2023
THU302 Protective Effects Of Lactation On Maternal Metabolism
Hens J, Ding Y, Brown S, Song H, Wysolmerski J, De Aguiar R. THU302 Protective Effects Of Lactation On Maternal Metabolism. Journal Of The Endocrine Society 2023, 7: bvad114.737. PMCID: PMC10554876, DOI: 10.1210/jendso/bvad114.737.Peer-Reviewed Original ResearchNL miceGlucose metabolismL miceBody compositionEuglycemic hyperinsulinemic clamp techniquePlasma free fatty acidsHistory of lactationMaternal glucose metabolismTissue triglyceride levelsGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampGlucose infusion rateAge-matched cohortNumber of isletsAge-matched virginsLiver triglyceridesInsulin levelsTriglyceride levelsLiver weightTolerance testInsulin secretionMaternal metabolismFree fatty acidsInfusion rate849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats
VIJAYAKUMAR A, MURAKAMI E, HUSS R, SRODA N, SHIMAZAKI A, KASHIWAGI Y, MYERS R, SUBRAMANIAN M, SHULMAN G. 849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats. Diabetes 2023, 72 DOI: 10.2337/db23-849-p.Peer-Reviewed Original ResearchZucker diabetic fattyZDF ratsInsulin sensitivityAcetyl-CoA carboxylase 2T2D progressionAntidiabetic effectsClamp glucose infusion rateIntramyocellular lipid contentImproved insulin sensitivityHyperinsulinemic-euglycemic clampType 2 diabetesGlucose infusion rateNovel therapeutic approachesΒ-cell failureFatty acid oxidationFortress BiotechCardiac lipidsInsulin resistanceInfusion rateTherapeutic approachesStrong rationaleRatsGilead SciencesJanssen ResearchIMCL
2021
The Optimal Cell Salvage Settings to Maximize Hematocrit and Minimize Potassium Using the Cobe BRAT2 Autologous Blood Recovery Unit
Smith N, Kim S, Simmons Q, Lin H, Romano D, Boydston E, DeMaria S, Zerillo J. The Optimal Cell Salvage Settings to Maximize Hematocrit and Minimize Potassium Using the Cobe BRAT2 Autologous Blood Recovery Unit. Journal Of Cardiothoracic And Vascular Anesthesia 2021, 36: 1893-1900. PMID: 34446326, DOI: 10.1053/j.jvca.2021.07.040.Peer-Reviewed Original ResearchConceptsRed blood cellsInfusion rateSingle-center studyRed cellsAssociated with decreased hematocritIndependent of infusion rateFaster infusion ratesHematocrit pre-Salvage settingPotassium changesBanked red blood cellsInfusionBlood cellsHigher hematocritHematocritML/minLow potassiumCellsLactateDevice settingsGlucose
2019
Effect of Injection Site Cooling and Warming on Insulin Glargine Pharmacokinetics and Pharmacodynamics
Bitton G, Rom V, Hadelsberg U, Raz I, Cengiz E, Weinzimer S, Tamborlane WV. Effect of Injection Site Cooling and Warming on Insulin Glargine Pharmacokinetics and Pharmacodynamics. Journal Of Diabetes Science And Technology 2019, 13: 1123-1128. PMID: 31067999, PMCID: PMC6835184, DOI: 10.1177/1932296819842151.Peer-Reviewed Original ResearchConceptsInjection siteGlucose levelsSerum glucoseSubcutaneous depotMultiple daily insulin injectionsOvernight glucose levelsDaily insulin injectionsBlood glucose controlType 1 diabetesSensor glucose levelsInsulin infusion rateDL increaseInsulin glargineSerum insulinGlucose controlMDI therapyInsulin injectionsInsulin concentrationsPharmacodynamic studiesInfusion rateSkin warmingSeparate daysControl dayRate of absorptionRandom order
2018
Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia
Belfort-DeAguiar R, Gallezot JD, Hwang JJ, Elshafie A, Yeckel CW, Chan O, Carson RE, Ding YS, Sherwin RS. Noradrenergic Activity in the Human Brain: A Mechanism Supporting the Defense Against Hypoglycemia. The Journal Of Clinical Endocrinology & Metabolism 2018, 103: 2244-2252. PMID: 29590401, PMCID: PMC6456998, DOI: 10.1210/jc.2017-02717.Peer-Reviewed Original ResearchConceptsHyperinsulinemic-hypoglycemic clampRaphe nucleusCounterregulatory hormonal responsesInsulin-treated patientsOptimal glycemic controlPositron emission tomographic imagingGlucose infusion rateBrain responsesLean healthy volunteersEmission tomographic imagingGlycemic controlNA outputGlucagon levelsPlasma epinephrineNoradrenergic activationNA responseNoradrenergic activityAutonomic outputIntravenous injectionHealthy volunteersInfusion rateHypoglycemiaMotor activityGrowth hormoneHormonal responses
2017
Intraoperative Feeding Improves Calorie and Protein Delivery in Acute Burn Patients
Varon D, Freitas G, Goel N, Wall J, Bharadia D, Sisk E, Vacanti J, Pomahac B, Sinha I, Patel V. Intraoperative Feeding Improves Calorie and Protein Delivery in Acute Burn Patients. Journal Of Burn Care & Research 2017, 38: 299-303. PMID: 28296670, DOI: 10.1097/bcr.0000000000000514.Peer-Reviewed Original ResearchConceptsEnteral feedsProtocol groupStandard groupAcute burn patientsEnteral nutrition supportMajor thermal injuryEnteral feeding tubesBurn center's experienceProtein-calorie deficitsRate of aspirationOperative positioningModern burn careCenter experienceNutrition supportPerioperative periodRetrospective reviewTube feedsBurn patientsFeeding tubeEarly initiationCutaneous burnsBurn careInfusion rateIntraoperative aspirationPatientsA Telemonitoring Service Supporting Preterm Newborns Care in a Neonatal Intensive Care Unit
Losiouk E, Lanzola G, Galderisi A, Trevisanuto D, Steil G, Facchinetti A, Cobelli C. A Telemonitoring Service Supporting Preterm Newborns Care in a Neonatal Intensive Care Unit. 2017, 1-6. DOI: 10.1109/rtsi.2017.8065890.Peer-Reviewed Original ResearchNeonatal intensive care unitIntensive care unitCare unitPreterm newbornsLow birth weight infantsBirth weight infantsGlucose infusion rateDifferent clinical trialsHealth care staffContinuous glucose monitoringWeight infantsHeel prickNewborn careClinical benefitUniversity HospitalClinical trialsInfusion rateCare staffArterial samplingGlucose monitoringWard roomsGlucose dataGlucose concentrationPatientsNewborns
2015
Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System
Chung LS, Tkach A, Lingenfelter EM, Dehoney SB, Rollo J, de Havenon A, DeWitt LD, Grantz MR, Wang H, Wold JJ, Hannon PM, Weathered NR, Majersik JJ. Tissue Plasminogen Activator Prescription and Administration Errors within a Regional Stroke System. Journal Of Stroke And Cerebrovascular Diseases 2015, 25: 565-571. PMID: 26698642, PMCID: PMC4779727, DOI: 10.1016/j.jstrokecerebrovasdis.2015.11.014.Peer-Reviewed Original ResearchConceptsComprehensive stroke centerRegional stroke systemAcute ischemic strokeCommunity hospitalAdministration errorsStroke systemsWeight-based dosingMean age 68Ischemic strokeStroke centersStroke outcomeAIS patientsCH patientsAge 68Infusion rateSystemic hemorrhageAIS casesBody weightPharmacy informationPatientsIncorrect dosageOutcomesPrescriptionTPAAssociationMeasuring the influence of blood component infusion rate on recipient vital signs
Gehrie EA, Hendrickson JE, Tormey CA. Measuring the influence of blood component infusion rate on recipient vital signs. Vox Sanguinis 2015, 109: 353-358. PMID: 26174450, DOI: 10.1111/vox.12310.Peer-Reviewed Original ResearchConceptsRed blood cellsInfusion rateVital signsBlood pressurePulse rateBlood product volumeClose patient monitoringEvidence-based guidelinesBlood component administrationFaster infusion rateRoutine transfusionTransfusionMultispecialty hospitalHospital wardsHealthcare providersHospital unitsInfusion timeBlood componentsBlood cellsInfusionPlateletsPatient monitoringSignsSignificant changes
2014
Mixing and administration times of bypassing agents: observations from the Dosing Observational Study in Hemophilia (DOSE)
Maahs J, Donkin J, Recht M, Cooper D. Mixing and administration times of bypassing agents: observations from the Dosing Observational Study in Hemophilia (DOSE). Journal Of Blood Medicine 2014, 5: 153-156. PMID: 25187744, PMCID: PMC4149444, DOI: 10.2147/jbm.s61859.Peer-Reviewed Original ResearchPd-aPCCBypassing agentsBleeding episodesPlasma-derived activated prothrombin complex concentrateRecombinant activated factor VIIAdministration timeDosing Observational StudyProthrombin complex concentrateFirst-line treatmentInitiation of treatmentCongenital hemophiliaAdult patientsSingle doseRFVIIaCombination preparationFactor VIIObservational studyInfusion rateComplex concentratePatientsAdministered productsDoseAdministrationInfusionMinutesRole of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia
Szepietowska B, Horvath TL, Sherwin RS. Role of Synaptic Plasticity and EphA5-EphrinA5 Interaction Within the Ventromedial Hypothalamus in Response to Recurrent Hypoglycemia. Diabetes 2014, 63: 1140-1147. PMID: 24222347, PMCID: PMC3931406, DOI: 10.2337/db13-1259.Peer-Reviewed Original ResearchConceptsRecurrent hypoglycemiaVentromedial hypothalamusEphA5 receptorNondiabetic ratsCounterregulatory responsesSynaptic plasticityAntecedent recurrent hypoglycemiaCounterregulatory hormone releaseDefective glucose counterregulationExpression of ephrinA5Counterregulatory hormone responsesIntensive insulin treatmentInsulin-induced hypoglycemiaHyperinsulinemic-hypoglycemic clamp studyGlucose infusion rateHypoglycemic clamp studiesGlucose counterregulationSynaptic coverageHypoglycemic stimulusGlucagon secretionGlucagon releaseAcute hypoglycemiaInsulin treatmentHormone releaseInfusion rate
2013
High-dose midazolam infusion for refractory status epilepticus
Fernandez A, Lantigua H, Lesch C, Shao B, Foreman B, Schmidt JM, Hirsch LJ, Mayer SA, Claassen J. High-dose midazolam infusion for refractory status epilepticus. Neurology 2013, 82: 359-365. PMID: 24363133, PMCID: PMC3929199, DOI: 10.1212/wnl.0000000000000054.Peer-Reviewed Original ResearchConceptsHigh-dose groupRefractory status epilepticusLow-dose groupStatus epilepticusLower mortalityHigh-dose midazolam infusionLower seizure ratesStatus epilepticus onsetClass III evidenceLow-dose protocolHigher infusion ratesHospital complicationsHospital courseSeizure recurrenceBaseline characteristicsSeizure controlWithdrawal seizuresMedian timeDischarge mortalityMidazolam dosesMidazolam infusionSeizure rateWorse outcomesTreatment protocolInfusion rateClinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD
Ding YS, Naganawa M, Gallezot JD, Nabulsi N, Lin SF, Ropchan J, Weinzimmer D, McCarthy TJ, Carson RE, Huang Y, Laruelle M. Clinical doses of atomoxetine significantly occupy both norepinephrine and serotonin transports: Implications on treatment of depression and ADHD. NeuroImage 2013, 86: 164-171. PMID: 23933039, DOI: 10.1016/j.neuroimage.2013.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic Uptake InhibitorsAnimalsAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityBrainDepressionDose-Response Relationship, DrugMacaca mulattaNorepinephrine Plasma Membrane Transport ProteinsPositron-Emission TomographyPropylaminesSerotonin Plasma Membrane Transport ProteinsTissue DistributionConceptsTreatment of depressionNorepinephrine transporterComparative PET imaging studyMetabolite-corrected arterial input functionFinal infusion rateDoses of atomoxetineDose-dependent occupancyPET imaging studiesSelective serotonin transporter (SERT) ligandNon-human primatesPlasma levelsSelective blockadeSaline infusionClinical dosesTherapeutic effectInfusion rateRelevant dosePET scansAtomoxetineRelevant dosesSerotonin transporter ligandDistribution volumeImaging studiesRhesus monkeysArterial input function
2011
The safety of studies with intravenous Δ9-tetrahydrocannabinol in humans, with case histories
Carbuto M, Sewell RA, Williams A, Forselius-Bielen K, Braley G, Elander J, Pittman B, Schnakenberg A, Bhakta S, Perry E, Ranganathan M, D’Souza D, The Yale THC Study Group. The safety of studies with intravenous Δ9-tetrahydrocannabinol in humans, with case histories. Psychopharmacology 2011, 219: 885-896. PMID: 21845389, DOI: 10.1007/s00213-011-2417-y.Peer-Reviewed Original ResearchConceptsAdverse eventsPost-study periodCareful subject selectionMinor adverse eventsPhysical adverse eventsFrequent side effectsLong-term followCannabinoid receptor systemFaster infusion rateCannabinoid receptor ligandsIntravenous THCPlacebo infusionCannabinoid systemInfusion rateStudy participationSide effectsAbuse liabilityHigh dosesReceptor systemΔ9-tetrahydrocannabinolInfusionPsychoactive effectsReceptor ligandsTest daySubjects
2008
Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine
Edgerton DS, Cherrington AD, Neal DW, Scott M, Lautz M, Brown N, Petro J, Hobbs CH, Leach C, Del Parigi A, Strack TR. Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine. Journal Of Pharmacology And Experimental Therapeutics 2008, 328: 970-975. PMID: 19098161, PMCID: PMC3202424, DOI: 10.1124/jpet.108.146985.Peer-Reviewed Original ResearchConceptsInhalation of insulinPlasma glucose levelsGlucose levelsDiabetic patientsGlucose disposalNet hepatic glucose uptakeGlucose uptakeArterial plasma glucose levelsHepatic sinusoidal insulinBasal plasma levelsNonhepatic glucose uptakeGlucose infusion rateHepatic glucose uptakeInhalation groupInsulin inhalationSubcutaneous insulinPeripheral veinPlasma levelsPortal veinPlasma insulin kineticsInsulin secretionInfusion rateInsulin actionGlucose utilizationInhalationEffect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy
Swan KL, Dziura JD, Steil GM, Voskanyan GR, Sikes KA, Steffen AT, Martin ML, Tamborlane WV, Weinzimer SA. Effect of Age of Infusion Site and Type of Rapid-Acting Analog on Pharmacodynamic Parameters of Insulin Boluses in Youth With Type 1 Diabetes Receiving Insulin Pump Therapy. Diabetes Care 2008, 32: 240-244. PMID: 19017777, PMCID: PMC2628686, DOI: 10.2337/dc08-0595.Peer-Reviewed Original ResearchConceptsInsulin pump therapyGlucose infusion rateType 1 diabetesDay 1Day 4Pump therapyInsulin aspartPharmacodynamic parametersInsulin actionInsulin bolusRapid acting analogsEuglycemic clamp procedureExogenous glucose infusionGIR curveEffect of agePharmacodynamic measuresPharmacodynamic characteristicsClamp procedureInfusion siteGlucose infusionInfusion rateInsulin analoguesType 1AspartOverall insulin action
2001
Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats
Bergeron R, Previs S, Cline G, Perret P, Russell III R, Young L, Shulman G. Effect of 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Infusion on In Vivo Glucose and Lipid Metabolism in Lean and Obese Zucker Rats. Diabetes 2001, 50: 1076-1082. PMID: 11334411, DOI: 10.2337/diabetes.50.5.1076.Peer-Reviewed Original ResearchMeSH KeywordsAdenylate KinaseAminoimidazole CarboxamideAnimalsBlood GlucoseBody WeightFatty Acids, NonesterifiedGlucoseGlycerolInfusions, IntravenousInjections, IntravenousInsulinInsulin ResistanceLactatesMaleModels, AnimalMuscle, SkeletalObesityRatsRats, ZuckerReference ValuesRibonucleotidesTriglyceridesConceptsWhole-body glucose disposalInsulin-resistant rat modelObese ratsEndogenous glucose productionObese Zucker ratsRed gastrocnemius muscleInsulin infusion rateLean ratsGlucose disposalInsulin infusionRat modelInfusion rateGastrocnemius muscleZucker ratsLipid metabolismGlucose productionEndogenous glucose production rateGlucose transport activitySkeletal muscle glucose transport activityType 2 diabetesWhole-body carbohydrateInsulin-stimulated glucose uptakeInsulin-independent pathwaySkeletal muscle AMPKGlucose production rate
2000
Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [123I]epidepride SPECT in humans.
Varrone A, Fujita M, Verhoeff NP, Zoghbi SS, Baldwin RM, Rajeevan N, Charney DS, Seibyl JP, Innis RB. Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [123I]epidepride SPECT in humans. Journal Of Nuclear Medicine 2000, 41: 1343-51. PMID: 10945525.Peer-Reviewed Original ResearchConceptsTest-retest variabilityTemporal cortexTest-retest reproducibilityOutcome measuresExtrastriatal regionsD2 receptorsPlasma clearanceExtrastriatal dopamine D2 receptorsGood test-retest variabilityConstant infusion paradigmExtrastriatal D2 receptorsDopamine D2 receptorsBrain radioactivityStriatal radioactivityHealthy volunteersReceptor densityInfusion rateParent tracerSPECT studiesLess test-retest variabilityCortexHigh test-retest variabilityFree fractionReceptor quantificationReceptors
1999
Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle
Jucker B, Barucci N, Shulman G. Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle. American Journal Of Physiology 1999, 277: e505-e512. PMID: 10484363, DOI: 10.1152/ajpendo.1999.277.3.e505.Peer-Reviewed Original ResearchConceptsInsulin-stimulated glucose disposalGlucose transport/phosphorylationGlucose disposalHyperinsulinemic clampAwake ratsInfusion protocolGlycogen synthesisSkeletal muscleGlucose infusion rateMuscle glucose disposalSkeletal muscle glucose disposalProtocol IRat skeletal muscleRate of glycolysisInfusion rateHindlimb musclesMajority of controls
1998
Comparative Evaluation of Four Different Infusion Rates of Ropivacaine (2 mg/mL) for Epidural Labor Analgesia
Cascio M, Gaiser R, Camann W, Venkateswaran P, Hawkins J, McCarthy D. Comparative Evaluation of Four Different Infusion Rates of Ropivacaine (2 mg/mL) for Epidural Labor Analgesia. Regional Anesthesia & Pain Medicine 1998, 23: 548-553. DOI: 10.1097/00115550-199823060-00006.Peer-Reviewed Original ResearchConceptsVisual analog pain scaleML/hourMotor blockLabor analgesiaInfusion ratePain reliefBolus dosageHours groupNeurological adaptive capacity scoresEpidural infusion rateLess motor blockAnalog pain scaleLumbar epidural catheterLabor pain managementEpidural labor analgesiaInstitutional review board approvalReview board approvalAdaptive capacity scoresDifferent infusion ratesSatisfactory labor analgesiaBromage scaleRescue analgesiaApgar scoreEpidural catheterMost patients
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