2025
1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity
MATSON B, GUNAWAN F, ROTHMAN D, MASON G, NEWGARD C, HWANG J. 1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1727-p.Peer-Reviewed Original ResearchCentral nervous systemAcute hyperglycemiaLean controlsBrain glucose levelsMass spectrometry-based metabolomic profilingMeasured plasma amino acidsInsulin resistanceGlucose levelsBranched chain amino acidsPlasma amino acidsDevelopment of insulin resistanceAromatic amino acid levelsChain amino acidsAcid suppressionResponse to hyperglycemiaMetabolomic profilesImpaired suppressionHyperglycemic clampObesityInsulin sensitivityHyperglycemiaNervous systemAmino acid changesBrain glucoseHealthy adults
2024
Adipose tissue insulin resistance in children and adolescents: linking glucose and free fatty acid metabolism to hepatic injury markers
Bonet J, Weiss R, Galderisi A, Man C, Caprio S, Santoro N. Adipose tissue insulin resistance in children and adolescents: linking glucose and free fatty acid metabolism to hepatic injury markers. AJP Endocrinology And Metabolism 2024, 327: e723-e728. PMID: 39503461, PMCID: PMC11684862, DOI: 10.1152/ajpendo.00270.2024.Peer-Reviewed Original ResearchImpaired glucose toleranceInsulin sensitivity indexAlanine transaminaseInsulin resistanceFree fatty acid metabolismInsulin sensitivityP<10<sup>-6</sup>Years of follow-upMeasurement of liver function testsLiver function testsFree fatty acidsAdipose tissue insulin resistanceAdipose tissue insulin sensitivityHepatic injury markersPlasma alanine transaminaseEstimated insulin sensitivity indexTissue insulin sensitivityMann-Whitney testTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceProgression of insulin resistanceOral minimal modelCardiometabolic complicationsInsulin-resistant statesDepletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance.
Springer C, Binsch C, Weide D, Toska L, Cremer A, Backes H, Scheel A, Espelage L, Kotzka J, Sill S, Kurowski A, Kim D, Karpinski S, Schnurr T, Hansen T, Hartwig S, Lehr S, Cames S, Brüning J, Lienhard M, Herwig R, Börno S, Timmermann B, Al-Hasani H, Chadt A. Depletion of TBC1D4 Improves the Metabolic Exercise Response by Overcoming Genetically Induced Peripheral Insulin Resistance. Diabetes 2024, 73: 1058-1071. PMID: 38608276, DOI: 10.2337/db23-0463.Peer-Reviewed Original ResearchWhite adipose tissueLoss-of-function variantsAnalysis of glucose uptakeRegulation of glucose transportInterscapular brown adipose tissueHigh-fat dietEnhanced expression levelsDevelopment of insulin resistanceBrown adipose tissueMitochondrial activityTBC1D4Gene variantsInsulin resistanceAdipose tissueGlucose uptakePeripheral insulin resistanceGlucose transportExpression levelsGenesPrecision medicineInsulin toleranceGeneticsIncreased glucose clearanceExercise responseIn vivo
2012
Role of Tissue Macrophages in the Development of Critical Illness Diabetes
Jiang S, Gavrikova T, Sharifov O, Messina J. Role of Tissue Macrophages in the Development of Critical Illness Diabetes. Shock 2012, 37: 70-76. PMID: 21841539, PMCID: PMC3237746, DOI: 10.1097/shk.0b013e31823180a4.Peer-Reviewed Original ResearchConceptsInsulin resistanceClodronate-liposomesMacrophage depletionGadolinium chlorideHepatic insulin resistanceAdministration of gadolinium chlorideIntravenous administration of gadolinium chlorideDepletion of macrophagesMacrophage-derived factorsInitial development of insulin resistanceSpleen of ratsDevelopment of insulin resistanceMacrophage-independentHepatic Insulin SignalingInsulin-resistant statesSurgical traumaIntravenous administrationResident macrophagesTNF-aLiver of ratsHemorrhage periodSpleen macrophagesTissue macrophagesRodent modelsCritical illness
2010
Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats
Lenaers E, De Feyter H, Hoeks J, Schrauwen P, Schaart G, Nabben M, Nicolay K, Prompers J, Hesselink M. Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats. Obesity 2010, 18: 1100-1107. PMID: 19875988, DOI: 10.1038/oby.2009.372.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAdenine Nucleotide Translocator 1AnimalsDiabetes Mellitus, ExperimentalHyperglycemiaHyperinsulinismIon ChannelsMaleMitochondria, MuscleMitochondrial ProteinsMuscle Fibers, SkeletalObesityOxidation-ReductionOxygen ConsumptionProtein CarbonylationRatsRats, ZuckerSeverity of Illness IndexUncoupling Protein 3ConceptsUncoupling protein 3Palmitoyl-CoAMitochondrial functionZucker diabetic fattyFat oxidative capacityReduced fat oxidative capacityProgressive development of insulin resistanceMitochondrial defectsDevelopment of insulin resistanceCarbonyl cyanide p-trifluoromethoxyphenylhydrazoneIntrinsic mitochondrial defectIntrinsic mitochondrial functionInsulin resistanceMitochondrial dysfunctionMuscle mitochondrial functionPyruvate oxidationMitochondrial adaptationsType 2 diabetesState 3Development of type 2 diabetesMitochondrial capacityProtein 3Fa/fa ratsP-trifluoromethoxyphenylhydrazonePyruvate
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