2025
Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults
Guo X, Ren H, Zhang J, Ma X, Tong S, Tang S, Mao C, Shi X. Association between Organochlorine Exposures and Lung Functions Modified by Thyroid Hormones and Mediated by Inflammatory Factors among Healthy Older Adults. Biomedical And Environmental Sciences 2025, 38: 144-153. PMID: 40159168, DOI: 10.3967/bes2025.015.Peer-Reviewed Original ResearchConceptsLung functionInflammatory factorsIL-13Hormone groupThyroid hormonesEffects of IL-2Organochlorine exposureHealthy older adultsInterleukin (IL)-2Thyroid hormone levelsAssociated with forced vital capacityOlder adultsForced Vital CapacityIL-7IL-2Hormone levelsIL-8Wearable passive samplersEffects of organochlorinesAssociated with changesVital capacityLungMediation analysisParticipants' lung functionBlood samples
2024
12611 The Thyroid Adapts Remarkably to Overnutrition to Mitigate Hypothyroidism
Rampy J, Manzo A, Hoffsmith K, Loberg M, Wang H, Weiss V, Carrasco N. 12611 The Thyroid Adapts Remarkably to Overnutrition to Mitigate Hypothyroidism. Journal Of The Endocrine Society 2024, 8: bvae163.2092. PMCID: PMC11453901, DOI: 10.1210/jendso/bvae163.2092.Peer-Reviewed Original ResearchThyroid-stimulating hormoneThyroid-stimulating hormone stimulationPathogenesis of obesityThyroid hormonesTH levelsThyroid functionTH availabilityIncreased thyroid-stimulating hormoneMatching energy intakeDiet-induced weight gainSerum TH levelsWeight lossMale C57BL/6J miceER stress-related proteinsHigh-fat dietMild hypothyroidismThyroid impairmentStimulating hormoneFemale miceHypothyroid stateC57BL/6J miceAdrenomedullin 2Whole-body energy balanceVascular changesEnergy intakeAssociation between exposure to chemical mixtures and epigenetic ageing biomarkers: modifying effects of thyroid hormones and physical activity
Shi W, Fang J, Tang S, Shi X. Association between exposure to chemical mixtures and epigenetic ageing biomarkers: modifying effects of thyroid hormones and physical activity. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0775.Peer-Reviewed Original ResearchEffects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress
da Cunha Menezes E, de Abreu F, Davis J, Maurer S, Roshko V, Richardson A, Dowell J, Cassella S, Stevens H. Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Developmental Biology 2024, 515: 112-120. PMID: 39048051, PMCID: PMC11330572, DOI: 10.1016/j.ydbio.2024.07.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell MovementFemaleGABAergic NeuronsGene Expression Regulation, DevelopmentalGlutamate DecarboxylaseGlutathione PeroxidaseGlutathione Peroxidase GPX1HypothyroidismMaleMethimazoleMiceNF-E2-Related Factor 2Oxidative StressPlacentaPregnancyPrenatal Exposure Delayed EffectsThyroid HormonesConceptsGestational hypothyroidismGABAergic system developmentMaternal thyroid hormone supplyThyroid hormone supplyCortical GABAergic interneuronsMaternal thyroid hormonesGene expressionCD-1 miceCentral nervous system developmentEmbryonic day 9Central nervous systemIntrauterine restrictionGABAergic interneuronsGABAergic systemGPx1 gene expressionBrain gene expressionMouse brain developmentCD-1HypothyroidismEmbryonic dayNervous system developmentThyroid hormonesRisk factorsNeural system developmentHormonal imbalanceHypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Mohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.Peer-Reviewed Original ResearchConceptsHypothalamic feeding centersHormone deficiencyHypothalamic arcuate nucleus neuronsArcuate nucleus neuronsThyroid hormone deficiencyFeeding centerEffects of ghrelinAnorexigenic effectNucleus neuronsPhysiological anorexiaThyroid hormonesNormal physiological functionsGround squirrelsInterbout arousalAnorexiaThirteen-lined ground squirrelsProlonged periodReduced sensitivityPhysiological functionsDeficiencyAssociations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study
Park S, Siwakoti R, Ferguson K, Cathey A, Hao W, Cantonwine D, Mukherjee B, McElrath T, Meeker J. Associations of urinary polycyclic aromatic hydrocarbon (PAH) metabolites and their mixture with thyroid hormone concentration during pregnancy in the LIFECODES cohort: A repeated measures study. Environmental Research 2024, 255: 119205. PMID: 38782334, PMCID: PMC11421857, DOI: 10.1016/j.envres.2024.119205.Peer-Reviewed Original ResearchMaternal thyroid hormonesThyroid hormone concentrationsPolycyclic aromatic hydrocarbon metabolitesThyroid hormonesPolycyclic aromatic hydrocarbonsPregnancy outcomesHormone concentrationsFetal sex-specific effectsPAH exposureBayesian kernel machine regressionPotential non-linear associationsHormone physiologyAromatic hydrocarbonsThyroid hormone physiologyPregnancy physiologyFetal growthFetal sexFetal developmentUrinary PAH metabolitesSerial measurementsPregnancyUrinary polycyclic aromatic hydrocarbonsPolycyclic aromatic hydrocarbon exposureStudy visitsThyroid
2023
Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study
Rosen Vollmar A, Lin E, Nason S, Santiago K, Johnson C, Ma X, Godri Pollitt K, Deziel N. Per- and polyfluoroalkyl substances (PFAS) and thyroid hormone measurements in dried blood spots and neonatal characteristics: a pilot study. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 737-747. PMID: 37730931, PMCID: PMC10541328, DOI: 10.1038/s41370-023-00603-4.Peer-Reviewed Original ResearchConceptsThyroid hormone concentrationsNeonatal characteristicsThyroid hormone measurementsHormone concentrationsThyroid hormonesBlood spotsPilot studyNewborn DBSHormone measurementsPopulation-based studyThyroid hormone levelsEnvironmental risk factorsPFAS concentrationsNewborn screening testNon-parametric WilcoxonThyroid diseaseRisk factorsHormone levelsKruskal-Wallis testPFAS exposureThyroid hormone dataScreening testNeonatal DBSEnvironmental exposuresPerformance liquid chromatography-mass spectrometryNovel Antimurine Thyroid-Stimulating Hormone Receptor Monoclonal Antibodies
Klee A, Torchia J, Freeman G. Novel Antimurine Thyroid-Stimulating Hormone Receptor Monoclonal Antibodies. Monoclonal Antibodies In Immunodiagnosis And Immunotherapy 2023, 42: 109-114. PMID: 37343169, PMCID: PMC10282802, DOI: 10.1089/mab.2022.0037.Peer-Reviewed Original ResearchConceptsThyroid-stimulating hormoneAnti-TSHR autoantibodiesThyroid-stimulating hormone receptorGraves' diseaseHashimoto's thyroiditisThyroid diseaseG protein-coupled receptorsMonoclonal antibodiesAnti-TSHR antibodiesReceptor monoclonal antibodyProduction of thyroxineImmune attackMouse modelAgonist activityAberrant productionThyroid hormonesAutoantibodiesDiseaseHormone receptorsAntibodiesThyroiditisThyroid proteinsThyroidHormoneRange of affinitiesThyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function
Vamesu B, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J. Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. JCI Insight 2023, 8: e160697. PMID: 36917181, PMCID: PMC10243814, DOI: 10.1172/jci.insight.160697.Peer-Reviewed Original ResearchConceptsUmbilical cord-derived mesenchymal stem cellsNeonatal lung injuryMild bronchopulmonary dysplasiaSevere bronchopulmonary dysplasiaBronchopulmonary dysplasiaLung injuryELBW infantsThyroid hormonesLung homogenatesMitochondrial dysfunctionTotal T4Newborn miceLow birth weight infantsMitochondrial functionNeonatal hyperoxic lung injuryPeroxisome proliferator-activated receptor γ coactivator 1αProliferator-activated receptor γ coactivator 1αHyperoxic lung injuryReceptor γ coactivator 1αLow total T4Murine lung fibroblastsΓ coactivator 1αNeonatal hypothyroxinemiaWeight infantsPulmonary fibrosis
2022
Dynamics of thyroid diseases and thyroid‐axis gland masses
