2025
Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET
Asch R, Naganawa M, Moisieienko K, Weed M, Kapinos M, Zheng M, Hillmer A, Carson R, Pietrzak R, Esterlis I. Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET. EJNMMI Research 2025, 15: 8. PMID: 39900828, PMCID: PMC11790547, DOI: 10.1186/s13550-025-01200-2.Peer-Reviewed Original ResearchMonitoring molecular markers associated with antimalarial drug resistance in south-east Senegal from 2021 to 2023
Wade A, Sene S, Caspar E, Diallo F, Platon L, Thiebaut L, Pouye M, Ba A, Thiam L, Fall M, Sadio B, Desamours I, Guerra N, Hagadorn K, Amambua-Ngwa A, Bei A, Vigan-Womas I, Ménard D, Mbengue A. Monitoring molecular markers associated with antimalarial drug resistance in south-east Senegal from 2021 to 2023. Journal Of Antimicrobial Chemotherapy 2025, 80: 828-839. PMID: 39846779, PMCID: PMC11879165, DOI: 10.1093/jac/dkaf006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntimalarialsArtemisininsChildChild, PreschoolDrug CombinationsDrug ResistanceFemaleHumansMalaria, FalciparumMaleMembrane Transport ProteinsMiddle AgedMultidrug Resistance-Associated ProteinsMutationPlasmodium falciparumProtozoan ProteinsPyrimethamineSenegalSulfadoxineTetrahydrofolate DehydrogenaseYoung AdultConceptsArtemisinin-based combination therapyMolecular markers associated with antimalarial drug resistanceArtemisinin-based combination therapy efficacyP. falciparum infectionSulfadoxine-pyrimethamine resistanceAntimalarial drug resistanceInvestigated gene polymorphismsCQ-RResistance in vitroVenous blood samplesClinical outcome studiesI356TK76TPfcrt mutationsChloroquine resistanceAntimalarial resistancePfmdr-1CQ useMalaria eliminationCombination therapyResistance surveillanceGene polymorphismsPlasmodium falciparumDrug resistanceAmplicon deep sequencing
2023
Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Schilsky M, Ott P, Sandahl T. Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans. Hepatology 2023, 79: 1065-1074. PMID: 38088886, PMCID: PMC11019997, DOI: 10.1097/hep.0000000000000708.Peer-Reviewed Original ResearchUrinary copper excretionStandard uptake valueIntestinal copper absorptionUptake valueCopper excretionIntestinal absorptionPositron emission tomography/CT scanMean standard uptake valueSame therapeutic targetsPET/CT studiesVenous blood samplesCopper absorptionIntestinal copper uptakeEffects of drugsUrinary excretionCT scanHealthy volunteersBlood samplesHealthy humansTrientineTherapeutic targetBody weightCT studiesWilson's diseaseD-penicillamineTrace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples
Lin E, Nason S, Zhong A, Fortner J, Godri Pollitt K. Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples. The Science Of The Total Environment 2023, 883: 163530. PMID: 37094673, PMCID: PMC10248884, DOI: 10.1016/j.scitotenv.2023.163530.Peer-Reviewed Original ResearchConceptsPolyfluoroalkyl substancesLiquid chromatography-high resolution mass spectrometryResolution mass spectrometryWater-repellent propertiesVenous blood samplesBlood samplesTrace levelsTrace analysisMass spectrometryWhole blood samplesChemical analysisAlkyl substancesHealthy adultsMan-made chemicalsAdverse health outcomesAnalytical methodBlank correctionHousehold productsHealth outcomesPFAS exposureInvasive methodBlood collectionBlood spotsCritical windowEnvironmental exposures
2022
Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies
Huang T, Howse F, Stachenfeld N, Usselman C. Correlations between salivary- and blood-derived gonadal hormone assessments and implications for inclusion of female participants in research studies. AJP Heart And Circulatory Physiology 2022, 324: h33-h46. PMID: 36426884, DOI: 10.1152/ajpheart.00399.2022.Peer-Reviewed Original ResearchConceptsMenstrual cycleGonadal hormonesFemale participantsVenous blood samplesGonadal hormone fluctuationsPrimary gonadalVascular functionBlood concentrationsCardiovascular diseaseHormone assessmentSerial measurementsHormone fluctuationsHormone monitoringBlood samplesStudy designGold standard measurementHuman physiology researchHormoneInclusion of femalesSalivaryResearch studiesCardiovascular researchersParticipantsFemalesHemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and biotransformation of erythrocyte epoxy fatty acids in peripheral tissue. Prostaglandins Leukotrienes And Essential Fatty Acids 2022, 181: 102453. PMID: 35633593, DOI: 10.1016/j.plefa.2022.102453.Peer-Reviewed Original ResearchConceptsRed blood cellsHD treatmentHemodialysis treatmentEnd-stage renal disease patientsHydroxyeicosatetraenoic acidHydroxyeicosapentaenoic acidSingle hemodialysis treatmentChronic kidney diseaseRenal disease patientsRenal replacement therapyFatty acid statusVenous blood samplesHydroxydocosahexaenoic acidEpoxy fatty acidsCause of mortalityLOX pathwayRenal failureFatty acidsKidney diseaseDisease patientsVenous bloodCardiovascular functionAcid statusArteriovenous differenceCardiovascular diseaseBioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis
Liu T, Dogan I, Rothe M, Reichardt J, Knauf F, Gollasch M, Luft F, Gollasch B. Bioaccumulation of Blood Long-Chain Fatty Acids during Hemodialysis. Metabolites 2022, 12: 269. PMID: 35323712, PMCID: PMC8949028, DOI: 10.3390/metabo12030269.Peer-Reviewed Original ResearchChronic kidney diseaseRed blood cellsLong-chain fatty acidsHD treatmentUpper limbEnd-stage renal disease patientsPeripheral tissue perfusionSingle HD treatmentRenal disease patientsFatty acid statusVenous blood samplesFatty acidsCardiovascular eventsESRD patientsHD patientsKidney diseaseDisease patientsVenous bloodHemodialysis treatmentAcid statusUremia altersBlood samplesTissue perfusionLCFA levelsFatty acids nAnemia Etiology in Ethiopia: Assessment of Nutritional, Infectious Disease, and Other Risk Factors in a Population-Based Cross-Sectional Survey of Women, Men, and Children
Andersen CT, Tadesse AW, Bromage S, Fekadu H, Hemler EC, Passarelli S, Spiegelman D, Sudfeld CR, Worku A, Berhane Y, Fawzi WW. Anemia Etiology in Ethiopia: Assessment of Nutritional, Infectious Disease, and Other Risk Factors in a Population-Based Cross-Sectional Survey of Women, Men, and Children. Journal Of Nutrition 2022, 152: 501-512. PMID: 34647598, PMCID: PMC8990104, DOI: 10.1093/jn/nxab366.Peer-Reviewed Original ResearchConceptsRisk factorsAnemia casesPopulation-based cross-sectional studyFolic acid food fortificationC-reactive protein levelsInfectious diseasesPopulation attributable risk percentageVitamin B12Proportion of anemiaDietary iron intakeCause of anemiaHelminth infection statusAttributable risk percentageLow serum ferritinLow serum folateVenous blood samplesPopulation-weighted prevalenceCross-sectional studyPublic health interventionsPotential public health interventionsCross-sectional surveyAssessment of NutritionalIron interventionsSerum ferritinAnemia etiologyHemodialysis and Plasma Oxylipin Biotransformation in Peripheral Tissue
Liu T, Dogan I, Rothe M, Kunz J, Knauf F, Gollasch M, Luft F, Gollasch B. Hemodialysis and Plasma Oxylipin Biotransformation in Peripheral Tissue. Metabolites 2022, 12: 34. PMID: 35050156, PMCID: PMC8781597, DOI: 10.3390/metabo12010034.Peer-Reviewed Original ResearchArteriovenous differenceEnd-stage renal disease patientsCytochrome P450Renal disease patientsVenous blood samplesArterial blood plasmaImpact of HDSoluble epoxide hydrolase activityVenous blood streamCardiovascular morbidityHemodialysis patientsDisease patientsVenous bloodHD treatmentUpper extremityPeripheral tissuesBlood samplesLipid mediatorsUpper limbEpoxide hydrolase activityBlood streamPatientsMetabolite levelsDeleterious effectsBlood plasma
2020
In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study
Pelletier-Galarneau M, Petibon Y, Ma C, Han P, Kim S, Detmer F, Yokell D, Guehl N, Normandin M, El Fakhri G, Alpert N. In vivo quantitative mapping of human mitochondrial cardiac membrane potential: a feasibility study. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 414-420. PMID: 32719915, PMCID: PMC7839097, DOI: 10.1007/s00259-020-04878-9.Peer-Reviewed Original ResearchConceptsMembrane potentialBolus injectionHealthy subjectsHematocrit levelsSerial venous blood samplesT1 mapping imagesVenous blood samplesExtracellular space fractionMethodsThirteen healthy subjectsDynamic PET acquisitionCellular membrane potentialGadolinium injectionPrognostic informationVentricular arrhythmiasHeart failureMyocardial hypertrophyMitochondrial membrane potentialCardiac diseaseIn vitro assessmentTherapy monitoringBlood concentrationsPET acquisitionImaging protocolBlood samplesPlasma tracer concentrationFick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension
Joseph P, Oliveira RKF, Eslam RB, Agarwal M, Waxman AB, Systrom DM. Fick principle and exercise pulmonary hemodynamic determinants of the six‐minute walk distance in pulmonary hypertension. Pulmonary Circulation 2020, 10: 1-9. PMID: 32994925, PMCID: PMC7502687, DOI: 10.1177/2045894020957576.Peer-Reviewed Original ResearchSix-minute walk distanceSix-minute walk testWalk distancePulmonary hypertensionOxygen deliveryCardiac reserveWalk testHemodynamic determinantsFick principleMixed venous blood samplesDepressed cardiac indexRight heart afterloadPulmonary vascular resistanceRight heart catheterizationRight ventricular afterloadStroke volume indexTotal pulmonary resistancePulmonary artery catheterPulmonary vascular pressuresSystemic oxygen deliveryVenous blood samplesImpaired oxygen deliveryFick cardiac outputCardiac indexHeart catheterizationThe effects of hemodilution on coagulation in term parturients: an in vitro study utilizing rotational thromboelastometry
Getrajdman C, Sison M, Lin H, Katz D. The effects of hemodilution on coagulation in term parturients: an in vitro study utilizing rotational thromboelastometry. The Journal Of Maternal-Fetal & Neonatal Medicine 2020, 35: 1969-1977. PMID: 32519906, PMCID: PMC7725917, DOI: 10.1080/14767058.2020.1776250.Peer-Reviewed Original ResearchConceptsArea under the curveDegree of hemodilutionRotational thromboelastometrySevere obstetric hemorrhageHistory of bleedingImpact of hemodilutionVenous blood samplesObservational pilot studyEffect of hemodilutionStatistically significant differenceIn vitro studiesObstetric hemorrhageFibrinogen replacementFIBTEM testPlasma-LyteFIBTEM assaysEXTEM assayEXTEM testClotting disordersCoagulation changesFIBTEMParturientsMedian CTThromboelastometry valuesHemodilution4402 The effects of hemodilution in vitro on coagulation in term parturients using thromboelastometry
Getrajdman C, Sison M, Lin H, Katz D. 4402 The effects of hemodilution in vitro on coagulation in term parturients using thromboelastometry. Journal Of Clinical And Translational Science 2020, 4: 147-147. PMCID: PMC8823515, DOI: 10.1017/cts.2020.434.Peer-Reviewed Original ResearchArea under the curveDegree of hemodilutionRotational thromboelastometrySevere obstetric hemorrhageHistory of bleedingBlood coagulationImpact of hemodilutionVenous blood samplesObservational pilot studyEffect of hemodilutionStatistically significant differenceObstetric hemorrhagePregnant patientsFibrinogen replacementObstetric patientsFIBTEM testPlasma-LyteFIBTEM assaysEXTEM assayEXTEM testClotting disordersClot strengthCoagulation changesFIBTEMThromboelastometry valuesIs hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
Cohall D, Ojeh N, Ferrario CM, Adams OP, Nunez-Smith M. Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes? Journal Of The Renin-Angiotensin-Aldosterone System 2020, 21: 1470320320908186. PMID: 32089050, PMCID: PMC7036504, DOI: 10.1177/1470320320908186.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAngiotensin IAngiotensin IIAngiotensin-Converting Enzyme 2Black PeopleHumansHypertensionMiddle AgedPeptide FragmentsPeptidesPeptidyl-Dipeptidase AProto-Oncogene MasProto-Oncogene ProteinsReceptor, Angiotensin, Type 1Receptors, G-Protein-CoupledRenin-Angiotensin SystemYoung AdultConceptsRenin angiotensin aldosterone systemAngiotensin aldosterone systemAldosterone systemClinical blood pressure readingsType 2 diabetes mellitusACE2/AngEnzyme 2 activityChronic renal diseaseBlood pressure readingsVenous blood samplesAfro-Caribbean originAntihypertensive treatmentMineralocorticoid blockersPressor armDiabetes mellitusRenal diseaseReceptor axisAfrican descentUrine collectionEnzyme 2Blood samplesHypertensionPressure readingsAnthropometric dataAfrican descent populations
2016
Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG
Hahn A, Gryglewski G, Nics L, Hienert M, Rischka L, Vraka C, Sigurdardottir H, Vanicek T, James GM, Seiger R, Kautzky A, Silberbauer L, Wadsak W, Mitterhauser M, Hacker M, Kasper S, Lanzenberger R. Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG. Journal Of Nuclear Medicine 2016, 57: 1933-1940. PMID: 27390156, DOI: 10.2967/jnumed.116.176156.Peer-Reviewed Original ResearchConceptsBaseline glucose metabolismTask-specific changesGlucose metabolismTime-activity curvesConstant infusionBolus applicationF-FDGBlood samplingBaseline metabolismPatlak plotVenous blood samplesCerebral metabolic rateVenous blood samplingGeneral linear modelHigh intrasubject variabilityMultimodal brain imagingArterial blood samplingMotor cortexHealthy subjectsCMRgluRegional time-activity curvesRight thumbArterial samplesBlood samplesDefault mode regions
2012
Circulating CD68 positive (+) leukocytes in blood samples from patients (pts) with breast cancer (BC).
Lustberg M, Miller B, Wu Y, Xue W, Deighan C, Carothers S, Berger M, Shapiro C, Chalmers J. Circulating CD68 positive (+) leukocytes in blood samples from patients (pts) with breast cancer (BC). Journal Of Clinical Oncology 2012, 30: 172-172. DOI: 10.1200/jco.2012.30.27_suppl.172.Peer-Reviewed Original ResearchBlood samplesBreast cancerLeukocyte populationsPeripheral blood leukocyte populationsNegative depletionAdvanced breast cancerMultiparameter flow cytometry analysisVenous blood samplesBlood leukocyte populationsPrimary breast tumorsMacrophages/monocytesProgression of diseaseBreast tumor stromaCell surface markersAdditional phenotypic characterizationFlow cytometry analysisPositive leukocytesBC patientsPeripheral bloodPredictive markerPoor responseCD 68Such tumorsPatient's stageT cells
2008
Expression Levels of CD11b, CD18, CD32, CD62L (L-Selectin) and CD62P (P-Selectin) and Its Role in Sickle Cell Anemia Inflammatory State
Cerqueira B, Boas W, Seixas M, Damasceno E, Souza C, Reis M, Goncalves M. Expression Levels of CD11b, CD18, CD32, CD62L (L-Selectin) and CD62P (P-Selectin) and Its Role in Sickle Cell Anemia Inflammatory State. Blood 2008, 112: 2504. DOI: 10.1182/blood.v112.11.2504.2504.Peer-Reviewed Original ResearchVaso-occlusive eventsInflammatory stateVascular occlusionSCA patientsRed blood cellsLeukocyte activationHemolytic stateExpression levelsSickle cell complicationsExpression of CD62LHigher CRP levelsSoluble adhesion moleculesChronic inflammatory stateVenous blood samplesNaïve T lymphocytesHigh endothelial venulesFetal hemoglobinActivation stateCD62L expression levelsCell surface antigensLeukocyte cell surface antigensVascular complicationsCD62L expressionCRP levelsEndothelial dysfunction
2007
Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers
Absalom A, Lee M, Menon D, Sharar S, De Smet T, Halliday J, Ogden M, Corlett P, Honey G, Fletcher P. Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers. British Journal Of Anaesthesia 2007, 98: 615-623. PMID: 17389691, PMCID: PMC3838936, DOI: 10.1093/bja/aem063.Peer-Reviewed Original ResearchConceptsTarget-controlled infusionKetamine infusionHealthy volunteersLow-dose ketamine infusionPlasma concentration-time courseVenous blood samplesCognitive function testsConcentration-time courseFunction testsKetamine administrationTarget concentrationBlood samplesKetamine modelInfusionMore occasionsTCI deviceFunctional neuroimagingVolunteers
2006
Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline
Mathew JP, Rinder HM, Smith BR, Newman MF, Rinder CS. Transcerebral Platelet Activation After Aortic Cross-Clamp Release is Linked to Neurocognitive Decline. The Annals Of Thoracic Surgery 2006, 81: 1644-1649. PMID: 16631650, DOI: 10.1016/j.athoracsur.2005.12.070.Peer-Reviewed Original ResearchConceptsCross-clamp removalAortic cross-clamp removalCardiopulmonary bypassPlatelet activationNeurocognitive injuryCognitive deficitsNeurocognitive declineElective coronary artery bypass graft surgeryCoronary artery bypass graft surgeryAortic cross-clamp releaseArtery bypass graft surgeryBypass graft surgeryCross-clamp releaseSubset of patientsVenous blood samplesJugular venous blood samplesJugular venous bloodCPB patientsGraft surgeryCardiac surgeryPatient subsetsInjury scoreAortic archVenous bloodCognitive injury
2005
Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study.
Weinzimer SA, Beck RW, Chase HP, Fox LA, Buckingham BA, Tamborlane WV, Kollman C, Coffey J, Xing D, Ruedy KJ. Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study. Diabetes Technology & Therapeutics 2005, 7: 675-80; discussion 681-3. PMID: 16241867, PMCID: PMC1351386, DOI: 10.1089/dia.2005.7.675.Peer-Reviewed Original ResearchConceptsHome glucose metersStandardized exercise protocolVenous blood samplesEffects of exerciseType 1 diabetesGlucose metersExercise protocolNocturnal hypoglycemiaExercise studiesVenous bloodGlucose levelsBlood samplesDetection of hypoglycemiaBlood glucose metersClinical settingHome blood glucose metersDiabetes researchCentral laboratoryHexokinase enzymatic methodGlucose measurementsGlucose concentration
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