2025
Hypertension after solid-organ transplantation: special considerations for management
Feliberti J, Alam A, Maulion C. Hypertension after solid-organ transplantation: special considerations for management. Current Opinion In Cardiology 2025, 40: 193-198. PMID: 40401425, DOI: 10.1097/hco.0000000000001230.Peer-Reviewed Original ResearchConceptsBaroreflex activation therapySolid organ transplantationHeart transplantationRenal denervationGLP-1R agonistsGLP-1RActive therapyMedical managementMedical management of hypertensionTherapy of heart failureReinitiation of therapyAngiotensin-converting enzyme inhibitorsCalcium channel blockersAngiotensin receptor blockersCardiovascular outcome trialsGlucagon-like peptide-1 receptorOptimal medical managementIncidence of hypertensionManagement of hypertensionImmunosuppressive therapyRefractory hypertensionPeptide-1 receptorChannel blockersRenal transplantationReceptor blockers
2020
A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow
Usselman CW, Adler TE, Coovadia Y, Leone C, Paidas MJ, Stachenfeld NS. A recent history of preeclampsia is associated with elevated central pulse wave velocity and muscle sympathetic outflow. AJP Heart And Circulatory Physiology 2020, 318: h581-h589. PMID: 32004082, DOI: 10.1152/ajpheart.00578.2019.Peer-Reviewed Original ResearchConceptsMuscle sympathetic nerve activitySympathetic nerve activityArterial stiffnessBaroreflex sensitivityPreeclamptic womenUncomplicated pregnanciesNerve activityBlood pressureCardiovascular diseaseCentral pulse wave velocityCardiovagal baroreflex sensitivityElevated arterial stiffnessMuscle sympathetic outflowElevated cardiovascular riskHistory of preeclampsiaNormal blood pressurePeripheral arterial stiffnessSympathetic baroreflex sensitivitySympathetic nervous systemPulse wave velocityHigher MSNACardiovascular dysregulationSympathetic outflowCardiovascular riskNormal pregnancyIs There a Role for Device Therapies in Resistant Hypertension?: The CON Side.
Peixoto AJ. Is There a Role for Device Therapies in Resistant Hypertension?: The CON Side. Kidney360 2020, 1: 9-13. PMID: 35372851, PMCID: PMC8808493, DOI: 10.34067/kid.0000742019.Peer-Reviewed Original Research
2015
Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control
Rao A, Bonyhay I, Dankwa J, Baimas-George M, Kneen L, Ballatori S, Freeman R, Adler G. Baroreflex Sensitivity Impairment During Hypoglycemia: Implications for Cardiovascular Control. Diabetes 2015, 65: 209-215. PMID: 26438610, PMCID: PMC4686952, DOI: 10.2337/db15-0871.Peer-Reviewed Original ResearchConceptsR-R interval responsesAcute effectsBaroreflex sensitivity impairmentSystolic blood pressure thresholdModified Oxford methodBlood pressure thresholdsExposure to hypoglycemiaCardiovascular autonomic controlImpairs cardiovascular homeostasisEffects of hypoglycemiaInterval responsesBaroreflex activationSensitivity impairmentHealthy volunteersBaroreflex functionBaroreflex sensitivityCardiovascular effectsCardiovascular controlExperimental hypoglycemiaCardiovascular homeostasisClamp protocolHypoglycemiaEuglycemic conditionsAcute effects of hypoglycemiaVagal control
2014
Dysautonomic responses during percutaneous carotid intervention
Bujak M, Stilp E, Meller SM, Cal N, Litsky J, Setaro JF, Mena C. Dysautonomic responses during percutaneous carotid intervention. Catheterization And Cardiovascular Interventions 2014, 85: 282-291. PMID: 25131191, DOI: 10.1002/ccd.25622.Peer-Reviewed Original ResearchConceptsCarotid artery stentingPercutaneous carotid artery stentingPostganglionic sympathetic nerve activityNeuro-vascular complicationsSympathetic nerve activityLong-term outcomesCarotid atherosclerotic diseaseLong-term safetyAutonomic dysfunctionBaroreceptor stimulationPeriprocedural managementPeriprocedural periodArtery stentingNerve activityAtherosclerotic diseaseCarotid endarterectomyPrognostic significanceRetrospective studyCarotid sinusRisk factorsBalloon inflationInvasive alternativeProcedural experienceConsistent findingHomeostasis results
2013
Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol
Wenner MM, Haddadin A, Taylor HS, Stachenfeld NS. Mechanisms contributing to low orthostatic tolerance in women: the influence of oestradiol. The Journal Of Physiology 2013, 591: 2345-2355. PMID: 23401618, PMCID: PMC3650699, DOI: 10.1113/jphysiol.2012.247882.Peer-Reviewed Original ResearchConceptsLow orthostatic toleranceE2 administrationOrthostatic toleranceVascular resistanceBlood pressureStroke volumeHeart rateGonadotrophin-releasing hormone antagonistLevels of LBNPLower central volumeReproductive hormone productionAdministration of E2Peripheral vascular resistanceBeat blood pressureAutonomic cardiovascular regulationLower stroke volumeLower body negative pressure testHeart rate responseInfluence of oestradiolBaroreflex controlTolerant womenHormone antagonistCardiovascular regulationPeripheral vasoconstrictionAutonomic control
2008
Paroxysmal hypertension due to baroreflex failure
Zar T, Peixoto A. Paroxysmal hypertension due to baroreflex failure. Kidney International 2008, 74: 126-131. PMID: 18322544, DOI: 10.1038/ki.2008.30.Peer-Reviewed Original Research
2007
Preventing tomorrow's sudden cardiac death today Part I: Current data on risk stratification for sudden cardiac death
Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis A, Curtis J, Fain E, Gersh BJ, Gold MR, Haghighi-Mood A, Hammill SC, Healey J, Hlatky M, Hohnloser S, Kim RJ, Lee K, Mark D, Mianulli M, Mitchell B, Prystowsky EN, Smith J, Steinhaus D, Zareba W, conference F. Preventing tomorrow's sudden cardiac death today Part I: Current data on risk stratification for sudden cardiac death. American Heart Journal 2007, 153: 941-950. PMID: 17540194, DOI: 10.1016/j.ahj.2007.03.003.Peer-Reviewed Original ResearchConceptsSudden cardiac deathRisk stratificationCardiac deathHeart diseasePrevention of SCDLeft ventricular ejection fractionDuke Clinical Research InstituteOvert heart diseaseVentricular ejection fractionStructural heart diseaseHeart Rhythm SocietyClinical Research InstituteImplantable cardioverter defibrillatorCurrent dataEjection fractionSuch patientsSCD eventsCardioverter defibrillatorUS FoodDrug AdministrationPredictive valuePatientsDuke CenterClinical cardiologyEffective prevention
2001
The importance of the peripheral circulation in critical illnesses
Peters J, Mack G, Lister G. The importance of the peripheral circulation in critical illnesses. Intensive Care Medicine 2001, 27: 1446-1458. PMID: 11685337, DOI: 10.1007/s001340101034.Peer-Reviewed Original Research
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