2025
Evidence of secondary Notch signaling within the rat small intestine.
Zagoren E, Dias N, Santos A, Smith Z, Ameen N, Sumigray K. Evidence of secondary Notch signaling within the rat small intestine. Development 2025, 152 PMID: 40371707, PMCID: PMC12188240, DOI: 10.1242/dev.204277.Peer-Reviewed Original ResearchConceptsSecretory lineageRegulate luminal pHSecretory cellsNotch signalingSecretory cell typesSmall intestinal epithelial cellsRNA sequencing dataIntestinal epithelial cellsIntestinal stem cellsSmall intestineFate in vivoFibrosis pathophysiologyRat small intestineCrypt progenitorsTranscription factorsEpithelial cellsRat jejunumStem cellsPseudotime trajectory analysisRare populationLuminal pHRatsHigher expressionIntestinal functionIn vitro
2024
A plain language summary of the NefIgArd trial: Nefecon for the treatment of patients with immunoglobulin A nephropathy
Lafayette R, Kristensen J, Stone A, Floege J, Tesař V, Trimarchi H, Zhang H, Eren N, Paliege A, Reich H, Rovin B, Barratt J. A plain language summary of the NefIgArd trial: Nefecon for the treatment of patients with immunoglobulin A nephropathy. Future Rare Diseases 2024, 4: 2380247. DOI: 10.1080/23995270.2024.2380247.Peer-Reviewed Original ResearchA spatial expression atlas of the adult human proximal small intestine
Harnik Y, Yakubovsky O, Hoefflin R, Novoselsky R, Bahar Halpern K, Barkai T, Korem Kohanim Y, Egozi A, Golani O, Addadi Y, Kedmi M, Keidar Haran T, Levin Y, Savidor A, Keren-Shaul H, Mayer C, Pencovich N, Pery R, Shouval D, Tirosh I, Nachmany I, Itzkovitz S. A spatial expression atlas of the adult human proximal small intestine. Nature 2024, 632: 1101-1109. PMID: 39112711, DOI: 10.1038/s41586-024-07793-3.Peer-Reviewed Original ResearchConceptsExpression atlasSingle-molecule fluorescence in situ hybridizationLipid droplet assemblyAdult human gutFluorescence in situ hybridizationHuman proximal small intestineHuman small intestineHuman gutSpatial proteomicsProximal small intestineTip cellsGene expressionSmall intestineIron uptakeSpatial transcriptomicsVillus tip cellsImmune cell typesMouse small intestineCell typesDroplet assemblyImmunosuppressive rolePro-immunogenicAdult human small intestineT cellsZonated expressionDistraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome
O’Quin C, Clayton S, Trosclair L, Meyer H, Dao N, Minagar A, White L, Welch V, Solitro G, Alexander J, Sorrells D. Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome. Pathophysiology 2024, 31: 388-397. PMID: 39189165, PMCID: PMC11348226, DOI: 10.3390/pathophysiology31030029.Peer-Reviewed Original ResearchTreatment of short bowel syndromeIn vivo rat studyRat intestinal modelShort bowel syndromeSprague Dawley ratsSmall intestineParenteral nutritionBowel histologyBowel lengthDawley ratsLength-tension relationshipMucosal erosionsRat small intestineRat studiesBowel syndromeEx vivoRatsBowel tissueFailure loadPost-deploymentPatientsBowelHistologyLoad test dataIntestinal modelAir Versus Carbon Dioxide Insufflation Versus Water Immersion During Colonoscopy
Pleskow D, Erim T, Ketwaroo G. Air Versus Carbon Dioxide Insufflation Versus Water Immersion During Colonoscopy. 2024, 27-37. DOI: 10.1201/9781003523307-3.Peer-Reviewed Original ResearchSingle-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells
Gu W, Eke C, Santiago E, Olaloye O, Konnikova L. Single-cell atlas of the small intestine throughout the human lifespan demonstrates unique features of fetal immune cells. Mucosal Immunology 2024, 17: 599-617. PMID: 38555026, PMCID: PMC11384551, DOI: 10.1016/j.mucimm.2024.03.011.Peer-Reviewed Original ResearchImmune cellsDevelopment of mucosal immunityComplex immune landscapeFetal immune cellsSevere intestinal complicationsComplications of prematurityMemory T cellsAdaptive immune cellsMucosal immune cellsSmall intestineT cell statesMemory T cell statesStem-like propertiesNecrotizing enterocolitisNeonatal samplesMyeloid populationsImmune landscapeFetal samplesT cellsExpression of activationPostnatal samplesMucosal diseaseMucosal immunitySingle-cell RNA sequencingSingle-cell atlasEpithelial zonation along the mouse and human small intestine defines five discrete metabolic domains
Zwick R, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis C, McKinley K, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta A, Gartner Z, Locksley R, Gardner J, Itzkovitz S, Boffelli D, Klein O. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nature Cell Biology 2024, 26: 250-262. PMID: 38321203, PMCID: PMC11654995, DOI: 10.1038/s41556-023-01337-z.Peer-Reviewed Original ResearchConceptsDomain identityLipid metabolism-associated genesMetabolism-associated genesNutrient absorptionHuman small intestineResponse to dietary changesTranscription patternsMammalian small intestineMetabolic domainsSmall intestineStem cell populationCell populationsDistal positionIndefinite bordersZonationNutrient-derived signals regulate eosinophil adaptation to the small intestine
Kutyavin V, Korn L, Medzhitov R. Nutrient-derived signals regulate eosinophil adaptation to the small intestine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2316446121. PMID: 38271336, PMCID: PMC10835075, DOI: 10.1073/pnas.2316446121.Peer-Reviewed Original ResearchConceptsRetinoic acid signalingCrypt-villus axisLocalization signalTissue-specific adaptationsAcid signalingAmino acidsFunctional significanceTranscriptional signatureHomeostatic conditionsSmall intestineTissue microenvironmentType 2 immunityPurified amino acidsSignalAccumulationEffector cellsBone marrowIL-5Eosinophil accumulationSubpopulationsIntestineEffectorAdaptationHigh-protein dietAn Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice
Vossen C, Schmidt P, Wunderlich C, Mittenbühler M, Tapken C, Wienand P, Mirabella P, Cabot L, Schumacher A, Folz-Donahue K, Kukat C, Voigt I, Brüning J, Fenselau H, Wunderlich F. An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice. Cells 2024, 13: 102. PMID: 38201306, PMCID: PMC10778503, DOI: 10.3390/cells13010102.Peer-Reviewed Original ResearchConceptsEnteroendocrine cellsIntestinal epithelial cellsEEC subtypesCrypt-villus axisSmall intestineTerminal villiMouse linesTriple transgenic miceLargest endocrine organIntersectional genetic approachMature enteroendocrine cellsCre recombinase miceGastrointestinal motilityCell type-specific targetingEndocrine organHormonal secretionGastrointestinal tractGlucose metabolismMature subtypesIntestinal stem cellsFunctional readaptationTransgene expressionStop cassetteIEC typesMice
2023
Management of Bleeding Due to Small-Intestinal Angiodysplasias
Laine L. Management of Bleeding Due to Small-Intestinal Angiodysplasias. New England Journal Of Medicine 2023, 389: 1718-1720. PMID: 37913510, DOI: 10.1056/nejme2310338.Commentaries, Editorials and LettersGasdermin D licenses MHCII induction to maintain food tolerance in small intestine
He K, Wan T, Wang D, Hu J, Zhou T, Tao W, Wei Z, Lu Q, Zhou R, Tian Z, Flavell R, Zhu S. Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine. Cell 2023, 186: 3033-3048.e20. PMID: 37327784, DOI: 10.1016/j.cell.2023.05.027.Peer-Reviewed Original ResearchConceptsIntestinal epithelial cellsCleavage fragmentsSmall intestineCaspase-3/7 inhibitorRegulatory hubTolerance phenotypeN-terminal fragmentHost cellsDifferential cleavageCaspase-3/7Upper small intestineTranscription of CIITAGasdermin DEpithelial cellsMHCII deficiencyMHCII inductionDietary antigensTr1 cellsImmune toleranceProtective immunityFood toleranceForeign antigensMHCII moleculesMiceCellsSingle-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis
Egozi A, Olaloye O, Werner L, Silva T, McCourt B, Pierce R, An X, Wang F, Chen K, Pober J, Shouval D, Itzkovitz S, Konnikova L. Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis. PLOS Biology 2023, 21: e3002124. PMID: 37205711, PMCID: PMC10234541, DOI: 10.1371/journal.pbio.3002124.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingSingle-cell atlasEpithelial cellsCell identityRNA sequencingBulk transcriptomicsCellular dysregulationAberrant interactionsNeonatal small intestinePotential targetCellular changesBiomarker discoveryGastrointestinal complicationsPremature infantsProinflammatory macrophagesProinflammatory genesClonal expansionT cellsEndothelial cellsImmune interactionsIntestinal tissueCellsSmall intestineComprehensive viewNECCecal bascule in pregnancy: a case report and review of the literature
Kreinces J, Robbins A, Kim D. Cecal bascule in pregnancy: a case report and review of the literature. Journal Of Surgical Case Reports 2023, 2023: rjad287. PMID: 37234082, PMCID: PMC10206289, DOI: 10.1093/jscr/rjad287.Peer-Reviewed Original ResearchMagnetic resonance imagingCecal basculeRight upper quadrant abdominal painUpper quadrant abdominal painAbdominal magnetic resonance imagingQuadrant abdominal painAir-fluid levelsAbdominal painHospital coursePregnant patientsPrior surgeryAbdominal ultrasoundCesarean sectionAbdominal explorationWeeks' gestationSurgical interventionFirst diagnosisCase reportSmall intestineResonance imagingOperating roomSecond dayBasculePregnancyGestation
2022
Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury
Palikuqi B, Rispal J, Reyes E, Vaka D, Boffelli D, Klein O. Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury. Cell Stem Cell 2022, 29: 1262-1272.e5. PMID: 35931034, PMCID: PMC9387209, DOI: 10.1016/j.stem.2022.07.007.Peer-Reviewed Original ResearchConceptsLymphatic endothelial cellsIntestinal stem cellsCytotoxic injuryEndothelial cellsIntestinal stem cell nicheWnt signalingProliferation of intestinal stem cellsCrypt epithelial cellsSource of Wnt signalingNiche cellsEpithelial renewalProgenitor cellsIntestinal recoveryIntestinal repairEpithelial cellsNiche componentsStem cellsInjury statesIntestinal epitheliumInjurySecreted moleculesSmall intestineCellsRepairL-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL
Finotti M, Barahona M, Maina R, Lysyy T, Agarwal R, Schmitt P, Caturegli G, Di Renzo C, Anselmo A, Mulligan D, Geibel J, D'Amico F. L-ARGININE PREVENTS ISCHEMIC INJURY IN EXPLANTED RAT INTESTINAL REGIONS IN AN EX VIVO PERFUSION MODEL. Transplantation Reports 2022, 7: 100096. DOI: 10.1016/j.tpr.2022.100096.Peer-Reviewed Original ResearchIschemic injuryIntestinal segmentsIschemic damageIntraluminal perfusionNitric oxide-arginine pathwayMale Sprague-Dawley ratsN-nitroarginine methyl esterSprague-Dawley ratsEx vivo perfusion modelVivo perfusion modelNon-ischemic conditionsSmall intestinal segmentsFITC-inulinExtraluminal sideL-NAMEReperfusion injuryProtective effectL-arginineSmall intestinePerfusion modelInjuryIntestinal regionsFluid secretionReduced susceptibilityPerfusionSerum and Glucocorticoid‐Inducible Kinase 1 (SGK1): An Important Contributor to Diarrhea and Malabsorption in Microvillus Inclusion Disease (MVID)
Ahsan K, dos Reis D, Barbieri A, Sumigray K, Nottoli T, Salas P, Ameen N. Serum and Glucocorticoid‐Inducible Kinase 1 (SGK1): An Important Contributor to Diarrhea and Malabsorption in Microvillus Inclusion Disease (MVID). The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r5730.Peer-Reviewed Original ResearchMicrovillus inclusion diseaseGlucocorticoid-inducible kinase 1Severe diarrheaF miceInclusion diseaseCystic fibrosis transmembrane conductance regulatorFluid secretionWorsening of diarrheaMicrovillus inclusionsPhosphorylation of PDK1Kinase 1Intestinal lysatesSGK1 pathwayCarbohydrate malabsorptionER miceTamoxifen inductionBeta-ENaCDiarrheaDiarrheal diseaseSmall intestineMalabsorptionMiceDCKO miceGlucose lossPhosphorylation of SGK1Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement
Barrasso K, Chac D, Debela M, Geigel C, Steenhaut A, Seda A, Dunmire C, Harris J, Larocque R, Midani F, Qadri F, Yan J, Weil A, Ng W. Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement. ELife 2022, 11: e73010. PMID: 35343438, PMCID: PMC8993218, DOI: 10.7554/elife.73010.Peer-Reviewed Original ResearchConceptsGut microbesOutcome of infectionHuman intestinal microbiotaMurine small intestineUninfected personsEnteric infectionsDisease outcomeIntestinal microbiotaSmall intestineHuman gut microbesCommensal bacteriumEtiological agentOutcomesDiarrheal disease choleraInfectionDisease choleraRecent studiesAir-liquid interfaceBacterium altersBiofilm enhancementStoolIntestineTCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk
Bhat N, Esteghamat F, Chaube BK, Gunawardhana K, Mani M, Thames C, Jain D, Ginsberg HN, Fernandes‐Hernando C, Mani A. TCF7L2 transcriptionally regulates Fgf15 to maintain bile acid and lipid homeostasis through gut‐liver crosstalk. The FASEB Journal 2022, 36: e22185. PMID: 35133032, PMCID: PMC9624374, DOI: 10.1096/fj.202101607r.Peer-Reviewed Original ResearchConceptsGut-liver crosstalkBile synthesisDiet-induced fatty liver diseaseSmall intestineHepatic bile saltIntestinal lipid uptakePlasma bile saltsFatty liver diseaseTreatment of NASHColorectal cancer cellsBile saltsConditional knockout modelHuman NASHFatty liverLiver diseaseFXR activationClinical trialsEnterohepatic circulationTranscription factor TCF4Fl/Hepatic levelsBile acidsEndocrine regulatorLipid uptakeIntestinal epithelium17 Diseases of the gastrointestinal system
Szabo C, Tantawy H. 17 Diseases of the gastrointestinal system. 2022, 347-364. DOI: 10.1016/b978-0-323-71860-8.00026-4.Peer-Reviewed Original ResearchSmall intestine
2021
Lower Gastrointestinal Functional and Motility Disorders in Children
Arbizu R, Freiberg B, Rodriguez L. Lower Gastrointestinal Functional and Motility Disorders in Children. Pediatric Clinics Of North America 2021, 68: 1255-1271. PMID: 34736588, DOI: 10.1016/j.pcl.2021.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnorectal MalformationsBiopsyChildChild, PreschoolColonic DiseasesConstipationErythromycinFemaleGastrointestinal DiseasesGastrointestinal MotilityHirschsprung DiseaseHumansInfantIntestinal Pseudo-ObstructionIntestine, SmallLower Gastrointestinal TractMaleManometryNutritional StatusQuality of LifeConceptsMotility disordersSignificant morbidityTherapeutic interventionsColorectal disordersPediatric gastroenterologistsClinical presentationSmall bowelGastrointestinal disordersCommon complaintDiagnostic evaluationSmall intestineDisordersMorbidityComplicationsSuch interventionsInterventionSocial stigmaPoor qualityBowelAnorectumGastroenterologistsColonMortalityComplaintsIntestine
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply