2022
CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesAssociation of BMIHigher Body Mass IndexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals
2021
Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts
Wong AY, MacKenna B, Morton CE, Schultze A, Walker AJ, Bhaskaran K, Brown JP, Rentsch CT, Williamson E, Drysdale H, Croker R, Bacon S, Hulme W, Bates C, Curtis HJ, Mehrkar A, Evans D, Inglesby P, Cockburn J, McDonald HI, Tomlinson L, Mathur R, Wing K, Forbes H, Eggo RM, Parry J, Hester F, Harper S, Evans SJ, Smeeth L, Douglas IJ, Goldacre B, Collaborative T. Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts. Annals Of The Rheumatic Diseases 2021, 80: 943-951. PMID: 33478953, PMCID: PMC7823433, DOI: 10.1136/annrheumdis-2020-219517.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsPrescribed non-steroidal anti-inflammatory drugsRheumatoid arthritis/osteoarthritisArthritis/osteoarthritisCurrent NSAID usersMultivariable-adjusted modelsAnti-inflammatory drugsNSAID prescriptionsNSAID usersGeneral populationCOVID-19Risk of deathNational Health Service EnglandRoutine therapeutic useRoutine clinical dataCohort studyCurrent useCox regressionClinical dataCohort analysisLower riskEvidence of differencesDeath dataTherapeutic useDeath
2020
Quasi-Experimental Evaluation of The Grassroot Project, a Sport-Based Sexual Health Promotion Program for Urban Middle School Students
Melendez-Torres G, Spencer T, Ingram L, Zimmerman R, Pettengill R, Mullman M, Otterbein M, Stein R, Kilburn C. Quasi-Experimental Evaluation of The Grassroot Project, a Sport-Based Sexual Health Promotion Program for Urban Middle School Students. American Journal Of Sexuality Education 2020, 15: 465-475. DOI: 10.1080/15546128.2020.1796866.Peer-Reviewed Original ResearchSexual health promotion programsHealth promotion programsPromotion programsKey outcome domainsFuture longitudinal evaluationUrban middle school studentsMiddle school studentsHIV stigmaEvidence of differencesLongitudinal evaluationOutcome domainsSexual riskSexual intercourseBiomedical outcomesAthlete role modelsSchool studentsQuasi-experimental evaluationInterventionRole modelsStudentsViolent behavior
2018
Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study
Wallach JD, Ciani O, Pease AM, Gonsalves GS, Krumholz HM, Taylor RS, Ross JS. Comparison of treatment effect sizes from pivotal and postapproval trials of novel therapeutics approved by the FDA based on surrogate markers of disease: a meta-epidemiological study. BMC Medicine 2018, 16: 45. PMID: 29562926, PMCID: PMC5863466, DOI: 10.1186/s12916-018-1023-9.Peer-Reviewed Original ResearchConceptsPostapproval trialsPivotal trialsActual clinical effectSurrogate markerTrial endpointsLarge treatment effectsPrimary endpointNovel therapeuticsNovel drugsTreatment effectsFDA approvalPatient-relevant outcomesMeta-epidemiological studyStandardized mean differenceTreatment effect sizeClinical effectsResultsBetween 2005Odds ratioDrug trialsSame indicationDrug AdministrationEvidence of differencesMean differenceU.S. FoodDisease
2015
Air pollution and mortality in São Paulo, Brazil: Effects of multiple pollutants and analysis of susceptible populations
Bravo MA, Son J, de Freitas CU, Gouveia N, Bell ML. Air pollution and mortality in São Paulo, Brazil: Effects of multiple pollutants and analysis of susceptible populations. Journal Of Exposure Science & Environmental Epidemiology 2015, 26: 150-161. PMID: 25586330, DOI: 10.1038/jes.2014.90.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAir PollutantsAir PollutionBrazilCarbon MonoxideCardiovascular DiseasesCase-Control StudiesDeath CertificatesEnvironmental MonitoringFemaleHumansLogistic ModelsMaleMiddle AgedNitrogen DioxideOzoneParticle SizeParticulate MatterRespiratory Tract DiseasesRisk FactorsSex DistributionSocioeconomic FactorsSulfur DioxideConceptsTime of deathSocioeconomic statusTime-stratified case-crossover analysisCase-crossover analysisResidential socioeconomic statusEducation groupHospital deathCardiovascular mortalityNon-accidental mortalityRespiratory mortalityMortality riskHigh education groupEvidence of differencesSignificant associationMortalityEffect estimatesDeathMortality effectsSusceptible populationHealth impactsAmbient monitorsIndividual-level health dataAir pollutionHealth dataAerodynamic diameter
2004
Differences, disparities, and biases: clarifying racial variations in health care use.
Rathore SS, Krumholz HM. Differences, disparities, and biases: clarifying racial variations in health care use. Annals Of Internal Medicine 2004, 141: 635-8. PMID: 15492343, DOI: 10.7326/0003-4819-141-8-200410190-00011.Peer-Reviewed Original ResearchConceptsHealth care useCare useRacial variationRacial differencesHealth care system factorsAdverse consequencesClinical factorsClinical contraindicationsTreatment eligibilityPatient preferencesObservational studyEvidence of differencesMedical literatureRacial disparitiesHealth careInitial reportSystem factorsDifferent causesTreatmentReports of variationReportDisparitiesContraindicationsDifferencesCare
2000
Distinct Innate and Acquired Immune Responses to Leishmania in Putative Susceptible and Resistant Human Populations Endemically Exposed to L. (Viannia) panamensis Infection
Bosque, Saravia, Valderrama, Milon. Distinct Innate and Acquired Immune Responses to Leishmania in Putative Susceptible and Resistant Human Populations Endemically Exposed to L. (Viannia) panamensis Infection. Scandinavian Journal Of Immunology 2000, 51: 533-541. PMID: 10792848, DOI: 10.1046/j.1365-3083.2000.00724.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedDisease SusceptibilityEndemic DiseasesFemaleHumansHypersensitivity, DelayedImmunity, InnateInterferon-gammaInterleukin-10Leishmania guyanensisLeishmaniasis, MucocutaneousMacrophagesMaleMiddle AgedMonocytesRecombinant ProteinsRecurrenceRisk FactorsTritiumTumor Necrosis Factor-alphaConceptsPeripheral blood mononuclear cellsRecurrent diseaseL. panamensis infectionsCD8 T lymphocytesType hypersensitivity responseBlood mononuclear cellsAcquired Immune ResponsesTumor necrosis factorProduction of interferonEntry of parasitesLeishmania Viannia panamensisPanamensis infectionRecurrent leishmaniasisHypersensitivity responseImmunological basisSkin testMononuclear cellsNecrosis factorT lymphocytesImmune responseSubclinical infectionLinear regression analysisEvidence of differencesDistinct innateIntracellular amastigotes
1996
Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion
Pezzotti P, Phillips A, Dorrucci M, Lepri A, Galai N, Vlahov D, Rezza G. Category of exposure to HIV and age in the progression to AIDS: longitudinal study of 1199 people with known dates of seroconversion. The BMJ 1996, 313: 583. PMID: 8806246, PMCID: PMC2352019, DOI: 10.1136/bmj.313.7057.583.Peer-Reviewed Original ResearchConceptsDate of seroconversionCategories of exposureExposure categoriesOlder subjectsInjected drugsMore rapid progressionHeterosexual sexLongitudinal studyHomosexual sexHIV treatmentAIDS pathogenesisUnivariate analysisRapid progressionAge effectsYoung subjectsHomosexual menHIVRate of developmentEvidence of differencesDisease controlAIDSSeroconversionSexAgeDefinitions of Center
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