2024
Sex-specific outcomes in cancer therapy: the central role of hormones
Bakhshi P, Ho J, Zanganeh S. Sex-specific outcomes in cancer therapy: the central role of hormones. Frontiers In Medical Technology 2024, 6: 1320690. PMID: 38362126, PMCID: PMC10867131, DOI: 10.3389/fmedt.2024.1320690.Peer-Reviewed Original ResearchHormone replacement therapyHormone-sensitive cancersSex hormonesTreatment outcomesCancer therapyCancer progressionEstrogen receptor-negativeEstrogen receptor-positiveAndrogen receptor signalingSex-specific outcomesInhibit cancer progressionReceptor-negativeReceptor-positiveAromatase inhibitorsReplacement therapyTreatment responseAnti-androgenHormone levelsTherapeutic outcomesPersonalized therapyHormonal profileReceptor signalingTherapyCancer treatmentCancer
2023
Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Lesions: Long-Term Sex-Specific Outcomes
Frampton J, Kearney K, Abbott J, Kereiakes D, Di Mario C, Saito S, Cristea E, Riley R, Fajadet J, Shlofmitz R, Ali Z, Klein A, Price M, Hill J, Stone G, Lansky A. Coronary Intravascular Lithotripsy for Treatment of Severely Calcified Lesions: Long-Term Sex-Specific Outcomes. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101069. PMID: 39129889, PMCID: PMC11307843, DOI: 10.1016/j.jscai.2023.101069.Peer-Reviewed Original ResearchIntravascular lithotripsyLesion failureIschemia-driven target lesion revascularizationMajor adverse cardiac event ratesAdverse cardiac event ratesDrug-eluting stent placementMajor adverse cardiac eventsSmaller reference vessel diameterTarget vessel myocardial infarctionCoronary intravascular lithotripsyAdverse cardiac eventsCardiac event ratePrimary end pointTarget lesion failureTarget lesion revascularizationVessel myocardial infarctionReference vessel diameterAdverse clinical eventsHigh procedural successSex-based outcomesSex-specific outcomesLesion revascularizationAngiographic outcomesCardiac eventsCardiac deathSex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study
Gupta A, Barthel A, Mahajan S, Dreyer R, Yaggi H, Bueno H, Lichtman J, Krumholz H. Sex‐Specific Associations of Obstructive Sleep Apnea Risk With Patient Characteristics and Functional Outcomes After Acute Myocardial Infarction: Evidence From the VIRGO Study. Journal Of The American Heart Association 2023, 12: e027225. PMID: 37702090, PMCID: PMC10547292, DOI: 10.1161/jaha.122.027225.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAcute myocardial infarctionHigh OSA riskOSA riskSex-specific associationsFunctional outcomeHealth statusHigh riskVIRGO StudyMyocardial infarctionDepressive symptomsHistory of OSATime of AMIImpact of OSAObstructive sleep apnea riskLow-risk patientsSleep apnea riskMajority of patientsTime of presentationSex-specific outcomesWorse health statusHigh-risk menPoor health statusMental health statusPoor health outcomes
2022
Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery
Safdar B, Mori M, Nowroozpoor A, Geirsson A, D'Onofrio G, Mangi AA. Clinical Profile and Sex-Specific Recovery With Cardiac Rehabilitation After Coronary Artery Bypass Grafting Surgery. Clinical Therapeutics 2022, 44: 846-858. PMID: 35570056, DOI: 10.1016/j.clinthera.2022.04.002.Peer-Reviewed Original ResearchConceptsCardiac rehabilitationElectronic health recordsComposite outcomeEndothelial functionClinical profileCoronary Artery Bypass Grafting SurgeryMajor adverse cardiac outcomesPostoperative blood transfusionTwelve-month mortalityCardiac risk factorsCoronary artery bypassPrimary composite outcomeRetrospective cohort studyHealth recordsAdverse cardiac outcomesCardiac risk profileKaplan-Meier analysisBody mass indexSex-specific outcomesKaplan-Meier plotsThoracic Surgeons registryAerobic exercise durationHigher hemoglobin AHealth care systemUrgent CABGSex-Specific Outcomes After Coronary Intravascular Lithotripsy: A Patient-Level Analysis of the Disrupt CAD Studies
Hussain Y, Kearney K, Abbott J, Kereiakes D, Di Mario C, Saito S, Cristea E, Riley R, Fajadet J, Shlofmitz R, Ali Z, Klein A, Price M, Hill J, Stone G, Lansky A. Sex-Specific Outcomes After Coronary Intravascular Lithotripsy: A Patient-Level Analysis of the Disrupt CAD Studies. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100011. PMID: 39130137, PMCID: PMC11307712, DOI: 10.1016/j.jscai.2021.100011.Peer-Reviewed Original ResearchPrimary efficacy end pointPrimary safety end pointMajor adverse cardiovascular eventsAdverse cardiovascular eventsEfficacy end pointSafety end pointIntravascular lithotripsyEnd pointCardiovascular eventsMyocardial infarctionHospital major adverse cardiovascular eventsMean reference vessel diameterCoronary intravascular lithotripsySevere coronary calcificationCoronary artery calcificationReference vessel diameterPercutaneous coronary interventionPrior myocardial infarctionSex-based outcomesSex-specific outcomesSide branch involvementPatient-level analysisSmall vessel sizeAngiographic complicationsLesion predilatation
2020
Sex-Specific Outcomes in Cardiovascular Device Evaluations
Ghare MI, Tirziu D, Abbott JD, Altin E, Yang Y, Ng V, Grines C, Lansky A. Sex-Specific Outcomes in Cardiovascular Device Evaluations. Journal Of Women's Health 2020, 29: 1246-1255. PMID: 32543268, PMCID: PMC9545802, DOI: 10.1089/jwh.2019.8068.Peer-Reviewed Original ResearchConceptsCoronary revascularizationHeart failureClinical trialsDevice trialsMajor clinical trialsStructural heart diseaseSex-specific outcomesBenefit/risk assessmentCardiac resynchronization defibrillatorImplantable cardioverter defibrillatorVentricular assist deviceBest available careDrug eluting stentsBetter treatment recommendationsCardiovascular outcomesDevice therapyTreatment recommendationsHeart diseaseCardioverter defibrillatorDevice clinical trialsTreatment selectionAvailable careAssist deviceNarrative reviewEluting stents
2019
Foot and Ankle Related Sex-Specific Analysis Within High-Impact Journals
Gianakos A, George N, Merklein M, Chambers L, Ferkel R, DiGiovanni C, Kennedy J. Foot and Ankle Related Sex-Specific Analysis Within High-Impact Journals. Foot & Ankle International 2019, 41: 356-363. PMID: 31855079, DOI: 10.1177/1071100719894530.Peer-Reviewed Original ResearchConceptsSex-specific analysesSex-matched cohortSex-specific outcomesSignificant differencesPrevalence of footPercent of studiesOrthopaedic FootPatient sexAnkle injuriesTreatment outcomesOrthopaedic literatureIndependent investigatorsLevel IIISubspecialty journalsDemographic characteristicsFemale outcomesOutcomesSexMultifactorial statistical modelCalendar yearFootSignificant improvementTotalHigh-impact journalsPercent
2018
Sex-Specific Outcomes After Transcatheter Aortic Valve Replacement: FDA Patient-Level Meta-Analysis of Premarket Clinical Trials
Zusterzeel R, Mishra NK, Beydoun H, Laschinger J, Wu C, Dong LM, Lin JA, Marinac-Dabic D, Strauss DG, Caños DA. Sex-Specific Outcomes After Transcatheter Aortic Valve Replacement: FDA Patient-Level Meta-Analysis of Premarket Clinical Trials. Journal Of Women's Health 2018, 27: 808-814. PMID: 29741978, DOI: 10.1089/jwh.2017.6760.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementClinical trialsPatient-level dataPremarket clinical trialsLower riskMajor bleedingKidney injuryIschemic strokeValve replacementPacemaker implantationMortality riskDichotomous outcomesEfficacy of TAVRInvasive alternative approachPatient-Level MetaLong-term outcomesSex-specific outcomesLower mortality riskRandom-effects modelReintervention riskTAVR armIndividual comorbiditiesPostprocedural complicationsAcute outcomes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply