2025
Early Aortic Valve Replacement Versus Conservative Management: A Meta-Analysis of Randomized Controlled Trials
Shah T, Shah Y, Lansky A, Giri J, Fanaroff A, Nathan A. Early Aortic Valve Replacement Versus Conservative Management: A Meta-Analysis of Randomized Controlled Trials. Structural Heart 2025, 9: 100461. PMID: 40599390, PMCID: PMC12207225, DOI: 10.1016/j.shj.2025.100461.Peer-Reviewed Original Research
2023
Clinical Impact of Standardized TAVR Technique and Care Pathway Insights From the Optimize PRO Study
Grubb K, Gada H, Mittal S, Nazif T, Rodés-Cabau J, Fraser D, Lin L, Rovin J, Khalil R, Sultan I, Gardner B, Lorenz D, Chetcuti S, Patel N, Harvey J, Mahoney P, Schwartz B, Jafar Z, Wang J, Potluri S, Vora A, Sanchez C, Corrigan A, Li S, Yakubov S. Clinical Impact of Standardized TAVR Technique and Care Pathway Insights From the Optimize PRO Study. JACC Cardiovascular Interventions 2023, 16: 558-570. PMID: 36922042, DOI: 10.1016/j.jcin.2023.01.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementPermanent pacemaker implantationCusp-overlap techniqueCare pathwaysPRO studiesAortic regurgitationSevere ARClinical outcomesThoracic Surgeons Predicted Risk of MortalityThoracic Surgeons Predicted RiskRisk of permanent pacemaker implantationPermanent pacemaker implantation rateSevere symptomatic aortic stenosisEarly dischargeRight bundle branch blockAortic valve replacementMedian length of stayResidual aortic regurgitationSymptomatic aortic stenosisPredicted risk of mortalitySelf-expanding valveBundle branch blockRisk of mortalityLength of stayHospital readmission
2022
Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis
Yousef S, Amabile A, Ram C, Singh S, Agarwal R, Milewski R, Assi R, Patel P, Krane M, Geirsson A, Vallabhajosyula P. Direct relationship between transvalvular velocity and cardiac dysfunction, morbidity, and mortality in patients with aortic stenosis. Journal Of Cardiac Surgery 2022, 37: 5052-5062. PMID: 36378856, DOI: 10.1111/jocs.17199.Peer-Reviewed Original ResearchConceptsDegree of ASCardiac structural changesAortic stenosisSevere symptomatic aortic stenosisEnd-organ morbiditiesStructural cardiac changesSymptomatic aortic stenosisEnd-organ diseaseKaplan-Meier curvesRisk of mortalityTransvalvular flow velocityCochran-Armitage testCause mortalityPatient characteristicsCardiac changesCardiac dysfunctionPatient morbidityTransvalvular velocityCurrent guidelinesGroup BGroup ACaucasian raceHigh riskCox modelEarly interventionImaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease
Ahmad Y, Agarwal V, Williams M, Wang D, Reardon M, Cavalcante J, Makkar R, Forrest J. Imaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100506. PMID: 39132366, PMCID: PMC11307905, DOI: 10.1016/j.jscai.2022.100506.Peer-Reviewed Original ResearchAortic valve replacementTranscatheter aortic valve replacementBicuspid aortic valve diseaseAortic valve diseaseValve replacementValve diseaseBAV diseaseSevere symptomatic aortic stenosisSurgical aortic valve replacementPivotal randomized trialsAortic valve surgerySymptomatic aortic stenosisRandomized clinical trialsValve surgeryHeart teamAortic stenosisSurgical riskPatient selectionRandomized trialsBicuspid valveSurgical approachTreatment optionsClinical trialsPatientsDiseaseSelf-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients
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McDermott M, Menees D, Pace R, Patel H, Prager R, Ramchandren S, Romano M, Stamper A, Wang M, Zahuranec D, Ziarkiewicz M, Charlebois C, Chilton C, Labinaz M, Ruel M, Glover C, Lam K, Masters R, Steffenhagen N, Enlow-Germovsek M, Konopka K, McGargle R, Travis M, Anderson K, Cavalcante J, Crock F, Edelman K, Katz W, Gleason T, Lee J, Sultan I, Aghaebrahim A, Al-Bayai A, Bonaccorsi C, Campbell D, Giurgiutiu D, Gulati D, Hawkes C, Henry L, Jadhav A, Kenmuir C, Klein B, Kliner D, Limaye K, Nanduri S, Navid F, Patel P, Rangaraju S, Rocha M, Schindler J, Shoirah H, Streib C, Tadi P, Tememe D, Totoraitis R, Walker G, Ziayee H, Caufield L, Yeager C, Forbes J, Schwart K, Knight P, Ling F, Benesch C, Bogachan S, Hicks G, Kelly A, Narins C, Stuver T, Adams K, Blair-Anton L, Haynes M, Watts C, Baker M, Mendes L, Ball S, Goel K, Kaiser C, Robbins M, Zhao D, Ahmad R, Crenshaw M, Fredi J, Hermann L, Hoff S, Kirshner H, Levack M, Mittal S, O'Duffy A, Petracek M, Baer J, Liang G, Nguyen S, Heidenreich P, Nguyen P, Burdon T, Giacomini J, Yong C, Buchbinder M, Fann J, Kilgore S, Mitchell R, McDaniel S, Pack A, White W, Young T, Burgess P, Pu M, Upadhya B, Applegate R, Kon N, Arnan M, Baghshomali S, Bishop L, Bradbury E, Gandhi S, Kincaid E, Lefkowitz D, Lisle B, Batteria M, Rerisi E, Stepinowski K, Senicola T, Goncalves J, Schubach S, Schwartz R, Antaky K, Christiansen C, Marzo K, Michel K, Misra A, Varghese P, Wirkowski E, Levesque L, Sugeng L, Cleman M, Forrest J, Hashim S, Mangi A, Amin H, Darr U, Dewar M, Faheem O, Geirsson A, Greer D, Kaleel A, Kaple R, Lansky A, MacGrory B, Pfau S, Schindler J, Thompson C, Youn T, Yuh D, Yun J. Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients. JAMA Cardiology 2022, 7: 1000-1008. PMID: 36001335, PMCID: PMC9403849, DOI: 10.1001/jamacardio.2022.2695.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSevere aortic valve stenosisIntermediate-risk patientsAortic valve stenosisValve replacementAdverse eventsAortic stenosisValve stenosisParavalvular leakClinical trialsIndependent echocardiographic core laboratorySurgical aortic valve replacementSymptomatic severe aortic stenosisIndependent clinical events committeePrespecified secondary end pointsEchocardiographic core laboratoryIntermediate surgical riskIntermediate-risk subjectsLocal heart teamSecondary end pointsSerious adverse eventsSevere aortic stenosisSymptomatic aortic stenosisAortic valve areaPeripheral access size evaluation in transfemoral transcatheter aortic valve replacement
Hameed I, Oakley CT, Hameed NUF, Jiang Y, Naeem N, Morsi M, Ahmed A, Amabile A, Hirji S, Truong QA, Gaudino M, Kaneko T, Salemi A. Peripheral access size evaluation in transfemoral transcatheter aortic valve replacement. Journal Of Cardiac Surgery 2022, 37: 801-807. PMID: 35137971, DOI: 10.1111/jocs.16293.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementMinimal luminal diameterBody mass indexAortic valve replacementPeripheral vascular diseaseAccess vessel sizeFemoral arteryValve replacementInguinal ligamentVascular diseaseOutcomes of TAVRTransfemoral transcatheter aortic valve replacementPatient's individual risk factorsMean body mass indexContrast-enhanced CTATomography Angiography AssessmentSymptomatic aortic stenosisChronic kidney diseaseCommon iliac arteryCoronary artery diseaseHigh-volume centersDeep femoral arteryTranscatheter heart valveGeneral patient populationIndividual risk factors
2020
Transcatheter vs surgical aortic valve replacement in patients with interstitial lung disease
Hirji S, Cote C, Lee J, Kiehm S, McGurk S, Pelletier M, Aranki S, Shekar P, Shah P, Kaneko T. Transcatheter vs surgical aortic valve replacement in patients with interstitial lung disease. Journal Of Cardiac Surgery 2020, 35: 571-579. PMID: 31981435, DOI: 10.1111/jocs.14421.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementInterstitial lung diseaseAortic valve replacementTranscatheter aortic valve replacement patientsIntensive care unitSurgical aortic valve replacement patientsInterstitial lung disease patientsShorter ventilation timeValve replacementOperative mortalityAortic stenosisVentilation timeLung diseaseRisk of postoperative pulmonary complicationsIsolated surgical aortic valve replacementDiagnosis of interstitial lung diseaseAssociated with significantly shorter hospitalRate of postoperative strokeIntensive care unit admissionPostoperative pulmonary complicationsSignificantly shorter hospitalSevere aortic stenosisPermanent pacemaker implantationSymptomatic aortic stenosisChapter 41 Embolic protection devices for stroke prevention during cardiac interventions
Ghare M, Zhou S, Tirziu D, Lansky A. Chapter 41 Embolic protection devices for stroke prevention during cardiac interventions. 2020, 941-960. DOI: 10.1016/b978-0-12-813704-8.00041-3.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationAortic stenosisSevere symptomatic aortic stenosisSurgical aortic valve replacementSymptomatic aortic stenosisAortic valve replacementHigh-risk patientsPrevention of strokeAortic valve implantationEmbolic protection devicesNeurologic eventsStroke preventionDevastating complicationIntermediate riskNeurologic injuryValve implantationValve replacementAdjunctive pharmacotherapyStroke rateCurrent evidenceTranscatheter proceduresCardiac interventionsPatientsStrokePreventionAdjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
Saito Y, Nazif T, Baumbach A, Tchétché D, Latib A, Kaple R, Forrest J, Prendergast B, Lansky A. Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. JAMA Cardiology 2020, 5: 92-101. PMID: 31721980, DOI: 10.1001/jamacardio.2019.4367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAdjunctive antithrombotic therapyDual antiplatelet therapyAntithrombotic therapyAntiplatelet therapyValve replacementAortic stenosisAortic stenosis (AS) undergoing transcatheter aortic valve replacementSevere symptomatic aortic stenosisSurgical aortic valve replacementGuideline-recommended regimenOral anticoagulant useSevere aortic stenosisSingle antiplatelet therapySymptomatic aortic stenosisPatient risk factorsOngoing clinical trialsRisk prediction modelMajor bleedingOral anticoagulationAnticoagulant useStroke riskTAVR proceduresThrombotic risk
2019
Should All Low-risk Patients Now Be Considered for TAVR? Operative Risk, Clinical, and Anatomic Considerations
Siddique S, Gada H, Mumtaz M, Vora A. Should All Low-risk Patients Now Be Considered for TAVR? Operative Risk, Clinical, and Anatomic Considerations. Current Cardiology Reports 2019, 21: 161. PMID: 31781976, DOI: 10.1007/s11886-019-1250-5.Peer-Reviewed Original ResearchConceptsLow-risk patientsComposite endpoint of deathEndpoint of deathOptimal treatment choiceRandomized studyComposite endpointNon-inferior to surgeryTreatment choiceLow surgical risk patientsSurgical risk patientsPARTNER 3 trialSymptomatic aortic stenosisSymptomatic ASLack of long-term dataAortic stenosisFDA indicationRisk patientsPacemaker implantationValve deteriorationAnatomical factorsSummaryRecent trialsTAVRPatientsHigher incidenceProcedural considerationsThree‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis
Rong LQ, Hameed I, Salemi A, Rahouma M, Khan FM, Wijeysundera HC, Angiolillo DJ, Shore‐Lesserson L, Biondi‐Zoccai G, Girardi LN, Fremes SE, Gaudino M. Three‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis. Journal Of The American Heart Association 2019, 8: e013463. PMID: 31549579, PMCID: PMC6806040, DOI: 10.1161/jaha.119.013463.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisEchocardiography, Three-DimensionalFemaleHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyObserver VariationPredictive Value of TestsProsthesis DesignRadiographic Image Interpretation, Computer-AssistedReproducibility of ResultsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve replacementParavalvular aortic regurgitationAortic regurgitationPrimary outcomeAnnular diameterAnnular perimeterTranscatheter aortic valve replacement sizingSystematic reviewSevere symptomatic aortic stenosisVentricular outflow tract areaBackground Transcatheter aortic valve replacementMean annular diameterOutflow tract areaPre-TAVR planningSymptomatic aortic stenosisAortic valve replacementStandard of careRandom-effects modelSystematic literature searchAnnular areaThree-dimensional echocardiographyContrast exposureRenal dysfunctionAortic stenosisSecondary outcomesTreating Symptomatic Aortic Stenosis With Transcatheter Aortic Valve Replacement: Is There Time to Wait?
Faridi KF, Yeh RW, Poulin M. Treating Symptomatic Aortic Stenosis With Transcatheter Aortic Valve Replacement: Is There Time to Wait? Journal Of The American Heart Association 2019, 8: e011527. PMID: 30612523, PMCID: PMC6405731, DOI: 10.1161/jaha.118.011527.Commentaries, Editorials and LettersGender-Related Differences in Transcatheter Aortic Valve Implantation
Stair B, Forrest J. Gender-Related Differences in Transcatheter Aortic Valve Implantation. 2019, 189-200. DOI: 10.1007/978-3-030-05912-5_16.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve implantationAortic valve implantationValve implantationSevere symptomatic aortic stenosisSymptomatic aortic stenosisAortic valve replacementLow surgical riskChronic pressure overloadStandard of careCardiovascular disease statesGender-related differencesTAVR studiesValve replacementAortic stenosisSurgical riskAdverse outcomesPressure overloadRisk factorsTreatment outcomesFemale genderFemale heartsPatientsDisease statesImpact of gender
2018
Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass
Gryaznov AA, Saeyeldin A, Abdelbaky M, Zafar MA, Tanweer M, Imran M, Papanikolaou D, Erben Y, Zefirova J, Ziganshin BA, Elefteriades JA. Antithrombotic Therapy after Bioprosthetic Aortic Valve Replacement: A Therapeutic Morass. Cardiology 2018, 140: 213-221. PMID: 30138919, DOI: 10.1159/000490924.Peer-Reviewed Original ResearchConceptsAortic valve replacementValve replacementAortic stenosisSurgical aortic valve replacementBioprosthetic aortic valve replacementCommon valvular disorderImpact of anticoagulationSymptomatic aortic stenosisHigh-risk patientsValvular heart diseaseCommon pathologic conditionsAntithrombotic therapyMultiple comorbiditiesPerioperative complicationsRemote complicationsSurgical managementEndovascular interventionHeart diseaseValvular disordersBiological valvesLower riskEuropean guidelinesPathologic conditionsComplicationsStenosisTAVI and the brain: update on definitions, evidence of neuroprotection and adjunctive pharmacotherapy.
Lansky A, Ghare MI, Tchétché D, Baumbach A. TAVI and the brain: update on definitions, evidence of neuroprotection and adjunctive pharmacotherapy. EuroIntervention 2018, 14: ab53-ab63. PMID: 30158096, DOI: 10.4244/eij-d-18-00454.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic stenosisAdjunctive pharmacotherapySevere symptomatic aortic stenosisIntermediate-risk patientsSymptomatic aortic stenosisHigh-risk patientsAortic valve implantationSurgical valve replacementEvidence of neuroprotectionNeurologic eventsDevastating complicationNeurologic injuryValve implantationValve replacementCurrent evidenceNeuroprotectionPharmacotherapyPatientsPreferred methodComplicationsStenosisInjuryStrokeIncidenceComparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism
Subahi A, Yassin A, Adegbala O, Akintoye E, Abubakar H, Elmoghrabi A, Ibrahim W, Ajam M, Pahuja M, Weinberger J, Levine D, Afonso L. Comparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism. The American Journal Of Cardiology 2018, 122: 838-843. PMID: 30037424, DOI: 10.1016/j.amjcard.2018.05.025.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationHypothyroid patientsImpact of hypothyroidismHospital outcomesSevere symptomatic aortic stenosisNational Inpatient Sample databasePropensity score-matched analysisSymptomatic aortic stenosisAdditional randomized trialsAortic valve implantationCost of hospitalizationHemorrhage requiring transfusionEffect of hypothyroidismHospital mortalityTAVR outcomesHospital stayInpatient mortalityPostprocedural complicationsSecondary outcomesValve implantationAortic stenosisBlood transfusionPrimary outcomeClinical outcomesRandomized trialsTranscatheter Aortic Valve Replacement after Transcatheter Mitral Valve Replacement
Kaneko T, Pelletier M, Berry N, Sobieszczyk P, Shah P. Transcatheter Aortic Valve Replacement after Transcatheter Mitral Valve Replacement. Structural Heart 2018, 2: 164-168. DOI: 10.1080/24748706.2017.1422086.Peer-Reviewed Original ResearchTranscatheter mitral valve replacementTranscatheter aortic valve replacementLeft ventricular outflow tractMitral valve replacementAortic valve replacementValve replacementAortic stenosisSimultaneous transcatheter aortic valve replacementVentricular outflow tractSevere aortic stenosisMitral annular calcificationSymptomatic aortic stenosisBalloon-expandable valveSelf-expanding valveOutflow tractAnnular calcificationTranscatheter valvesDeteriorated prosthesesTranscatheterPatientsValve selectionStenosisValve frameBalloonValveMolecular imaging of calcific aortic valve disease
Jung JJ, Jadbabaie F, Sadeghi MM. Molecular imaging of calcific aortic valve disease. Journal Of Nuclear Cardiology 2018, 25: 1148-1155. PMID: 29359271, PMCID: PMC6054901, DOI: 10.1007/s12350-017-1158-7.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseAortic stenosisValve diseaseSymptomatic aortic stenosisProgression of CAVDSubset of patientsRisk of complicationsMolecular imagingAsymptomatic patientsValvular calcificationDisease progressionFluoride PETTherapeutic interventionsClinical settingImaging protocolValvular biologyStenosisPatientsDiseaseCalcificationProgressionImagingEchocardiographyComplicationsEarly Outcomes With the Evolut PRO Repositionable Self-Expanding Transcatheter Aortic Valve With Pericardial Wrap
Forrest JK, Mangi AA, Popma JJ, Khabbaz K, Reardon MJ, Kleiman NS, Yakubov SJ, Watson D, Kodali S, George I, Tadros P, Zorn GL, Brown J, Kipperman R, Saul S, Qiao H, Oh JK, Williams MR. Early Outcomes With the Evolut PRO Repositionable Self-Expanding Transcatheter Aortic Valve With Pericardial Wrap. JACC Cardiovascular Interventions 2018, 11: 160-168. PMID: 29348010, DOI: 10.1016/j.jcin.2017.10.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisCause of DeathEchocardiographyFemaleHeart Valve ProsthesisHemodynamicsHumansMaleMitral Valve InsufficiencyPericardiumProspective StudiesProsthesis DesignRisk FactorsSeverity of Illness IndexStrokeTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsSelf-expanding transcatheter aortic valveSevere symptomatic aortic stenosisEvolut PRO valveSymptomatic aortic stenosisTranscatheter aortic valveAortic stenosisParavalvular leakAortic valveValve Academic Research Consortium-2 criteriaIndependent echocardiographic core laboratoryTranscatheter aortic valve replacementTranscatheter aortic valve systemEchocardiographic core laboratoryPrimary safety endpointPrimary efficacy endpointRemainder of patientsAortic valve replacementProportion of patientsProsthetic valve regurgitationSupra-annular valveEffective orifice areaDisabling strokeCause mortalityEfficacy endpointSafety endpoint
2017
The medically managed patient with severe symptomatic aortic stenosis in the TAVR era: Patient characteristics, reasons for medical management, and quality of shared decision making at heart valve treatment centers
Dharmarajan K, Foster J, Coylewright M, Green P, Vavalle JP, Faheem O, Huang PH, Krishnaswamy A, Thourani VH, McCoy LA, Wang TY. The medically managed patient with severe symptomatic aortic stenosis in the TAVR era: Patient characteristics, reasons for medical management, and quality of shared decision making at heart valve treatment centers. PLOS ONE 2017, 12: e0175926. PMID: 28430791, PMCID: PMC5400246, DOI: 10.1371/journal.pone.0175926.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementPhysician-reported reasonsSevere symptomatic aortic stenosisSymptomatic aortic stenosisAortic valve replacementMedical managementAortic stenosisTreatment centersPatient characteristicsValve replacementTreatment optionsPatient preferencesTreatment decisionsInadequate vascular accessSevere symptomatic ASMedical record reviewFinal treatment decisionSurvey of patientsExperience of careSymptomatic ASTAVR eraRecord reviewVascular accessThirty-day
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