DOI: 10.2217/fmb-2020-0072.Peer-Reviewed Original Research
2019
Exploring the Drivers of Potential Clinical Benefit in Initial Patients Treated in the Hgb-206 Study of Lentiglobin for Sickle Cell Disease (SCD) Gene Therapy
Walters M, Tisdale J, Kwiatkowski J, Krishnamurti L, Mapara M, Schmidt M, Miller A, Pierciey F, Huang W, Ribeil J, Kanter J, Thompson A. Exploring the Drivers of Potential Clinical Benefit in Initial Patients Treated in the Hgb-206 Study of Lentiglobin for Sickle Cell Disease (SCD) Gene Therapy. Blood 2019, 134: 2061. DOI: 10.1182/blood-2019-128814.Peer-Reviewed Original ResearchAcute chest syndromeVaso-occlusive crisisGroup A patientsRate of VOCAdverse eventsA patientsPatient 1Group AClinical benefitLast visitBluebird BioHematopoietic stem cellsInitial patientsPatient 2Busulfan conditioningGroup BHbF levelsVeno-occlusive liver diseaseRed blood cell transfusionFull hematological recoveryBlood cell transfusionCases of gradeLentiviral vectorsGene therapyPotential clinical benefitEffect of drugs containing glucose on FDG-PET image quality
Okamoto S, Toyonaga T, Matsuzawa K, Aizawa M, Mouri T, Suzuki Y, Miyamoto N, Inubushi M. Effect of drugs containing glucose on FDG-PET image quality. Annals Of Nuclear Medicine 2019, 33: 828-834. PMID: 31407148, DOI: 10.1007/s12149-019-01394-1.Peer-Reviewed Original ResearchConceptsFDG-PETStandard uptake valueGrams of glucoseGroup CFDG-PET imagesPrescription drugsBrain/liver ratioFluorodeoxyglucose positron emission tomographySignificant differencesBrain/blood ratioQuantitative variablesBlood glucose levelsVisual scoresAmount of glucoseResultsIn group CPositron emission tomographyEffects of drugsBlood glucoseFDG injectionMethodsIn totalBlood ratioGroup BLiver ratioGlucose levelsGroup AEffect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherenceChloride Homeostasis in End Stage Heart Failure and LVAD Recipients
Stawiarski K, Agboola O, Jacoby D, Bellumkonda L, Ahmad T, Sugeng L, Chen M, McCloskey G, Geirsson A, Anwar M, Bonde P. Chloride Homeostasis in End Stage Heart Failure and LVAD Recipients. The Journal Of Heart And Lung Transplantation 2019, 38: s382-s383. DOI: 10.1016/j.healun.2019.01.974.Peer-Reviewed Original ResearchSerum chloride levelsChloride homeostasisLVAD patientsHeart failureLVAD therapyEnd-stage heart failureCardio-renal axisChronic heart failureStage heart failureChloride levelsLong-term survivalKaplan-Meir plotsLog-rank statisticsL riseCause mortalityLVAD recipientsWorse survivalSingle centerNeurohormonal responsesPrognostic implicationsPrognostic valueLVAD implantsRetrospective analysisGroup ACox modelEffects of high dose atorvastatin before elective percutaneous coronary intervention on highly sensitive troponin T and one year major cardiovascular events; a randomized clinical trial
Pourhosseini H, Lashkari R, Aminorroaya A, Soltani D, Jalali A, Tajdini M. Effects of high dose atorvastatin before elective percutaneous coronary intervention on highly sensitive troponin T and one year major cardiovascular events; a randomized clinical trial. IJC Heart & Vasculature 2019, 22: 96-101. PMID: 30671535, PMCID: PMC6328087, DOI: 10.1016/j.ijcha.2018.12.003.Peer-Reviewed Original ResearchGroup AGroup BElective PCIPatients of group ACompared to group BAssociated with worse outcomesElective percutaneous coronary interventionHigh dose atorvastatinMedian Follow-UpElevated cardiac enzymesSensitivity troponin THigh-dose treatmentOccurrence of MACEPretreatment of patientsProportional hazards regression modelsMajor cardiovascular eventsHazards regression modelsPercutaneous coronary interventionDose atorvastatinCardiac enzymesDaily dosageStable anginaWorse outcomesCardiovascular eventsFollow-up
2018
Outcomes for Initial Patient Cohorts with up to 33 Months of Follow-up in the Hgb-206 Phase 1 Trial
Kanter J, Tisdale J, Kwiatkowski J, Krishnamurti L, Mapara M, Schmidt M, Miller A, Pierciey F, Shi W, Ribeil J, Walters M, Thompson A. Outcomes for Initial Patient Cohorts with up to 33 Months of Follow-up in the Hgb-206 Phase 1 Trial. Blood 2018, 132: 1080. DOI: 10.1182/blood-2018-99-113477.Peer-Reviewed Original ResearchSevere sickle cell diseaseGroup B patientsSickle cell diseaseGroup A patientsB patientsAdverse eventsGroup ALast visitTotal bilirubinBluebird BioHematopoietic stem cellsA patientsPeripheral bloodBusulfan conditioningReticulocyte countTotal HbVeno-occlusive liver diseaseAdvisory CommitteeMedical directorsNormalization of HbVaso-occlusive painSerious adverse eventsLong-term followPhase 1 trialSignificant clinical benefit
2017
Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study
Zhu Y, Lin L, Wang C, Jia H, Hu S, Li L, Zhang X, Zheng G, Wang Y, Sun R, Afolabi A, Mustafina I, Hou J, Zhang S, Yu B. Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study. Oncotarget 2017, 5: 27401-27411. PMID: 28404965, PMCID: PMC5432344, DOI: 10.18632/oncotarget.16172.Peer-Reviewed Original ResearchConceptsImpact of statin therapyLipid-rich plaquesStatin therapyFibrous cap thicknessGroup BFramingham risk scoreGroup AOptical coherence tomography studiesRisk scoreBaseline to 6 monthsLower risk group ARisk group ABaseline characteristicsRisk group BMorphological changesTherapyOCT imagesPatientsLipid indicesTomography studiesStatinsPlaqueCHDFraminghamBaseline
2016
Simple Technique of Circular Stapled Anastomosis in Ivor Lewis Esophagectomy
Singhal S, Kailasam A, Akimoto S, Masuda T, Bertellotti C, Mittal S. Simple Technique of Circular Stapled Anastomosis in Ivor Lewis Esophagectomy. Journal Of Laparoendoscopic & Advanced Surgical Techniques 2016, 27: 288-294. PMID: 27705608, DOI: 10.1089/lap.2016.0443.Peer-Reviewed Original ResearchConceptsIvor Lewis esophagectomyEnd-to-end anastomosisGroup AAnastomotic leakMedian postoperative ICU stayAnastomotic techniqueStapled end-to-end anastomosisMinimally-invasive esophagectomyPostoperative hospital stayPostoperative ICU stayCircular stapled anastomosisStapled anastomotic techniquePerioperative deathsPerioperative outcomesRedo anastomosisHospital stayIntrathoracic anastomosisSequential cohortsEndoscopic interventionEsophagectomyICU stayGroup BIRB approvalStapled anastomosisPatients
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