2024
Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers
Moura F, Kamanu F, Wiviott S, Giugliano R, Udler M, Florez J, Ellinor P, Sabatine M, Ruff C, Marston N. Type 2 diabetes genetic risk and incident diabetes across diabetes risk enhancers. Diabetes Obesity And Metabolism 2024, 27: 1287-1295. PMID: 39696834, DOI: 10.1111/dom.16123.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntibodies, Monoclonal, HumanizedAnticholesteremic AgentsCardiovascular DiseasesCholesterol, LDLDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGlycated HemoglobinHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedMultifactorial InheritancePCSK9 InhibitorsPolymorphism, Single NucleotideProprotein Convertase 9Risk FactorsConceptsT2D polygenic scoreBody mass indexProprotein convertase subtilisin/kexin type 9Incident diabetesPolygenic scoresGenetic riskIncident T2DHazard ratioStable atherosclerotic cardiovascular diseaseProprotein convertase subtilisin/kexin type 9 inhibitionYears of median follow-upFurther Cardiovascular Outcomes ResearchRisk factorsMean body mass indexCases of incident diabetesMedian Follow-UpLower body mass indexPredictor of incident diabetesEffects of evolocumabGenetic risk categoriesLDL cholesterol levelsT2D genetic riskDiabetes risk factorsType 2 diabetes genetic riskAtherosclerotic cardiovascular disease
2023
A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis
Yang J, Cheng Z, Zhang D, Zheng T, Yin C, Liu S, Zhang L, Wang Z, Wang Y, Chen R, Dou Q, Bai Y. A nested case-control study of serum zinc and incident diabetes among Chinese adults: Effect modifications and mediation analysis. The Science Of The Total Environment 2023, 910: 168678. PMID: 37981151, DOI: 10.1016/j.scitotenv.2023.168678.Peer-Reviewed Original ResearchConceptsSerum zinc levelsRisk of diabetesCase-control studySerum zincDiabetes riskEffect modificationZinc levelsMediation proportionBaseline serum zinc concentrationPositive linear dose-response relationshipConditional logistic regression modelsHistory of hypertensionProspective population studyBody mass indexCoronary heart diseasePotential effect modificationSerum zinc concentrationLinear dose-response relationshipPopulation studiesDose-response relationshipLogistic regression modelsIncident diabetesHighest quartileMass indexFourth quartilePolysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study.
Wojeck B, Inzucchi S, Qin L, Yaggi H. Polysomnographic predictors of incident diabetes and pre-diabetes: an analysis of the DREAM study. Journal Of Clinical Sleep Medicine 2023, 19: 703-710. PMID: 36689314, PMCID: PMC10071389, DOI: 10.5664/jcsm.10414.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexBody mass indexIncident diabetesPolysomnographic predictorsMass indexOxygen saturationMean nocturnal oxygen saturationObstructive sleep apnea (OSA) evaluationObstructive sleep apnea populationEpworth Sleepiness Scale scoreSleep apnea populationGlucose-lowering medicationsNocturnal oxygen saturationSleep-disordered breathingIncidence of diabetesPeriodic limb movementsLaboratory-based polysomnographyCheyne-Stokes respirationSleep apnea severitySleep apnea evaluationIncident prediabetesOxygen desaturationCentral apneaHemoglobin A1cPrimary outcomePhthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN). The Journal Of Clinical Endocrinology & Metabolism 2023, 108: 1947-1957. PMID: 36752637, PMCID: PMC10348472, DOI: 10.1210/clinem/dgad033.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncidence of diabetesWomen's healthIncident diabetesMono-carboxyisononyl phthalatePhthalate metabolitesAssociated with diabetes incidenceHazard ratioCohort of midlife womenHealth-related factorsRacially/ethnically diverse cohortHigh-molecular-weight phthalate metabolitesTime-varying exposureCox proportional hazards modelsProportional hazards modelEffect modificationMono-isobutyl phthalateRacial/ethnic groupsDiabetes incidenceMono(3-carboxypropyl) phthalateMidlife womenMono-carboxyoctyl phthalateWhite womenAsian womenLongitudinal evidence
2022
Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Ding N, Karvonen-Gutierrez C, Calafat A, Herman W, Mukherjee B, Harlow S. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022, 65: 1157-1168. PMID: 35399113, PMCID: PMC9177697, DOI: 10.1007/s00125-022-05695-5.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncident diabetesWomen's healthPolyfluoroalkyl substancesDiabetes riskMidlife womenSelf-reported diabetesTotal energy intakeProspective cohort studyIncreased diabetes riskCox proportional hazards modelsPhysical activityGlucose-lowering medicationsProportional hazards modelResultsAfter adjustmentNation Multi-Pollutant StudyBottom tertileSmoking statusHighest tertileAlcohol consumptionDiabetes-free womenFollow-up visitG-computationQuantile-based g-computationCohort study
2021
Circulating CD4+ TEMRA and CD4+ CD28− T cells and incident diabetes among persons with and without HIV
Bailin SS, Kundu S, Wellons M, Freiberg MS, Doyle MF, Tracy RP, Justice AC, Wanjalla CN, Landay AL, So-Armah K, Mallal S, Kropski JA, Koethe JR. Circulating CD4+ TEMRA and CD4+ CD28− T cells and incident diabetes among persons with and without HIV. AIDS 2021, 36: 501-511. PMID: 34860194, PMCID: PMC8881388, DOI: 10.1097/qad.0000000000003137.Peer-Reviewed Original ResearchConceptsT cell subsetsIncident diabetesT cellsVeterans Aging Cohort StudyPeripheral mononuclear blood cellsIncident diabetes diagnosisPrevalent diabetes mellitusT effector memoryHIV-negative personsHIV-negative individualsTraditional risk factorsAging Cohort StudyCD28- T cellsSenescent T cellsT cell populationsProportional hazards modelMononuclear blood cellsHigh baseline frequencyCytomegalovirus serostatusCirculating CD4Chart reviewCohort studyEffector memoryInflammatory biomarkersMemory CD4Urinary concentrations of phenols and parabens and incident diabetes in midlife women
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Harlow S, Park S. Urinary concentrations of phenols and parabens and incident diabetes in midlife women. Environmental Epidemiology 2021, 5: e171. PMID: 34934892, PMCID: PMC8683147, DOI: 10.1097/ee9.0000000000000171.Peer-Reviewed Original ResearchIncident diabetesHazard ratioAssociated with incident diabetesStudy of Women's HealthMid-life womenAdjusted hazard ratiosAssociation of incident diabetesProspective cohort studyWomen's healthNo significant associationWomen's backgroundConcentration of phenolJoint effectsExposure variablesG-computationQuantile-based g-computationWithin-person variabilityBenzophenone-3Cohort studyDiabetes-freeBisphenol ANonlinear associationSignificant associationJoint effect of mixturesConcentrations of bisphenol A
2020
Per- and Polyfluoroalkyl Substances (PFAS) and Incident Diabetes in Midlife Women: Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Herman W, Mukherjee B, Harlow S. Per- and Polyfluoroalkyl Substances (PFAS) and Incident Diabetes in Midlife Women: Study of Women’s Health Across the Nation (SWAN). ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-0862.Peer-Reviewed Original ResearchHigh concordance between chart review adjudication and electronic medical record data to identify prevalent and incident diabetes mellitus among persons with and without HIV
McGinnis KA, Justice AC, Bailin S, Wellons M, Freiberg M, Koethe JR. High concordance between chart review adjudication and electronic medical record data to identify prevalent and incident diabetes mellitus among persons with and without HIV. Pharmacoepidemiology And Drug Safety 2020, 29: 1432-1439. PMID: 33006179, PMCID: PMC7810212, DOI: 10.1002/pds.5111.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationElectronic medical recordsChart reviewVeterans Aging Cohort Study Biomarker CohortElectronic medical record dataPhysician chart reviewHIV-negative participantsIncident diabetes mellitusICD-9 codesMedical record dataIndication of diabetesPhysician adjudicationIncident diabetesDiabetes mellitusHIV infectionBiomarker cohortHIV statusDiabetes prevalenceMedical recordsMedication recordsLaboratory valuesEpidemiologic studiesDiabetes diagnosisDiagnostic criteriaDiabetesUrinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN)
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN). BMJ Open Diabetes Research & Care 2020, 8: e001233. PMID: 32747380, PMCID: PMC7398092, DOI: 10.1136/bmjdrc-2020-001233.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsMetal concentrationsMetal mixturesUrinary excretion of zincStudy of Women's HealthExposure to metal mixturesExcretion of zincIncident diabetesWomen's healthAssociated with higher risk of diabetesSelf-reported doctor-diagnosed diabetesMidlife womenAssociated with higher riskUrinary metalsHigh risk of diabetesCox proportional hazards modelsIncreased urinary excretionMultiethnic Cohort StudyFree of diabetesHigher overall exposureIncreased urinary excretion of zincAssociated with elevated riskRisk of diabetesDoctor-diagnosed diabetesHigher urinary concentrations
2019
Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood
Bendor CD, Bardugo A, Zucker I, Cukierman-Yaffe T, Lutski M, Derazne E, Shohat T, Mosenzon O, Tzur D, Sapir A, Pinhas-Hamiel O, Kibbey RG, Raz I, Afek A, Gerstein HC, Tirosh A, Twig G. Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood. Diabetes Care 2019, 43: 145-151. PMID: 31694859, PMCID: PMC7011197, DOI: 10.2337/dc19-1562.Peer-Reviewed Original ResearchConceptsIsraeli National Diabetes RegistryIncident diabetesAcute pancreatitisNormal pancreatic functionUnexposed groupPancreatic functionOdds ratioChildhood pancreatitisIncident type 2 diabetesNational Diabetes RegistryPopulation-based studyType 2 diabetesDiagnosis of diabetesLogistic regression analysisYears of ageBaseline BMINormal BMIDiabetes RegistryRisk factorsPancreatitisCase subjectsSociodemographic confoundersDiabetesYounger ageFurther adjustment
2018
Vasomotor symptom characteristics
Gray KE, Katon JG, LeBlanc ES, Woods NF, Bastian LA, Reiber GE, Weitlauf JC, Nelson KM, LaCroix AZ. Vasomotor symptom characteristics. Menopause The Journal Of The North American Menopause Society 2018, 25: 520-530. PMID: 29206771, PMCID: PMC5898980, DOI: 10.1097/gme.0000000000001033.Peer-Reviewed Original ResearchConceptsVasomotor symptomsDiabetes riskNight sweatsHazard ratioHot flashesWomen's Health Initiative participantsElevated diabetes riskConfidence intervalsProportional hazards modelIncident diabetesMetabolic riskPostmenopausal symptomsMenopause transitionMean durationSymptom characteristicsInitiative participantsSymptomsDiabetesRiskBehavior changeSeverityWomenDurationSweatAssociation
2017
Do Tumor Necrosis Factor (TNF) Inhibitors Improve the Glycemic Control in Patients with Rheumatoid Arthritis and Concomitant Diabetes Mellitus?
Danve AS, Kulkarni S. Do Tumor Necrosis Factor (TNF) Inhibitors Improve the Glycemic Control in Patients with Rheumatoid Arthritis and Concomitant Diabetes Mellitus? American Journal Of Therapeutics 2017, 24: e347-e350. PMID: 26103543, DOI: 10.1097/mjt.0000000000000297.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisGlycemic controlTNF inhibitorsInsulin resistanceInsulin sensitivityTumor necrosis factor inhibitorsTumor necrosis factor alphaConcomitant rheumatoid arthritisInflammatory rheumatic diseasesNecrosis factor inhibitorsNecrosis factor alphaIncident diabetesDiabetes mellitusRheumatic diseasesFactor inhibitorsProinflammatory cytokinesFactor alphaPatientsMellitusArthritisInhibitorsDiabetesInflammationCytokinesDisease
2016
Weight Gain and Incident Diabetes Among HIV-Infected Veterans Initiating Antiretroviral Therapy Compared With Uninfected Individuals
Herrin M, Tate JP, Akgün KM, Butt AA, Crothers K, Freiberg MS, Gibert CL, Leaf DA, Rimland D, Rodriguez-Barradas MC, Ruser CB, Herold KC, Justice AC. Weight Gain and Incident Diabetes Among HIV-Infected Veterans Initiating Antiretroviral Therapy Compared With Uninfected Individuals. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 73: 228-236. PMID: 27171741, PMCID: PMC5023454, DOI: 10.1097/qai.0000000000001071.Peer-Reviewed Original ResearchConceptsRisk of DMVeterans Aging Cohort StudyAntiretroviral therapyAging Cohort StudyDiabetes mellitusBody mass indexUninfected individualsWeight gainART initiationIncident diabetesCohort studyHazard ratioMass indexIncident type 2 diabetes mellitusAvailable body mass indexBaseline body mass indexType 2 diabetes mellitusNational observational studyConfidence intervalsSubstantial weight gainHIV infectionCox regressionPounds of weightObservational studyLow prevalence
2015
Glycosylated hemoglobin is associated with decreased endothelial function, high inflammatory response, and adverse clinical outcome in non-diabetic STEMI patients
Moura F, Figueiredo V, Teles B, Barbosa M, Pereira L, Costa A, Carvalho L, Cintra R, Almeida O, Quinaglia e Silva J, Nadruz W, Sposito A, Study B. Glycosylated hemoglobin is associated with decreased endothelial function, high inflammatory response, and adverse clinical outcome in non-diabetic STEMI patients. Atherosclerosis 2015, 243: 124-130. PMID: 26385505, DOI: 10.1016/j.atherosclerosis.2015.09.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlood GlucoseBrachial ArteryC-Reactive ProteinCoronary AngiographyDiabetes MellitusDietEndothelium, VascularFemaleFollow-Up StudiesGlycated HemoglobinHumansInflammationMagnetic Resonance ImagingMaleMiddle AgedMyocardial InfarctionNitric OxidePatient AdmissionPercutaneous Coronary InterventionProspective StudiesRisk FactorsROC CurveSensitivity and SpecificityTreatment OutcomeConceptsST-elevation myocardial infarctionFlow-mediated dilationNon-diabetic STEMI patientsC-reactive proteinSTEMI patientsEndothelial functionFollow-upInflammatory responseLong-term risk of MACEIncident diabetesLower HbA1cMedian Follow-UpClinical follow-upDecreased endothelial functionNon-diabetic patientsRisk of MACEAdverse cardiac eventsAdverse clinical outcomesIncreased inflammatory responseROC curve analysisSudden cardiac deathMeasured plasma glucoseNon-fatal MIPercutaneous coronary interventionLong-term risk
2014
Dietary Sodium Restriction Decreases Insulin Secretion Without Affecting Insulin Sensitivity in Humans
Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ. Dietary Sodium Restriction Decreases Insulin Secretion Without Affecting Insulin Sensitivity in Humans. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e1895-e1902. PMID: 25029426, PMCID: PMC4184066, DOI: 10.1210/jc.2014-2122.Peer-Reviewed Original ResearchConceptsHigh sodium dietHigh sodium intakeInsulin sensitivity indexSodium intakeInsulin secretionAldosterone systemAldosterone infusionInsulin sensitivityAcademic clinical research centerAcute insulin secretory responseLow dietary sodium intakeDecrease insulin secretionC-peptide responsePlasma renin activityDietary sodium intakeLow sodium dietSystolic blood pressureClinical Research CenterInsulin secretory responseAcute insulin responseHigh-risk individualsImpairs insulin secretionGlucose-stimulated insulinIncident diabetesNormotensive volunteers
2009
Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes
Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes. The American Journal Of Medicine 2009, 122: 1122-1127. PMID: 19958890, PMCID: PMC2799991, DOI: 10.1016/j.amjmed.2009.04.026.Peer-Reviewed Original ResearchConceptsMore severe sleep apneaPositive airway pressure useSevere sleep apneaObstructive sleep apneaRisk of diabetesSleep apneaRisk factorsIncident diabetesMAIN OUTCOMEPositive airway pressure therapyType 2 diabetes mellitusVeterans Affairs Connecticut Healthcare SystemAirway pressure therapyObservational cohort studyApnea-hypopnea indexSleep-disordered breathingBody mass indexCross-sectional studyCohort studyDiagnostic polysomnogramGlucose intoleranceConsecutive patientsDiabetes mellitusMass indexPhysician diagnosis
2004
Sleep duration and risk of diabetes in middle-aged and older men: prospective results from the Massachusetts male aging study
Araujo A, Yaggi H, McKinlay J. Sleep duration and risk of diabetes in middle-aged and older men: prospective results from the Massachusetts male aging study. Annals Of Epidemiology 2004, 14: 598. DOI: 10.1016/j.annepidem.2004.07.019.Peer-Reviewed Original ResearchRisk of diabetesDevelopment of diabetesSleep durationRelative riskHours sleepClinical diabetesRisk factorsIncidence ratePopulation-based prospective cohortMassachusetts Male Aging StudyEstimated relative risksSleep duration categoriesIndependent risk factorYear of diagnosisImpaired glucose metabolismCases of diabetesSelf-reported diagnosisShort sleep durationEnd of studyLong sleep durationSelf-reported average numberSelf-rated healthIncident diabetesCohort studyEffect of age
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