2023
Clinical Practices Surrounding the Prescription of Home Oxygen in Patients With COPD and Desaturation.
Zaeh S, Case M, Au D, DaSilva M, Deitemeyer K, DeLisa J, Feemster L, Gerald L, Krishnan J, Sculley J, Woodruff A, Eakin M. Clinical Practices Surrounding the Prescription of Home Oxygen in Patients With COPD and Desaturation. Chronic Obstructive Pulmonary Diseases Journal Of The COPD Foundation 2023, 10: 343-354. PMID: 37433062, PMCID: PMC10699490, DOI: 10.15326/jcopdf.2023.0402.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseHome oxygenPrescription of oxygenObstructive pulmonary diseaseClinical Research CenterHome oxygen therapyNumber of patientsClinician practice patternsExertional desaturationSurvival benefitClinical factorsOxygen therapyPulmonary diseaseDiscussion of risksPatient preferencesClinical guidelinesPractice patternsClinician practiceMost cliniciansNurse practitionersSemi-structured qualitative interviewsPatientsClinical experienceClinical practicePatient values
2022
Validation of bladder health scales and function indices for women’s research
Constantine M, Rockwood T, Rickey L, Bavendam T, Low L, Lowder J, Markland A, McGwin G, Mueller E, Newman D, Putnam S, Rudser K, Smith A, Stapleton A, Miller J, Lukacz E, Consortium O, Brubaker L, Mueller E, Acevedo-Alvarez M, Fitzgerald C, Hardacker C, Hebert-Beirne J, Lavender M, Griffith J, Kenton K, Simon M, Geynisman-Tan J, Markland A, Coyne-Beasley T, Burgio K, Lewis C, McGwin G, Vaughan C, Williams B, Lukacz E, Gahagan S, LaCoursiere D, Nodora J, Miller J, Low L, Harlow B, Rudser K, Brady S, Chu H, Constantine M, Fok C, Scal P, Rockwood T, Newman D, Smith A, Berry A, Bilger A, Klusaritz H, Lipman T, Stapleton A, Wyman J, Sutcliffe S, James A, Lowder J, Meister M, Rickey L, Brault M, Camenga D, Cunningham S, Barthold J. Validation of bladder health scales and function indices for women’s research. American Journal Of Obstetrics And Gynecology 2022, 228: 566.e1-566.e14. PMID: 36596439, PMCID: PMC10425263, DOI: 10.1016/j.ajog.2022.12.319.Peer-Reviewed Original ResearchConceptsFunction IndexKnown-groups validityBladder healthHealth ScaleLower urinary tract symptomsPopulation-based validation studyUrinary tract symptomsClinical Research CenterCondition-specific questionnaireIntraclass correlation coefficient modelT-testWomen's health researchHealth researchMode of administrationConvergent validityIntraclass correlation coefficientComparison of womenTract symptomsBladder diaryUrinary conditionFunction testingOptimal healthAdult womenChi-squareWomenRISE FOR HEALTH: Rationale and protocol for a prospective cohort study of bladder health in women
Smith A, Rudser K, Harlow B, McGwin G, Barthold J, Brady S, Brubaker L, Cunningham S, Griffith J, Kenton K, Klusaritz H, Lewis C, Lukacz E, Maki J, Markland A, Mueller E, Newman D, Nodora J, Rickey L, Rockwood T, Simon M, Wyman J, Sutcliffe S, Consortium F. RISE FOR HEALTH: Rationale and protocol for a prospective cohort study of bladder health in women. Neurourology And Urodynamics 2022, 42: 998-1010. PMID: 36321762, PMCID: PMC10151425, DOI: 10.1002/nau.25074.Peer-Reviewed Original ResearchConceptsLower urinary tract symptomsBladder healthCohort studyLower Urinary Tract Symptoms (PLUS) Research ConsortiumProspective longitudinal cohort studyStudy designBladder health promotionProspective cohort studyUrinary tract symptomsClinical Research CenterLongitudinal cohort studySubset of participantsTract symptomsPrevention interventionsHealth promotionHealth StudySelf-administered surveyAdult womenEvidence basePerson assessmentNecessary evidence baseStudy proceduresWomenMultilevel factorsHealth
2015
Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial
Ramirez CE, Nian H, Yu C, Gamboa JL, Luther JM, Brown NJ, Shibao CA. Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. The Journal Of Clinical Endocrinology & Metabolism 2015, 100: 4533-4540. PMID: 26580240, PMCID: PMC4667163, DOI: 10.1210/jc.2015-3415.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlbuminuriaDouble-Blind MethodEndothelium, VascularFemaleFibrinolysisGlucoseGlucose Clamp TechniqueGlucose Tolerance TestHemodynamicsHumansInsulinInsulin ResistanceMaleMiddle AgedOverweightPhosphodiesterase 5 InhibitorsPlasminogen Activator Inhibitor 1Prediabetic StateSildenafil CitrateConceptsPhosphodiesterase-5 inhibitionGlucose-stimulated insulin secretionInsulin sensitivity indexInsulin sensitivityInsulin secretionBaseline insulin sensitivity indexPlacebo-controlled studyClinical Research CenterBody mass indexEnd of treatmentPlasminogen activator inhibitor-1Tissue plasminogen activatorActivator inhibitor-1Placebo groupUrine albuminSildenafil groupCreatinine ratioEndothelial functionPrimary outcomeMass indexTreatment armsFibrinolytic balanceDisposition indexHyperglycemic clampOverweight individuals
2014
Dietary Sodium Restriction Decreases Insulin Secretion Without Affecting Insulin Sensitivity in Humans
Luther JM, Byrne LM, Yu C, Wang TJ, Brown NJ. Dietary Sodium Restriction Decreases Insulin Secretion Without Affecting Insulin Sensitivity in Humans. The Journal Of Clinical Endocrinology & Metabolism 2014, 99: e1895-e1902. PMID: 25029426, PMCID: PMC4184066, DOI: 10.1210/jc.2014-2122.Peer-Reviewed Original ResearchConceptsHigh sodium dietHigh sodium intakeInsulin sensitivity indexSodium intakeInsulin secretionAldosterone systemAldosterone infusionInsulin sensitivityAcademic clinical research centerAcute insulin secretory responseLow dietary sodium intakeDecrease insulin secretionC-peptide responsePlasma renin activityDietary sodium intakeLow sodium dietSystolic blood pressureClinical Research CenterInsulin secretory responseAcute insulin responseHigh-risk individualsImpairs insulin secretionGlucose-stimulated insulinIncident diabetesNormotensive volunteers
2012
Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents
Sakharova OV, Lleva RR, Dziura JD, Spollett GR, Howell SK, Beisswenger PJ, Inzucchi SE. Effects on post-prandial glucose and AGE precursors from two initial insulin strategies in patients with Type 2 diabetes uncontrolled by oral agents. Journal Of Diabetes And Its Complications 2012, 26: 333-338. PMID: 22541894, DOI: 10.1016/j.jdiacomp.2012.03.027.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedBlood GlucoseBody WeightCross-Over StudiesDiabetes Mellitus, Type 2FastingFemaleGlycated HemoglobinGlycation End Products, AdvancedHumansHypoglycemic AgentsInsulin GlargineInsulin LisproInsulin, Long-ActingMaleMiddle AgedPostprandial PeriodTreatment FailureTreatment OutcomeConceptsOral anti-hyperglycemic drugsPost-prandial glucoseInsulin strategiesFree fatty acidsType 2Post-prandial glucose metabolismProgressive β-cell dysfunctionType 2 diabetes patientsPost-prandial glucose levelsDaily insulin glargineInitial insulin regimenPrecursor of AGEsSingle-center studyClinical Research CenterLong-term diabetic complicationsAnti-hyperglycemic drugsType 2 diabetesΒ-cell dysfunctionCross-over designInitial insulinInsulin regimenOral agentsInsulin regimensInsulin therapyOAD therapy
2009
Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa
Lawson EA, Donoho D, Miller KK, Misra M, Meenaghan E, Lydecker J, Wexler T, Herzog DB, Klibanski A. Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 4710-4716. PMID: 19837921, PMCID: PMC2795653, DOI: 10.1210/jc.2009-1046.Peer-Reviewed Original ResearchConceptsBone mineral densityDual-energy X-ray absorptiometryHypothalamic amenorrheaHAM-D scoresLow bone densityBone lossAnorexia nervosaCortisol levelsBone densityMood disturbanceFunctional hypothalamic amenorrheaClinical Research CenterHamilton Rating ScaleCross-sectional studyX-ray absorptiometrySignificant hypercortisolemiaCushing's diseaseAverage cortisol levelsMineral densityHypercortisolemiaCortisol dysregulationSerum samplesRating ScalePotential mediatorsDepressionThe psychosocial transition associated with spontaneous 46,XX primary ovarian insufficiency: illness uncertainty, stigma, goal flexibility, and purpose in life as factors in emotional health
