2025
A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 9: 716-729. PMID: 40044816, PMCID: PMC12092265, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasma
2013
Pharmacotherapy for Preeclampsia in Low and Middle Income Countries: An Analysis of Essential Medicines Lists
Lalani S, Firoz T, Magee LA, Sawchuck D, Payne B, Gordon R, Vidler M, von Dadelszen P. Pharmacotherapy for Preeclampsia in Low and Middle Income Countries: An Analysis of Essential Medicines Lists. Journal Of Obstetrics And Gynaecology Canada 2013, 35: 215-223. PMID: 23470109, DOI: 10.1016/s1701-2163(15)30993-2.Peer-Reviewed Original ResearchConceptsEssential Medicines ListAntihypertensive therapyMiddle-income countriesMedicines ListOral antihypertensive therapyParenteral antihypertensive therapyNational essential medicines listsEclampsia/preeclampsiaPrevalence of drugIncome countriesWorld Health OrganizationOral furosemidePreeclampsia complicationsLabor inductionPreterm birthPulmonary edemaParenteral dexamethasoneSodium nitroprussideCalcium gluconatePreeclampsiaTherapyHealth OrganizationMagnesium sulfateComprehensive managementPharmacotherapy
2012
Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans
Marczak ED, Marzec J, Zeldin DC, Kleeberger SR, Brown NJ, Pretorius M, Lee CR. Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans. Pharmacogenetics And Genomics 2012, 22: 620-628. PMID: 22668754, PMCID: PMC3599320, DOI: 10.1097/fpc.0b013e32835516e5.Peer-Reviewed Original ResearchConceptsForearm vascular resistanceForearm blood flowVariant allele carriersVasodilator responseSodium nitroprussideVascular functionAllele carriersStrain-gauge venous occlusion plethysmographyLower forearm blood flowEndothelial-independent mannerForearm vasodilator responseVenous occlusion plethysmographyWild-type individualsTranscription factor Nrf2Endothelial dysfunctionOcclusion plethysmographyVascular resistanceIncremental dosesCardiovascular diseaseBlood flowG genotypeA polymorphismSignificant associationBasal conditionsFactor Nrf2
2011
Estrogen enhances baroreflex sensitivity in women with low orthostatic tolerance
Wenner M, Taylor H, Haddadin A, Stachenfeld N. Estrogen enhances baroreflex sensitivity in women with low orthostatic tolerance. The FASEB Journal 2011, 25: 647.3-647.3. DOI: 10.1096/fasebj.25.1_supplement.647.3.Peer-Reviewed Original ResearchCardiovagal baroreflex sensitivityBaroreflex sensitivityLow orthostatic toleranceOrthostatic toleranceCumulative stress indexPlasma E2Endogenous sex hormone productionGnRH antagonist administrationBlood pressure responseSex hormone productionLower body negative pressure testBaseline BPAntagonist administrationBaroreflex functionSystolic BPE2 administrationOrthostatic intoleranceE2 conditionsBolus infusionHT womenNegative pressure testProgesterone concentrationsSodium nitroprussideGnRHaDay 5
2010
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With Forearm Vasodilator Responses in Humans
Lee CR, Pretorius M, Schuck RN, Burch LH, Bartlett J, Williams SM, Zeldin DC, Brown NJ. Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With Forearm Vasodilator Responses in Humans. Hypertension 2010, 57: 116-122. PMID: 21098312, PMCID: PMC3020911, DOI: 10.1161/hypertensionaha.110.161695.Peer-Reviewed Original ResearchConceptsForearm blood flowVariant allele carriersForearm vasodilator responseForearm vascular resistanceSoluble epoxide hydrolaseVascular resistanceVasodilator responseBlood flowAllele carriersSodium nitroprussideVascular functionStrain-gauge venous occlusion plethysmographyHighest forearm blood flowLower forearm vascular resistanceSignificant associationCytochrome P450-derived epoxyeicosatrienoic acidsEpoxide hydrolaseVenous occlusion plethysmographyCardiovascular disease riskEndothelium-independent mannerWild-type individualsOcclusion plethysmographyPotent vasodilatorEpoxyeicosatrienoic acidsPreclinical models