Korem Kohanim Y, Milo T, Raz M, Karin O, Bar A, Mayo A, Mendelson Cohen N, Toledano Y, Alon U. Dynamics of thyroid diseases and thyroid‐axis gland masses. Molecular Systems Biology 2022, 18: msb202210919. PMID: 35938225, PMCID: PMC9358402, DOI: 10.15252/msb.202210919.Peer-Reviewed Original ResearchConceptsThyroid disordersThyroid hormonesSerum thyroid stimulating hormone (TSHThyroid-stimulating hormone (TSHTreatment of thyroid disordersLifelong hormone replacementTreat thyroid disordersPeripheral thyroid hormonesHormone replacementGraves' diseaseHashimoto's thyroiditisThyroid diseaseGland massPituitary glandClinical stateThyroidThyroid axisMedical recordsTSHAtrophied glandsHormoneLife yearsDisordersGlandWeeksAutoantibody mimicry of hormone action at the thyrotropin receptor
Faust B, Billesbølle C, Suomivuori C, Singh I, Zhang K, Hoppe N, Pinto A, Diedrich J, Muftuoglu Y, Szkudlinski M, Saghatelian A, Dror R, Cheng Y, Manglik A. Autoantibody mimicry of hormone action at the thyrotropin receptor. Nature 2022, 609: 846-853. PMID: 35940205, PMCID: PMC9678024, DOI: 10.1038/s41586-022-05159-1.Peer-Reviewed Original ResearchConceptsExtracellular domainMembrane bilayerCryo-electron microscopy structureGraves' diseaseGlycoprotein hormone receptorsTSHR extracellular domainG protein-coupled receptorsSteric clashesThyroid hormone synthesisConformational changesThyrotropin receptorHormone synthesisReceptor activationAutoantibodiesHormone receptorsThyroid hormonesThyrotropinTSHRHormone actionThyroidReceptorsChapter 3 Thyroid gland
Holt E, Lupsa B, Lee G, Bassyouni H, Peery H. Chapter 3 Thyroid gland. 2022, 75-99. DOI: 10.1016/b978-0-12-815844-9.00003-8.Chapters
2021
PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury
Zhang Y, Yu G, Kaminski N, Lee P. PINK1 mediates the protective effects of thyroid hormone T3 in hyperoxia-induced lung injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2021, 320: l1118-l1125. PMID: 33851544, PMCID: PMC8285622, DOI: 10.1152/ajplung.00598.2020.Peer-Reviewed Original ResearchConceptsLung injuryWT miceThyroid hormonesBronchoalveolar lavageHyperoxia exposureBAL total cell countT3 pretreatmentAdult wild-type miceAdministration of PTULung cellular infiltratesAcute lung injuryWild-type miceNovel protective roleRespiratory failureCellular infiltrateThyroid hormone T3Total cell countHistological changesProtective effectPotential therapyProtective roleCell countCytoprotective effectsMitochondrial injuryHyperoxia
2020
Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years
Luo J, Xiao J, Gao Y, Ramlau-Hansen CH, Toft G, Li J, Obel C, Andersen SL, Deziel NC, Tseng WL, Inoue K, Bonefeld-Jørgensen EC, Olsen J, Liew Z. Prenatal exposure to perfluoroalkyl substances and behavioral difficulties in childhood at 7 and 11 years. Environmental Research 2020, 191: 110111. PMID: 32846178, PMCID: PMC7657987, DOI: 10.1016/j.envres.2020.110111.Peer-Reviewed Original ResearchConceptsPrenatal PFAS exposureMaternal thyroid hormonesThyroid hormonesOdds ratioPFAS exposureDanish National Birth CohortMaternal thyroid functionPrenatal perfluoroalkyl substancesMaternal thyroid dysfunctionFree thyroxine levelsNational Birth CohortAdjusted odds ratioBehavioral difficultiesPerfluoroalkyl substancesNatural indirect effectThyroid dysfunctionPFNA exposureFetal neurodevelopmentPrenatal exposureEpidemiological evidenceThyroid functionEarly gestationThyroxine levelsBirth cohortMaternal plasma
2019
Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment
Huang CY, Peres Moreno Maia-Joca R, Ong CS, Wilson I, DiSilvestre D, Tomaselli GF, Reich DH. Enhancement of human iPSC-derived cardiomyocyte maturation by chemical conditioning in a 3D environment. Journal Of Molecular And Cellular Cardiology 2019, 138: 1-11. PMID: 31655038, DOI: 10.1016/j.yjmcc.2019.10.001.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-1HiPSC-CMsSarcoplasmic reticulum functionGrowth factor-1Pluripotent stem cell-derived cardiomyocytesStem cell-derived cardiomyocytesCell-derived cardiomyocytesAdult cardiac phenotypeTDI treatmentContractile propertiesElectrophysiological propertiesThyroid hormonesCardiac phenotypeAdult myocardiumCardiac microtissuesPharmacological propertiesRecapitulate aspectsFactor 1Gene expression profilesHuman iPSCBiochemical factorsImmature stateMyocardiumStem cellsPluripotent stem cellsPerfluoroalkyl Substances and thyroid hormones in early pregnancy; findings in the Danish National Birth Cohort (DNBC)
Z L, K I, B R, S A, C R, B H, B B, T H, E B, J O. Perfluoroalkyl Substances and thyroid hormones in early pregnancy; findings in the Danish National Birth Cohort (DNBC). Environmental Epidemiology 2019, 3: 240-240. DOI: 10.1097/01.ee9.0000608512.83637.07.Peer-Reviewed Original ResearchNew Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone
Manning EP, Losier A, Emeagwali N, Ryu C, Honiden S. New Applications of Old Drugs as Novel Therapies in Idiopathic Pulmonary Fibrosis. Metformin, Hydroxychloroquine, and Thyroid Hormone. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1561-1563. PMID: 30822095, PMCID: PMC7051474, DOI: 10.1164/rccm.201809-1700rr.Peer-Reviewed Original ResearchA repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort
Aker A, Ferguson K, Rosario Z, Mukherjee B, Alshawabkeh A, Calafat A, Cordero J, Meeker J. A repeated measures study of phenol, paraben and Triclocarban urinary biomarkers and circulating maternal hormones during gestation in the Puerto Rico PROTECT cohort. Environmental Health 2019, 18: 28. PMID: 30940137, PMCID: PMC6444601, DOI: 10.1186/s12940-019-0459-5.Peer-Reviewed Original ResearchConceptsUrinary biomarkersAssociated with adverse birth outcomesAdverse birth outcomesPregnant womenBirth outcomesAdverse outcomesSerum hormonesStudy visitsParaben biomarkersThyroid hormonesParaben exposurePercent changeHormoneBiomarker concentrationsMaternal hormonesBiomarkersOutcomesVisitsAssociationExposureGestationRandom interceptPregnancyThyroid
2018
Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures
Kiss DS, Ioja E, Toth I, Barany Z, Jocsak G, Bartha T, Horvath TL, Zsarnovszky A. Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures. International Journal Of Molecular Sciences 2018, 19: 1440. PMID: 29751674, PMCID: PMC5983839, DOI: 10.3390/ijms19051440.Peer-Reviewed Original ResearchConceptsQuantitative reverse transcription polymerase chain reactionThyroid hormonesExpression levelsAbsence of gliaExpression of TRsReverse transcription-polymerase chain reactionThyroid receptor alphaTranscription-polymerase chain reactionPrimary cerebellar neuronsPrimary cerebellar granule cellsPrimary cerebellar cell culturesPostnatal brain developmentCerebellar granule cellsSerious health problemCerebellar cell culturesHormonal milieuGlial cellsBeta expressionGranule cellsReceptor alphaReceptor αThyroid receptor αHealth problemsLow dosesCerebellar neuronsAssociations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study
Aker A, Johns L, McElrath T, Cantonwine D, Mukherjee B, Meeker J. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment International 2018, 113: 341-349. PMID: 29366524, PMCID: PMC5866216, DOI: 10.1016/j.envint.2018.01.006.Peer-Reviewed Original ResearchConceptsThyroid hormonesAssociated with altered thyroid hormone levelsFetal health outcomesThyroid hormone levelsIQR increaseMultivariate regression analysisGestational ageMultivariate linear regression modelFetal neurodevelopmentPregnant womenFree thyroxinePotential biological mechanismsTime of exposureUrinary biomarkersCohort studyHormone levelsParaben biomarkersTotal triiodothyronineCase-control samplePregnancyBlood samplesTotal thyroxineHormone concentrationsHealth outcomesHormone
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