2022
Response of enthesopathy in ENPP1 deficiency to enzyme replacement therapy in murine models and enthesopathy comorbidities and quality of life in ENPP1‐deficient adults
Ansh A, Nester C, O'Brien C, Stabach P, Murtada S, Lester E, Khursigara G, Molloy L, Carpenter T, Ferreira C, Braddock D. Response of enthesopathy in ENPP1 deficiency to enzyme replacement therapy in murine models and enthesopathy comorbidities and quality of life in ENPP1‐deficient adults. The FASEB Journal 2022, 36 DOI: 10.1096/fasebj.2022.36.s1.r5311.Peer-Reviewed Original ResearchENPP1 deficiencyQuality of lifeMusculoskeletal complicationsReplacement therapyBrief Pain Inventory-Short FormPhysical Function Short FormAchilles tendon calcificationHealth-related qualityMajority of patientsCervical spine fusionPresence of enthesopathyAnalgesic medicationRegular chowResidual painAdult patientsDose escalationPhysical functionCardiovascular calcificationTendon calcificationAchilles tendonSpine fusionMurine modelHypophosphatemic ricketsEnzyme replacementPatients
2020
Musculoskeletal Comorbidities and Quality of Life in ENPP1‐Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models
Ferreira CR, Ansh AJ, Nester C, O'Brien C, Stabach PR, Murtada S, Lester ER, Khursigara G, Molloy L, Carpenter TO, Braddock DT. Musculoskeletal Comorbidities and Quality of Life in ENPP1‐Deficient Adults and the Response of Enthesopathy to Enzyme Replacement Therapy in Murine Models. Journal Of Bone And Mineral Research 2020, 37: 494-504. PMID: 34882836, PMCID: PMC9667476, DOI: 10.1002/jbmr.4487.Peer-Reviewed Original ResearchConceptsENPP1 deficiencyAsj/Musculoskeletal complicationsBrief Pain Inventory-Short FormPhysical Function Short FormFibroblast growth factor 23Achilles tendon calcificationHealth-related qualityMajority of patientsGrowth factor 23Cervical spine fusionPresence of enthesopathyQuality of lifeAnalgesic medicationRegular chowResidual painAdult patientsDose escalationFactor 23Replacement therapyPhysical functionCardiovascular calcificationTendon calcificationAchilles tendonSpine fusionUse of recombinant human bone morphogenetic protein for revision cervical spine fusion in children with Down syndrome: a case series.
Cohen LL, Yang BW, O'Neill NP, Proctor MR, Glotzbecker MP, Hedequist DJ. Use of recombinant human bone morphogenetic protein for revision cervical spine fusion in children with Down syndrome: a case series. Journal Of Neurosurgery Pediatrics 2020, 25: 535-539. PMID: 32005018, DOI: 10.3171/2019.11.peds19622.Peer-Reviewed Original ResearchCervical spine fusionSpine fusionAtlantoaxial instabilityRecombinant human bone morphogenetic protein-2Postoperative complicationsCase seriesFirst case seriesLength of stayIliac crest boneSolid fusion massNeurological deteriorationCervical fusionLast radiographRetrospective reviewDural tearPosterior fusionPseudarthrosis rateSurgical dataHalo useRevision surgeryImplant revisionCrest boneDS populationInclusion criteriaRecombinant human bone morphogenetic protein
2019
Acute Implant-related Complications in Pediatric Cervical Spine Fusion
O’Neill N, Hresko MT, Emans JB, Glotzbecker MP, Verhofste BP, Karlin LI, Proctor MR, Hedequist DJ. Acute Implant-related Complications in Pediatric Cervical Spine Fusion. Journal Of Pediatric Orthopaedics 2019, 40: e662-e666. PMID: 31743291, DOI: 10.1097/bpo.0000000000001471.Peer-Reviewed Original ResearchConceptsImplant-related complicationsCervical fusionInstrumented cervical fusionsMonths of surgeryDay of surgeryCervical spine fusionLateral mass screwsComputed tomography (CT) imagingLate surgeryRetrospective reviewCase seriesMedian timeOverall incidenceSurgical revisionImplant complicationsSyndromic diagnosisDifferent etiologiesScrew protrusionSpine fusionCervical instrumentationIntraoperative useComplicationsLoeys-DietzAnterior plateAverage ageIntraoperative Use of O-arm in Pediatric Cervical Spine Surgery
Verhofste BP, Glotzbecker MP, Hresko MT, MacDougall RD, Birch CM, O’Neill N, Karlin LI, Emans JB, Proctor MR, Hedequist DJ. Intraoperative Use of O-arm in Pediatric Cervical Spine Surgery. Journal Of Pediatric Orthopaedics 2019, 40: e266-e271. PMID: 31192887, DOI: 10.1097/bpo.0000000000001416.Peer-Reviewed Original ResearchConceptsIntraoperative O-armCervical spine instrumentationO-armSpine instrumentationScrew positionPediatric cervical spine surgerySingle-center retrospective studyMean CT dose indexIntraoperative screw revisionsCervical spine surgeryVertebral artery injuryCervical spine fusionPostoperative CT scansDose-length productO-arm imagingCT dose indexFree-hand techniqueOptimal implant positionArtery injuryDural injuryNeurologic deficitsNeurovascular complicationsPediatric patientsPrimary outcomeFrequent indication
2007
The safety and utility of bone morphogenetic protein in anterior and posterior cervical-spine fusions
Lee R, White A, Grauer J. The safety and utility of bone morphogenetic protein in anterior and posterior cervical-spine fusions. Current Orthopaedic Practice 2007, 18: 270-275. DOI: 10.1097/bco.0b013e32810c00f6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCervical spine surgeryRecombinant human bone morphogenetic proteinHuman bone morphogenetic proteinAnterior cervical spine surgeryAutologous bone graft harvestPosterior cervical spine fusionBone morphogenetic proteinSoft tissue edemaProspective clinical studyCervical spine fusionHigh fusion rateBone graft harvestMorphogenetic proteinsLocal complicationsBone graft alternativesCervical fusionCohort studyBony unionCervical spineClinical studiesSurgical techniqueLumbar spineAppropriate dosePurpose of ReviewInterestLocal swelling
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