2008
Role of the NO-cGMP cascade in regulation of L-type Ca2+ currents in isolated cardiomyocytes
Grushin K, Nenov M, Dynnik V, Semushina S, Pakhomova I, Murashev A, Kokoz Y. Role of the NO-cGMP cascade in regulation of L-type Ca2+ currents in isolated cardiomyocytes. Biochemistry (Moscow), Supplement Series A: Membrane And Cell Biology 2008, 2: 243. DOI: 10.1134/s1990747808030082.Peer-Reviewed Original ResearchL-type Ca2NO-cGMP cascadeSodium nitroprussideVoltage-dependent L-type Ca2Basal L-type Ca2Inhibitory effectNO synthase blockerCombination of acetylcholineInhibition of amplitudeRat ventricular myocytesSynthase blockerEffect of arginineEffects of compoundsCyclic nucleotide systemVentricular myocytesBasal currentNitroprussideMM arginineMammalian cardiomyocytesPKG-dependent phosphorylationAcetylcholineExogenous NO sourcesInhibitionCGMP-dependent phosphorylationCa2
2007
The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance
Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ. The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance. Clinical Pharmacology & Therapeutics 2007, 83: 122-129. PMID: 17522594, DOI: 10.1038/sj.clpt.6100250.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanBlood Flow VelocityBlood PressureBradykininDose-Response Relationship, DrugFemaleForearmGene FrequencyGenotypeHumansInfusions, Intra-ArterialMaleNitroprussidePhenotypePolymorphism, GeneticReceptor, Bradykinin B2Regional Blood FlowVascular ResistanceVasodilator AgentsWhite PeopleConceptsSystolic blood pressureForearm vascular resistanceVascular resistanceBlood pressureEndothelium-independent agonist sodium nitroprussideEndothelium-dependent agonist bradykininIntrabrachial artery infusionsLeft ventricular massBradykinin B2 receptor geneB2 receptor geneNormotensive subjectsVentricular massPulse pressureB2 receptorsAgonist bradykininSodium nitroprussideReceptor geneBradykininGroupPolymorphismInfusionWhite AmericansNitroprussideBaselineBlack AmericansStem Cell Transplantation: The Lung Barrier
Schrepfer S, Deuse T, Reichenspurner H, Fischbein M, Robbins R, Pelletier M. Stem Cell Transplantation: The Lung Barrier. Transplantation Proceedings 2007, 39: 573-576. PMID: 17362785, DOI: 10.1016/j.transproceed.2006.12.019.Peer-Reviewed Original ResearchConceptsMesenchymal stem cellsSodium nitroprussideMesenchymal stem cell passagingIV injectionMesenchymal stem cell injectionIntravenous (IVAssessed in vitroFluorescence-labeled microspheresMesenchymal stem cell migrationPulmonary microvasculatureTransplantation strategiesSN injectionInjured organsLung sectionsMouse mesenchymal stem cellsMSCs in vitroMesenchymal lineagesStem cellsLungLung capillariesCell trappingDifferentiation capacityPulmonary capillariesCellsInjection
2004
Relationship Between Carbamoyl-Phosphate Synthetase Genotype and Systemic Vascular Function
Summar ML, Gainer JV, Pretorius M, Malave H, Harris S, Hall LD, Weisberg A, Vaughan DE, Christman BW, Brown NJ. Relationship Between Carbamoyl-Phosphate Synthetase Genotype and Systemic Vascular Function. Hypertension 2004, 43: 186-191. PMID: 14718356, DOI: 10.1161/01.hyp.0000112424.06921.52.Peer-Reviewed Original ResearchConceptsForearm blood flowNitric oxide metabolite concentrationsNitric oxide metabolitesBlood flowOxide metabolitesNitric oxide-mediated vasodilationVascular smooth muscle reactivityAllele homozygotesTissue-type plasminogen activator antigenSystemic vascular functionSmooth muscle reactivityPlasminogen activator antigenC allele homozygotesNitric oxide productionMetabolite concentrationsVasodilator responseBrachial arteryMuscle reactivityVascular functionHealthy subjectsBlood samplesSodium nitroprussideC alleleOxide productionCarbamoyl phosphate synthetase 1
2003
No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention
Resnic F, Wainstein M, Lee M, Behrendt D, Wainstein R, Ohno-Machado L, Kirshenbaum J, Rogers C, Popma J, Piana R. No-reflow is an independent predictor of death and myocardial infarction after percutaneous coronary intervention. American Heart Journal 2003, 145: 42-46. PMID: 12514653, DOI: 10.1067/mhj.2003.36.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPostprocedural myocardial infarctionStrong independent predictorMyocardial infarctionIndependent predictorsSodium nitroprussideInhospital outcomesCoronary interventionClinical outcomesSaphenous vein graft interventionIntracoronary vasodilator therapyVein graft interventionAdministration of verapamilAcute myocardial infarctionRate of deathInhospital mortalityVasodilator therapyCardiogenic shockBaseline demographicsGraft interventionUnstable anginaAdverse eventsConsecutive patientsIntracoronary verapamilInfarction
2002
Ethnicity Affects Vasodilation, but Not Endothelial Tissue Plasminogen Activator Release, in Response to Bradykinin
Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown NJ. Ethnicity Affects Vasodilation, but Not Endothelial Tissue Plasminogen Activator Release, in Response to Bradykinin. Arteriosclerosis Thrombosis And Vascular Biology 2002, 22: 1023-1028. PMID: 12067915, DOI: 10.1161/01.atv.0000017704.45007.1d.Peer-Reviewed Original ResearchConceptsForearm blood flowFibrinolytic functionSodium nitroprussideEffect of ethnicityAge-matched normotensive subjectsTissue plasminogen activator antigenTissue plasminogen activator releaseDoses of bradykininPlasminogen activator antigenPlasminogen activator releaseFBF responseVasodilator responseNormotensive subjectsBrachial arteryIndependent agonistsArterial samplesBlood flowAntigen releaseActivator releaseBradykininMethacholineAcetylcholineWhite AmericansNitroprussideBlack Americans
2001
NO Synthase Blockade Induces Chaotic Cerebral Vasomotion via Activation of Thromboxane Receptors
Lacza Z, Hermán P, Görlach C, Hortobágyi T, Sándor P, Wahl M, Benyó Z. NO Synthase Blockade Induces Chaotic Cerebral Vasomotion via Activation of Thromboxane Receptors. Stroke 2001, 32: 2609-2614. PMID: 11692025, DOI: 10.1161/hs1101.098526.Peer-Reviewed Original ResearchConceptsThromboxane receptorL-NACerebral vasomotionThromboxane receptor agonist URat middle cerebral arteriesIntact vesselsGuanylyl cyclase inhibitor 1HNitro-L-arginineMiddle cerebral arteryNO-cGMP pathwayNO donor sodium nitroprussideDonor sodium nitroprussideLack of NOSignificant vasomotionUTP administrationEndothelial dysfunctionSynthase blockadeAgonist UCerebral arteryVascular tensionCerebrovascular diseaseVascular toneCerebral vesselsSynthase inhibitionSodium nitroprussideInteractive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity
Gainer JV, Stein CM, Neal T, Vaughan DE, Brown NJ. Interactive Effect of Ethnicity and ACE Insertion/Deletion Polymorphism on Vascular Reactivity. Hypertension 2001, 37: 46-51. PMID: 11208755, DOI: 10.1161/01.hyp.37.1.46.Peer-Reviewed Original ResearchACE insertion/deletion polymorphismGreater vasodilator responseVasodilator responseACE D alleleSodium nitroprussideInsertion/deletion polymorphismVascular reactivityEndothelium-independent vasodilator sodium nitroprussideD allelePotent endothelium-dependent vasodilatorVascular smooth muscle reactivityACE I/D genotypeEffect of angiotensinForearm blood flowSmooth muscle reactivityEndothelium-dependent vasodilatorVasodilator sodium nitroprussideDeletion polymorphismTreatment of hypertensionACE gene locusVascular sensitivityNormotensive subjectsNormotensive blacksVenous plethysmographyBlood pressureSerotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition
Métais C, Bianchi C, Li J, Li J, Simons M, Sellke F. Serotonin-induced human coronary microvascular contraction during acute myocardial ischemia is blocked by COX-2 inhibition. Basic Research In Cardiology 2001, 96: 59-67. PMID: 11215533, DOI: 10.1007/s003950170078.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary VesselsCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsFemaleHeart AtriaHumansIsoenzymesMaleMembrane ProteinsMicrocirculationMiddle AgedMyocardial IschemiaMyocardiumNitric Oxide SynthaseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIINitroprussideProstaglandin-Endoperoxide SynthasesSerotoninSubstance PVasoconstrictionConceptsAcute myocardial ischemiaMyocardial ischemiaContractile responseCoronary arteriolesPotent contractile responseAcute coronary syndromeCOX-2 expressionCOX-2 inhibitionCOX-2 mRNAMicrovascular contractionSNP relaxationCoronary spasmCoronary syndromeL-NNACardiac surgeryAtherosclerotic patientsSubstance PNOS-2Prostaglandin releaseCOX-1IschemiaAtrial tissueSodium nitroprussideNOS-3Prostacyclin synthase
2000
Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ
Blasits S, Maune S, Santos-Sacchi J. Nitric oxide uncouples gap junctions of supporting Deiters cells from Corti's organ. Pflügers Archiv - European Journal Of Physiology 2000, 440: 710-712. PMID: 11007311, DOI: 10.1007/s004240000355.Peer-Reviewed Original ResearchConceptsDeiters' cellsCorti's organNO/cGMP pathwayNitric oxide donor sodium nitroprussideWhole-cell voltage-clamp conditionsNO synthase inhibitorUncouple gap junctionsNormal sensory functionDonor sodium nitroprussideGap junctionsVoltage-clamp conditionsOtotoxic mechanismsMinutes of applicationCGMP pathwayGap junctional communicationSodium nitroprussideSynthase inhibitorCochlear homeostasisSensory functionElectrical uncouplingNitric oxideCGMP analogJunctional communicationOrgansCellsTemporal Events Underlying Arterial Remodeling After Chronic Flow Reduction in Mice
Rudic R, Bucci M, Fulton D, Segal S, Sessa W. Temporal Events Underlying Arterial Remodeling After Chronic Flow Reduction in Mice. Circulation Research 2000, 86: 1160-1166. PMID: 10850968, DOI: 10.1161/01.res.86.11.1160.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarotid Artery, CommonCell DeathDrug CombinationsIn Vitro TechniquesMaleMiceMice, Inbred C57BLMuscle, Smooth, VascularNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IINitric Oxide Synthase Type IIIRegional Blood FlowTime FactorsTunica MediaVasodilator AgentsVasomotor SystemConceptsLeft common carotid arteryRight common carotid arteryCommon carotid arteryCarotid arteryBlood flowLeft external carotid arteryEndothelial NO synthase (eNOS) functionEndothelial NO synthase (eNOS) mRNAExternal carotid arteryNO synthase mRNANitrovasodilator sodium nitroprussideAcute ligationEndothelial dysfunctionArterial remodelingControl arteriesVascular remodelingAdult miceSodium nitroprussideDay 7Structural remodelingArteryLuminal remodelingMarked reductionProtein levelsMiceCerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.
Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.Peer-Reviewed Case Reports and Technical NotesConceptsArterial blood pressureBlood pressureWKY ratsSHR ratsMean arterial blood pressureNormal blood pressureLarge cerebral arteriesHypertensive SHR ratsNormotensive patientsHypertensive levelsAutoregulation curveHypertensive ratsBrain biopsyCerebral arteryCerebral hemorrhageExcessive hemorrhageIntracerebral hemorrhageMore hemorrhageNormotensive ratsEdema volumeNeedle biopsyLarge hemorrhageRodent modelsHemorrhageSodium nitroprusside
1999
Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension
Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann R, Sessa W. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. American Journal Of Physiology 1999, 277: g463-g468. PMID: 10444461, DOI: 10.1152/ajpgi.1999.277.2.g463.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsBenzoquinonesBlood VesselsHSP90 Heat-Shock ProteinsHypertension, PortalIn Vitro TechniquesLactams, MacrocyclicMaleMethoxamineMicrocirculationNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIIQuinonesRatsRats, Sprague-DawleySplanchnic CirculationTissue DistributionVasoconstrictor AgentsVasodilationVasodilator AgentsConceptsEndothelial nitric oxide synthasePortal vein ligationNitric oxide synthasePortal hypertensionMesenteric vasculatureOxide synthaseNormal animalsACh-dependent vasodilationExperimental portal hypertensionExcessive NO productionNO-dependent responsesNOS catalytic activityDependent vasodilationVein ligationVascular controlMesenteric circulationPVL animalsMesenteric vesselsHeat shock protein 90Sodium nitroprussideNO productionEndothelial liningHypertensionShock protein 90MethoxamineAttenuation of Endothelium-Dependent Dilation of Pig Pulmonary Arterioles After Cardiopulmonary Bypass Is Prevented by Monoclonal Antibody to Complement C5a
Park K, Tofukuji M, Metais C, Comunale M, Dai H, Simons M, Stahl G, Agah A, Sellke F. Attenuation of Endothelium-Dependent Dilation of Pig Pulmonary Arterioles After Cardiopulmonary Bypass Is Prevented by Monoclonal Antibody to Complement C5a. Anesthesia & Analgesia 1999, 89: 42-48.. DOI: 10.1213/00000539-199907000-00008.Peer-Reviewed Original ResearchConceptsNitric oxide synthasePulmonary endothelial dysfunctionCardiopulmonary bypassEndothelial dysfunctionMonoclonal antibodiesPulmonary arteriolesComplement C5aPrevious administrationConstitutive nitric oxide synthaseAnti-C5a monoclonal antibodyEndothelium-dependent dilatorsEndothelium-dependent dilationTissue myeloperoxidase activityNormothermic cardiopulmonary bypassReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionNeutrophil sequestrationMyeloperoxidase activityMPO activityPolymerase chain reactionSubstance POxide synthaseSodium nitroprussideComplement activationRelaxation responseBradykinin Stimulates Tissue Plasminogen Activator Release in Human Vasculature
Brown N, Gainer J, Stein C, Vaughan D. Bradykinin Stimulates Tissue Plasminogen Activator Release in Human Vasculature. Hypertension 1999, 33: 1431-1435. PMID: 10373228, DOI: 10.1161/01.hyp.33.6.1431.Peer-Reviewed Original ResearchConceptsForearm blood flowPlasminogen activator inhibitor antigenTissue plasminogen activator releaseDose-dependent increasePlasminogen activator releaseTPA releaseInhibitor antigenBlood flowActivator releaseMean arterial pressureStrain-gauge plethysmographyHuman vasculatureInfused armNormotensive volunteersArterial pressureVasodilator nitroprussidePlasma levelsTPA antigenHeart rateSystemic effectsSodium nitroprussideAcetylcholineBradykininNitroprussideRandom order
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