2023
Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential age
2015
Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression
Jorgensen A, Magnusson P, Hanson L, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen J, Fink-Jensen A, Knudsen G, Paulson O, Bolwig T, Jorgensen M. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. Acta Psychiatrica Scandinavica 2015, 133: 154-164. PMID: 26138003, DOI: 10.1111/acps.12462.Peer-Reviewed Original ResearchElectroconvulsive therapyDiffusion tensor imagingDorsolateral prefrontal cortexAntidepressant effectsSevere depressionMetabolite changesRegional brain volumesBrain metabolite concentrationsProton MR spectroscopyT MR scanAntidepressant actionClinical responseHippocampal plasticityHippocampal volumeAmygdala volumeMagnetic resonanceBrain volumeOrbitofrontal cortexPrefrontal cortexBrain structuresTensor imagingMR spectroscopyMR scansLack of correlationMetabolite concentrations
2011
A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression
Mason WP, Belanger K, Nicholas G, Vallières I, Mathieu D, Kavan P, Desjardins A, Omuro A, Reymond D. A phase II study of the Ras-MAPK signaling pathway inhibitor TLN-4601 in patients with glioblastoma at first progression. Journal Of Neuro-Oncology 2011, 107: 343-349. PMID: 22048878, DOI: 10.1007/s11060-011-0747-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic AgentsBrain NeoplasmsChromatography, LiquidDibenzazepinesErbB ReceptorsFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticGlioblastomaHumansInfusions, IntraventricularKaplan-Meier EstimateMagnetic Resonance ImagingMaleMiddle AgedPTEN PhosphohydrolaseTandem Mass SpectrometryConceptsPharmacokinetic evaluationProgressive glioblastomaFirst progressionM2/dayPhase II studyMR scansPhase II trialContinuous intravenous administrationBlood-brain barrierLack of efficacyPeripheral benzodiazepine receptorEvaluable patientsStable diseaseII trialRadiographic progressionAdverse eventsII studyRecurrent glioblastomaDisease progressionDrug levelsIntravenous administrationBiomarker assessmentPatientsAnimal modelsBenzodiazepine receptors
1997
A systematic approach for interpreting MR images of the seizure patient.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD. A systematic approach for interpreting MR images of the seizure patient. American Journal Of Roentgenology 1997, 169: 241-7. PMID: 9207533, DOI: 10.2214/ajr.169.1.9207533.Peer-Reviewed Original ResearchConceptsSubtle cortical abnormalitiesFalse-negative diagnosesHippocampal sclerosisAbnormal findingsEpileptogenic lesionsCortical thickeningSeizure patientsCortical abnormalitiesLateral ventriclePeriventricular regionEpilepsy patientsMR findingsHigh indexMorphologic abnormalitiesPeriventricular heterotopiaDual abnormalitiesGray matterDevelopmental anomaliesAbnormalitiesMR scansCortical processesMass effectHead rotationPatientsHippocampus
1995
Regional distribution of MR findings in hippocampal sclerosis.
Bronen RA, Fulbright RK, Kim JH, Spencer SS, Spencer DD, al-Rodhan NR. Regional distribution of MR findings in hippocampal sclerosis. American Journal Of Neuroradiology 1995, 16: 1193-200. PMID: 7677010, PMCID: PMC8337833.Peer-Reviewed Original ResearchConceptsHippocampal sclerosisHippocampal bodyHippocampal headMR findingsHippocampal tailMR abnormalitiesLimbic structuresAbnormal MR findingsConsecutive patientsIpsilateral hippocampusMost patientsSignal changesSeizure generatorPathologic analysisHyperintense signalRegional atrophyEntire hippocampusPatientsSclerosisHippocampusAmygdalaAtrophyMR changesMR scansWidespread involvementMR characteristics of neoplasms and vascular malformations associated with epilepsy
Bronen R, Fulbright R, Spencer D, Spencer S, Kim J, Lange R. MR characteristics of neoplasms and vascular malformations associated with epilepsy. Magnetic Resonance Imaging 1995, 13: 1153-1162. PMID: 8750330, DOI: 10.1016/0730-725x(95)02026-p.Peer-Reviewed Original ResearchConceptsVascular malformationsCalvarial remodellingPathologic categoriesAdjacent tissuesTemporal lobe locationTypical imaging featuresMR characteristicsBlinded retrospective analysisMagnetic resonanceRefractory epilepsyPathologic findingsCortical involvementEpileptogenic substratePathologic substrateVascular lesionsImaging featuresCommon siteRetrospective analysisTemporal lobeLobe locationEpilepsyLesionsMalformationsNeoplasmsMR scans
1993
MR findings after depth electrode implantation for medically refractory epilepsy.
Merriam M, Bronen R, Spencer D, McCarthy G. MR findings after depth electrode implantation for medically refractory epilepsy. American Journal Of Neuroradiology 1993, 14: 1343-6. PMID: 8279329, PMCID: PMC8367502.Peer-Reviewed Original ResearchConceptsDepth electrode implantationProbe tractRefractory epilepsyChronic changesElectrode implantationEvidence of gliosisElectrode placementProbe placementRare complicationDepth electrode placementRetrospective reviewIntraparenchymal hemorrhageSignificant hemorrhageSeizure focusBrain parenchymaSignal abnormalitiesStereotactic placementLower incidenceMR findingsAngiographic dataHemorrhagePatientsDepth electrodesSpin-echo imagesMR scans
1990
High-field MRI and US evaluation of the pelvis in women with leiomyomas
Zawin M, McCarthy S, Scoutt L, Comite F. High-field MRI and US evaluation of the pelvis in women with leiomyomas. Magnetic Resonance Imaging 1990, 8: 371-376. PMID: 2202877, DOI: 10.1016/0730-725x(90)90044-3.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCul-de-sac fluidEndometrial stripeUterine volumeTransabdominal ultrasonographyUS evaluationCul de sacMarked enlargementUS examinationUterine leiomyomaContour abnormalitiesUltrasonographyEntire pelvisLeiomyomaResonance imagingJunctional zoneSac fluidHigh-field magnetic resonance imagingMR scansWomenUterusPelvisOvariesExaminationSubmucosal
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply