2023
Dual organ transplantation: when heart alone is not enough
Nuqali A, Bellumkonda L. Dual organ transplantation: when heart alone is not enough. Current Opinion In Organ Transplantation 2023, 28: 370-375. PMID: 37582057, DOI: 10.1097/mot.0000000000001093.Peer-Reviewed Original ResearchConceptsDual-organ transplantationOrgan transplantationPatient selectionBetter long-term outcomesDual organ transplantsSingle organ transplantationTransplant center experienceLong-term outcomesAdvanced disease processLong-term managementPosttransplant outcomesCenter experienceImmunological advantageOrgan transplantsDisease processPartial toleranceSecond organPatientsTransplantationLack of standardizationOutcomesOrgansUrgent needTransplant
2022
Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications
Albert C, Bracaglia L, Koide A, DiRito J, Lysyy T, Harkins L, Edwards C, Richfield O, Grundler J, Zhou K, Denbaum E, Ketavarapu G, Hattori T, Perincheri S, Langford J, Feizi A, Haakinson D, Hosgood SA, Nicholson ML, Pober JS, Saltzman WM, Koide S, Tietjen GT. Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications. Nature Communications 2022, 13: 5998. PMID: 36220817, PMCID: PMC9553936, DOI: 10.1038/s41467-022-33490-8.Peer-Reviewed Original ResearchConceptsTargeted delivery applicationsTargeted nanoparticlesAntibody immobilizationAntigen-binding functionNanoparticlesNP surfaceDelivery applicationsRobust deliveryEndothelial cellsAmine couplingAntibody displayClinical translationIntracellular drug levelsVascular endothelial cellsCultured endothelial cellsNanomedicineDrug levelsVivo perfusionOrgan transplantsAdapterClinical settingHuman kidneyHuman settingImmobilizationEfficacyFactors Associated With COVID-19 Death in the United States: Cohort Study
Chen U, Xu H, Krause T, Greenberg R, Dong X, Jiang X. Factors Associated With COVID-19 Death in the United States: Cohort Study. JMIR Public Health And Surveillance 2022, 8: e29343. PMID: 35377319, PMCID: PMC9132142, DOI: 10.2196/29343.Peer-Reviewed Original ResearchConceptsCOVID-19-related deathsCohort studyPatient characteristicsElectronic health record data setsLarge national cohort studyNational cohort studyChronic respiratory diseasesProportional hazards modelCOVID-19COVID-19 deathsImmunosuppressive conditionsKidney functionMale sexLung cancerCOVID-19 casesRecent diagnosisRisk factorsRespiratory diseaseCardiac diseaseOrgan transplantsHigh incidenceHazards modelNeurological diseasesOlder ageDiseaseVaccination in pediatric solid organ transplant: A primer for the immunizing clinician
Chen JK, Cheng J, Liverman R, Serluco A, Corbo H, Yildirim I. Vaccination in pediatric solid organ transplant: A primer for the immunizing clinician. Clinical Transplantation 2022, 36: e14577. PMID: 34997642, DOI: 10.1111/ctr.14577.Peer-Reviewed Original ResearchConceptsVaccine-preventable illnessesPediatric solid organ transplant recipientsSolid organ transplant recipientsPediatric solid organ transplantCorrect immunization schedulesPrevention's Advisory CommitteeOrgan transplant recipientsSolid organ transplantsInfectious Diseases SocietyTime of transplantTransplant recipientsDiseases SocietyVaccine recommendationsIncomplete immunizationImmunization scheduleAntibody titersInadequate responseOrgan transplantsElevated riskPreventable illnessMultiple guidelinesVaccine managementRapid catchDisease controlAmerican Society
2021
Factors Associated With Access to and Receipt of Liver Transplantation in Veterans With End-stage Liver Disease
Kanwal F, Hernaez R, Liu Y, Taylor TJ, Rana A, Kramer JR, Naik AD, Smith D, Taddei T, Asch SM. Factors Associated With Access to and Receipt of Liver Transplantation in Veterans With End-stage Liver Disease. JAMA Internal Medicine 2021, 181: 949-959. PMID: 34028505, PMCID: PMC8145153, DOI: 10.1001/jamainternmed.2021.2051.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseAdvanced liver diseaseLiver diseaseLiver transplantationCohort studyMedical recordsOrgan transplantsVeterans Affairs Health Care SystemLower ratesRetrospective cohort studyWait-listed patientsAfrican American patientsComprehensive electronic medical recordsElectronic medical recordsHealth care systemReferral stepsLiver allograftsLiver transplantAdult patientsAlcohol etiologyLow annual incomePatient ageCurative therapyLiver cirrhosisSodium score
2020
Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing)
Briasoulis A, Akintoye E, Kuno T, Alvarez P. Characteristics and Outcomes of Patients Undergoing Combined Organ Transplantation (from the United Network for Organ Sharing). The American Journal Of Cardiology 2020, 129: 42-45. PMID: 32540168, DOI: 10.1016/j.amjcard.2020.05.034.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCardiomyopathy, DilatedCardiomyopathy, RestrictiveFemaleGraft RejectionHeart Defects, CongenitalHeart FailureHeart TransplantationHeart-Lung TransplantationHispanic or LatinoHumansKidney DiseasesKidney TransplantationLiver DiseasesLiver TransplantationLung DiseasesMaleMiddle AgedMortalityProportional Hazards ModelsRegistriesReoperationSurvival RateWhite PeopleConceptsHeart-liver transplantPrimary heart transplantationLong-term survivalHeart transplantationOrgan transplantsStage D heart failureD heart failureOutcomes of patientsOrgan Sharing registryLong-term outcomesCongenital heart diseaseAdult patientsMedian survivalHeart failureTransplantation ratesUnited NetworkList timeHeart diseaseOperative characteristicsOrgan transplantationSurvival analysisPatientsTransplantInverse probabilityStudy periodTemporal Trends and Outcomes of Patients Undergoing Combined Organ Transplantation: Insights from the United Network for Organ Sharing (UNOS)
Briasoulis A, Akintoye E, Alvarez P. Temporal Trends and Outcomes of Patients Undergoing Combined Organ Transplantation: Insights from the United Network for Organ Sharing (UNOS). The Journal Of Heart And Lung Transplantation 2020, 39: s167-s168. DOI: 10.1016/j.healun.2020.01.1126.Peer-Reviewed Original ResearchHeart-liver transplantPrimary heart transplantationLong-term survivalHeart transplantationUnited NetworkOrgan transplantsStage D heart failureD heart failureMethods Adult patientsOutcomes of patientsOrgan Sharing registryLong-term outcomesCongenital heart diseaseAdult patientsMedian survivalHeart failureTransplantation ratesList timeHeart diseaseOperative characteristicsOrgan transplantationOrgan SharingSurvival analysisPatientsTransplant
2019
Graft-Versus-Host Disease After Pancreatic Transplantation
Saffo S, Peng C, Kibbi N, Patel N, Robert ME, Adekolu E, Asch WS, Sanchez M. Graft-Versus-Host Disease After Pancreatic Transplantation. ACG Case Reports Journal 2019, 6: e00214. PMID: 31750381, PMCID: PMC6831153, DOI: 10.14309/crj.0000000000000214.Peer-Reviewed Original ResearchHost diseasePancreatic transplantationHematopoietic stem cell transplantationSolid organ transplantsStem cell transplantationAggressive immunosuppressionDiabetic womenGraft-VersusLiver transplantMultiorgan failureBiopsy findingsCommon complicationEndoscopic confirmationSmall bowelCell transplantationOrgan transplantsBone marrowTransplantationMinimal responseGVHDTransplantDiseaseImmunosuppressionBowelComplicationsClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: 1611-1615. PMID: 31506700, DOI: 10.1093/cid/ciz021.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: e83-e110. PMID: 30895288, DOI: 10.1093/cid/ciy1121.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomen
2017
Perceived changes in behavior and values after a red blood cell transfusion
Broccolo M, Favez N, Karam O. Perceived changes in behavior and values after a red blood cell transfusion. International Journal Of Clinical Transfusion Medicine 2017, 6: 1-5. DOI: 10.2147/ijctm.s155338.Peer-Reviewed Original ResearchVascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering
Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y. Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering. Biomaterials 2017, 147: 116-132. PMID: 28942128, PMCID: PMC5638652, DOI: 10.1016/j.biomaterials.2017.09.019.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsPluripotent stem cellsFunctional vascular smooth muscle cellsMassachusetts General Hospital miniature swineMuscle cellsSelf-assembly approachBiodegradable polyglycolic acid (PGA) scaffoldsPrimary vascular smooth muscle cellsSmooth muscle myosin heavy chainMuscle myosin heavy chainVascular tissue engineeringStem cellsTissue engineeringPolyglycolic acid scaffoldsReprogramming factorsVascular diseaseContractile functionVascular constructsImmunodeficient miceOrgan transplantsMiniature swinePreclinical investigationsGreat potentialMyosin heavy chainThe American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation
Levitsky J, Formica R, Bloom R, Charlton M, Curry M, Friedewald J, Friedman J, Goldberg D, Hall S, Ison M, Kaiser T, Klassen D, Klintmalm G, Kobashigawa J, Liapakis A, O’Conner K, Reese P, Stewart D, Terrault N, Theodoropoulos N, Trotter J, Verna E, Volk M. The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation. American Journal Of Transplantation 2017, 17: 2790-2802. PMID: 28556422, DOI: 10.1111/ajt.14381.Peer-Reviewed Original ResearchConceptsSolid organ transplantationOrgan transplantationHepatitis C viremic donorsHepatitis C virus infectionEnd-stage organ diseaseHCV-viremic organsHCV-viremic patientsProspective research protocolC virus infectionChronic HCV infectionAmerican SocietyViremic donorsViremic organsViremic recipientsHCV infectionHepatitis CTransplant waitlistMeeting of expertsOrgan diseaseVirus infectionOrgan transplantsYoung donorsAntiviral agentsConsensus conferenceTransplantationOutcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements
Aycart M, Alhefzi M, Sharma G, Krezdorn N, Bueno E, Talbot S, Carty M, Tullius S, Pomahac B. Outcomes of Solid Organ Transplants After Simultaneous Solid Organ and Vascularized Composite Allograft Procurements. Transplantation 2017, 101: 1381-1386. PMID: 27140518, PMCID: PMC6347371, DOI: 10.1097/tp.0000000000001262.Peer-Reviewed Original ResearchMeSH KeywordsAdultComposite Tissue AllograftsFacial TransplantationFemaleGraft SurvivalHumansMaleMiddle AgedOperative TimeOrgan TransplantationPostoperative ComplicationsRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTissue and Organ HarvestingTissue DonorsTreatment OutcomeUnited StatesYoung AdultConceptsGraft survival ratesSolid organsSurvival rateLiver recipientsTransplant recipientsAllograft procurementSolid organ allograftsSolid organ transplantsBrain-dead donorsLong-term outcomesShort-term resultsHeart recipientsIntraoperative parametersDonor surgeryOperative durationOrgan allograftsPostoperative outcomesScientific RegistryTransplantation outcomesPopulation of subjectsCase reportOperative characteristicsUnknown causeNationwide analysisOrgan transplantsCost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing
Hauser RG, Campbell SM, Brandt CA, Wang S. Cost-Effectiveness Study of Criteria for Screening Cerebrospinal Fluid To Determine the Need for Herpes Simplex Virus PCR Testing. Journal Of Clinical Microbiology 2017, 55: 1566-1575. PMID: 28298450, PMCID: PMC5405275, DOI: 10.1128/jcm.00119-17.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidHerpes simplex virus (HSV) central nervous system (CNS) infectionPCR testingCentral nervous system infectionCSF white blood cellsHSV PCR testingNervous system infectionLarge health care systemWhite blood cellsCost-effectiveness studiesHealth care systemDecision analysis modelHSV encephalitisCNS infectionSystem infectionHSV infectionAbsence of markersImmunocompetent hostsNecessary diagnostic testsOrgan transplantsPatient careDiagnostic testsBlood cellsCare systemPCR test
2016
Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction
Baghban A, Azar MM, Bernardo RM, Malinis M. Disseminated Mycobacterium tuberculosis following renal transplant with alemtuzumab induction. BMJ Case Reports 2016, 2016: bcr2016217998. PMID: 27852682, PMCID: PMC5129162, DOI: 10.1136/bcr-2016-217998.Peer-Reviewed Case Reports and Technical NotesConceptsMycobacterium tuberculosisDisseminated Mycobacterium tuberculosisIsoniazid preventative therapyHigh-risk patientsSolid organ transplantsOngoing risk factorsAlemtuzumab inductionDisseminated tuberculosisInduction immunosuppressionPeritransplant periodRenal transplantRenal transplantationPulmonary tuberculosisTuberculosis infectionPreventative therapyRisk factorsOrgan transplantsTuberculosisPatientsTransplantAvailable literatureImmunosuppressionTransplantationUnique challengesTherapyManagement of Complications of Acute Otomastoiditis in Solid Organ Transplant Patients.
