2025
Prevalence of Hypertension in the Late Postpartum Period by Hypertensive Status in Pregnancy
Sinnott C, Culhane J, Lundsberg L, Partridge C, Denoble A. Prevalence of Hypertension in the Late Postpartum Period by Hypertensive Status in Pregnancy. O&G Open 2025, 2: e093-e093. PMID: 41000089, PMCID: PMC12421962, DOI: 10.1097/og9.0000000000000093.Peer-Reviewed Original ResearchElevated blood pressureLate postpartum periodBlood pressurePostpartum periodAcademic health care systemHypertension statusDelivery hospitalization dischargeWeeks of gestationRetrospective cohort studyHealth care systemNormal blood pressureDiastolic blood pressureElectronic medical recordsPrevalence of hypertensionSystolic blood pressureRates of hypertensionPostpartum hypertensionMm HgCare systemCohort studyMonths postpartumPregnancyLate postpartumPatient attributesMedical records
2024
Tirzepatide and blood pressure reduction: stratified analyses of the SURMOUNT-1 randomised controlled trial
Krumholz H, de Lemos J, Sattar N, Linetzky B, Sharma P, Mast C, Ahmad N, Bunck M, Stefanski A. Tirzepatide and blood pressure reduction: stratified analyses of the SURMOUNT-1 randomised controlled trial. Heart 2024, 110: 1165-1171. PMID: 39084707, PMCID: PMC11420724, DOI: 10.1136/heartjnl-2024-324170.Peer-Reviewed Original ResearchBlood pressure reductionBlood pressure subgroupBlood pressurePost Hoc AnalysisPressure reductionTirzepatide groupsAdverse eventsDiastolic blood pressure reductionHoc AnalysisAssociated with reduced blood pressureEffects of tirzepatideWeight-related complicationsOverall blood pressureLower blood pressure levelsWeight lossNormal blood pressureDiastolic blood pressureLower blood pressureBlood pressure levelsRandomised controlled trialsMediation analysisTirzepatideClinical subgroupsControlled hypertensionPlaceboImpact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre study
Zhong P, Lu Z, Li Z, Li T, Lan Q, Liu J, Chen S, Wang Z, Huang Q. Impact of premorbid hypertension and renin-angiotensin-aldosterone system inhibitors on the severity of aneurysmal subarachnoid haemorrhage: a multicentre study. Stroke And Vascular Neurology 2024, 10: e003052. PMID: 38889918, PMCID: PMC12107460, DOI: 10.1136/svn-2023-003052.Peer-Reviewed Original ResearchRenin-angiotensin-aldosterone systemWorld Federation of Neurological SurgeonsAneurysmal subarachnoid haemorrhageRenin-angiotensin-aldosterone system inhibitorsHunt-Hess scaleClinical grading scaleClinical outcomesUncontrolled hypertensionGrading scaleWorld Federation of Neurological Surgeons scaleRisk of adverse clinical outcomesHypertension statusElevated risk of poor outcomesSubarachnoid haemorrhageRisk of adverse outcomesComparison to patientsAdverse clinical outcomesRisk of poor outcomesNormal blood pressureMultivariate logistic regressionIntracranial aneurysm ruptureRisk of intracranial aneurysm rupturePremorbid hypertensionSystem inhibitorsMulticentre study
2020
Association Between Cost-Related Medication Nonadherence and Hypertension Management Among US Adults
Fang J, Chang T, Wang G, Loustalot F. Association Between Cost-Related Medication Nonadherence and Hypertension Management Among US Adults. American Journal Of Hypertension 2020, 33: 879-886. PMID: 32369108, DOI: 10.1093/ajh/hpaa072.Peer-Reviewed Original ResearchConceptsCurrent antihypertensive medication useCost-related medication nonadherenceAntihypertensive medication useNormal blood pressureSelf-reported hypertensionBlood pressureMedication useHypertension managementMedication nonadherenceUS adultsPrevalence ratiosSelf-reported antihypertensive medication useNational Health Interview SurveyAdjusted prevalence ratiosHealth Interview SurveyAdherence persistUncontrolled hypertensionAdjusted prevalenceHypertensionAdjusted percentageNonadherenceInterview SurveyMonthsFinancial barriersAdultsA recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancy
2019
Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
