2025
Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches
Sahutoglu T, Perazella M. Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches. Kidney International Reports 2025, 10: 1643-1656. DOI: 10.1016/j.ekir.2025.03.050.Peer-Reviewed Original ResearchAcute tubulointerstitial nephritisAcute kidney injuryC-reactive proteinAcute kidney diseaseTubulointerstitial nephritisType IV hypersensitivity mechanismKidney diseaseAcute kidney injury etiologyTh2-mediated immune responsesSerum C-reactive proteinTriggered by medicationsTumor necrosis factor (TNF)-aInterleukin (IL)-9Urinary retinol-binding proteinT helper (Th)1T cell polarizationIrreversible kidney damageInflammatory endotypesImprove patient outcomesPrompt diagnosisKidney biopsyT cellsClinical featuresDiagnostic challengeImmune heterogeneityAssociation of dilated aortic root on point-of-care ultrasound with aortic aneurysm and dissection
Hesami M, Denkewicz R, Boivin Z, Bhalodkar S, Li J, Moore C. Association of dilated aortic root on point-of-care ultrasound with aortic aneurysm and dissection. The American Journal Of Emergency Medicine 2025, 95: 89-94. PMID: 40440820, DOI: 10.1016/j.ajem.2025.05.039.Peer-Reviewed Original ResearchThoracic aortic aneurysmThoracic aortic dissectionPoint-of-care ultrasound measurementsPoint-of-care ultrasoundPositive predictive valueAortic aneurysmEfficacy of point-of-care ultrasoundAccuracy of point-of-care ultrasoundDiagnostic accuracy of point-of-care ultrasoundCardiac point-of-care ultrasoundAssociated with thoracic aortic dissectionPredictive valueDilated aortic rootAssociated with thoracic aortic aneurysmAortic root measurementsLife-threatening conditionBland-Altman plotsChest CTAortic measurementsPrompt diagnosisAortic dissectionAortic rootDiagnostic accuracyPatientsMedical recordsClinical Aspects of Gestational Trophoblastic Disease
Clark M, Ratner E, Schwartz P. Clinical Aspects of Gestational Trophoblastic Disease. 2025, 253-260. DOI: 10.1007/978-3-031-83545-2_15.Peer-Reviewed Original ResearchMolar pregnancyRefractory to initial treatmentIntermediate trophoblastic tumorInvasive molar pregnancyGestational trophoblastic diseaseComplex clinical scenariosRate of regressionTrophoblastic tumorTrophoblastic diseasePrompt diagnosisInitial treatmentClinical entityClinical scenariosPregnancyCenters of excellenceDiseaseChoriocarcinomaImmunotherapySurgeryTumorDiagnosisSubarachnoid Haemorrhage
Busl K, Akkus S, Maciel C. Subarachnoid Haemorrhage. 2025, 225-242. DOI: 10.1093/med/9780198864714.003.0017.Peer-Reviewed Original ResearchSubarachnoid haemorrhageDegree of neurological impairmentDelayed cerebral ischaemiaCulprit aneurysmRescue therapyEarly complicationsPrompt diagnosisSystemic complicationsCardiac dysfunctionSevere headacheSurgical clippingRespiratory compromiseEndovascular interventionCerebral ischaemiaDay 4Improve outcomesNeurological impairmentInfluence outcomesNeuroprotective agentsComplicationsPatientsVariable degreesHæmorrhageTreatmentOutcomes
2024
Interstitial Lung Diseases and Non-Small Cell Lung Cancer: Particularities in Pathogenesis and Expression of Driver Mutations
Sampsonas F, Bosgana P, Bravou V, Tzouvelekis A, Dimitrakopoulos F, Kokkotou E. Interstitial Lung Diseases and Non-Small Cell Lung Cancer: Particularities in Pathogenesis and Expression of Driver Mutations. Genes 2024, 15: 934. PMID: 39062713, PMCID: PMC11276289, DOI: 10.3390/genes15070934.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseLung cancerLung diseaseDriver mutationsImproved survivalTreatment optionsChronic inflammationPathogenetic pathwaysNon-small cell lung cancerConcurrent interstitial lung diseaseCell lung cancerSites of chronic inflammationAnti-fibrotic medicationsCurrent treatment optionsIdiopathic pulmonary fibrosisDiseases associated with chronic inflammationIncidence of lung cancerPersonalized medicine approachPrompt diagnosisClinical entityNon-smallPulmonary fibrosisNSCLCSurvival ratePatientsUnforeseen and Immediate: A Case of a Post-Watchman Device-Related Thrombus
Sethi S, Stolear A, Dulgher M, Nwokeocha N, Mejia V, Shkolnik E. Unforeseen and Immediate: A Case of a Post-Watchman Device-Related Thrombus. Cureus 2024, 16: e63442. PMID: 39077225, PMCID: PMC11284824, DOI: 10.7759/cureus.63442.Peer-Reviewed Original ResearchDevice-related thrombusLeft atrial appendageOral anticoagulantsLAA occlusionLong-term oral anticoagulationAssociated with increased morbidityLeft atrial appendage occlusionHeparin dripPeriprocedural managementPrompt diagnosisThrombus resolutionSafety profileRare caseWatchman deviceArterial thromboembolismAtrial fibrillationAtrial appendageLeft atriumPersistent AFibAtrial sideRisk factorsBlood clot formationThrombusPatientsTherapeutic interventionsContemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemia
2023
Botulism mimicking Guillain‐Barre syndrome: The question of plasma exchange in an unusual case of acute paralysis
Campos J, Abels E, Rinder H, Tormey C, Jacobs J. Botulism mimicking Guillain‐Barre syndrome: The question of plasma exchange in an unusual case of acute paralysis. Journal Of Clinical Apheresis 2023, 38: 760-763. PMID: 37519071, DOI: 10.1002/jca.22081.Peer-Reviewed Original ResearchConceptsGuillain-Barré syndromeAcute flaccid paralysisFlaccid paralysisPlasma exchangeImmune-mediated polyradiculoneuropathyIntravenous immune globulinCranial nerve palsyGuillain-Barre syndromeCerebrospinal fluid analysisAppropriate therapeutic modalityCases of botulismAlbuminocytological dissociationNerve palsyRespiratory failureEmpiric administrationImmune globulinLaboratory featuresPrompt diagnosisIngestion/inhalationPoor outcomeAcute paralysisBotulinum toxinCommon causeTherapeutic modalitiesUnusual caseConsiderations on the Management of Acute Postoperative Ischemia After Cardiac Surgery: A Scientific Statement From the American Heart Association
Gaudino M, Dangas G, Angiolillo D, Brodt J, Chikwe J, DeAnda A, Hameed I, Rodgers M, Sandner S, Sun L, Yong C, Council O. Considerations on the Management of Acute Postoperative Ischemia After Cardiac Surgery: A Scientific Statement From the American Heart Association. Circulation 2023, 148: 442-454. PMID: 37345559, DOI: 10.1161/cir.0000000000001154.Peer-Reviewed Original ResearchConceptsPostoperative myocardial ischemiaCardiac surgeryMyocardial ischemiaRedo coronary artery bypassCoronary artery bypassLife-threatening complicationsPercutaneous coronary interventionAmerican Heart AssociationLow methodological qualityArtery bypassPostoperative ischemiaCoronary interventionPrompt diagnosisPostoperative careHeart AssociationClinical guidanceSurgical proceduresMethodological qualityCurrent evidenceSurgeryIschemiaMultidisciplinary groupDiagnosisScientific statementConservative strategyVulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report
Brioso X, Banks D, Christison-Lagay E, Phatak U, Vash-Margita A. Vulvovaginal Complaints as the First Manifestation of Crohn's Disease in Children: Case Report. Journal Of Pediatric And Adolescent Gynecology 2023, 36: 494-496. PMID: 37196754, DOI: 10.1016/j.jpag.2023.05.007.Peer-Reviewed Original ResearchConceptsCrohn's diseasePediatric gynecologistImprovement of symptomsGastrointestinal inflammatory conditionsChronic constipationPrompt diagnosisPediatric populationVulvar irritationPremenarchal femalesVulvar complaintsCase reportInflammatory conditionsFirst manifestationVulvovaginal complaintsClear diagnosisHigh indexDiseaseDiagnosisFirst signAnatomical changesGynecologistsComplaintsTreatmentChildrenPoor growthDelayed cancer diagnosis in the pregnant patient: navigating a complex medical and ethical dilemma
Revzin M, Solomon N, Langdon J, Czeyda-Pommersheim F, Menias C. Delayed cancer diagnosis in the pregnant patient: navigating a complex medical and ethical dilemma. Abdominal Radiology 2023, 48: 1599-1604. PMID: 36951988, DOI: 10.1007/s00261-023-03860-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsChronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy
Spadaro J, Chow R, Sinard J, Watsky K, Habib L. Chronic Lymphocytic Leukemia Presenting as Bilateral Periorbital Edema Treated With Low-dose Radiation Therapy. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: e78-e81. PMID: 36852835, DOI: 10.1097/iop.0000000000002338.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaLow-dose radiation therapyPeriorbital edemaRadiation therapyChronic Lymphocytic Leukemia PresentingBilateral periorbital edemaLeukemia cutisOcular involvementOcular manifestationsPrompt diagnosisBlood dyscrasiasCase reportNeoplastic lymphocytesLymphocytic leukemiaTissue infiltrationTherapeutic interventionsEdemaPatientsTherapyLeukemiaInfiltrationEcchymosisPresentingDyscrasiasLymphocytesEpstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case
Tabor J, Lei H, Morales-Valero S, O’Brien J, Gopal P, Erson-Omay E, Fulbright R, Moliterno J. Epstein-Barr virus–associated primary intracranial leiomyosarcoma in an immunocompetent patient: illustrative case. Journal Of Neurosurgery Case Lessons 2023, 5: case22532. PMID: 36692065, PMCID: PMC10550697, DOI: 10.3171/case22532.Peer-Reviewed Original ResearchEpstein-Barr virusPrimary intracranial leiomyosarcomaHuman immunodeficiency virusImmunocompetent statusImmunocompetent patientsIntracranial leiomyosarcomaMainstay of treatmentGross total resectionLeft-sided headacheSmooth muscle tumorsLeft middle cranial fossaMagnetic resonance imagingMiddle cranial fossaDura-based massUncomplicated resectionPrompt diagnosisTotal resectionAssociated edemaImmunodeficiency virusPoor prognosisMuscle tumorsRare diagnosisRare tumorImmunocompromised individualsPatientsImpact of the COVID-19 pandemic on treatment approaches of multiple myeloma
Theprungsirikul P, Neparidze N. Impact of the COVID-19 pandemic on treatment approaches of multiple myeloma. Medical Research Archives 2023, 11 DOI: 10.18103/mra.v11i6.3912.Peer-Reviewed Original ResearchMultiple myelomaCOVID-19 infectionHematologic malignanciesTreatment approachesCOVID-19 pandemicAutologous stem cell transplantCoronavirus disease-19 (COVID-19) patientsImmune therapy approachesCellular immune dysfunctionRefractory multiple myelomaManagement of patientsStem cell transplantClinical practice guidelinesCommon hematologic malignancySevere clinical outcomesEarly pandemic periodCOVID-19Stable diseaseMajor comorbiditiesSteroid regimensCytotoxic chemotherapySupportive careImmune dysfunctionPrompt diagnosisTreatment initiation
2022
The many faces and pathologic diagnostic challenges of autoimmune hepatitis
Zhang X, Jain D. The many faces and pathologic diagnostic challenges of autoimmune hepatitis. Human Pathology 2022, 132: 114-125. PMID: 35753409, DOI: 10.1016/j.humpath.2022.06.019.Peer-Reviewed Original ResearchConceptsAutoimmune hepatitisHistological featuresLiver diseaseAcute-onset autoimmune hepatitisDiagnosis of AIHEnd-stage liver diseaseChronic inflammatory liver diseasePathologic diagnostic challengeFatal liver failureInflammatory liver diseaseTypical histological featuresCareful clinicopathological correlationRoutine clinical practiceMajor differential diagnosisImmunosuppressive treatmentLiver histologySpecific autoantibodiesLiver failurePrompt diagnosisHistological presentationClinicopathological correlationInternational Working GroupPathological featuresDiagnostic challengeHistopathologic spectrumEmergency room imaging findings in patients presenting after COVID-19 vaccination
Solomon N, Sailer A, Patel A, Revzin MV. Emergency room imaging findings in patients presenting after COVID-19 vaccination. Journal Of Clinical Imaging Science 2022, 12: 33. PMID: 35769091, PMCID: PMC9235420, DOI: 10.25259/jcis_44_2022.Peer-Reviewed Original ResearchCOVID-19 vaccinationShortness of breathChest painSide effectsCommon presenting signs/symptomsRecent COVID-19 vaccinationVaccine-related complicationsCommon presenting symptomVertebral artery occlusionSigns/symptomsChest X-rayEmergency room patientsCOVID-19 vaccinePotential side effectsMagnetic resonance imagingInstitutional review boardSaddle embolusPresenting symptomVascular complicationsArtery occlusionAxillary adenopathyPrompt diagnosisVascular findingsChief complaintClinical presentationSystematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome
Adjei NN, Lynn AY, Grimshaw A, Brault MA, Dugan K, Vash-Margita A. Systematic Literature Review of Pediatric Male and Female Genital Hair Thread Tourniquet Syndrome. Pediatric Emergency Care 2022, 38: e799-e804. PMID: 35100779, DOI: 10.1097/pec.0000000000002383.Peer-Reviewed Original ResearchConceptsHair-thread tourniquet syndromeTourniquet syndromeAdolescent health care providersSystematic literature reviewHealth care providersEmergency medicine physiciansLiterature reviewUrinary symptomsSerious sequelaeAnesthetic typePrompt diagnosisFemale patientsGeneral anesthesiaAdolescent patientsFemale casesMale casesMAIN OUTCOMECare providersMedicine physiciansNational guidelinesAverage agePrevention strategiesPediatric malesLabia minoraPatient care
2021
Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis
Cattamanchi A, Reza T, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete P, Handley M, Ackerman S, Joloba M, Moore D, Davis J, Dowdy D, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. New England Journal Of Medicine 2021, 385: 2441-2450. PMID: 34936740, PMCID: PMC9212879, DOI: 10.1056/nejmoa2105470.Peer-Reviewed Original ResearchConceptsSame-day treatmentSame-day diagnosisHealth centersMolecular testingTuberculosis testingHuman immunodeficiency virus (HIV) infectionDiagnostic strategiesImmunodeficiency virus infectionCommunity health centersCluster-randomized trialTreatment of tuberculosisSecondary outcomesMore patientsPrimary outcomePrompt diagnosisRoutine careEligible adultsIntervention groupIntervention periodHigh burdenVirus infectionIntervention centersControl groupPatientsTuberculosisGlobal estimates of paediatric tuberculosis incidence in 2013–19: a mathematical modelling analysis
Yerramsetti S, Cohen T, Atun R, Menzies NA. Global estimates of paediatric tuberculosis incidence in 2013–19: a mathematical modelling analysis. The Lancet Global Health 2021, 10: e207-e215. PMID: 34895517, PMCID: PMC8800006, DOI: 10.1016/s2214-109x(21)00462-9.Peer-Reviewed Original ResearchConceptsPediatric tuberculosisTuberculosis incidenceStudy periodIncident tuberculosis casesTuberculosis incidence rateReporting systemHigh-burden settingsGlobal tuberculosis burdenTuberculosis natural historyPediatric incidenceInfectious exposurePrompt diagnosisSubstantial morbidityTuberculosis burdenTuberculosis casesIncidence rateRisk factorsCase detectionGlobal incidenceProbability of infectionInfected individualsAge groupsNatural historyTuberculosisIncidence
2020
Clinical presentation of hereditary angioedema.
Azmy V, Brooks JP, Hsu FI. Clinical presentation of hereditary angioedema. Allergy & Asthma Proceedings 2020, 41: s18-s21. PMID: 33109320, DOI: 10.2500/aap.2020.41.200065.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHereditary angioedemaHAE attacksSevere abdominal painHalf of patientsAutosomal dominant diseaseC1 inhibitor proteinLaryngeal angioedemaOropharyngeal swellingAbdominal attacksAbdominal painErythema marginatumSignificant hypotensionLaryngeal edemaPrompt diagnosisClinical presentationMinor traumaSignificant morbiditySubmucosal edemaBowel soundsPhysical examinationRecurrent episodesGenitourinary tractFrequent precipitantUnpredictable severityVariable presentation
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