Hildrew D, Adams A, Winters R, Aslam R. Management of Complications of Acute Otomastoiditis in Solid Organ Transplant Patients. Journal Of The Louisiana State Medical Society 2016, 168: 104-6. PMID: 27389380.Peer-Reviewed Original ResearchConceptsSolid organ transplantsAcute otomastoiditisSigmoid sinus thrombosisSinus thrombosisOrgan transplantsSolid organ transplant patientsCadaveric renal transplantsResidual neurologic deficitsAcute otitis mediaOrgan transplant patientsTympanostomy tube placementManagement of complicationsYear old manRenal transplantSystemic complicationsTransplant patientsAggressive treatmentNeurologic deficitsPrompt recognitionCortical mastoidectomyFatal sequelaeTube placementOtitis mediaCase reportEarly recognitionComplement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice
Qin L, Li G, Kirkiles-Smith N, Clark P, Fang C, Wang Y, Yu Z, Devore D, Tellides G, Pober J, Jane-Wit D. Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice. American Journal Of Transplantation 2016, 16: 2865-2876. PMID: 27104811, PMCID: PMC5075274, DOI: 10.1111/ajt.13834.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAllograft vasculopathyEndothelial cell activationReperfusion injuryCell activationComplement C5 inhibitionNuclear factor kappa BSolid organ transplantsT cell infiltrationTerminal complement activationVCAM-1 expressionComplement C5 activationFactor kappa BNeutrophil infiltrationHumanized miceDiffuse stenosisIntraluminal thrombosisArterial graftsC5 inhibitionCell infiltrationHumanized modelNeointimal hyperplasiaOrgan transplantsAlloantibodiesNF-kB
2015
Patients with Psychotic Disorders in Solid-Organ Transplant
Zimbrean P, Emre S. Patients with Psychotic Disorders in Solid-Organ Transplant. Progress In Transplantation 2015, 25: 289-296. PMID: 26645920, DOI: 10.7182/pit2015296.Peer-Reviewed Original ResearchConceptsPsychotic disordersOrgan transplantsTransplant candidatesComorbid conditionsMedical comorbid conditionsOutcomes of patientsType of transplantAssociated comorbid conditionsNumber of hospitalizationsSeverity of psychosisToxic effectsPosttransplant variablesTransplant recipientsAbsolute contraindicationClinical courseOrgan failureMedication adherenceOrgan recipientsPsychiatric hospitalizationPsychotic episodeWaiting listPatientsPsychotic patientsTransplantDescriptive study
2014
Incidence, Trends, and Diagnosis of Perioperative Acute Kidney Injury
Belcher J, Parikh C. Incidence, Trends, and Diagnosis of Perioperative Acute Kidney Injury. 2014, 3-14. DOI: 10.1007/978-1-4939-1273-5_1.Peer-Reviewed Original ResearchAcute kidney injuryAcute Kidney Injury NetworkKidney injuryKidney diseaseIncidence of AKIUnderstanding of AKIPerioperative acute kidney injuryPostoperative acute kidney injuryEnd-stage kidney diseaseException of patientsSolid organ transplantsIntensive care unitAKI incidenceAKI definitionAKI ratesNoncardiac surgeryPostoperative patientsCardiac surgeryCare unitEpidemiologic studiesOrgan transplantsMortality rateGlobal outcomeIncidenceInjury
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