2019
Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood
Bendor CD, Bardugo A, Zucker I, Cukierman-Yaffe T, Lutski M, Derazne E, Shohat T, Mosenzon O, Tzur D, Sapir A, Pinhas-Hamiel O, Kibbey RG, Raz I, Afek A, Gerstein HC, Tirosh A, Twig G. Childhood Pancreatitis and Risk for Incident Diabetes in Adulthood. Diabetes Care 2019, 43: 145-151. PMID: 31694859, PMCID: PMC7011197, DOI: 10.2337/dc19-1562.Peer-Reviewed Original ResearchConceptsIsraeli National Diabetes RegistryIncident diabetesAcute pancreatitisNormal pancreatic functionUnexposed groupPancreatic functionOdds ratioChildhood pancreatitisIncident type 2 diabetesNational Diabetes RegistryPopulation-based studyType 2 diabetesDiagnosis of diabetesLogistic regression analysisYears of ageBaseline BMINormal BMIDiabetes RegistryRisk factorsPancreatitisCase subjectsSociodemographic confoundersDiabetesYounger ageFurther adjustment
2017
Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest
Sheth SG, Conwell DL, Whitcomb DC, Alsante M, Anderson MA, Barkin J, Brand R, Cote GA, Freedman SD, Gelrud A, Gorelick F, Lee LS, Morgan K, Pandol S, Singh VK, Yadav D, Wilcox CM, Hart PA. Academic Pancreas Centers of Excellence: Guidance from a multidisciplinary chronic pancreatitis working group at PancreasFest. Pancreatology 2017, 17: 419-430. PMID: 28268158, PMCID: PMC5525332, DOI: 10.1016/j.pan.2017.02.015.Peer-Reviewed Original ResearchConceptsChronic pancreatitisPancreas centerManagement of CPDisease-related morbidityProgressive inflammatory diseaseMultidisciplinary managementSurgical treatmentPancreatic functionInflammatory diseasesMedical treatmentGuidance statementsConsensus opinionPancreatitisAcademic physiciansTreatmentWorking GroupLiterature reviewMorbidityGroupEpidemiologyDiseasePhysiciansDiagnosis
2014
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice
Kim JD, Toda C, D’Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 11876-11881. PMID: 25071172, PMCID: PMC4136568, DOI: 10.1073/pnas.1406000111.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseGene ExpressionGene Knockdown TechniquesGlucagonGlucose Clamp TechniqueGlucose IntoleranceHypothalamusIndolesInsulinInsulin SecretionIon ChannelsMaleMiceMice, TransgenicMitochondrial ProteinsPancreasPhosphorylationProlyl OligopeptidasesReceptor, InsulinRecombinant ProteinsSerine EndopeptidasesSerine Proteinase InhibitorsThiazolidinesUncoupling Protein 1Ventromedial Hypothalamic NucleusConceptsWild-type miceGlucose intoleranceGlucagon secretionProlyl endopeptidaseHyperinsulinemic-euglycemic clamp studiesWild-type control miceGlucose-induced insulin releaseGlucose-induced insulin secretionEuglycemic clamp studiesAutonomic nervous systemVMH injectionsSympathetic outflowWild-type controlsNorepinephrine levelsGlucagon levelsGlucose toleranceControl miceInsulin levelsCentral infusionPancreatic functionVentromedial nucleusInsulin secretionNeuronal activationGlucose-intolerant phenotypeCentral regulation
2013
Defining the Accuracy of Secretin Pancreatic Function Testing in Patients With Suspected Early Chronic Pancreatitis
Ketwaroo G, Brown A, Young B, Kheraj R, Sawhney M, Mortele K, Najarian R, Tewani S, Dasilva D, Freedman S, Sheth S. Defining the Accuracy of Secretin Pancreatic Function Testing in Patients With Suspected Early Chronic Pancreatitis. The American Journal Of Gastroenterology 2013, 108: 1360. PMID: 23711627, PMCID: PMC5388854, DOI: 10.1038/ajg.2013.148.Peer-Reviewed Original ResearchConceptsEarly chronic pancreatitisNegative predictive valueChronic pancreatitisPancreatic function testingPositive predictive valueHistologic evidenceFunction testingPredictive valuePancreatic imagingTertiary care institutionMedian followPositive patientsRetrospective reviewPancreatic functionMedical recordsPancreatitisPatientsDiagnostic accuracyCharacteristic symptomsCare institutionsFollowSubsequent developmentImagingEvidenceSymptoms
1992
Uremic Pancreopathy: Impaired Secretory Function In Vitro
Abu-Alfa A, Mujais S. Uremic Pancreopathy: Impaired Secretory Function In Vitro. American Journal Of Kidney Diseases 1992, 20: 585-588. PMID: 1462987, DOI: 10.1016/s0272-6386(12)70223-8.Peer-Reviewed Original ResearchConceptsSecretory responsePair-fed shamResult of derangementsExocrine pancreatic functionLeucine incorporationRenal failurePancreatic functionProtein synthesisProtein secretionSecretory functionPancreatic aciniExocrine pancreasAbnormalitiesCarbacholSecretionPresent studyAciniDNA contentUremiaDerangementShamPancreasRats
1988
Sarcoidosis and the pancreas
McCormick P, O’Donnell M, McGeeney K, FitzGerald O, McCormick D, FitzGerald M. Sarcoidosis and the pancreas. Irish Journal Of Medical Science 1988, 157: 181-183. PMID: 2460419, DOI: 10.1007/bf02949293.Peer-Reviewed Original Research
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