2024
Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort
Gonzales M, O’Donnell A, Ghosh S, Thibault E, Tanner J, Satizabal C, Decarli C, Fakhri G, Johnson K, Beiser A, Seshadri S, Pase M. Examining early cerebral amyloid beta and tau accumulation in association with cognition in a predominantly middle‐aged cohort. Alzheimer's & Dementia 2024, 20: e087431. PMCID: PMC11716433, DOI: 10.1002/alz.087431.Peer-Reviewed Original ResearchStratified analysisPoorer visuospatial functionFramingham Heart StudyTau positron emission tomographyPositron emission tomographyMiddle-aged cohortApolipoprotein E4 statusCommunity-based cohortTau accumulationAssociated with cognitive declineVisuospatial functionLow cognitive reserveAssociated with cognitionAmyloid-betaHeart StudyOlder adultsE4 statusLinear regression modelsCerebral amyloid-betaPoor cognitionMeasures of ABCognitive AssessmentCollege degreeCognitive reserveMidlifeASSOCIATION OF LONG-TERM TIME IN TARGET RANGE FOR SYSTOLIC BLOOD PRESSURE SINCE CHILDHOOD WITH ARTERIAL STIFFNESS IN MIDLIFE: A 36-YEAR PROSPECTIVE COHORT STUDY
Wang Y, Qi H, Jia H, Wang D, Sun Y, Du M, Hu G, Man Z, Chu C, Chang J, Delles C, Zhang L, Mu J. ASSOCIATION OF LONG-TERM TIME IN TARGET RANGE FOR SYSTOLIC BLOOD PRESSURE SINCE CHILDHOOD WITH ARTERIAL STIFFNESS IN MIDLIFE: A 36-YEAR PROSPECTIVE COHORT STUDY. Journal Of Hypertension 2024, 42: e54. DOI: 10.1097/01.hjh.0001019768.43096.d1.Peer-Reviewed Original ResearchRisk of arterial stiffnessSystolic blood pressureOdds ratioDecreased riskArterial stiffness in adulthoodAssociated with adult hypertensionRisk factorsModifiable risk factorsAdolescents aged 6Arterial stiffnessBlood pressureYears of follow-upCardiovascular risk factorsTraditional cardiovascular risk factorsAssociated with arterial stiffnessElevated blood pressureLowest quartileSystolic blood pressure variabilityCohort studyAged 6MidlifeTarget rangeCardiovascular diseaseAdult hypertensionTime-in-target
2023
Is the number of ideal cardiovascular health metrics in midlife associated with lower risk of cancer? Evidence from 3 European prospective cohorts
van Sloten T, Climie R, Deraz O, Périer M, Valentin E, Fayosse A, Sabia S, Weiderpass E, Jouven X, Goldberg M, Zins M, Touvier M, Deschasaux-Tanguy M, Fezeu L, Hercberg S, Singh-Manoux A, Empana J. Is the number of ideal cardiovascular health metrics in midlife associated with lower risk of cancer? Evidence from 3 European prospective cohorts. CMAJ Open 2023, 11: e774-e781. PMID: 37607746, PMCID: PMC10449017, DOI: 10.9778/cmajo.20220175.Peer-Reviewed Original ResearchIdeal cardiovascular health metricsCardiovascular health metricsHealth metricsWhitehall IIPrimordial preventionCancer eventsCancer riskAssociated with lower cancer riskHazard ratioPrevention of cardiovascular risk factorsAggregated hazard ratiosRisk factorsCommonality of risk factorsLower cancer riskCardiovascular risk factorsIncident cancerRandom-effects modelPrevention of cancerFollow-upSmoking metricsIdeal metricsOnset of cancerGAZELMidlifeEuropean cohort
2022
Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study
Felt JM, Harrington KD, Ram N, O'Donnell KJ, Sliwinski MJ, Benson L, Zhang Z, Meaney MJ, Putnam FW, Noll JG, Shenk CE. Receptive Language Abilities for Females Exposed to Early Life Adversity: Modification by Epigenetic Age Acceleration at Midlife in a 30-Year Prospective Cohort Study. The Journals Of Gerontology Series B 2022, 78: 585-595. PMID: 36190812, PMCID: PMC10066744, DOI: 10.1093/geronb/gbac158.Peer-Reviewed Original ResearchConceptsReceptive language abilityChild sexual abuseEarly life adversityLanguage abilityCognitive agingLife adversityPeabody Picture VocabularyPPVT-R scoresReceptive languageCognitive functioningPicture VocabularyComparison conditionNormative trajectoriesSexual abuseInterindividual differencesIndependent measuresMidlifeAdversityEpigenetic age accelerationDevelopment studiesQuadratic trendQuadratic growth modelAge accelerationEpigenetic agingAbilityPhthalates and Adipokines in Midlife Women: A Cross-sectional Study in the Study of Women’s Health Across the Nation (SWAN)
Peng M, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Phthalates and Adipokines in Midlife Women: A Cross-sectional Study in the Study of Women’s Health Across the Nation (SWAN). ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.p-0990.Peer-Reviewed Original ResearchAssociation of perfluoroalkyl substances (PFAS) with lipid trajectories in midlife women: the Study of Women's Health Across the Nation
Kang H, Ding N, Karvonen-Gutierrez C, Mukherjee B, Park S. Association of perfluoroalkyl substances (PFAS) with lipid trajectories in midlife women: the Study of Women's Health Across the Nation. ISEE Conference Abstracts 2022, 2022 DOI: 10.1289/isee.2022.p-1055.Peer-Reviewed Original Research
2021
Exposure to Phthalates May Accelerate Body Fat Gain in Midlife Women: The Study of Women’s Health Across the Nation (SWAN)
Peng M, Karvonen Gutierrez C, Herman W, Mukherjee B, Park S. Exposure to Phthalates May Accelerate Body Fat Gain in Midlife Women: The Study of Women’s Health Across the Nation (SWAN). ISEE Conference Abstracts 2021, 2021 DOI: 10.1289/isee.2021.p-169.Peer-Reviewed Original ResearchPer- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition
Harlow S, Hood M, Ding N, Mukherjee B, Calafat A, Randolph J, Gold E, Park S. Per- and Polyfluoroalkyl Substances and Hormone Levels During the Menopausal Transition. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: e4427-e4437. PMID: 34181018, PMCID: PMC8677593, DOI: 10.1210/clinem/dgab476.Peer-Reviewed Original ResearchConceptsMidlife womenSex hormone-binding globulinFollicle-stimulating hormoneInverse associationStudy of Women's HealthPositive associationMenopausal transitionBody mass indexReproductive ageWomen's healthSignificant linear trendNo significant associationNulliparous womenLinear mixed modelsSmoking statusYears of ageMass indexHormone-binding globulinMenopausal statusLongitudinal serum concentrationsSignificant associationSerum PFAS concentrationsMidlifeWomenPolyfluoroalkyl substances
2020
Per- and Polyfluoroalkyl Substances (PFAS) and Incident Diabetes in Midlife Women: Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Herman W, Mukherjee B, Harlow S. Per- and Polyfluoroalkyl Substances (PFAS) and Incident Diabetes in Midlife Women: Study of Women’s Health Across the Nation (SWAN). ISEE Conference Abstracts 2020, 2020 DOI: 10.1289/isee.2020.virtual.p-0862.Peer-Reviewed Original Research
2019
Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation
Ding N, Harlow S, Batterman S, Mukherjee B, Park S. Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: The Study of Women′s Health Across the Nation. Environment International 2019, 135: 105381. PMID: 31841808, PMCID: PMC7374929, DOI: 10.1016/j.envint.2019.105381.Peer-Reviewed Original ResearchConceptsMidlife womenWomen's healthBlack womenStudy of Women's HealthChinese womenLongitudinal trendsTemporal trendsBody mass indexSerum concentrationsLinear mixed modelsParous womenFollow-up visitPFAS homologuesPFNA concentrationsRace/ethnicityMass indexSerum PFAS concentrationsMidlifePatterns of exposurePolyfluoroalkyl substances concentrationsLongitudinal declineWomenAssociated with lower concentrationsHealthMixed models
2016
Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
Zokaei N, Giehl K, Sillence A, Neville M, Karpe F, Nobre A, Husain M. Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife. Cortex 2016, 88: 98-105. PMID: 28086184, PMCID: PMC5333781, DOI: 10.1016/j.cortex.2016.12.016.Peer-Reviewed Original ResearchConceptsMedial temporal lobeMisbinding errorsShort-term memoryDelayed estimation taskE4 carriersInteraction of genderMemory advantageInfluence of APOEMeasure memoryBehavioral advantageAntagonistic pleiotropy hypothesisTemporal lobeFeature bindingMemory decaySensitive tasksAPOE e4 carriersEstimation taskMemoryMisbindingPleiotropy hypothesisMiddle-aged individualsGene dosageMidlifeAPOE genotypeAPOE allelesComplementary health approaches for health and wellness in midlife and older US adults
Johnson PJ, Jou J, Rhee TG, Rockwood TH, Upchurch DM. Complementary health approaches for health and wellness in midlife and older US adults. Maturitas 2016, 89: 36-42. PMID: 27180158, DOI: 10.1016/j.maturitas.2016.04.012.Peer-Reviewed Original ResearchConceptsComplementary health approachesOlder US adultsOlder adultsUS adultsNational Health Interview Survey dataHealth approachHealth Interview Survey dataDesign-based F testsMultiple logistic regressionInterview Survey dataSample of midlifeRepresentative US sampleHigher oddsHealth problemsGood sleepHealthy lifestyleLogistic regressionHealthy agingAnalytic sampleAdultsMidlifeHealth/TreatmentWellnessHealth
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