Davis M, Ventura JL, Wieners M, Covington SN, Vanderhoof VH, Ryan ME, Koziol DE, Popat VB, Nelson LM. The psychosocial transition associated with spontaneous 46,XX primary ovarian insufficiency: illness uncertainty, stigma, goal flexibility, and purpose in life as factors in emotional health. Fertility And Sterility 2009, 93: 2321-2329. PMID: 19243752, PMCID: PMC3013503, DOI: 10.1016/j.fertnstert.2008.12.122.Peer-Reviewed Original ResearchConceptsPrimary ovarian insufficiencySpontaneous primary ovarian insufficiencySignificant independent factorsOvarian insufficiencyIllness uncertaintyIndependent factorsEpidemiologic Studies Depression ScaleClinical Research CenterHealthy control womenCase-control studyState-Trait Anxiety InventoryControl womenProspective studyMean ageDepression ScaleMAIN OUTCOMEInsufficiencyFamily planningWomenEmotional healthSelf-report instrumentAnxiety InventorySimilar ageAgeStigma
2008
Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance
Yeckel CW, Dziura J, DiPietro L. Abdominal Obesity in Older Women: Potential Role for Disrupted Fatty Acid Reesterification in Insulin Resistance. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 1285-1291. PMID: 18198225, PMCID: PMC2291490, DOI: 10.1210/jc.2007-1875.Peer-Reviewed Original ResearchConceptsFatty acid reesterificationPeripheral insulin resistanceAbdominal obesityInsulin resistanceHepatic glucose productionAbdominal adiposityOlder womenGlucose utilizationGeneral Clinical Research CenterBasal hepatic glucose productionGlucose productionFree fatty acid metabolismExcess abdominal adiposityPerturbed glucose metabolismGlucose-lowering medicationsHormone replacement therapyClinical Research CenterPeripheral glucose utilizationGlycerol appearance rateInactive older womenTotal body fatCross-sectional studyAbdominal circumference valuesInsulin-stimulated suppressionFree fatty acid ratio
2006
A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls
Carpenter TO, DeLucia MC, Zhang JH, Bejnerowicz G, Tartamella L, Dziura J, Petersen KF, Befroy D, Cohen D. A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls. The Journal Of Clinical Endocrinology & Metabolism 2006, 91: 4866-4872. PMID: 17018656, PMCID: PMC2995550, DOI: 10.1210/jc.2006-1391.Peer-Reviewed Original ResearchConceptsBone mineral contentHip bone mineral contentDietary Mg intakeMg supplementationBone massMg intakeSpinal bone mineral contentMid-late pubertyOld Caucasian girlDouble-blind trialClinical Research CenterPrimary outcome measureBone mineral densityCommunity pediatricians' officesSerum mineral levelsMagnesium oxide supplementationPill countDietary diariesTotal hipFemoral neckInterventional studyMineral densityHealthy girlsBone markersOutcome measures
2005
Impact of Exercise on Overnight Glycemic Control in Children with Type 1 Diabetes Mellitus
Tsalikian E, Mauras N, Beck RW, Tamborlane WV, Janz KF, Chase HP, Wysocki T, Weinzimer SA, Buckingham BA, Kollman C, Xing D, Ruedy KJ. Impact of Exercise on Overnight Glycemic Control in Children with Type 1 Diabetes Mellitus. The Journal Of Pediatrics 2005, 147: 528-534. PMID: 16227041, PMCID: PMC2258153, DOI: 10.1016/j.jpeds.2005.04.065.Peer-Reviewed Original ResearchConceptsGlucose levelsExercise nightsOvernight hypoglycemiaType 1 diabetes mellitusOvernight glycemic controlClinical Research CenterRisk of hypoglycemiaEffects of exerciseImpact of exerciseBlood glucose levelsAfternoon exerciseDiabetes mellitusGlycemic controlInsulin dosesSedentary dayExercise dayExercise sessionsDiabetes managementHypoglycemiaSeparate daysClinical sitesType 1Central laboratoryMellitusT1DMPerceived Barriers to Trying Self‐Management Approaches for Chronic Pain in Older Persons
Austrian JS, Kerns RD, Reid MC. Perceived Barriers to Trying Self‐Management Approaches for Chronic Pain in Older Persons. Journal Of The American Geriatrics Society 2005, 53: 856-861. PMID: 15877564, DOI: 10.1111/j.1532-5415.2005.53268.x.Peer-Reviewed Original ResearchConceptsChronic painRelaxation therapyGeneral Clinical Research CenterOlder personsOlder primary care patientsPain management strategiesPatient-level barriersPrimary care patientsClinical Research CenterFear of painAmbulatory care practicesCross-sectional surveySelf-management approachWeill Cornell Medical CollegeCurrent usePain statusCare patientsCornell Medical CollegeExercise programPainCare practicesEfficacy concernsMedical CollegeRestricted activityRelaxation programPrevalence of Abnormal Glucose Tolerance Following a Transient Ischemic Attack or Ischemic Stroke
Kernan WN, Viscoli CM, Inzucchi SE, Brass LM, Bravata DM, Shulman GI, McVeety JC. Prevalence of Abnormal Glucose Tolerance Following a Transient Ischemic Attack or Ischemic Stroke. JAMA Internal Medicine 2005, 165: 227-233. PMID: 15668371, DOI: 10.1001/archinte.165.2.227.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overBlood GlucoseCohort StudiesFemaleGlucose IntoleranceGlucose Tolerance TestHumansIschemic Attack, TransientLogistic ModelsMaleMiddle AgedOdds RatioPrevalenceProbabilityPrognosisProspective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionStrokeConceptsTransient ischemic attackDiabetic glucose toleranceImpaired glucose toleranceAbnormal glucose tolerancePlasma glucose levelsRecent transient ischemic attackGlucose toleranceIschemic strokeGlucose levelsIschemic attackPhysician-diagnosed diabetes mellitusOral glucose tolerance testStepwise logistic regression modelIncident vascular diseaseRecurrent brain diseaseVascular disease mortalityHistory of diabetesClinical Research CenterGlucose tolerance testLower waist circumferencePlasma glucose valuesForward stepwise logistic regression modelLogistic regression modelsEligible patientsAntihyperglycemic therapy
2004
The Effect of Short‐Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer
Taxel P, Stevens MC, Trahiotis M, Zimmerman J, Kaplan RF. The Effect of Short‐Term Estradiol Therapy on Cognitive Function in Older Men Receiving Hormonal Suppression Therapy for Prostate Cancer. Journal Of The American Geriatrics Society 2004, 52: 269-273. PMID: 14728639, DOI: 10.1111/j.1532-5415.2004.52067.x.Peer-Reviewed Original ResearchConceptsProstate cancerOlder menCognitive functionShort-term estradiol therapyGeneral Clinical Research CenterCognitive deficitsSex hormone-binding globulinE replacement therapyHormonal suppression therapyClinical Research CenterCommunity-dwelling menSelf-reported cognitive deficitsHormone-binding globulinEffects of estrogenSymptoms of depressionSignificant differencesStandardized neurocognitive testsEstradiol therapyHypogonadal menPostmenopausal womenSuppression therapyReplacement therapyBone turnoverHormone levelsDepressive symptoms
1995
Enhanced adrenomedullary response and increased susceptibility to neuroglycopenia: Mechanisms underlying the adverse effects of sugar ingestion in healthy children
Jones TW, Borg WP, Boulware SD, McCarthy G, Sherwin RS, Tamborlane WV. Enhanced adrenomedullary response and increased susceptibility to neuroglycopenia: Mechanisms underlying the adverse effects of sugar ingestion in healthy children. The Journal Of Pediatrics 1995, 126: 171-177. PMID: 7844661, DOI: 10.1016/s0022-3476(95)70541-4.Peer-Reviewed Original ResearchConceptsClinical Research CenterHealthy childrenPlasma glucose concentrationAdrenomedullary responseHypoglycemic clampSymptom scoresSugar ingestionStandard oral glucose loadOral glucose loadPlasma epinephrine levelsPlasma glucose levelsGlucose concentrationCognitive effectsSugar-free drinksP300 potentialEpinephrine levelsP300 auditoryGlucose loadInsulin levelsSymptomatic responsePlasma glucoseOral administrationGlucose levelsHormone concentrationsPhysiologic mechanisms
1993
Effect of caffeine on the recognition of and responses to hypoglycemia in humans.
Kerr D, Sherwin RS, Pavalkis F, Fayad PB, Sikorski L, Rife F, Tamborlane WV, During MJ. Effect of caffeine on the recognition of and responses to hypoglycemia in humans. Annals Of Internal Medicine 1993, 119: 799-804. PMID: 8379601, DOI: 10.7326/0003-4819-119-8-199310150-00005.Peer-Reviewed Original ResearchConceptsGlucose levelsHypoglycemic symptomsCaffeine consumptionCounter-regulatory hormone levelsHyperinsulinemic glucose clamp techniqueMiddle cerebral artery velocityLarge carbohydrate loadCerebral artery velocityAcute caffeine ingestionClinical Research CenterLevels of norepinephrineAwareness of hypoglycemiaCerebral blood flowDouble-blind designGlucose clamp techniqueLate postprandial periodPlasma glucose levelsLevels of epinephrineBrain glucose useCaffeine-free colaEffects of caffeineAcute ingestionSympathoadrenal activationArtery velocityPlasma glucose
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms
1986
A Randomized Clinical Trial of the Insulin Pump vs Intensive Conventional Therapy in Diabetic Pregnancies
Coustan D, Reece E, Sherwin R, Rudolf M, Bates S, Sockin S, Holford T, Tamborlane W. A Randomized Clinical Trial of the Insulin Pump vs Intensive Conventional Therapy in Diabetic Pregnancies. JAMA 1986, 255: 631-636. PMID: 3511311, DOI: 10.1001/jama.1986.03370050073024.Peer-Reviewed Original ResearchConceptsDiabetic womenGlucose levelsIntensive conventional insulin therapyInpatient clinical research centerExcellent metabolic controlPregnant diabetic womenConventional insulin therapyClinical Research CenterMean glucose levelPrevention of hyperglycemiaHome glucose monitoringIntensive conventional therapyFrequent telephone contactChemical hypoglycemiaPerinatal outcomesSymptomatic hypoglycemiaDiabetic controlDiabetic pregnanciesInsulin therapyGlycemic excursionsHemoglobin levelsConventional therapyClinical trialsInsulin administrationTelephone contact
1972
Metabolic and Ultrastructural Studies in a Patient With Pustular Psoriasis (von Zumbusch)
Braverman I, Cohen I, O'Keefe E. Metabolic and Ultrastructural Studies in a Patient With Pustular Psoriasis (von Zumbusch). JAMA Dermatology 1972, 105: 189-196. PMID: 4334267, DOI: 10.1001/archderm.1972.01620050003001.Peer-Reviewed Original ResearchConceptsChronic hypoalbuminemiaPustular psoriasisClinical Research CenterPersistent hypocalcemiaUninvolved skinAbnormal vesselsElectron microscopic examinationSkin lesionsWhite womenPatientsEndothelial cellsEndothelial wallMicroscopic examinationHypoalbuminemiaUltrastructural studyPsoriasisCapillary segmentsSerum albuminVesselsHypocalcemiaLesionsMicrocirculationAbnormalitiesMonthsWomen
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply