2024
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
Galuppo B, Mannam P, Bonet J, Pierpont B, Trico’ D, Haskell-Luevano C, Ericson M, Freeman K, Philbrick W, Bale A, Caprio S, Santoro N. Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity. International Journal Of Obesity 2024, 49: 819-826. PMID: 39738493, PMCID: PMC12095050, DOI: 10.1038/s41366-024-01706-0.Peer-Reviewed Original ResearchOral glucose tolerance testVisceral adipose tissueMelanocortin-4 receptor geneSubcutaneous adipose tissueVariant groupYale Pediatric Obesity ClinicInsulin resistanceEarly-onset obesityBMI z-scorePediatric obesity clinicRare variantsAdipose tissueAbdominal fat distributionDegree of obesityGlucose tolerance testTotal body fatIntrahepatic fat contentLower insulin sensitivityIntrahepatic fat accumulationAssociated with abdominal fatAbdominal MRIObesity clinicMetabolic sequelaePathogenic variantsFat distribution
2022
342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth
GALDERISI A, LAT J, SAMUELS S, PIERPONT B, VAN NAME M, SANTORO N, CAPRIO S. 342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth. Diabetes 2022, 71 DOI: 10.2337/db22-342-or.Peer-Reviewed Original ResearchBeta-cell functionIncretin effectInsulin sensitivityInsulin secretionCell functionFirst-phase insulin secretionIsoglycemic intravenous glucose infusionLongitudinal declineReduced β-cell functionEarly insulin secretionLower insulin sensitivityIntravenous glucose infusionΒ-cell functionOral minimal modelIncretin groupsObese youthGlucose infusionRelative increaseNational InstituteTertileLongitudinal trajectoriesObesitySecretionGlucoseGroup
2018
Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth
TRICO D, CAPRIO S, UMANO G, GALDERISI A, MATA M, NOUWS J, PIERPONT B, KIM G, SANTORO N. Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth. Diabetes 2018, 67 DOI: 10.2337/db18-313-or.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseasePediatric nonalcoholic fatty liver diseaseType 2 diabetesInsulin resistanceObese adolescentsInsulin sensitivityPrevalence of NAFLDHigher C-peptide levelsOral glucose tolerance testAfrican AmericansC-peptide levelsHigh fasting glucoseFatty liver diseaseGlucose tolerance testLower insulin sensitivityMajor risk factorZ-score BMIHepatic fat contentStrongest predictorCommon gene variantsFasting GlucoseNAFLD developmentGlucose toleranceLiver diseaseTolerance test
2005
Association between Impaired Insulin Sensitivity and Stroke
Bravata DM, Wells CK, Kernan WN, Concato J, Brass LM, Gulanski BI. Association between Impaired Insulin Sensitivity and Stroke. Neuroepidemiology 2005, 25: 69-74. PMID: 15947493, DOI: 10.1159/000086286.Peer-Reviewed Original ResearchConceptsHomeostasis model assessmentInsulin sensitivityGlycemic controlMultivariable logistic regression analysisStroke risk factorsLower insulin sensitivityThird National HealthImpaired insulin sensitivityLogistic regression analysisStroke historyInsulin resistancePlasma insulinPlasma glucoseRisk factorsNational HealthNutrition SurveyModel assessmentStrokeRegression analysisAssociationParticipantsClaudicationInsulin
1997
Metabolic Defects in Lean Nondiabetic Offspring of NIDDM Parents: A Cross-Sectional Study
Perseghin G, Ghosh S, Gerow K, Shulman G. Metabolic Defects in Lean Nondiabetic Offspring of NIDDM Parents: A Cross-Sectional Study. Diabetes 1997, 46: 1001-1009. PMID: 9166672, DOI: 10.2337/diab.46.6.1001.Peer-Reviewed Original ResearchConceptsInsulin resistanceInsulin sensitivityControl subjectsInsulin secretionNIDDM parentsNIDDM patientsFFA metabolismFFA concentrationsAbove confounding factorsInsulin-resistant offspringFree fatty acid levelsInverse correlationLDL cholesterol levelsHealthy control subjectsNormal insulin sensitivityIntravenous glucose bolusLower insulin sensitivityPlasma FFA concentrationEuglycemic hyperinsulinemic clampCross-sectional studyFirst-degree relativesPathogenesis of NIDDMDefective insulin secretionFatty acid levelsHigh free fatty acid levels
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