2024
Cardiovascular and Cerebrovascular Adverse Events Associated with Intravitreal Anti-VEGF Monoclonal Antibodies A World Health Organization Pharmacovigilance Study
Yang J, Jung S, Kim M, Lee S, Yon D, Shin J, Lee J. Cardiovascular and Cerebrovascular Adverse Events Associated with Intravitreal Anti-VEGF Monoclonal Antibodies A World Health Organization Pharmacovigilance Study. Ophthalmology 2024, 132: 62-78. PMID: 39004231, DOI: 10.1016/j.ophtha.2024.07.008.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Drug Reaction Reporting SystemsAgedAngiogenesis InhibitorsAntibodies, Monoclonal, HumanizedBevacizumabCardiovascular DiseasesCerebrovascular DisordersDatabases, FactualFemaleHumansIntravitreal InjectionsMaleMiddle AgedOdds RatioPharmacovigilanceRanibizumabReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsVascular Endothelial Growth Factor AWorld Health OrganizationConceptsIntravitreal anti-VEGF treatmentAdverse drug reactionsAnti-VEGF treatmentAnti-VEGFAtrial fibrillationIntravitreal anti-VEGF therapyCerebral hemorrhageIndividual case safety reportsInter-drugReports of myocardial infarctionMyocardial infarctionDisproportionate Bayesian reportingIntravitreal anti-VEGFAnti-VEGF therapyCarotid artery stenosisIncreasing reportsHypertensive crisisCase-noncase studySupraventricular tachycardiaAtrial flutterSubarachnoid hemorrhageIntravitrealArtery stenosisAngina pectorisOdds ratio
2023
Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke
Sabbagh M, van Dyck C. Response to: Multiple Cerebral Hemorrhages in a Patient Receiving Lecanemab and Treated with t-PA for Stroke. New England Journal Of Medicine 2023, 388: 480-480. PMID: 36599073, DOI: 10.1056/nejmc2215907.Peer-Reviewed Original Research
2022
Epileptiform activity predicts epileptogenesis in cerebral hemorrhage
Kong THJ, Azeem M, Naeem A, Allen S, Kim JA, Struck AF. Epileptiform activity predicts epileptogenesis in cerebral hemorrhage. Annals Of Clinical And Translational Neurology 2022, 9: 1475-1480. PMID: 36030385, PMCID: PMC9463945, DOI: 10.1002/acn3.51637.Peer-Reviewed Original ResearchConceptsEpileptiform activitySubarachnoid hemorrhageRisk factorsRetrospective case-control studyNontraumatic intraparenchymal hemorrhagesDevelopment of epilepsyCase-control studyS scoresClinical seizuresAcute phaseCerebral hemorrhageIntraparenchymal hemorrhageHemorrhageSeizuresEpilepsyScoresEpileptogenesisPatientsActivityIntraparenchymal8 Mechanisms of Damage After Cerebral Hemorrhage
Aronowski J, Sansing L, Xi G, Zhang J. 8 Mechanisms of Damage After Cerebral Hemorrhage. 2022, 92-102.e9. DOI: 10.1016/b978-0-323-69424-7.00008-9.ChaptersIntracerebral hemorrhageBrain damageTreatment of ICHPathogenesis of ICHPre-clinical animal modelsIschemic brain injuryNeurovascular unitCerebral hemorrhageSecondary injuryBrain injuryAnimal modelsTherapeutic interventionsOxidative stressPromising targetHemorrhageInjuryMechanisms of damageNoxious componentsDamageInflammationPathogenesisPathobiologyBlood
2021
Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model
Zhou HJ, Qin L, Jiang Q, Murray KN, Zhang H, Li B, Lin Q, Graham M, Liu X, Grutzendler J, Min W. Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model. Nature Communications 2021, 12: 504. PMID: 33495460, PMCID: PMC7835246, DOI: 10.1038/s41467-020-20774-0.Peer-Reviewed Original ResearchConceptsCerebral cavernous malformationsCCM lesionsSmooth muscle actin-positive pericytesEndothelial cell lossRegions of brainCCM pathogenesisPost-capillary venulesCerebral hemorrhagePharmacological blockadeVascular abnormalitiesEC-specific deletionCavernous malformationsMouse modelCell lossMicrovascular bedGenetic deletionLesion formationLesionsVascular dynamicsBarrier functionMicrovascular structureTwo-photon microscopyTie2PathogenesisMice
2017
Neurology Concepts: Young Women and Ischemic Stroke—Evaluation and Management in the Emergency Department
Chang BP, Wira C, Miller J, Akhter M, Barth BE, Willey J, Nentwich L, Madsen T. Neurology Concepts: Young Women and Ischemic Stroke—Evaluation and Management in the Emergency Department. Academic Emergency Medicine 2017, 25: 54-64. PMID: 28646558, PMCID: PMC6415947, DOI: 10.1111/acem.13243.Peer-Reviewed Original ResearchConceptsIschemic strokeYoung womenEmergency departmentRisk factorsSex-specific risk factorsIschemic stroke evaluationAcute ischemic strokeOral contraceptive useBoard-certified emergency physiciansPremenopausal womenAcute settingBroad differentialCerebral hemorrhageStroke evaluationVascular neurologistsNonpregnant individualsPostpartum periodLeading causeEmergency physiciansTimely diagnosisContraceptive useThrombolytic agentsCurrent evidenceStrokeOlder population
2015
KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Cuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations. EMBO Molecular Medicine 2015, 8: 6-24. PMID: 26612856, PMCID: PMC4718159, DOI: 10.15252/emmm.201505433.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Morphogenetic Protein 6Cell ProliferationDisease Models, AnimalDisease ProgressionEndothelial CellsHEK293 CellsHemangioma, Cavernous, Central Nervous SystemHumansKRIT1 ProteinKruppel-Like Factor 4Kruppel-Like Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutMicrotubule-Associated ProteinsMitogen-Activated Protein Kinase 7MutationProto-Oncogene ProteinsRNA InterferenceSignal TransductionSmad1 ProteinTransforming Growth Factor betaConceptsKruppel-like factor 4Cerebral cavernous malformationsEndothelial cellsCavernous malformationsFamilial cerebral cavernous malformationsCentral nervous systemDouble knockout miceGrowth factor-beta/bone morphogenetic protein signalingCerebral hemorrhageMouse mortalityPharmacological treatmentCurrent therapiesVascular malformationsKnockout miceTherapeutic targetNervous systemMesenchymal transitionKLF4 transcriptional activityMalformationsCCM3 genesFactor 4Function mutationsEndMTMorphogenetic protein signalingBone morphogenetic protein (BMP) signaling
2013
Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin
Bakchoul T, Bassler D, Heckmann M, Thiele T, Kiefel V, Gross I, Arnold DM, DiTomasso J, Smith JW, Paes B, Greinacher A. Management of infants born with severe neonatal alloimmune thrombocytopenia: the role of platelet transfusions and intravenous immunoglobulin. Transfusion 2013, 54: 640-645. PMID: 23869512, DOI: 10.1111/trf.12336.Peer-Reviewed Original ResearchConceptsNeonatal alloimmune thrombocytopeniaSevere neonatal alloimmune thrombocytopeniaRandom donor plateletsPosttransfusion PLT countsIntravenous immunoglobulinPLT countPLT transfusionsPLT transfusion requirementsFirst-line treatmentLow PLT countHPA-1a alloantibodiesMajor bleedingTransfusion requirementsSevere complicationsCerebral hemorrhageCompatible plateletsIntracranial hemorrhageAlloimmune thrombocytopeniaFetomaternal incompatibilityTransfusionAffected newbornsNewbornsStudy designPlateletsHemorrhage
2012
Neuroradiology Critical Findings Lists: Survey of Neuroradiology Training Programs
Babiarz L, Trotter S, Viertel V, Nagy P, Lewin J, Yousem D. Neuroradiology Critical Findings Lists: Survey of Neuroradiology Training Programs. American Journal Of Neuroradiology 2012, 34: 735-739. PMID: 23042926, PMCID: PMC4332716, DOI: 10.3174/ajnr.a3300.Peer-Reviewed Original ResearchConceptsNeuroradiology fellowshipsNational Patient Safety GoalsPatient Safety GoalsE-mailJoint CommissionSafety goalsAcute strokeClinical judgmentComparative statisticsSurveyed directorsCritical resultsOtolaryngology departmentSpinal cord compressionFellowshipDepartmentRadiology departmentCord compressionProgramWorking areaListSurveyCerebral hemorrhageBrain herniationFrequent entityFinding lists
2010
Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack
Furie KL, Kasner SE, Adams RJ, Albers GW, Bush RL, Fagan SC, Halperin JL, Johnston SC, Katzan I, Kernan WN, Mitchell PH, Ovbiagele B, Palesch YY, Sacco RL, Schwamm LH, Wassertheil-Smoller S, Turan TN, Wentworth D. Guidelines for the Prevention of Stroke in Patients With Stroke or Transient Ischemic Attack. Stroke 2010, 42: 227-276. PMID: 20966421, DOI: 10.1161/str.0b013e3181f7d043.Peer-Reviewed Original ResearchMeSH KeywordsAnemia, Sickle CellAnticoagulantsAtherosclerosisCerebral HemorrhageEmbolismEvidence-Based MedicineFemaleForamen Ovale, PatentHeart DiseasesHumansHyperhomocysteinemiaIschemic Attack, TransientMalePlatelet Aggregation InhibitorsPregnancyPregnancy Complications, CardiovascularRecurrenceRisk FactorsStrokeThrombophiliaThrombosisConceptsTransient ischemic attackEvidence-based recommendationsIschemic attackIschemic strokeCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approaches
2009
Prior antiplatelet use does not affect hemorrhage growth or outcome after ICHSYMBOL
Sansing LH, Messe SR, Cucchiara BL, Cohen SN, Lyden PD, Kasner SE. Prior antiplatelet use does not affect hemorrhage growth or outcome after ICHSYMBOL. Neurology 2009, 72: 1397-1402. PMID: 19129506, PMCID: PMC2677505, DOI: 10.1212/01.wnl.0000342709.31341.88.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrainBrain EdemaCausalityCerebral HemorrhageDisease ProgressionDrug-Related Side Effects and Adverse ReactionsFemaleHumansIatrogenic DiseaseImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOutcome Assessment, Health CarePlatelet Aggregation InhibitorsProspective StudiesTomography, X-Ray ComputedTreatment OutcomeConceptsAntiplatelet medication useAntiplatelet medicationsIntracerebral hemorrhageSpontaneous intracerebral hemorrhageHemorrhage expansionMedication useClinical outcomesICH onsetHemorrhage growthTime of ICHVolume of ICHInitial ICH volumeIntracerebral hemorrhage onsetPrior antiplatelet usePlacebo-controlled trialRecent clinical trialsAssociation of useGrowth of ICHAntiplatelet useEdema growthOral anticoagulationRankin scorePlacebo armCerebral hemorrhageMultivariable analysis
2007
Sickle cell disease complicated by post‐streptococcal glomerulonephritis, cerebral hemorrhage and reversible posterior leucoencephalopathy syndrome
Pashankar FD, Ment LR, Pearson HA. Sickle cell disease complicated by post‐streptococcal glomerulonephritis, cerebral hemorrhage and reversible posterior leucoencephalopathy syndrome. Pediatric Blood & Cancer 2007, 50: 864-866. PMID: 17973321, DOI: 10.1002/pbc.21321.Peer-Reviewed Original ResearchConceptsReversible posterior leucoencephalopathy syndromeAcute post-streptococcal glomerulonephritisPost-streptococcal glomerulonephritisSickle cell diseaseCell diseaseHomozygous hemoglobin SS diseaseCentral nervous system eventsHemoglobin SS diseasePrimary cerebral infarctionNervous system eventsSickle cell nephropathyReversible causesCerebral infarctionCerebral hemorrhageIntracerebral hemorrhageSS diseaseHemorrhageDiseaseGlomerulonephritisPatientsPrognosisSyndromeHypertensionNephropathyComplications
2006
Prognostic indicators in cerebral venous sinus thrombosis.
Hameed B, Syed N. Prognostic indicators in cerebral venous sinus thrombosis. Journal Of The Pakistan Medical Association 2006, 56: 551-4. PMID: 17183990.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCerebral venous sinus thrombosisVenous sinus thrombosisSinus thrombosisRisk of recurrencePyramidal deficitsOverall prognosisFocal deficitsIntracranial hypertensionTranstentorial herniationVisual lossBetter prognosisCerebral hemorrhageWorse prognosisPrognostic indicatorMental statusFirst episodeCognitive impairmentPatientsFunctional independenceAge groupsPrognosisMajor causeLong termThrombosisStrongest predictorGuidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack
Sacco R, Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Schwamm L, Tomsick T. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack. Circulation 2006, 113: e409-49. PMID: 16534023, DOI: 10.1161/circ.113.10.e409.Peer-Reviewed Original ResearchConceptsTransient ischemic attackEvidence-based recommendationsIschemic strokeIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approachesGuidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack
Sacco R, Adams R, Albers G, Alberts M, Benavente O, Furie K, Goldstein L, Gorelick P, Halperin J, Harbaugh R, Johnston S, Katzan I, Kelly-Hayes M, Kenton E, Marks M, Schwamm L, Tomsick T. Guidelines for Prevention of Stroke in Patients With Ischemic Stroke or Transient Ischemic Attack. Stroke 2006, 37: 577-617. PMID: 16432246, DOI: 10.1161/01.str.0000199147.30016.74.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlcohol DrinkingAnti-Inflammatory Agents, Non-SteroidalBlood PressureBrain IschemiaClinical Trials as TopicComorbidityCoronary DiseaseDiabetes ComplicationsFemaleHumansHypertensionIschemic Attack, TransientMaleMiddle AgedObesityPrevalenceRiskRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokingStrokeUnited StatesConceptsTransient ischemic attackEvidence-based recommendationsIschemic strokeIschemic attackCerebral venous sinus thrombosisTimely evidence-based recommendationsUse of anticoagulationVenous sinus thrombosisPrevention of strokeHigh-risk populationSickle cell diseaseImplementation of guidelinesAntithrombotic treatmentRecurrent strokeSinus thrombosisNoncardioembolic strokePostmenopausal hormonesAntiplatelet agentsArterial dissectionHypercoagulable statePatent foramenAtherosclerotic diseaseCerebral hemorrhageRisk factorsInterventional approaches
2002
KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein
Gunel M, Laurans MS, Shin D, DiLuna ML, Voorhees J, Choate K, Nelson-Williams C, Lifton RP. KRIT1, a gene mutated in cerebral cavernous malformation, encodes a microtubule-associated protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 10677-10682. PMID: 12140362, PMCID: PMC125011, DOI: 10.1073/pnas.122354499.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAortaCattleCells, CulturedCentral Nervous System Vascular MalformationsChlorocebus aethiopsCOS CellsEndothelium, VascularGene ExpressionMicrotubule-Associated ProteinsMicrotubulesMitosisMolecular Sequence DataMutagenesisPrecipitin TestsProto-Oncogene ProteinsRadiographyTubulinConceptsCerebral cavernous malformationsCavernous malformationsCerebral cavernous malformation lesionsMicrotubule-associated proteinsProtein-1 alphaAutosomal dominant diseaseEndothelial tube formationCerebral hemorrhageCerebral capillariesEndothelial cellsDominant diseaseMalformationsTube formationPlus endsSite of cytokinesisSpindle pole bodyEvidence of interactionGene 1Possible roleCell-matrix interactionsKRIT1Late phaseEnds of microtubulesEndothelial cell shapePole body
2000
Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure.
Benveniste H, Kim K, Hedlund L, Kim J, Friedman A. Cerebral hemorrhage and edema following brain biopsy in rats: significance of mean arterial blood pressure. Journal Of Neurosurgery 2000, 92: 100-7. PMID: 10616088, DOI: 10.3171/jns.2000.92.1.0100.Peer-Reviewed Case Reports and Technical NotesConceptsArterial blood pressureBlood pressureWKY ratsSHR ratsMean arterial blood pressureNormal blood pressureLarge cerebral arteriesHypertensive SHR ratsNormotensive patientsHypertensive levelsAutoregulation curveHypertensive ratsBrain biopsyCerebral arteryCerebral hemorrhageExcessive hemorrhageIntracerebral hemorrhageMore hemorrhageNormotensive ratsEdema volumeNeedle biopsyLarge hemorrhageRodent modelsHemorrhageSodium nitroprusside
1996
A Founder Mutation as a Cause of Cerebral Cavernous Malformation in Hispanic Americans
Günel M, Awad I, Finberg K, Anson J, Steinberg G, Batjer H, Kopitnik T, Morrison L, Giannotta S, Nelson-Williams C, Lifton R. A Founder Mutation as a Cause of Cerebral Cavernous Malformation in Hispanic Americans. New England Journal Of Medicine 1996, 334: 946-951. PMID: 8596595, DOI: 10.1056/nejm199604113341503.Peer-Reviewed Original ResearchConceptsCavernous malformationsCerebral cavernous malformationsSporadic casesFamilial diseaseSame mutationSporadic cavernous malformationsDevelopment of symptomsHispanic AmericansCerebral hemorrhageVascular diseaseAsymptomatic carriersHigh prevalenceClinical casesMalformationsDiseaseFounder mutationPatientsAge dependenceAffected membersKindredsMarkersMexican descentEthnic groupsMutationsSame allele
1992
Cerebral Hemorrhage With Biopsy-Proved Amyloid Angiopathy
Yong W, Robert M, Secor D, Kleikamp T, Vinters H. Cerebral Hemorrhage With Biopsy-Proved Amyloid Angiopathy. JAMA Neurology 1992, 49: 51-58. PMID: 1728264, DOI: 10.1001/archneur.1992.00530250055016.Peer-Reviewed Original ResearchConceptsBiopsy specimensAcute clinical presentationComputed tomographic scanFocal neurological deficitsBrain biopsy specimensTransient ischemic attackBiopsy-provedClinical presentationRing enhancementLoss of consciousnessRadiological featuresImpending hemorrhageTomographic scanIntracerebral hemorrhageLobar hemorrhageNeurological deficitsBiopsy materialImmunohistochemical findingsImmunohistochemical studiesIntraparenchymal bleedingHemorrhageCerebral hemorrhageIschemic attackBrain hemorrhagePatients
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