Ding J, Davis-Plourde KL, Sedaghat S, Tully PJ, Wang W, Phillips C, Pase MP, Himali JJ, Windham B, Griswold M, Gottesman R, Mosley TH, White L, Guðnason V, Debette S, Beiser AS, Seshadri S, Ikram MA, Meirelles O, Tzourio C, Launer LJ. Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies. The Lancet Neurology 2019, 19: 61-70. PMID: 31706889, PMCID: PMC7391421, DOI: 10.1016/s1474-4422(19)30393-x.Peer-Reviewed Original ResearchConceptsBlood pressure strataAntihypertensive medicationsBlood pressureRisk of dementiaIndividual participant dataIncident dementiaAlzheimer's diseaseDementia eventsDrug classesAging Intramural Research ProgramHigh blood pressure strataProspective community-based studyStudy-specific effect estimatesParticipant dataSpecific antihypertensive medicationsAlzheimer's Drug Discovery FoundationNormal blood pressureProspective cohort studyEligible observational studiesHigh blood pressureClinical Alzheimer's diseaseBurden of diseaseCommunity-based studyFuture clinical guidelinesCommunity-dwelling adults
2018
Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women
Adler TE, Usselman CW, Takamata A, Stachenfeld NS. Blood pressure predicts endothelial function and the effects of ethinyl estradiol exposure in young women. AJP Heart And Circulatory Physiology 2018, 315: h925-h933. PMID: 29906227, DOI: 10.1152/ajpheart.00188.2018.Peer-Reviewed Original ResearchMeSH KeywordsAdiposityAdministration, OralAdolescentAdultAntihypertensive AgentsArterial PressureBrachial ArteryDrug Administration ScheduleEndothelium, VascularEthinyl EstradiolExercise TestFemaleHand StrengthHumansHypertensionIschemiaObesityTime FactorsTreatment OutcomeVasodilator AgentsYoung AdultConceptsEthinyl estradiol administrationEndothelial functionBlood pressureEstradiol administrationEthinyl estradiol exposureEndothelial dysfunctionShear stress stimulusEndothelial impairmentEstradiol exposureHBP groupExercise responseNBP groupFlow-mediated dilation responseHigh blood pressure groupYoung womenIschemic handgrip exerciseOral ethinyl estradiolOvert cardiovascular dysfunctionBlood pressure groupFlow-mediated dilationNormal blood pressureHigh blood pressureMild hypertensionFMD responseHandgrip exerciseManagement of Pheochromocytoma in The Setting of Acute Stroke
Oak S, Javid M, Callender G, Carling T, Gibson C. Management of Pheochromocytoma in The Setting of Acute Stroke. AACE Clinical Case Reports 2018, 4: 245-248. PMID: 40191615, PMCID: PMC11969262, DOI: 10.4158/accr-2017-0077.Peer-Reviewed Original ResearchPeri-operative strokeNormal blood pressureTiming of surgeryCase of pheochromocytomaRare presenting symptomWeeks of treatmentPre-operative managementComputed tomography scanLaparoscopic transabdominal adrenalectomyWeeks of recoverySimilar casesAntihypertensive medicationsMedical blockadeMetaiodobenzylguanidine scanHemorrhagic transformationOrthostatic hypotensionPresenting symptomSevere hypertensionAcute strokeHemodynamic stabilityIschemic strokeOperative complicationsBlood pressureClinical courseTransabdominal adrenalectomy
2013
Reproducibility of ambulatory blood pressure changes from the initial values on two different days
Ash GI, Walker TJ, Olson KM, Stratton JH, Gómez AL, Kraemer WJ, Volek JS, Pescatello LS. Reproducibility of ambulatory blood pressure changes from the initial values on two different days. Clinics 2013, 68: 1509-1515. PMID: 24473508, PMCID: PMC3840371, DOI: 10.6061/clinics/2013(12)06.Peer-Reviewed Original ResearchConceptsAmbulatory BP changesAmbulatory BP monitorBP changesBlood pressureDay 1Day 2BP monitorAmbulatory blood pressure changesDiastolic BP changesNormal blood pressureAmbulatory blood pressureBlood pressure changesCardiovascular health outcomesAlerting reactionReproducibility of changesDifferent daysBP reactivityHealth outcomesHealthy adultsSame investigatorNext morningWomenMeasures analysisMenTotal sample
2005
Hypertension, age, and location predict rupture of small intracranial aneurysms.
Nahed BV, DiLuna ML, Morgan T, Ocal E, Hawkins AA, Ozduman K, Kahle KT, Chamberlain A, Amar AP, Gunel M. Hypertension, age, and location predict rupture of small intracranial aneurysms. Neurosurgery 2005, 57: 676-83; discussion 676-83. PMID: 16239879, DOI: 10.1227/01.neu.0000175549.96530.59.Peer-Reviewed Original ResearchConceptsUnruptured intracranial aneurysmsRisk factorsIntracranial aneurysmsSubarachnoid hemorrhageUnruptured aneurysmsMinimal long-term morbidityHistory of hypertensionNormal blood pressureLong-term morbidityTertiary medical centerAge of patientsAnterior circulation aneurysmsPosterior circulation aneurysmsSignificant risk factorsSignificant independent predictorsRupture of IAsMortality of treatmentLogistic regression modelsSmall intracranial aneurysmsHypertensive patientsIndependent predictorsPosterior circulationBlood pressureAneurysm characteristicsCurrent guidelines
2004
Renal and intestinal transport defects in Slc26a6-null mice
Wang Z, Wang T, Petrovic S, Tuo B, Riederer B, Barone S, Lorenz JN, Seidler U, Aronson PS, Soleimani M. Renal and intestinal transport defects in Slc26a6-null mice. American Journal Of Physiology - Cell Physiology 2004, 288: c957-c965. PMID: 15574486, DOI: 10.1152/ajpcell.00505.2004.Peer-Reviewed Original ResearchConceptsWild-type miceProximal tubulesSlc26a6-null miceHCO3- secretionKidney proximal tubulesApical membrane ClNull miceBaseline rateNormal blood pressureCl-/formate exchangeBlood pressureKidney functionElectrolyte profileMucosal tissuesIntestinal physiologyUssing chambersSmall intestineMiceFluid absorptionNaCl absorptionStatistical significanceCl-/HCO3NaCl transportDuodenumTubules
2000
Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.
Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.Peer-Reviewed Case Reports and Technical NotesConceptsArterial blood pressureBlood pressureWKY ratsSHR ratsMean arterial blood pressureNormal blood pressureLarge cerebral arteriesHypertensive SHR ratsNormotensive patientsHypertensive levelsAutoregulation curveHypertensive ratsBrain biopsyCerebral arteryCerebral hemorrhageExcessive hemorrhageIntracerebral hemorrhageMore hemorrhageNormotensive ratsEdema volumeNeedle biopsyLarge hemorrhageRodent modelsHemorrhageSodium nitroprusside
1998
Effect of Bradykinin-Receptor Blockade on the Response to Angiotensin-Converting–Enzyme Inhibitor in Normotensive and Hypertensive Subjects
Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ. Effect of Bradykinin-Receptor Blockade on the Response to Angiotensin-Converting–Enzyme Inhibitor in Normotensive and Hypertensive Subjects. New England Journal Of Medicine 1998, 339: 1285-1292. PMID: 9791144, DOI: 10.1056/nejm199810293391804.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBlood PressureBradykininBradykinin Receptor AntagonistsCaptoprilDiet, Sodium-RestrictedDrug InteractionsDrug Therapy, CombinationFemaleHumansHypertensionKidneyLosartanMaleReference ValuesRenin-Angiotensin SystemSingle-Blind MethodConceptsPlasma renin activityBlood pressureACE inhibitionHypertensive subjectsShort-term effectsRenin activitySpecific bradykinin receptor antagonistAngiotensin converting enzyme (ACE) inhibitorsAdministration of captoprilAdministration of losartanBradykinin receptor blockadeCoadministration of icatibantContribution of bradykininRenal hemodynamic responseNormal blood pressureRenin-angiotensin systemSeparate study daysBradykinin receptor antagonistDegradation of bradykininAntagonist losartanHypertensive personsHypotensive effectAngiotensin IIAngiotensin-ConvertingHemodynamic response
1996
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
Shesely E, Maeda N, Kim H, Desai K, Krege J, Laubach V, Sherman P, Sessa W, Smithies O. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 13176-13181. PMID: 8917564, PMCID: PMC24066, DOI: 10.1073/pnas.93.23.13176.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBlood PressureCattleChimeraDNA PrimersEndothelium, VascularFemaleGenotypeHeterozygoteHypertensionIsoenzymesKidneyLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide SynthasePolymerase Chain ReactionReninRNA, MessengerStem CellsTranscription, GeneticConceptsEndothelial nitric oxide synthaseBlood pressureNitric oxide synthaseHeart rateENOS proteinOxide synthaseENOS mutant miceLipopolysaccharide-induced deathElevated blood pressureNormal blood pressurePlasma renin concentrationBlood pressure regulationLower body weightKidney renin mRNAAnti-eNOS antibodiesAppropriate genetic controlsENOS locusENOS genotypesRenin concentrationVascular toneFemale miceRenin mRNAENOS geneENOS mutationBody weight
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