2025
358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans
MATSON B, CHANG W, PALMIOTTO J, ROTHMAN D, BELFORT DE AGUIAR R, MASON G, HWANG J. 358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans. Diabetes 2025, 74 DOI: 10.2337/db25-358-or.Peer-Reviewed Original ResearchElevation of non-esterified fatty acidsNon-esterified fatty acid levelsHyperglycemic clampBrain glucose uptakeCirculating non-esterified fatty acidsBrain glucoseAcute elevationIntralipid infusionInsulin resistanceIntravenous infusion of salineAbsence of insulin resistanceNon-esterified fatty acidsInduce peripheral insulin resistanceHealthy adultsInfusion of salinePresence of hyperglycemiaGlucose uptakeMeasures of insulin sensitivityPeripheral insulin resistanceHigh-fat dietGlucose infusion rateIntravenous infusionPlasma glucoseLean individualsMRS scansMortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study
Njei B, Mezzacappa C, John B, Serper M, Kaplan D, Taddei T, Mahmud N. Mortality, Hepatic Decompensation, and Cardiovascular Outcomes in Lean vs. Non-lean MASLD Cirrhosis: A Veterans Affairs Cohort Study. Digestive Diseases And Sciences 2025, 70: 802-813. PMID: 39779587, PMCID: PMC11839701, DOI: 10.1007/s10620-024-08764-4.Peer-Reviewed Original ResearchConceptsNon-lean individualsAll-Cause MortalityMajor adverse cardiovascular eventsIncreased risk of all-cause mortalityRisk of all-cause mortalityVeterans Health AdministrationRisk of hepatic decompensationPrevalence of diabetesRisk of cardiovascular mortalityHepatic decompensationHigher mortality riskCardiovascular-related mortalityCox proportional hazards modelsCohort study of patientsCardiovascular outcomesIncident major adverse cardiovascular eventsRetrospective cohort study of patientsProportional hazards modelNon-HispanicRetrospective cohort studyCompeting risk regressionHealth AdministrationMultivariate Cox proportional hazards modelLean individualsAssessed associations
2024
Cardiovascular morbidity and mortality in lean vs. non-lean MASLD: A comprehensive meta-analysis
Nso N, Mergen D, Ikram M, Macrinici V, Hussain K, Lee K, Ugwendum D, Trimingham M, Balasubramanian S, Sam R, Njei B. Cardiovascular morbidity and mortality in lean vs. non-lean MASLD: A comprehensive meta-analysis. Current Problems In Cardiology 2024, 49: 102569. PMID: 38599554, DOI: 10.1016/j.cpcardiol.2024.102569.Peer-Reviewed Original ResearchConceptsOdds ratioConfidence intervalsCardiovascular mortality riskPooled odds ratioAll-Cause MortalityCardiometabolic profileMortality oddsMortality riskSecondary outcomesPrimary outcomeOddsMACE rateCardiovascular morbidityMeta-analysisCardiovascular outcomesLiver diseaseLean individualsSteatotic liver diseasePublication dateSample sizePatientsMACEOutcomesCohortMortalityGenetic and epigenetic determinants of non-alcoholic fatty liver disease (NAFLD) in lean individuals: a systematic review
Njei B, Al-Ajlouni Y, Ugwendum D, Abdu M, Forjindam A, Mohamed M. Genetic and epigenetic determinants of non-alcoholic fatty liver disease (NAFLD) in lean individuals: a systematic review. Translational Gastroenterology And Hepatology 2024, 9: 11-11. PMID: 38317742, PMCID: PMC10838615, DOI: 10.21037/tgh-23-31.Peer-Reviewed Original ResearchNewcastle Ottawa ScaleLean non-alcoholic fatty liver diseaseNon-alcoholic fatty liver diseaseSystematic reviewDeterminants of non-alcoholic fatty liver diseaseAscertainment of exposureLean individualsEpigenetic factorsModerate overall qualityFatty liver diseaseRisk of biasGene variantsPeer-reviewed studiesLiver diseaseQuality assessmentFrequent genetic risk factorGenetic risk factorsOttawa ScaleHistone variantsQualitative synthesisStudy designNAFLD riskPRISMA guidelinesEpigenetic determinantsEpigenetic contributions
2023
1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity
CHUNG T, DEAJON-JACKSON J, BINI J, SONG H, SANCHEZ RANGEL E, YECKEL C, HWANG J, STACHENFELD N, BELFORT-DEAGUIAR R. 1541-P: Sympathetic Nervous System Activity in Response to Food Ingestion Is Impacted by Obesity. Diabetes 2023, 72 DOI: 10.2337/db23-1541-p.Peer-Reviewed Original ResearchSympathetic nervous system activityMuscle sympathetic nerve activityMixed meal testNormal weightNervous system activityDistribution volume ratioPET-CTHeart rateSympathetic nerve activitySystem activityIngestion of foodMSNA increasesEndogenous NEMeal testNE releaseNerve activityOB subjectsObesity altersKidney diseaseDeltoid muscleLean individualsOB individualsNE transporterObeseFood ingestionGenomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study
Zheng M, Huang D, Konkwo C, Agrawal S, Khera A, Loomba R, Vilarinho S, Ajmera V. Genomic analysis of lean individuals with NAFLD identifies monogenic disorders in a prospective cohort study. JHEP Reports 2023, 5: 100692. PMID: 36937991, PMCID: PMC10017416, DOI: 10.1016/j.jhepr.2023.100692.Peer-Reviewed Original ResearchNon-alcoholic fatty liver diseaseLean non-alcoholic fatty liver diseaseFatty liver diseaseBiopsy-proven non-alcoholic fatty liver diseaseLiver diseaseWhole-exome sequencingLean patientsVisceral adiposityPatient 2Liver fatLean individualsMonogenic disordersMagnetic Resonance Imaging AssessmentExome sequencingHigh liver fatProspective cohort studyCohort of patientsEvaluation of patientsHereditary fructose intoleranceHomozygous pathogenic mutationNAFLD subtypesUnique genetic mutationsCohort studyLiver biopsyRare heterozygous mutations
2022
AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review
Long MT, Noureddin M, Lim JK. AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review. Gastroenterology 2022, 163: 764-774.e1. PMID: 35842345, PMCID: PMC9398982, DOI: 10.1053/j.gastro.2022.06.023.Peer-Reviewed Original ResearchConceptsLean Nonalcoholic Fatty Liver DiseaseNonalcoholic fatty liver diseaseType 2 diabetes mellitusClinical Practice Updates CommitteeBiopsy-confirmed nonalcoholic steatohepatitisFatty liver diseaseBody mass indexDiabetes mellitusLean individualsLiver diseaseNonalcoholic steatohepatitisLean personsLiver cirrhosisMass indexHepatic steatosisNoninvasive testsManagement of NAFLDSodium-glucose cotransporter 2 inhibitorsGlucagon-like peptide-1 agonistsLysosomal acid lipase deficiencyPrognosis of NAFLDAGA Governing BoardLiver biochemical testsModest weight lossCotransporter 2 inhibitorsEthnic and gender differences in hepatic lipid content and related cardiometabolic parameters in lean individuals
Petersen KF, Dufour S, Li F, Rothman DL, Shulman GI. Ethnic and gender differences in hepatic lipid content and related cardiometabolic parameters in lean individuals. JCI Insight 2022, 7 PMID: 35167495, PMCID: PMC9057590, DOI: 10.1172/jci.insight.157906.Peer-Reviewed Original ResearchConceptsCardiometabolic risk factorsInsulin resistanceRisk factorsHDL cholesterolLDL cholesterolTotal cholesterolLean individualsMatsuda insulin sensitivity indexAI menCardiovascular risk factorsHomeostatic model assessmentHepatic triglyceride contentInsulin sensitivity indexType 2 diabetesHepatic lipid contentNovo Nordisk FoundationUric acid concentrationCardiometabolic parametersCardiovascular riskPremenopausal womenFatty liverPlasma insulinInsulin sensitivityPlasma concentrationsModel assessmentCardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals
Aneni E, Saeed G, Bittencourt M, Cainzos-Achirica M, Osondu C, Budoff M, Parise E, Santos R, Nasir K. Cardiometabolic disorders, inflammation and the incidence of non-alcoholic fatty liver disease: A longitudinal study comparing lean and non-lean individuals. PLOS ONE 2022, 17: e0266505. PMID: 35385529, PMCID: PMC8985996, DOI: 10.1371/journal.pone.0266505.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseRisk of NAFLDElevated blood glucoseElevated blood pressureFatty liver diseaseBlood glucoseLean individualsBlood pressureCardiometabolic disordersPhysical inactivityWaist circumferenceLiver diseaseDevelopment of NAFLDHigh-sensitivity C-reactive proteinCardiovascular disease risk stratificationSensitivity C-reactive proteinCardiometabolic risk factorsAlcohol Use Disorders Identification TestC-reactive proteinMain exposure variableDisease risk stratificationHospital Israelita Albert EinsteinDisorders Identification TestAppropriate preventive measuresAtherogenic dyslipidemia
2020
The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study
Aneni E, Bittencourt M, Teng C, Cainzos-Achirica M, Osondu C, Soliman A, Al-Mallah M, Buddoff M, Parise E, Santos R, Nasir K. The risk of cardiometabolic disorders in lean non-alcoholic fatty liver disease: A longitudinal study. American Journal Of Preventive Cardiology 2020, 4: 100097. PMID: 34327473, PMCID: PMC8315654, DOI: 10.1016/j.ajpc.2020.100097.Peer-Reviewed Original ResearchLean non-alcoholic fatty liver diseaseNon-alcoholic fatty liver diseaseFatty liver diseaseAlcohol Use Disorders Identification TestLean individualsAtherogenic dyslipidemiaElevated glucoseElevated BPLiver diseaseFatty liverCardiovascular risk stratificationYoung asymptomatic individualsHealth promotion evaluationDisorders Identification TestAppropriate preventive measuresMedian followNAFLD individualsCardiometabolic consequencesCardiometabolic disordersRisk stratificationAsymptomatic individualsHigh riskBlood samplesAnthropometric measuresPopulation cohortA Longitudinal Study of Life Trauma, Chronic Stress and Body Mass Index on Weight Gain over a 2-Year Period
Fogelman N, Magin Z, Hart R, Sinha R. A Longitudinal Study of Life Trauma, Chronic Stress and Body Mass Index on Weight Gain over a 2-Year Period. Behavioral Medicine 2020, 48: 162-170. PMID: 32552603, PMCID: PMC7744435, DOI: 10.1080/08964289.2020.1780192.Peer-Reviewed Original ResearchConceptsBody mass indexCumulative Adversity InterviewLife traumaWeight gainChronic stressMass indexObesity-related health outcomesTrauma copingGreater weight gainLean individualsTrauma eventsObesity epidemicLongitudinal effectsHealth outcomesCurrent findingsLongitudinal studyTraumaVulnerable individualsObesitySignificant increaseTwo-year periodIndividualsCopingHigh levelsOverweightCharacterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women
Johnson AW, Snegovskikh D, Parikh L, DeAguiar RB, Han CS, Hwang JJ. Characterizing the Effects of Diabetes and Obesity on Insulin and Leptin Levels amongst Pregnant Women. American Journal Of Perinatology 2020, 37: 1094-1101. PMID: 32120424, DOI: 10.1055/s-0040-1702988.Peer-Reviewed Original ResearchConceptsDiabetes mellitusLeptin levelsCerebrospinal fluidLean mothersPlasma ratioMaternal cerebrospinal fluidMaternal metabolic environmentElective cesarean deliveryImpact of obesityCord blood insulinEffect of diabetesLow cerebrospinal fluidUncomplicated singleton pregnanciesMaternal plasma ratioArtery plasmaDM mothersCesarean deliveryObese patientsSingleton pregnanciesFetal exposureBlood insulinLower cordPregnant womenMaternal brainLean individuals
2019
Reduction in Serum Cholesterol in Subjects Consuming the Fermented Soy Beverage Q-CAN® Plus (P06-118-19)
Mehal W, Dioletis E, Paiva R, Secor E, Weiss T, Fields M, Ouyang X, Ali A. Reduction in Serum Cholesterol in Subjects Consuming the Fermented Soy Beverage Q-CAN® Plus (P06-118-19). Current Developments In Nutrition 2019, 3: nzz031.p06-118-19. PMCID: PMC6576748, DOI: 10.1093/cdn/nzz031.p06-118-19.Peer-Reviewed Original ResearchTotal cholesterol levelsLDL cholesterolCholesterol levelsLipid parametersTotal cholesterolVisit 1Obese individualsPercentage changeTreatment total cholesterolSerum lipid profileMethods Prospective studyLDL cholesterol valuesPost treatmentVisit 7Clinic visitsHDL cholesterolObese subjectsLean subjectsProspective studyVisit 3Hypolipidemic effectsSerum cholesterolLean individualsLipid profileVisit 8
2014
The internalization of weight bias is associated with severe eating pathology among lean individuals
Schvey NA, White MA. The internalization of weight bias is associated with severe eating pathology among lean individuals. Eating Behaviors 2014, 17: 1-5. PMID: 25514799, DOI: 10.1016/j.eatbeh.2014.11.001.Peer-Reviewed Original ResearchConceptsWeight Bias Internalization ScaleWeight biasPurge behaviorsInternalized weight biasBinge/purge behaviorsLean individualsEDE-Q subscalesWBIS scoresInternalization ScaleBehavioral criteriaBivariate correlationsAnonymous online surveyBingeConvergence of responsesOnline surveyPositive associationOverweight adultsIndividualsParticipantsBiasLogistic regressionAdultsPathologyQEWPNovel findings
2013
Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine
Li CS, Potenza MN, Lee DE, Planeta B, Gallezot JD, Labaree D, Henry S, Nabulsi N, Sinha R, Ding YS, Carson RE, Neumeister A. Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[11C]O-methylreboxetine. NeuroImage 2013, 86: 306-310. PMID: 24121204, PMCID: PMC3947246, DOI: 10.1016/j.neuroimage.2013.10.004.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Norepinephrine transporterNoradrenergic dysfunctionObese individualsLean individualsStructural MR scansBPND valuesNorepinephrine transporter availabilityReference tissue model 2Positron emission tomography (PET) imagingEmission Tomography ImagingPositron emission tomographyBrain norepinephrine transportersNE clearanceMass indexRaphe nucleusLocus coeruleusSynaptic availabilityObese peopleTransporter availabilityOccipital cortexComparison subjectsHealthy individualsObesityNeural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels
Jastreboff AM, Sinha R, Lacadie C, Small DM, Sherwin RS, Potenza MN. Neural Correlates of Stress- and Food Cue–Induced Food Craving in Obesity Association with insulin levels. Diabetes Care 2013, 36: 394-402. PMID: 23069840, PMCID: PMC3554293, DOI: 10.2337/dc12-1112.Peer-Reviewed Original ResearchConceptsFood cuesFood cravingsStress cuesBrain responsesSubjective food cravingsFavorite-food cuesBrain regionsInsulin levelsNeural correlatesBrain activationHOMA-IRObese individualsInsulin sensitivityFood motivationNeural activityFunctional MRICuesCravingHOMA-IR levelsNeurocircuitryLean subjectsInsulin resistanceLean individualsObesity associationHypothalamic regions
2008
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Stice E, Spoor S, Bohon C, Small DM. Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele. Science 2008, 322: 449-452. PMID: 18927395, PMCID: PMC2681095, DOI: 10.1126/science.1161550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesBasal GangliaBody Mass IndexCaudate NucleusCorpus StriatumCuesDeoxyribonucleases, Type II Site-SpecificDopamineEatingFemaleFoodHumansHyperphagiaMagnetic Resonance ImagingObesityPolymorphism, Restriction Fragment LengthPutamenReceptors, Dopamine D2Regression AnalysisRewardSignal TransductionWeight GainConceptsDorsal striatumTaqIA restriction fragment length polymorphismConsummatory food rewardMagnetic resonance imaging studyStriatal dopamine receptorsDevelopment of obesityA1 alleleResonance imaging studyFunctional magnetic resonance imaging studyDopamine D2 receptor geneTaqIA A1 alleleObese individualsStriatal dopamineD2 receptor geneProspective dataLean individualsDopamine receptorsFood intakeStriatumImaging studiesStriatal responsesStriatal activationGenetic polymorphismsReceptor geneObesity
2006
Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
Petersen KF, Dufour S, Feng J, Befroy D, Dziura J, Man C, Cobelli C, Shulman GI. Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 18273-18277. PMID: 17114290, PMCID: PMC1693873, DOI: 10.1073/pnas.0608537103.Peer-Reviewed Original ResearchConceptsAsian Indian menInsulin resistanceInsulin sensitivity indexLiver diseaseNonalcoholic fatty liver diseaseOral glucose tolerance testType 2 diabetes mellitusAsian IndiansWhole-body insulin sensitivityFatty liver diseaseIL-6 concentrationsTreatment of T2DMIntramyocellular lipid contentGlucose tolerance testPathogenesis of T2DMProton magnetic resonance spectroscopyImportant therapeutic implicationsEthnic groupsDiabetes mellitusImportant ethnic differencesCaucasian manTolerance testInsulin sensitivityIntramyocellular lipidsLean individuals
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